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Dietary supplement

Tribulus 625 mg Caps Ingredients & Drug Interactions

by Optimum Nutrition

Tribulus 625 mg Caps label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Tribulus 625 mg Caps against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Tribulus 625 mg Caps is a dietary supplement by Optimum Nutrition with 2 active ingredients. Its ingredients are commonly taken for low libido and sexual function, athletic performance and muscle building, testosterone support.Based on those ingredients, 259 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Tribulus terrestris extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Tribulus 625 mg Caps by Optimum Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Tribulus 625 mg Caps by Optimum Nutrition — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Tribulus 625 mg Caps by Optimum Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.
  • “Proprietary Tribulus Blend” is a proprietary blend — the label gives one combined amount (625 mg) without saying how much of each component you get.

This product contains 2 active ingredients: a proprietary tribulus blend and tribulus terrestris extract. Both are the same botanical — tribulus terrestris — supplied in different forms to deliver 625 mg total per capsule.

The inactive ingredients are gelatin (the capsule), silica, and magnesium stearate (a binding agent).

Does it work?

Leans against
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Leans against

The strongest graded evidence we hold for the stated purpose leans against a benefit.

Why this rating?
  • The label markets this product for: athletic performance and strength support.
  • We looked for evidence on: Athletic performance, Exercise-induced muscle damage, Male infertility, Testosterone support, Muscle building, Sexual function.
  • The closest evidence on file: Tribulus is rated "Possibly Ineffective" for Athletic performance (Natural Medicines).
  • Also on file: Tribulus is rated "Insufficient Reliable Evidence To Rate" for Male infertility, Exercise-induced muscle damage.

Tribulus terrestris is possibly effective for sexual dysfunction based on clinical evidence we have on file. For athletic performance, the data suggests it's probably not effective — don't expect it to boost strength or endurance.

For benign prostatic hyperplasia (enlarged prostate), we don't yet have reliable evidence to rate it one way or the other.

The evidence, ingredient by ingredient Tribulus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Tribulus is generally well tolerated over the short term in healthy adults, but quality and long-term safety data are limited — we don't know much about what happens if you take it for months or years. Gastrointestinal upset (abdominal pain, nausea, vomiting, diarrhea, constipation) can occur, though in one study these complaints matched the rate seen with placebo.

Rare serious side effects including liver and kidney injury and seizures have been reported. Avoid this product if you're pregnant — it may affect hormones and safety hasn't been established.

Do not take it while breastfeeding due to lack of reliable safety information.

Side effects, ingredient by ingredient Tribulus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Tribulus.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications; lithium.
  • For scale: 259 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist before taking this if you're on blood pressure medications, diabetes medications, or lithium. All three carry Moderate-severity interaction risks — your blood pressure could drop too low, your blood sugar could tank, or lithium could build up to unsafe levels.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with graded evidence leaning against its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Tribulus may help with sexual function if that's your goal, but it's not effective for athletic performance. If you take blood pressure pills, diabetes medication, or lithium, you need to check with your pharmacist before starting — the interaction risk is real.

Steer clear if you're pregnant or nursing.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 24, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Tribulus 625 mg Caps, straight from the product label.

Brand Optimum Nutrition
Barcode (UPC) 748927023053
Net contents 100 Capsule(s)
Market status On market
Date entered into DSLD Mar 24, 2016
DSLD ID 57572
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Tribulus 625 mg Caps by Optimum Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
50
UPC/BARCODE
748927023053
IngredientAmount% DV
Proprietary Tribulus Blend625 mg--
Tribulus terrestris extract0 NP--
Tribulus terrestris0 NP--

Other ingredients: Gelatin, Silica, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

THE TRUE STRENGTH OF TRIBULUS Our tribulus 625 Caps are made with the finest standardized extracts and powders available, so they provide compounds unique to Tribulus terrestris.

Standardized tribulus extract blend

Precautions

WARNING: CONSULT YOUR PHYSICIAN BEFORE USING THIS PRODUCT IF YOU ARE TAKING ANY MEDICATIONS OR ARE UNDER A PHYSICIAN'S CARE FOR A MEDICAL CONDITION. NOT FOR USE BY THOSE UNDER THE AGE OF 18 OR WOMEN THAT ARE PREGNANT, TRYING TO GET PREGNANT, OR NURSING.

NOT FOR USE BY THOSE UNDER THE AGE OF 18 OR WOMEN THAT ARE PREGNANT, TRYING TO GET PREGNANT, OR NURSING.

General Statements

Intended for use in healthy adults and as part of a healthy, balanced diet and exercise program.

Brand IP Statement(s)

TRUE STRENGTH WWW.OPTIMUMNUTRITION.COM

General

V2.304.1215US 6036496

FDA Statement of Identity

DIETARY SUPPLEMENT

THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THIS PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT, CURE, OR PREVENT ANY DISEASE.

Suggested/Recommended/Usage/Directions

SUGGESTED USE: Consume 1-2 capsules daily with meals.

Storage

STORE IN A COOL, DRY PLACE.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Tribulus 625 mg Caps by Optimum Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Tribulus 625 mg Caps label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Tribulus 625 mg Caps by Optimum Nutrition

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container50 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Tribulus Blend

625 mg per serving

Other (inactive) ingredients: Gelatin, Silica, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Tribulus 625 mg Caps by Optimum Nutrition Drug Interactions

Want to check YOUR meds against Tribulus 625 mg Caps?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
259Drugs
259 Moderate

Ingredients driving the most interactions

Tribulus terrestris extract 259

Individual Drug Interactions

The ingredients in Tribulus 625 mg Caps interact with 259 drugs. Click any drug to see the details.

1 of the 2 ingredients in Tribulus 625 mg Caps interact with drugs. Each result below shows which ingredient is responsible. Tribulus terrestris extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Tribulus 625 mg Caps with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Tribulus terrestris extract3 drug types · 259 drugs

Antidiabetes Drugs

Taking tribulus with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that Tribulus can lower blood glucose levels in adults with type 2 diabetes who are taking antidiabetes medications.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that tribulus can lower blood pressure by inhibiting angiotensin-converting enzyme (ACE). Tribulus has also demonstrated hypotensive effects in pre-hypertensive adults.

Likelihood Possible Evidence D
Lithium

Theoretically, tribulus might increase the levels and clinical effects of lithium.
Tribulus is thought to have diuretic properties. Due to these potential diuretic effects, tribulus might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Tribulus terrestris extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Tribulus 625 mg Caps, from the product label.

Optimum Nutrition

Name
Optimum Nutrition, Inc.
Street Address
3500 Lacey Road, Suite 1200
City
Downers Grove
State
IL
ZipCode
60515
Phone Number
1(800)705-5226
Pharmacist Counseling Corner

Tribulus 625 mg Caps by Optimum Nutrition: Common Questions

Does Tribulus 625 mg Caps by Optimum Nutrition interact with any medications?
Yes. Based on its ingredients, Tribulus 625 mg Caps has a known interaction with 259 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Tribulus 625 mg Caps contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is tribulus terrestris used for?
The evidence supports its use for sexual dysfunction — it's possibly effective for that. It's not effective for athletic performance, and we don't have enough reliable data to say whether it works for enlarged prostate.
Can I take this if I'm pregnant or breastfeeding?
No — avoid it during pregnancy because it may affect hormones and safety hasn't been established. Don't take it while breastfeeding either, since we don't have reliable safety information for that.
What side effects might I get?
Most people tolerate it well, but some experience stomach upset — abdominal pain, nausea, vomiting, diarrhea, or constipation. Serious side effects like liver or kidney injury and seizures are rare but have been reported.
How long can I safely take tribulus?
Short-term use in healthy adults is generally well tolerated, but we have limited data on long-term safety. Talk with your pharmacist about how long you plan to use it.
Does this product have fillers?
Yes — it contains gelatin (capsule material), silica, and magnesium stearate as inactive ingredients to hold the capsule together and help it dissolve.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Tribulus 625 mg Caps is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Tribulus 625 mg Caps label
Go deeper

The Full Monographs Behind Tribulus 625 mg Caps’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Tribulus

Interacts with 259 drugs

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims is weak and inconsistent. It is general...

Read the full Tribulus monograph →
Sources

Sources & How We Checked

Tribulus 625 mg Caps's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 10 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Tribulus 10 references
  1. Sharifi AM, Darabi R, Akbarloo N. Study of antihypertensive mechanism of Tribulus terrestris in 2K1C hypertensive rats: role of tissue ACE activity. Life Sci 2003;73:2963-71. PubMed
  2. Walker D, Bird A, Flora T, O'Sullivan B. Some effects of feeding Tribulus terrestris, Ipomoea lonchophylla and the seed of Abelmoschus ficulneus on fetal development and the outcome of pregnancy in sheep. Reprod Fertil Dev 1992;4:135-44. PubMed
  3. Al-Ali M, Wahbi S, Twaij H, Al-Badr A. Tribulus terrestris: preliminary study of its diuretic and contractile effects and comparison with Zea mays. J Ethnopharmacol 2003;85:257-60. PubMed
  4. Tabakova, P., Dimitrov, M., Ognyanov, K., and et al. Clinical study of Tribestan in females with endocrine sterility. Documentation for Registration (unpublished) 1999.
  5. Akhtari E, Raisi F, Keshavarz M, et al. Tribulus terrestris for treatment of sexual dysfunction in women: randomized double-blind placebo-controlled study. Daru 2014;22:40. PubMed
  6. Ryan M, Lazar I, Nadasdy GM, et al. Acute kidney injury and hyperbilirubinemia in a young male after ingestion of Tribulus terrestris. Clin Nephrol 2015;83(3):177-83. PubMed
  7. Postigo S, Lima SM, Yamada SS, et al. Assessment of the effects of Tribulus terrestris on sexual function of menopausal women. Rev Bras Ginecol Obstet 2016;38(3):140-6. PubMed
  8. Talasaz AH, Abbasi MR, Abkhiz S, Dashti-Khavidaki S. Tribulus terrestris-induced severe nephrotoxicity in a young healthy male. Nephrol Dial Tranplant 2010;25(11):3792-3. PubMed
  9. Samani NB, Jokar A, Soveid M, Heydari M, Mosavat SH. Efficacy of the hydroalcoholic extract of Tribulus terrestris on the serum glucose and lipid profile of women with diabetes mellitus: a double-blind randomized placebo-controlled clinical trial. J Evid
  10. Siddiqui MA, Itrat M, Mobeen A, Khan MI. Efficacy of khar-i-khasak (Tribulus terrestris Linn.) in prehypertension: a randomized, double-blind, placebo-controlled trial. J Complement Integr Med. 2021.

See these in context on the Tribulus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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