Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Tribulus 625 mg Caps Ingredients & Drug Interactions

by Optimum Nutrition

Tribulus 625 mg Caps label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Tribulus 625 mg Caps against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Tribulus 625 mg Caps is a dietary supplement by Optimum Nutrition with 2 active ingredients. Its ingredients are commonly taken for low libido and sexual function, athletic performance and muscle building, testosterone support.Based on those ingredients, 259 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Tribulus terrestris extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Tribulus 625 mg Caps by Optimum Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Tribulus 625 mg Caps by Optimum Nutrition — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Tribulus 625 mg Caps by Optimum Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 17, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.
  • “Proprietary Tribulus Blend” is a proprietary blend — the label gives one combined amount (625 mg) without saying how much of each component you get.

This product contains 2 active ingredients, both tribulus. The first is a Proprietary Tribulus Blend—a mix of tribulus components—and the second is a Tribulus terrestris extract.

Together they make up the 625 mg dose. The capsule itself is filled with gelatin, silica, and magnesium stearate (a flow agent to keep powder moving during manufacturing).

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Tribulus's overall clinical evidence instead.

Moderate

Some clinical evidence supports Tribulus for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Sexual dysfunction — rated "Possibly Effective" (Natural Medicines).

Tribulus is possibly effective for sexual dysfunction—that's where the evidence leans. For athletic performance, it appears possibly ineffective.

The data on benign prostatic hyperplasia (BPH), a prostate condition that makes urination harder, is too thin to say either way. Short-term, it's usually well tolerated in healthy people, but long-term safety data aren't robust.

The evidence, ingredient by ingredient Tribulus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Tribulus is generally well tolerated over short periods in healthy adults, though quality and long-term data are limited. Rare serious side effects include liver and kidney injury, seizures, and long-lasting painful erections.

Stomach upset—cramping, nausea, diarrhea, constipation—can occur, but in one study these complaints were no more common than placebo. Avoid this supplement during pregnancy because it may affect your hormones and its safety isn't established.

Also avoid it while breastfeeding due to lack of reliable safety data.

Side effects, ingredient by ingredient Tribulus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Tribulus.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications; lithium.
  • For scale: 259 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Tribulus 625 mg, double-check with your pharmacist or doctor if you're on blood pressure medication (antihypertensives), diabetes medication, or lithium. All three are Moderate-severity interactions.

Tribulus can lower your pressure and blood sugar and may increase lithium levels in your system.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Tribulus may help with sexual function based on current evidence, but it's not proven for athletic performance and the data on prostate issues is unclear. If you take blood pressure medication, diabetes drugs, or lithium, you need to talk with your doctor or pharmacist before adding this—the interactions are real enough to warrant a check.

Overall, it's short-term well tolerated in healthy people, but long-term safety isn't well studied.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 24, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Tribulus 625 mg Caps, straight from the product label.

Brand Optimum Nutrition
Barcode (UPC) 748927023053
Net contents 100 Capsule(s)
Market status On market
Date entered into DSLD Mar 24, 2016
DSLD ID 57572
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Tribulus 625 mg Caps by Optimum Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
50
UPC/BARCODE
748927023053
IngredientAmount% DV
Proprietary Tribulus Blend625 mg--
Tribulus terrestris extract0 NP--
Tribulus terrestris0 NP--

Other ingredients: Gelatin, Silica, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

THE TRUE STRENGTH OF TRIBULUS Our tribulus 625 Caps are made with the finest standardized extracts and powders available, so they provide compounds unique to Tribulus terrestris.

Standardized tribulus extract blend

Precautions

WARNING: CONSULT YOUR PHYSICIAN BEFORE USING THIS PRODUCT IF YOU ARE TAKING ANY MEDICATIONS OR ARE UNDER A PHYSICIAN'S CARE FOR A MEDICAL CONDITION. NOT FOR USE BY THOSE UNDER THE AGE OF 18 OR WOMEN THAT ARE PREGNANT, TRYING TO GET PREGNANT, OR NURSING.

NOT FOR USE BY THOSE UNDER THE AGE OF 18 OR WOMEN THAT ARE PREGNANT, TRYING TO GET PREGNANT, OR NURSING.

General Statements

Intended for use in healthy adults and as part of a healthy, balanced diet and exercise program.

Brand IP Statement(s)

TRUE STRENGTH WWW.OPTIMUMNUTRITION.COM

General

V2.304.1215US 6036496

FDA Statement of Identity

DIETARY SUPPLEMENT

THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THIS PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT, CURE, OR PREVENT ANY DISEASE.

Suggested/Recommended/Usage/Directions

SUGGESTED USE: Consume 1-2 capsules daily with meals.

Storage

STORE IN A COOL, DRY PLACE.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Tribulus 625 mg Caps by Optimum Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Tribulus 625 mg Caps label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Tribulus 625 mg Caps by Optimum Nutrition

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container50 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Tribulus Blend

625 mg per serving

Other (inactive) ingredients: Gelatin, Silica, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Tribulus 625 mg Caps by Optimum Nutrition Drug Interactions

Want to check YOUR meds against Tribulus 625 mg Caps?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
259Drugs
259 Moderate

Ingredients driving the most interactions

Tribulus terrestris extract 259

Individual Drug Interactions

The ingredients in Tribulus 625 mg Caps interact with 259 drugs. Click any drug to see the details.

1 of the 2 ingredients in Tribulus 625 mg Caps interact with drugs. Each result below shows which ingredient is responsible. Tribulus terrestris extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Tribulus 625 mg Caps with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Tribulus terrestris extract3 drug types · 259 drugs

Antidiabetes Drugs

Taking tribulus with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that Tribulus can lower blood glucose levels in adults with type 2 diabetes who are taking antidiabetes medications.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that tribulus can lower blood pressure by inhibiting angiotensin-converting enzyme (ACE). Tribulus has also demonstrated hypotensive effects in pre-hypertensive adults.

Likelihood Possible Evidence D
Lithium

Theoretically, tribulus might increase the levels and clinical effects of lithium.
Tribulus is thought to have diuretic properties. Due to these potential diuretic effects, tribulus might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Tribulus terrestris extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Tribulus 625 mg Caps, from the product label.

Optimum Nutrition

Name
Optimum Nutrition, Inc.
Street Address
3500 Lacey Road, Suite 1200
City
Downers Grove
State
IL
ZipCode
60515
Phone Number
1(800)705-5226
Pharmacist Counseling Corner

Tribulus 625 mg Caps by Optimum Nutrition: Common Questions

Does Tribulus 625 mg Caps by Optimum Nutrition interact with any medications?
Yes. Based on its ingredients, Tribulus 625 mg Caps has a known interaction with 259 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Tribulus 625 mg Caps contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
No. The safety data advise against it during pregnancy because tribulus may affect your hormones and safety isn't established. While breastfeeding, there's not enough reliable safety information, so it's best to avoid it then too. Talk with your doctor or pharmacist about your specific situation.
What side effects should I watch for?
Most people tolerate it okay, but you may notice stomach cramping, nausea, diarrhea, or constipation—though these are no more common than placebo in one study. Serious side effects are rare but have included liver or kidney problems, seizures, and in one case, severe weakness and kidney injury after very high doses.
Will this help with athletic performance?
The evidence suggests it's probably not effective for athletic performance. It may help with sexual function, but boosting strength or endurance isn't supported by the current data.
How long does it take to work for sexual dysfunction?
The facts don't tell us that. What we know is that tribulus is possibly effective for sexual dysfunction, but the timeline and individual results vary. Your pharmacist or doctor can give you better guidance on timing and what to expect.
What exactly is in this capsule besides the tribulus?
The capsule itself is made of gelatin and filled with silica (a drying agent) and magnesium stearate (which keeps the powder flowing smoothly during manufacturing). These are standard inactive ingredients, not active ones.
Is this safe to use long-term?
Short-term it's usually well tolerated in healthy people, but we don't have solid long-term safety data. Quality studies are limited. If you're thinking about using it beyond a short period, check with your doctor or pharmacist about what makes sense for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Tribulus 625 mg Caps is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Tribulus 625 mg Caps label
Go deeper

The Full Monographs Behind Tribulus 625 mg Caps’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Tribulus

Interacts with 259 drugs

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims is weak and inconsistent. It is general...

Read the full Tribulus monograph →
Sources

Sources & How We Checked

Tribulus 625 mg Caps's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 10 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Tribulus 10 references
  1. Sharifi AM, Darabi R, Akbarloo N. Study of antihypertensive mechanism of Tribulus terrestris in 2K1C hypertensive rats: role of tissue ACE activity. Life Sci 2003;73:2963-71. PubMed
  2. Walker D, Bird A, Flora T, O'Sullivan B. Some effects of feeding Tribulus terrestris, Ipomoea lonchophylla and the seed of Abelmoschus ficulneus on fetal development and the outcome of pregnancy in sheep. Reprod Fertil Dev 1992;4:135-44. PubMed
  3. Al-Ali M, Wahbi S, Twaij H, Al-Badr A. Tribulus terrestris: preliminary study of its diuretic and contractile effects and comparison with Zea mays. J Ethnopharmacol 2003;85:257-60. PubMed
  4. Tabakova, P., Dimitrov, M., Ognyanov, K., and et al. Clinical study of Tribestan in females with endocrine sterility. Documentation for Registration (unpublished) 1999.
  5. Akhtari E, Raisi F, Keshavarz M, et al. Tribulus terrestris for treatment of sexual dysfunction in women: randomized double-blind placebo-controlled study. Daru 2014;22:40. PubMed
  6. Ryan M, Lazar I, Nadasdy GM, et al. Acute kidney injury and hyperbilirubinemia in a young male after ingestion of Tribulus terrestris. Clin Nephrol 2015;83(3):177-83. PubMed
  7. Postigo S, Lima SM, Yamada SS, et al. Assessment of the effects of Tribulus terrestris on sexual function of menopausal women. Rev Bras Ginecol Obstet 2016;38(3):140-6. PubMed
  8. Talasaz AH, Abbasi MR, Abkhiz S, Dashti-Khavidaki S. Tribulus terrestris-induced severe nephrotoxicity in a young healthy male. Nephrol Dial Tranplant 2010;25(11):3792-3. PubMed
  9. Samani NB, Jokar A, Soveid M, Heydari M, Mosavat SH. Efficacy of the hydroalcoholic extract of Tribulus terrestris on the serum glucose and lipid profile of women with diabetes mellitus: a double-blind randomized placebo-controlled clinical trial. J Evid
  10. Siddiqui MA, Itrat M, Mobeen A, Khan MI. Efficacy of khar-i-khasak (Tribulus terrestris Linn.) in prehypertension: a randomized, double-blind, placebo-controlled trial. J Complement Integr Med. 2021.

See these in context on the Tribulus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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