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Dietary supplement

Tribulus Black 1300 Ingredients & Drug Interactions

by Nutrex Research Black Series

Tribulus Black 1300 label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Tribulus Black 1300 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Tribulus Black 1300 is a dietary supplement by Nutrex Research Black Series with 1 active ingredient. Its ingredients are commonly taken for low libido and sexual function, athletic performance and muscle building, testosterone support.Based on those ingredients, 259 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Tribulus terrestris (fruit) extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Tribulus Black 1300 by Nutrex Research Black Series

Ask about any prescription or over-the-counter medication and we check it for interactions with Tribulus Black 1300 by Nutrex Research Black Series — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Tribulus Black 1300 by Nutrex Research Black Series

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Tribulus Black 1300 contains one active ingredient: tribulus terrestris fruit extract at 1,300 mg per dose. Tribulus is a plant used traditionally and studied for sexual function and athletic performance.

The capsule itself is made from cellulose and filled with inactive ingredients including vegetable stearates, silicon dioxide, and food colorings (FD&C Blue No. 1 and FD&C Red No.

40).

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Natural testosterone support for male vitality and strength.
  • We looked for evidence on: Athletic performance, Exercise-induced muscle damage, Male infertility, Erectile dysfunction (ED), Sexual dysfunction, Testosterone levels — and 2 related terms.
  • The strongest evidence on file: Tribulus is rated "Possibly Effective" for Sexual dysfunction (Natural Medicines).
  • Also on file: Tribulus is rated "Possibly Ineffective" for Athletic performance.
  • Also on file: Tribulus is rated "Insufficient Reliable Evidence To Rate" for Erectile dysfunction (ED), Male infertility, Exercise-induced muscle damage.

Tribulus terrestris is rated possibly effective for sexual dysfunction — the clinical evidence suggests it may help, though more research would strengthen that confidence. For athletic performance, the data we hold rates it possibly ineffective, meaning evidence doesn't currently support its use for that goal.

For benign prostatic hyperplasia (enlarged prostate), we have insufficient reliable evidence to rate it either way.

The evidence, ingredient by ingredient Tribulus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Orally, tribulus is generally well tolerated in the short term by healthy adults, but long-term safety data are limited and quality varies depending on the source. Gastrointestinal side effects — abdominal pain, cramping, nausea, vomiting, diarrhea, and constipation — can occur, though in one study these rates matched placebo.

Serious adverse effects are rare but have been reported, including liver and kidney injury, seizures, and painful erection with sexual dysfunction. One case tied extremely high intake (2 liters of tribulus water daily for two days) to weakness, seizures, hepatitis, and acute kidney injury.

During pregnancy, safety is not established and tribulus may affect hormones, so it should be avoided. The same goes for breastfeeding — there isn't reliable safety information, so it's best to skip it while nursing.

Side effects, ingredient by ingredient Tribulus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Tribulus.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications; lithium.
  • For scale: 259 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start Tribulus Black 1300, check whether you take blood pressure medications (antihypertensive drugs), diabetes medications (antidiabetes drugs), or lithium. All three have Moderate interactions with tribulus and require a conversation with your pharmacist about whether this product is right for you.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Tribulus may help with sexual dysfunction, but it's only one of many options and your mileage will vary. If you take blood pressure medication, diabetes medication, or lithium, you need to check this product first — it can interact with all three and change how your drugs work.

Talk to your pharmacist before starting, especially if you're pregnant, breastfeeding, or on any regular medication.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 24, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Tribulus Black 1300, straight from the product label.

Brand Nutrex Research Black Series
Barcode (UPC) 859400007412
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Aug 24, 2023
DSLD ID 288674
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Women (not pregnant or lactating), Adult Male (18-50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Tribulus Black 1300 by Nutrex Research Black Series, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
60
UPC/BARCODE
859400007412
IngredientAmount% DV
Tribulus terrestris (fruit) extract1300 mg--

Other ingredients: Cellulose, vegetable stearates, Silicon Dioxide, FD&C Blue No. 1, FD&C Red No. 40

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Natural testosterone support

Renews vitality, energy & stamina Helps support muscle & strength

Testosterone support

Maximum strength

Formula

Helps enhance male performance

Tribulus Black 1300 utilizes a potent extract of 1300 mg Tribulus Terrestris per serving to help support and strengthen healthy testosterone levels.

It is a great natural choice for the active male to aid in vitality, muscle recovery and strength.

Precautions

Warning: This product is intended to be used by normal healthy adults and should not be taken by anyone with any known medical conditions.

Do not use if pregnant or nursing.

Not intended for individuals under the age of 18. Keep out of reach of children.

Do not use if packaging has been tampered with.

Storage

Store out of sunlight in a cool, dry place (60 degrees F to 80 degrees F).

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Recommended use: Take 2 capsules once a day with water. This product can be taken with or without food. Use daily for best results.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Tribulus Black 1300 by Nutrex Research Black Series label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Tribulus Black 1300 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Tribulus Black 1300 by Nutrex Research Black Series

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Tribulus terrestris (fruit) extract

Interacts with
259 drugs
1300 mg per serving Form: Saponins

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims...

Tribulus terrestris (fruit) extract monograph & interactions

Other (inactive) ingredients: Cellulose, Vegetable stearates, Silicon Dioxide, FD&C Blue No. 1, FD&C Red No. 40. These complete the product’s ingredient list but are not active constituents.

Interaction report

Tribulus Black 1300 by Nutrex Research Black Series Drug Interactions

Want to check YOUR meds against Tribulus Black 1300?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
259Drugs
259 Moderate

Ingredients driving the most interactions

Tribulus terrestris (fruit) extract 259

Individual Drug Interactions

The ingredients in Tribulus Black 1300 interact with 259 drugs. Click any drug to see the details.

1 of the 1 ingredient in Tribulus Black 1300 interact with drugs. Each result below shows which ingredient is responsible. Tribulus terrestris (fruit) extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Tribulus Black 1300 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Tribulus terrestris (fruit) extract3 drug types · 259 drugs

Antidiabetes Drugs

Taking tribulus with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that Tribulus can lower blood glucose levels in adults with type 2 diabetes who are taking antidiabetes medications.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that tribulus can lower blood pressure by inhibiting angiotensin-converting enzyme (ACE). Tribulus has also demonstrated hypotensive effects in pre-hypertensive adults.

Likelihood Possible Evidence D
Lithium

Theoretically, tribulus might increase the levels and clinical effects of lithium.
Tribulus is thought to have diuretic properties. Due to these potential diuretic effects, tribulus might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Tribulus terrestris (fruit) extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Tribulus Black 1300, from the product label.

Nutrex Research Black Series

See all Nutrex Research Black Series products
Name
Nutrex Research, Inc.
City
Oviedo
State
FL
ZipCode
32765
Phone Number
1-888-368-8739
Web Address
Nutrex.com
Pharmacist Counseling Corner

Tribulus Black 1300 by Nutrex Research Black Series: Common Questions

Does Tribulus Black 1300 by Nutrex Research Black Series interact with any medications?
Yes. Based on its ingredients, Tribulus Black 1300 has a known interaction with 259 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Tribulus Black 1300 contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help with sexual function?
Tribulus is rated possibly effective for sexual dysfunction, meaning clinical evidence suggests it may help some people, though more research would make us more confident in that claim. Results vary, and it's one option among several — talk to your pharmacist about what might work best for your situation.
Can I take this if I'm trying to improve athletic performance?
The data we have rates tribulus as possibly ineffective for athletic performance, so evidence doesn't currently support using it for that goal. If you're an athlete, there may be better-studied options to discuss with your pharmacist.
Is tribulus safe to take long-term?
Tribulus is often well tolerated in the short term, but long-term safety data are limited. Quality also varies depending on where the product comes from. If you're thinking about taking it regularly, check with your pharmacist about what the current evidence suggests for your specific situation.
What side effects might I notice?
Common side effects are mostly gastrointestinal — abdominal pain, cramping, nausea, vomiting, diarrhea, or constipation. Interestingly, in one study these rates were similar to placebo. Serious effects like liver or kidney injury are rare but have been reported in isolated cases.
Can I take this while pregnant or breastfeeding?
No — tribulus should be avoided during pregnancy because it may affect hormones and safety isn't established. The same applies to breastfeeding, where there isn't enough reliable safety information. Talk to your doctor or pharmacist if you're pregnant, planning to become pregnant, or nursing.
What's in the capsule besides the active ingredient?
The capsule itself is cellulose, and it contains vegetable stearates, silicon dioxide, and two food colorings: FD&C Blue No. 1 and FD&C Red No. 40. These are all inactive fillers and binders.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Tribulus Black 1300 is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Tribulus Black 1300 label
Go deeper

The Full Monographs Behind Tribulus Black 1300’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Tribulus

Interacts with 259 drugs

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims is weak and inconsistent. It is general...

Read the full Tribulus monograph →
Sources

Sources & How We Checked

Tribulus Black 1300's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 10 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Tribulus 10 references
  1. Sharifi AM, Darabi R, Akbarloo N. Study of antihypertensive mechanism of Tribulus terrestris in 2K1C hypertensive rats: role of tissue ACE activity. Life Sci 2003;73:2963-71. PubMed
  2. Walker D, Bird A, Flora T, O'Sullivan B. Some effects of feeding Tribulus terrestris, Ipomoea lonchophylla and the seed of Abelmoschus ficulneus on fetal development and the outcome of pregnancy in sheep. Reprod Fertil Dev 1992;4:135-44. PubMed
  3. Al-Ali M, Wahbi S, Twaij H, Al-Badr A. Tribulus terrestris: preliminary study of its diuretic and contractile effects and comparison with Zea mays. J Ethnopharmacol 2003;85:257-60. PubMed
  4. Tabakova, P., Dimitrov, M., Ognyanov, K., and et al. Clinical study of Tribestan in females with endocrine sterility. Documentation for Registration (unpublished) 1999.
  5. Akhtari E, Raisi F, Keshavarz M, et al. Tribulus terrestris for treatment of sexual dysfunction in women: randomized double-blind placebo-controlled study. Daru 2014;22:40. PubMed
  6. Ryan M, Lazar I, Nadasdy GM, et al. Acute kidney injury and hyperbilirubinemia in a young male after ingestion of Tribulus terrestris. Clin Nephrol 2015;83(3):177-83. PubMed
  7. Postigo S, Lima SM, Yamada SS, et al. Assessment of the effects of Tribulus terrestris on sexual function of menopausal women. Rev Bras Ginecol Obstet 2016;38(3):140-6. PubMed
  8. Talasaz AH, Abbasi MR, Abkhiz S, Dashti-Khavidaki S. Tribulus terrestris-induced severe nephrotoxicity in a young healthy male. Nephrol Dial Tranplant 2010;25(11):3792-3. PubMed
  9. Samani NB, Jokar A, Soveid M, Heydari M, Mosavat SH. Efficacy of the hydroalcoholic extract of Tribulus terrestris on the serum glucose and lipid profile of women with diabetes mellitus: a double-blind randomized placebo-controlled clinical trial. J Evid
  10. Siddiqui MA, Itrat M, Mobeen A, Khan MI. Efficacy of khar-i-khasak (Tribulus terrestris Linn.) in prehypertension: a randomized, double-blind, placebo-controlled trial. J Complement Integr Med. 2021.

See these in context on the Tribulus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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