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Dietary supplement

Tribulus Terrestris 1.25 g Ingredients & Drug Interactions

by Bodybuilding.com Foundation Series

Tribulus Terrestris 1.25 g label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Tribulus Terrestris 1.25 g against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Tribulus Terrestris 1.25 g is a dietary supplement by Bodybuilding.com Foundation Series with 1 active ingredient. Its ingredients are commonly taken for low libido and sexual function, athletic performance and muscle building, testosterone support.Based on those ingredients, 259 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Tribulus extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Tribulus Terrestris 1.25 g by Bodybuilding.com Foundation Series

Ask about any prescription or over-the-counter medication and we check it for interactions with Tribulus Terrestris 1.25 g by Bodybuilding.com Foundation Series — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Tribulus Terrestris 1.25 g by Bodybuilding.com Foundation Series

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: tribulus extract at 1.25 g per capsule. The capsule itself is made from gelatin, and the formula includes magnesium stearate, silica, and microcrystalline cellulose as inactive ingredients to help with absorption and shelf stability.

Does it work?

Leans against
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Leans against

The strongest graded evidence we hold for the stated purpose leans against a benefit.

Why this rating?
  • The label markets this product for: Performance support.
  • We looked for evidence on: Athletic performance, Exercise-induced muscle damage, Muscle strength, Endurance, Sports recovery.
  • The closest evidence on file: Tribulus is rated "Possibly Ineffective" for Athletic performance (Natural Medicines).
  • Also on file: Tribulus is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced muscle damage.

The evidence supports that tribulus is possibly effective for sexual dysfunction. That rating appears multiple times in our data, so it's the strongest claim we can make for this ingredient.

For athletic performance, the evidence leans toward possibly ineffective. For benign prostatic hyperplasia (enlarged prostate), we don't have enough reliable evidence to rate it one way or the other.

The evidence, ingredient by ingredient Tribulus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Tribulus is generally well tolerated in the short term for healthy adults, but quality and long-term safety data are limited — so we don't have great information on what happens if you take it for months or years. Serious side effects are rare, but cases of liver and kidney injury, seizures, and chronic painful erection have been reported.

Gastrointestinal complaints like nausea, cramping, and diarrhea can occur, though in one study they happened at similar rates in people taking tribulus and those taking placebo. Do not take tribulus during pregnancy — it may affect hormones and safety is not established.

Avoid it while breastfeeding as well, since we don't have reliable safety information for nursing infants.

Side effects, ingredient by ingredient Tribulus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Tribulus.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications; lithium.
  • For scale: 259 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your blood pressure medications (antihypertensives), diabetes medications, and lithium before you start. All three have Moderate interactions with tribulus.

Use the medication search tool on this page to verify your exact drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with graded evidence leaning against its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Tribulus may help with sexual dysfunction, but the evidence is modest. It's generally well tolerated short-term, though long-term safety data are thin.

If you take blood pressure or diabetes medications, or lithium, talk with your pharmacist before starting — the interactions could require dose adjustments. Pregnant and nursing women should skip it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 22, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Tribulus Terrestris 1.25 g, straight from the product label.

Brand Bodybuilding.com Foundation Series
Barcode (UPC) 000633
Net contents 100 Capsule(s)
Market status On market
Date entered into DSLD Sep 22, 2016
DSLD ID 64266
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Tribulus Terrestris 1.25 g by Bodybuilding.com Foundation Series, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
50
UPC/BARCODE
000633
IngredientAmount% DV
Tribulus extract1.25 Gram(s)--

Other ingredients: Gelatin, Magnesium Stearate, Silica, Microcrystalline Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Foundation Series

Bodybuilding.com products have been formulated to the highest standards with high-quality, effective ingredients that product real results. If you are not completely satisfied with any product, return it any time for a full refund.

Performance Support Tribulus Terrestris is a vine plant that has a long history of use. People around the world have turned to Tribulus Terrestis as an herbal supplement. Supplement with Bodybuilding.com Tribulus Terrestris to support your results!*

BBCOM633- 110816 - V9

Sports Nutrition

This product was produced in a GMP facility. Good Manufacturing Practices, or GMPs, are a set of standards which ensure the purity and proper labeling of dietary supplements.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Precautions

Allergen Information: This product is manufactured in a facility that uses materials containing milk, soy, wheat, egg, fish and shellfish.

Warnings: Consult your physician before using this or any other dietary supplement.

Do not use if you are pregnant or nursing.

Not intended for use by persons under the age of 18.

This product contains chemicals known to the State of California to cause cancer and birth defects or reproductive harm.

Suggested/Recommended/Usage/Directions

Directions: Take one serving 1-2 times daily with meals.

Storage

Store at room temperature.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Tribulus Terrestris 1.25 g by Bodybuilding.com Foundation Series label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Tribulus Terrestris 1.25 g label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Tribulus Terrestris 1.25 g by Bodybuilding.com Foundation Series

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container50 Amounts shown are per serving.

Tribulus extract

Interacts with
259 drugs
1.25 Gram(s) per serving Form: Saponins

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims...

Tribulus extract monograph & interactions

Other (inactive) ingredients: Gelatin, Magnesium Stearate, Silica, Microcrystalline Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Tribulus Terrestris 1.25 g by Bodybuilding.com Foundation Series Drug Interactions

Want to check YOUR meds against Tribulus Terrestris 1.25 g?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
259Drugs
259 Moderate

Ingredients driving the most interactions

Tribulus extract 259

Individual Drug Interactions

The ingredients in Tribulus Terrestris 1.25 g interact with 259 drugs. Click any drug to see the details.

1 of the 1 ingredient in Tribulus Terrestris 1.25 g interact with drugs. Each result below shows which ingredient is responsible. Tribulus extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Tribulus Terrestris 1.25 g with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Tribulus extract3 drug types · 259 drugs

Antidiabetes Drugs

Taking tribulus with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that Tribulus can lower blood glucose levels in adults with type 2 diabetes who are taking antidiabetes medications.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that tribulus can lower blood pressure by inhibiting angiotensin-converting enzyme (ACE). Tribulus has also demonstrated hypotensive effects in pre-hypertensive adults.

Likelihood Possible Evidence D
Lithium

Theoretically, tribulus might increase the levels and clinical effects of lithium.
Tribulus is thought to have diuretic properties. Due to these potential diuretic effects, tribulus might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Tribulus extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Tribulus Terrestris 1.25 g, from the product label.

Bodybuilding.com Foundation Series

See all Bodybuilding.com Foundation Series products
Name
Bodybuilding.com
Street Address
4900 Engineers Way, Suite 107
City
N. Las Vegas
State
Nevada
ZipCode
89081
Phone Number
1-866-236-8417
Pharmacist Counseling Corner

Tribulus Terrestris 1.25 g by Bodybuilding.com Foundation Series: Common Questions

Does Tribulus Terrestris 1.25 g by Bodybuilding.com Foundation Series interact with any medications?
Yes. Based on its ingredients, Tribulus Terrestris 1.25 g has a known interaction with 259 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Tribulus Terrestris 1.25 g contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does tribulus actually work for sexual dysfunction?
The evidence says it's possibly effective — meaning some research supports it, but the data aren't rock-solid. It's worth discussing with your doctor or pharmacist if you're curious about trying it.
Can I take this if I'm trying to improve my athletic performance?
The evidence suggests tribulus is possibly ineffective for athletic performance, so it's not a reliable choice for that goal. You'd be better off talking with a coach or sports dietitian about other options.
What side effects should I watch for?
Most people tolerate it well. You might notice stomach upset — nausea, cramping, diarrhea, or constipation — but those also happen in people taking placebo. Serious effects like liver or kidney injury are rare but have been reported.
Is it safe to take long-term?
We have good short-term safety data for healthy adults, but long-term safety information is limited. If you're thinking about taking it for months, check in with your pharmacist about what we know and don't know.
Can I take this while pregnant or breastfeeding?
No — avoid it during pregnancy because it may affect hormones and safety isn't established. Avoid it while breastfeeding too, since we don't have reliable safety data for nursing infants.
What is tribulus used for?
It's most commonly taken for sexual dysfunction. There's also interest in it for benign prostatic hyperplasia (enlarged prostate), though we don't have enough evidence to say how well it works for that.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Tribulus Terrestris 1.25 g is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Tribulus Terrestris 1.25 g label
Go deeper

The Full Monographs Behind Tribulus Terrestris 1.25 g’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Tribulus

Interacts with 259 drugs

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims is weak and inconsistent. It is general...

Read the full Tribulus monograph →
Sources

Sources & How We Checked

Tribulus Terrestris 1.25 g's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 10 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Tribulus 10 references
  1. Sharifi AM, Darabi R, Akbarloo N. Study of antihypertensive mechanism of Tribulus terrestris in 2K1C hypertensive rats: role of tissue ACE activity. Life Sci 2003;73:2963-71. PubMed
  2. Walker D, Bird A, Flora T, O'Sullivan B. Some effects of feeding Tribulus terrestris, Ipomoea lonchophylla and the seed of Abelmoschus ficulneus on fetal development and the outcome of pregnancy in sheep. Reprod Fertil Dev 1992;4:135-44. PubMed
  3. Al-Ali M, Wahbi S, Twaij H, Al-Badr A. Tribulus terrestris: preliminary study of its diuretic and contractile effects and comparison with Zea mays. J Ethnopharmacol 2003;85:257-60. PubMed
  4. Tabakova, P., Dimitrov, M., Ognyanov, K., and et al. Clinical study of Tribestan in females with endocrine sterility. Documentation for Registration (unpublished) 1999.
  5. Akhtari E, Raisi F, Keshavarz M, et al. Tribulus terrestris for treatment of sexual dysfunction in women: randomized double-blind placebo-controlled study. Daru 2014;22:40. PubMed
  6. Ryan M, Lazar I, Nadasdy GM, et al. Acute kidney injury and hyperbilirubinemia in a young male after ingestion of Tribulus terrestris. Clin Nephrol 2015;83(3):177-83. PubMed
  7. Postigo S, Lima SM, Yamada SS, et al. Assessment of the effects of Tribulus terrestris on sexual function of menopausal women. Rev Bras Ginecol Obstet 2016;38(3):140-6. PubMed
  8. Talasaz AH, Abbasi MR, Abkhiz S, Dashti-Khavidaki S. Tribulus terrestris-induced severe nephrotoxicity in a young healthy male. Nephrol Dial Tranplant 2010;25(11):3792-3. PubMed
  9. Samani NB, Jokar A, Soveid M, Heydari M, Mosavat SH. Efficacy of the hydroalcoholic extract of Tribulus terrestris on the serum glucose and lipid profile of women with diabetes mellitus: a double-blind randomized placebo-controlled clinical trial. J Evid
  10. Siddiqui MA, Itrat M, Mobeen A, Khan MI. Efficacy of khar-i-khasak (Tribulus terrestris Linn.) in prehypertension: a randomized, double-blind, placebo-controlled trial. J Complement Integr Med. 2021.

See these in context on the Tribulus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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