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Dietary supplement

Tribulus terrestris 1000 mg Ingredients & Drug Interactions

by KRK Supplements

Tribulus terrestris 1000 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Tribulus terrestris 1000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Tribulus terrestris 1000 mg is a dietary supplement by KRK Supplements with 1 active ingredient. Its ingredients are commonly taken for low libido and sexual function, athletic performance and muscle building, testosterone support.Based on those ingredients, 259 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Tribulus terrestris Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Tribulus terrestris 1000 mg by KRK Supplements

Ask about any prescription or over-the-counter medication and we check it for interactions with Tribulus terrestris 1000 mg by KRK Supplements — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Tribulus terrestris 1000 mg by KRK Supplements

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

KRK Supplements' Tribulus terrestris 1000 mg is a single-ingredient product: one capsule contains tribulus terrestris extract. The rest is inactive ingredients — gelatin (the capsule itself), microcrystalline cellulose, magnesium stearate, and silicon dioxide — which are binders and fillers that help the capsule hold together and flow smoothly.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Tribulus's overall clinical evidence instead.

Moderate

Some clinical evidence supports Tribulus for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Sexual dysfunction — rated "Possibly Effective" (Natural Medicines).

The evidence on tribulus for sexual dysfunction is rated possibly effective — meaning there's some clinical support, but it's not ironclad. For athletic performance, the data suggests it's possibly ineffective.

And for benign prostate enlargement (benign prostatic hyperplasia), the evidence isn't established well enough to rate it one way or the other.

The evidence, ingredient by ingredient Tribulus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Tribulus is generally well tolerated in the short term in healthy adults, but long-term safety data are limited and quality varies between products. Gastrointestinal side effects like nausea, cramping, diarrhea, and constipation can occur, though in one study they were no more common than with placebo.

Rare serious side effects — liver injury, kidney injury, seizures, and chronic painful erection — have been reported. Avoid it during pregnancy because it may affect hormones and safety is not established.

Do not take it while breastfeeding due to lack of reliable safety information.

Side effects, ingredient by ingredient Tribulus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Tribulus.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications; lithium.
  • For scale: 259 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this, double-check with your pharmacist if you're on blood pressure–lowering drugs (antihypertensive medications), diabetes medications, or lithium. All three carry Moderate-severity interaction risks with tribulus.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Tribulus may help with sexual dysfunction, but the evidence is modest. It interacts with blood pressure medicines, diabetes drugs, and lithium — all Moderate-severity concerns.

If you're on any of those, check with your pharmacist before starting. Pregnant or breastfeeding?

Skip it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Tribulus terrestris 1000 mg, straight from the product label.

Brand KRK Supplements
Barcode (UPC) 610373852207
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Aug 22, 2025
DSLD ID 337336
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Tribulus terrestris 1000 mg by KRK Supplements, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
45
UPC/BARCODE
610373852207
IngredientAmount% DV
Tribulus terrestris Extract1000 mg--

Other ingredients: Gelatin, Microcrystalline Cellulose, Magnesium Stearate, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use - As a dietary supplement, take two (2) capsules one to two times daily prior to meals.

Precautions

Warning - Not intended for persons under 18 years of age.

Consult your physician before using this or any dietary supplement.

Do not use if you rare pregnant or nursing or at risk of or being treated for high blood pressure and heart disease.

Caution - Keep out of reach of children.

Do not use if safety seal is broken.

Storage

Store in a cool dry place, avoid excessive heat.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease, but rather a dietary supplement intended for nutritional support.

Formula

Tribulus terrestris 1000 mg serving

Brand IP Statement(s)

Helps Naturally Boost Testosterone Helps Increase Lean Muscle Mass Helps Improves Drive & Performance Helps Increase Energy & Stamina Helps Speed Muscle Recovery

FDA Statement of Identity

Dietary Supplement

Formulation

Non GMO

Seals/Symbols

Made in USA GMP Facility

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Tribulus terrestris 1000 mg by KRK Supplements label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Tribulus terrestris 1000 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Tribulus terrestris 1000 mg by KRK Supplements

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container45 Amounts shown are per serving.

Tribulus terrestris Extract

Interacts with
259 drugs
1000 mg per serving Form: Saponins

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims...

Tribulus terrestris Extract monograph & interactions

Other (inactive) ingredients: Gelatin, Microcrystalline Cellulose, Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Tribulus terrestris 1000 mg by KRK Supplements Drug Interactions

Want to check YOUR meds against Tribulus terrestris 1000 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
259Drugs
259 Moderate

Ingredients driving the most interactions

Tribulus terrestris Extract 259

Individual Drug Interactions

The ingredients in Tribulus terrestris 1000 mg interact with 259 drugs. Click any drug to see the details.

1 of the 1 ingredient in Tribulus terrestris 1000 mg interact with drugs. Each result below shows which ingredient is responsible. Tribulus terrestris Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Tribulus terrestris 1000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Tribulus terrestris Extract3 drug types · 259 drugs

Antidiabetes Drugs

Taking tribulus with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that Tribulus can lower blood glucose levels in adults with type 2 diabetes who are taking antidiabetes medications.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that tribulus can lower blood pressure by inhibiting angiotensin-converting enzyme (ACE). Tribulus has also demonstrated hypotensive effects in pre-hypertensive adults.

Likelihood Possible Evidence D
Lithium

Theoretically, tribulus might increase the levels and clinical effects of lithium.
Tribulus is thought to have diuretic properties. Due to these potential diuretic effects, tribulus might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Tribulus terrestris Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Tribulus terrestris 1000 mg, from the product label.

KRK Supplements

See all KRK Supplements products
Name
KRK Supplements
Street Address
PO Box 380494
City
Clinton TWP
State
MI
ZipCode
48038-0066
Web Address
www.krksupplement.com
Pharmacist Counseling Corner

Tribulus terrestris 1000 mg by KRK Supplements: Common Questions

Does Tribulus terrestris 1000 mg by KRK Supplements interact with any medications?
Yes. Based on its ingredients, Tribulus terrestris 1000 mg has a known interaction with 259 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Tribulus terrestris 1000 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm trying to get pregnant or breastfeeding?
No. The safety data advises against tribulus during pregnancy because it may affect hormones and safety isn't established. Also avoid it while breastfeeding — there isn't reliable safety information. Talk to your OB or pharmacist about alternatives.
What are the side effects?
Most people tolerate it well short-term. The common ones are stomach upset — nausea, cramping, diarrhea, or constipation — but they occurred at similar rates to placebo in one study. Rare serious side effects like liver or kidney injury and seizures have been reported, though they're uncommon.
Does tribulus actually work for sexual dysfunction?
The evidence suggests it's possibly effective, meaning there's some clinical support but it's not definitive. Results vary, and quality of products can differ. Your results may vary.
Is this product safe long-term?
Short-term use in healthy adults is generally well tolerated, but long-term safety data are limited. That's one reason it's especially important to talk to your pharmacist if you're on chronic medications — we can watch for any issues.
What is tribulus used for?
It's primarily marketed for sexual dysfunction and athletic performance. The evidence strongest for sexual dysfunction (possibly effective), weaker for athletic performance (possibly ineffective). It's also used for prostate health, but we don't have enough reliable evidence to rate that claim.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Tribulus terrestris 1000 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Tribulus terrestris 1000 mg label
Go deeper

The Full Monographs Behind Tribulus terrestris 1000 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Tribulus

Interacts with 259 drugs

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims is weak and inconsistent. It is general...

Read the full Tribulus monograph →
Sources

Sources & How We Checked

Tribulus terrestris 1000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 10 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Tribulus 10 references
  1. Sharifi AM, Darabi R, Akbarloo N. Study of antihypertensive mechanism of Tribulus terrestris in 2K1C hypertensive rats: role of tissue ACE activity. Life Sci 2003;73:2963-71. PubMed
  2. Walker D, Bird A, Flora T, O'Sullivan B. Some effects of feeding Tribulus terrestris, Ipomoea lonchophylla and the seed of Abelmoschus ficulneus on fetal development and the outcome of pregnancy in sheep. Reprod Fertil Dev 1992;4:135-44. PubMed
  3. Al-Ali M, Wahbi S, Twaij H, Al-Badr A. Tribulus terrestris: preliminary study of its diuretic and contractile effects and comparison with Zea mays. J Ethnopharmacol 2003;85:257-60. PubMed
  4. Tabakova, P., Dimitrov, M., Ognyanov, K., and et al. Clinical study of Tribestan in females with endocrine sterility. Documentation for Registration (unpublished) 1999.
  5. Akhtari E, Raisi F, Keshavarz M, et al. Tribulus terrestris for treatment of sexual dysfunction in women: randomized double-blind placebo-controlled study. Daru 2014;22:40. PubMed
  6. Ryan M, Lazar I, Nadasdy GM, et al. Acute kidney injury and hyperbilirubinemia in a young male after ingestion of Tribulus terrestris. Clin Nephrol 2015;83(3):177-83. PubMed
  7. Postigo S, Lima SM, Yamada SS, et al. Assessment of the effects of Tribulus terrestris on sexual function of menopausal women. Rev Bras Ginecol Obstet 2016;38(3):140-6. PubMed
  8. Talasaz AH, Abbasi MR, Abkhiz S, Dashti-Khavidaki S. Tribulus terrestris-induced severe nephrotoxicity in a young healthy male. Nephrol Dial Tranplant 2010;25(11):3792-3. PubMed
  9. Samani NB, Jokar A, Soveid M, Heydari M, Mosavat SH. Efficacy of the hydroalcoholic extract of Tribulus terrestris on the serum glucose and lipid profile of women with diabetes mellitus: a double-blind randomized placebo-controlled clinical trial. J Evid
  10. Siddiqui MA, Itrat M, Mobeen A, Khan MI. Efficacy of khar-i-khasak (Tribulus terrestris Linn.) in prehypertension: a randomized, double-blind, placebo-controlled trial. J Complement Integr Med. 2021.

See these in context on the Tribulus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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