Major interaction on record — check this product against your medications before combining. Based on 6 of 8 ingredients. Check your meds →
Dietary supplement

Triple Action Stress Shield Nighttime Ingredients & Drug Interactions

by Country Life

Triple Action Stress Shield Nighttime label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Triple Action Stress Shield Nighttime against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Triple Action Stress Shield Nighttime is a dietary supplement by Country Life with 8 active ingredients. Its ingredients are commonly taken for anxiety and stress, relaxation and calm, sleep support.Based on those ingredients, 1,514 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Sensoril Ashwagandha extract, Passion Flower extract, L-Theanine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Triple Action Stress Shield Nighttime by Country Life

Ask about any prescription or over-the-counter medication and we check it for interactions with Triple Action Stress Shield Nighttime by Country Life — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Triple Action Stress Shield Nighttime by Country Life

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 5 of its 8 active ingredients.
  • “Botanical Support Blend” is a proprietary blend — the label gives one combined amount (230 mg) without saying how much of each component you get.

Triple Action Stress Shield Nighttime contains 8 ingredients, six of which we can identify. The active ingredients are L-Theanine, magnesium, pantothenic acid (also called vitamin B5), GABA (gamma-aminobutyric acid), passion flower extract, and Sensoril ashwagandha extract — each chosen to support relaxation and sleep.

The product also lists a Botanical Support Blend (a blend of plant components listed separately), plus medium chain triglycerides (MCT) concentrate and wild jujube extract, for which we hold no interaction data. The remaining ingredients are inactive — cellulose, rice bran extract, vegetable glaze, sunflower oil, and silica — which serve as the capsule and binding materials.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: support stress management and sleep quality.
  • We looked for evidence on: Anxiety, Adjustment disorders, Restlessness, Nervous tension.
  • The strongest evidence on file: Passion Flower is rated "Possibly Effective" for Pre-procedural anxiety (Natural Medicines).
  • Also on file: Ashwagandha is rated "Possibly Effective" for Anxiety, Generalized anxiety disorder (GAD).
  • Also on file: Gamma-aminobutyric Acid (gaba) is rated "Insufficient Reliable Evidence To Rate" for Anxiety.

Magnesium is rated Effective for constipation and dyspepsia (indigestion). Both passion flower extract and ashwagandha are rated Possibly Effective for insomnia and stress-related anxiety, which aligns with this product's nighttime focus.

Pantothenic acid (vitamin B5) is rated Effective for pantothenic acid deficiency but carries Insufficient Reliable Evidence for the other conditions listed. L-Theanine is rated Possibly Effective for cognitive function but Insufficient Reliable Evidence for anxiety, which is relevant given the product's calming intent.

GABA carries Insufficient Reliable Evidence for anxiety and other relaxation-focused uses. Overall, the evidence base is modest — the ingredients with the strongest backing are magnesium and ashwagandha for their respective uses.

The evidence, ingredient by ingredient Theanine Magnesium Pantothenic Acid Gamma-aminobutyric Acid (gaba) Ashwagandha Passion Flower

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Magnesium is generally safe at recommended doses and often well tolerated, though oral doses can cause diarrhea, nausea, or gastrointestinal irritation. L-Theanine is generally well tolerated for short-term use in healthy adults, though long-term safety hasn't been well studied; reported side effects include headaches and drowsiness.

Passion flower is generally well tolerated but can cause drowsiness, dizziness, and confusion; a rare case of severe nausea, vomiting, and heart rhythm disturbance has been reported with very high doses. Ashwagandha is generally well tolerated short-term, though gastrointestinal upset, nausea, and drowsiness can occur at typical doses; rare cases of liver injury have been reported.

GABA seems well tolerated orally but long-term safety is not well studied; common side effects include drowsiness, nausea, and muscle weakness. Pantothenic acid is considered safe at typical supplement doses with few side effects.

For pregnancy, L-Theanine, GABA, passion flower, and ashwagandha all advise against use due to insufficient safety data — the facts state to avoid them. Magnesium is needed in pregnancy but use supplements only under your doctor's guidance.

Pantothenic acid at food and prenatal-vitamin amounts is fine; check with your doctor before high-dose supplements. For breastfeeding, L-Theanine, GABA, passion flower, and ashwagandha all advise avoidance due to insufficient data.

Magnesium at normal dietary amounts is appropriate; consult your doctor before supplements. Pantothenic acid at normal dietary and prenatal-vitamin amounts is fine.

Side effects, ingredient by ingredient Theanine Magnesium Pantothenic Acid Gamma-aminobutyric Acid (gaba) Ashwagandha Passion Flower

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 5 of the 6 matched ingredients can interact with medications — Gamma-aminobutyric Acid (gaba), Passion Flower, Ashwagandha, Magnesium, Theanine.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; heart-rhythm medications; Parkinson's medications.
  • For scale: 1,515 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before starting this product, double-check if you take any of these Moderate-severity medications: antihypertensive drugs (blood pressure medications), CNS depressants (sedatives, sleep aids, anti-anxiety drugs), antidiabetes medications, thyroid hormones, benzodiazepines (like Valium or Xanax), calcium channel blockers (heart/blood pressure drugs), skeletal muscle relaxants, immunosuppressants, sulfonylureas (older diabetes drugs), or hepatotoxic drugs (medications that stress the liver). A Major interaction exists if you take levodopa/carbidopa (Sinemet) for Parkinson's — magnesium can significantly reduce its effectiveness.

Minor interactions are documented with serotonergic drugs, quinolone antibiotics, bisphosphonates, and certain drug-transporting proteins. Use the checker below for your specific medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This product may be worth considering if you're looking for herbal and nutrient support for nighttime relaxation and sleep, as ashwagandha and passion flower both have Possibly Effective evidence for insomnia. However, you'll want to be especially careful if you take blood pressure medications, diabetes drugs, thyroid medication, sedatives, heart drugs, or Parkinson's medication — ashwagandha and magnesium in particular have several moderate interactions.

Definitely check your exact medications with the tool below before you start. If you're pregnant or breastfeeding, talk with your doctor or pharmacist first — several ingredients here advise against use.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Triple Action Stress Shield Nighttime, straight from the product label.

Brand Country Life
Barcode (UPC) 015794050421
Net contents 60 Vegan Capsule(s)
Market status On market
Date entered into DSLD Apr 22, 2021
DSLD ID 248981
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Triple Action Stress Shield Nighttime by Country Life, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
015794050421
IngredientAmount% DV
L-Theanine150 mg--
Magnesium25 mg6%
Pantothenic Acid100 mg2000%
GABA200 mg--
Passion Flower extract0 NP--
Sensoril Ashwagandha extract250 mg--
Botanical Support Blend230 mg--
Medium Chain Triglycerides (MCT) concentrate0 NP--
Wild Jujube extract0 NP--

Other ingredients: Cellulose, Cellulose, Rice Bran extract, Vegetable Glaze, Sunflower Oil, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Stress Shield Nighttime is a unique multi-ingredient complex designed to support the body's ability to deal with stress while encouraging sleep.

1 - Supports sleep The combination of Sensoril Ashwagandha and L-theanine reduces occasional sleeplessness and elevates the presence of alpha waves in the brain that support calmness, and sleep, respectively. Other well-known botanicals have been added to round out this formula. 2 - Supports Relaxation Includes 150 mg L-Theanine which has been shown to effectively relax the mind and 200 mg of GABA, an amino acid primarily known for relaxing the body's central nervous system. 3 - Helps alleviate the effects of stress Includes 250 mg of clinically studied Sensoril Ashwagandha which has been shown to effectively equip the body to deal with stress & irritability and diminish occasional tension. Per serving

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

Yes certified Gluten free by GFCO.org

Yes Certified Vegan by the AVA

This product has been manufactured at a GMP registered facility.

Ingredients are shown to: Support sleep Support relaxation Help alleviate the effects of stress

What does your body need? Deal with every day stress Relax the mind Reduction of sleeplessness Fatigue reduction

Why Stress Shield Nighttime? Sleep is vital for the body. During sleep, the body restores its energy, supports its immune system's renewal, as well as recovers from the stress of the day. Without quality sleep, your body may not be able to fully recover and perform at its maximum potential the next day. Stress Shield Nighttime is a unique multi-ingredient complex designed to support the body's ability to deal with stress while encouraging sleep

(Melatonin-Free)

General Statements

Yes recyclable packaging Yes manufacturing supports wind power

Established 1971

Our Pledge of Integrity Authenticity Cleanliness Freshness Consistency Accuracy

Triple Action Approach

Please help us in our mission; Recycle this box & bottle after use. Like/Follow us on our social platforms for new product news, recipes, giveaways and more! Tag us for a chance to be featured @CountryLifevitamins Facebook, Instagram

Also try... Stress Shield Contains clinically studied ingredients that: Diminish occasional tension Support emotional well-being Support energy

Precautions

No yeast, wheat or soy No milk, salt or preservatives No artificial colors or artificial sweeteners No magnesium stearate

Caution: Not to be used during pregnancy.

Do not operate heavy machinery or drive a motor vehicle after taking this supplement. May potentiate the effects of barbiturates.

If you are nursing, taking medication (including sleep medications), have a medical condition, or planning surgery, consult a doctor before using this product.

Stop using and consult a doctor if any adverse reactions occur. Do not accept if seal is broken.

Keep out of the reach of children.

Read label warnings prior to use. Do not exceed recommended dose. As a reminder, discuss the supplements and medications that you take with your health care providers.

Storage

Store in a dry place between 59 degrees - 86 degrees F.

Brand IP Statement(s)

Sensoril is a trademark of Natreon, Inc.

Seals/Symbols

Certified B Corporation GFCO.org

FSC www.fsc.org MIX Paper from responsible sources FSC C018101

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: Adults, take two (2) capsules 30 minutes before bedtime.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Triple Action Stress Shield Nighttime by Country Life label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Triple Action Stress Shield Nighttime label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Triple Action Stress Shield Nighttime by Country Life

These are the 8 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

L-Theanine

Interacts with
565 drugs
150 mg per serving

Theanine (usually L-theanine) is an amino acid found naturally in tea leaves that many people take to feel calmer and less stressed without strong dro...

L-Theanine monograph & interactions

Magnesium

Interacts with
295 drugs
25 mg per serving Form: Magnesium Citrate

Magnesium is an essential mineral your body needs for muscles, nerves, blood pressure, and many other functions, and supplements are useful for preven...

Magnesium monograph & interactions

Pantothenic Acid

No known
interactions
100 mg per serving Form: Calcium D-Pantothenate, Pantethine

Pantothenic acid is vitamin B5, an essential nutrient your body uses to turn food into energy. True deficiency is very rare because it is found in nea...

Pantothenic Acid monograph & interactions

GABA

Interacts with
419 drugs
200 mg per serving Form: Gamma-Aminobutyric Acid

GABA is a calming chemical messenger (neurotransmitter) that your body makes on its own, and it is sold as a supplement for stress, anxiety, and sleep...

GABA monograph & interactions

Sensoril Ashwagandha extract

Interacts with
1,372 drugs
250 mg per serving Form: Withanolide Glycosides

Ashwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, though the evid...

Sensoril Ashwagandha extract monograph & interactions

Botanical Support Blend

230 mg per serving

Other (inactive) ingredients: Cellulose, Cellulose, Rice Bran extract, Vegetable Glaze, Sunflower Oil, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Triple Action Stress Shield Nighttime by Country Life Drug Interactions

Want to check YOUR meds against Triple Action Stress Shield Nighttime?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,514Drugs
6 Major 1,006 Moderate 502 Minor

Ingredients driving the most interactions

Sensoril Ashwagandha extract 1,372
Passion Flower extract 836
L-Theanine 565
GABA 419
Magnesium 295

Individual Drug Interactions

The ingredients in Triple Action Stress Shield Nighttime interact with 1,514 drugs. Click any drug to see the details.

5 of the 8 ingredients in Triple Action Stress Shield Nighttime interact with drugs. Each result below shows which ingredient is responsible. Sensoril Ashwagandha extract Passion Flower extract L-Theanine GABA Magnesium

Each ingredient & the kinds of drugs it affects

For each ingredient in Triple Action Stress Shield Nighttime with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Sensoril Ashwagandha extract10 drug types · 1,372 drugs

Antidiabetes Drugs

Theoretically, taking ashwagandha with antidiabetes drugs might increase the risk of hypoglycemia.
There is preliminary clinical evidence suggesting that ashwagandha might lower blood glucose levels. Theoretically, ashwagandha might have additive effects when used with antidiabetes drugs and increase the risk of hypoglycemia.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Animal research suggests that ashwagandha might lower systolic and diastolic blood pressure. Theoretically, ashwagandha might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.

Likelihood Possible Evidence D
Benzodiazepines

Theoretically, taking ashwagandha might increase the sedative effects of benzodiazepines.
There is preliminary evidence that ashwagandha might have an additive effect with diazepam (Valium) and clonazepam (Klonopin). This may also occur with other benzodiazepines.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Ashwagandha seems to have sedative effects. Theoretically, this may potentiate the effects of barbiturates, other sedatives, and anxiolytics.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Ashwagandha has been linked to cases of acute hepatitis, liver failure, hepatic encephalopathy, autoimmune hepatitis, the need for liver transplantation, and death due to liver failure.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Ashwagandha has demonstrated immunostimulant effects in humans. Animal research has shown that ashwagandha can attenuate the immunosuppression caused by cyclophosphamide.

Likelihood Possible Evidence D
Thyroid Hormone

Ashwagandha might increase the effects and adverse effects of thyroid hormone.
Concomitant use of ashwagandha with thyroid hormones may cause additive therapeutic and adverse effects. Preliminary clinical research and animal studies suggest that ashwagandha boosts thyroid hormone synthesis and secretion. In one clinical study, ashwagandha increased triiodothyronine (T3) and thyroxine (T4) levels by 41.5% and 19.6%, respectively, and reduced serum TSH levels by 17.4% from baseline in adults with subclinical hypothyroidism.

Likelihood Probable Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that ashwagandha extract induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that ashwagandha extract induces CYP3A4 enzymes.

Likelihood Possible Evidence D
Serotonergic Drugs

Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors. However, there is no evidence to suggest that ashwagandha increases the risk of serotonin-related effects, and there have been no published case reports of serotonin syndrome when combined with other serotonergic drugs. Nevertheless, due to the lack of extensive studies on the matter and the fact that ashwagandha appears to affect serotonergic pathways, it would be prudent to exercise caution when combining it with drugs that affect serotonin. [References: - Effects of Withania somnifera (Ashwaga ndha) on Stress and the Stress-Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia. Curr Neuropharmacol. 2021 Sep 14; 19: 1468–1495. - A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573577/]

Likelihood Possible Evidence C
Sensoril Ashwagandha extract full monograph & interactions

Passion Flower extract3 drug types · 836 drugs

Cns Depressants

Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Research in animals and humans shows that passion flower has sedative effects which can be additive when used with sedative medications like lorazepam.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
In vitro research suggests that passion flower can induce CYP3A4 enzymes, albeit to a much lower degree than rifampin, a known CYP3A4 inducer.

Likelihood Possible Evidence D
Organic Anion-Transporting Polypeptide Substrates (Oatp)

Theoretically, passion flower might reduce the bioavailability of OATP2B1 and OATP1A2 substrates.
In vitro research shows that the passion flower constituents apigenin and vitexin inhibit OATP2B1 and OATP1A2. This inhibition may be dose-dependent. One specific high-flavonoid passion flower extract (Valverde) seems to inhibit OATP2B1 and OATP1A2, while another extract with a lower flavonoid concentration (Arkocaps) shows less potent inhibition. OATPs are responsible for the uptake of drugs and other compounds into the body; however, the specific activities of OATP2B1 and OATP1A2 are not well characterized.

Likelihood Possible Evidence D
Passion Flower extract full monograph & interactions

L-Theanine3 drug types · 565 drugs

Antihypertensive Drugs

Theanine might lower blood pressure, potentiating the effects of antihypertensive drugs.
Animal research shows that theanine can lower blood pressure in spontaneously hypertensive animals. Theoretically, concomitant use of theanine and antihypertensive drugs might potentiate the antihypertensive activity.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, theanine might have additive sedative effects when used in conjunction with CNS depressants. However, it is unclear if this concern is clinically relevant.
Theoretically, theanine may compete with glutamate and/or increase plasma gamma-aminobutyric acid (GABA) levels, which could cause CNS depression. In one clinical study, some subjects taking oral theanine reported drowsiness.

Likelihood Unlikely Evidence D
Serotonergic Drugs

Clinical studies regarding the effects of L-theanine on serotonin levels are conflicting. Some studies suggest it can increase serotonin levels in the brain while others report that it may decrease them. Nevertheless, there have been no reports of l-theanine being a causative agent in serotonergic-related side effects or serotonin syndrome.

Likelihood Unlikely Evidence C
L-Theanine full monograph & interactions

GABA2 drug types · 419 drugs

Antihypertensive Drugs

Theoretically, taking GABA with antihypertensive drugs might increase the risk of hypotension.
Some clinical research shows that GABA can decrease blood pressure in patients with hypertension.

Likelihood Possible Evidence B
Cns Depressants

Theoretically, GABA might have additive sedative effects when used in conjunction with CNS depressants. However, it is unclear if this concern is clinically relevant.
Endogenous GABA has well-established relaxant effects and GABA(A) receptors have an established physiological role in sleep. However, the effects of GABA supplements are unclear, as it is unknown whether exogenous GABA crosses the blood-brain barrier. Although there have been limited reports of drowsiness or tiredness with GABA supplements, these effects have not been widely reported in clinical studies. Additionally, intravenous GABA 0.1-1 mg/kg has been shown to induce anxiety in a dose-dependent manner.

Likelihood Unlikely Evidence D
GABA full monograph & interactions

Magnesium15 drug types · 295 drugs

Levodopa/Carbidopa (Sinemet)

Magnesium can reduce the bioavailability of levodopa/carbidopa.
Clinical research in healthy volunteers shows that taking magnesium oxide 1000 mg with levodopa 100 mg/carbidopa 10 mg reduces the area under the curve (AUC) of levodopa by 35% and of carbidopa by 81%. In vitro and animal research shows that magnesium produces an alkaline environment in the digestive tract, which might lead to degradation and reduced bioavailability of levodopa/carbidopa.

Likelihood Probable Evidence B
Aminoglycoside Antibiotics

Concomitant use of aminoglycoside antibiotics and magnesium can increase the risk for neuromuscular weakness.
Both aminoglycosides and magnesium reduce presynaptic acetylcholine release, which can lead to neuromuscular blockade and possible paralysis. This is most likely to occur with high doses of magnesium given intravenously.

Likelihood Possible Evidence D
Antacids

Use of acid reducers may reduce the laxative effect of magnesium oxide.
A retrospective analysis shows that, in the presence of H2 receptor antagonists (H2RAs) or proton pump inhibitors (PPIs), a higher dose of magnesium oxide is needed for a laxative effect. This may also occur with antacids. Under acidic conditions, magnesium oxide is converted to magnesium chloride and then to magnesium bicarbonate, which has an osmotic laxative effect. By reducing acidity, antacids may reduce the conversion of magnesium oxide to the active bicarbonate salt.

Likelihood Possible Evidence D
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Magnesium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide should be taken at least 2 hours before or 6 hours after magnesium containing products.

Likelihood Probable Evidence D
Bisphosphonates

Magnesium can decrease absorption of bisphosphonates.
Cations, including magnesium, can decrease bisphosphonate absorption. Advise patients to separate doses of magnesium and these drugs by at least 2 hours.

Likelihood Probable Evidence B
Calcium Channel Blockers

Magnesium can have additive effects with calcium channel blockers, although evidence is conflicting.
Magnesium inhibits calcium entry into smooth muscle cells and may therefore have additive effects with calcium channel blockers. Severe hypotension and neuromuscular blockades may occur when nifedipine is used with intravenous magnesium, although some contradictory evidence suggests that concurrent use of magnesium with nifedipine does not increase the risk of neuromuscular weakness. High doses of magnesium could theoretically have additive effects with other calcium channel blockers.

Likelihood Possible Evidence D
Digoxin

Magnesium salts may reduce absorption of digoxin.
Clinical evidence suggests that treatment with oral magnesium hydroxide or magnesium trisilicate reduces absorption of digoxin from the intestines. This may reduce the blood levels of digoxin and decrease its therapeutic effects.

Likelihood Possible Evidence B
Potassium-Sparing Diuretics

Potassium-sparing diuretics decrease excretion of magnesium, possibly increasing magnesium levels.
Potassium-sparing diuretics also have magnesium-sparing properties, which can counteract the magnesium losses associated with loop and thiazide diuretics. Theoretically, increased magnesium levels could result from concomitant use of potassium-sparing diuretics and magnesium supplements.

Likelihood Probable Evidence D
Quinolone Antibiotics

Magnesium decreases absorption of quinolones.
Magnesium can form insoluble complexes with quinolones and decrease their absorption. Advise patients to take these drugs at least 2 hours before, or 4 to 6 hours after, magnesium supplements.

Likelihood Probable Evidence D
Skeletal Muscle Relaxants

Parenteral magnesium alters the pharmacokinetics of skeletal muscle relaxants, increasing their effects and accelerating the onset of effect.
Parenteral magnesium shortens the time to onset of skeletal muscle relaxants by about 1 minute and prolongs the duration of action by about 2 minutes. Magnesium potentiates the effects of skeletal muscle relaxants by decreasing calcium-mediated release of acetylcholine from presynaptic nerve terminals, reducing postsynaptic sensitivity to acetylcholine, and having a direct effect on the membrane potential of myocytes. Magnesium also has vasodilatory actions and increases cardiac output, allowing a greater amount of muscle relaxant to reach the motor end plate. A clinical study found that low-dose rocuronium (0.45 mg/kg), when given after administration of magnesium 30 mg/kg over 10 minutes, has an accelerated onset of effect, which matches the onset of effect seen with a full-dose rocuronium regimen (0.6 mg/kg). In another clinical study, onset times for rocuronium doses of 0.3, 0.6, and 1.2 mg/kg were 86, 76, and 50 seconds, respectively, when given alone, but were reduced to 66, 44, and 38 seconds, respectively, when the doses were given after a 15-minute infusion of magnesium sulfate 60 mg/kg. Giving intraoperative intravenous magnesium sulfate, 50 mg/kg loading dose followed by 15 mg/kg/hour, reduces the onset time of rocuronium, enhances its clinical effects, reduces the dose of intraoperative opiates, and prolongs the spontaneous recovery time. It does not affect the activity of subsequently administered neostigmine.

Likelihood Probable Evidence A
Sulfonylureas

Magnesium increases the systemic absorption of sulfonylureas, increasing their effects and side effects.
Clinical research shows that administration of magnesium hydroxide with glyburide increases glyburide absorption, increases maximal insulin response by 35-fold, and increases the risk of hypoglycemia, when compared with glyburide alone. A similar interaction occurs between magnesium hydroxide and glipizide. The mechanism of this effect appears to be related to the elevation of gastrointestinal pH by magnesium-based antacids, increasing solubility and enhancing absorption of sulfonylureas.

Likelihood Probable Evidence B
Tetracycline Antibiotics

Magnesium decreases absorption of tetracyclines.
Magnesium can form insoluble complexes with tetracyclines in the gut and decrease their absorption and antibacterial activity. Advise patients to take these drugs 1 hour before or 2 hours after magnesium supplements.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, magnesium may have antiplatelet effects, but the evidence is conflicting.
In vitro evidence shows that magnesium sulfate inhibits platelet aggregation, even at low concentrations. Some preliminary clinical evidence shows that infusion of magnesium sulfate increases bleeding time by 48% and reduces platelet activity. However, other clinical research shows that magnesium does not affect platelet aggregation, although inhibition of platelet-dependent thrombosis can occur.

Likelihood Unlikely Evidence B
Gabapentin (Neurontin)

Gabapentin absorption can be decreased by magnesium.
Clinical research shows that giving magnesium oxide orally along with gabapentin decreases the maximum plasma concentration of gabapentin by 33%, time to maximum concentration by 36%, and area under the curve by 43%. Advise patients to take gabapentin at least 2 hours before, or 4 to 6 hours after, magnesium supplements.

Likelihood Unlikely Evidence B
Sevelamer (Renagel, Renvela)

Sevelamer may increase serum magnesium levels.
In patients on hemodialysis, sevelamer use was associated with a 0.28 mg/dL increase in serum magnesium. The mechanism of this interaction remains unclear.

Likelihood Possible Evidence B
Magnesium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Triple Action Stress Shield Nighttime, from the product label.

Country Life

See all Country Life products
Name
Country Life, LLC
Street Address
180 Vanderbilt Motor Parkway
City
Hauppauge
State
NY
ZipCode
11788
Web Address
CountryLifeVitamins.com
Pharmacist Counseling Corner

Triple Action Stress Shield Nighttime by Country Life: Common Questions

Does Triple Action Stress Shield Nighttime by Country Life interact with any medications?
Yes. Based on its ingredients, Triple Action Stress Shield Nighttime has a known interaction with 1,514 medications, including 6 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Triple Action Stress Shield Nighttime contains 8 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this make me drowsy during the day if I take it at night?
Drowsiness is a known side effect of several ingredients here — L-Theanine, GABA, passion flower, and ashwagandha can all cause it. The product is designed for nighttime use, so daytime drowsiness depends on how you personally respond and when you take it. If you're sensitive to sedating herbs, take it closer to bedtime.
Is this safe if I'm pregnant or nursing?
No, not without your doctor's approval. L-Theanine, GABA, passion flower, and ashwagandha all advise against use in pregnancy and breastfeeding due to insufficient safety data. The magnesium is needed in pregnancy but only under your doctor's guidance. Talk with your OB or midwife before taking this product.
What is ashwagandha supposed to do in here?
Ashwagandha is rated Possibly Effective for anxiety and insomnia, so it's included to help with stress and sleep at night. It's an adaptogenic herb — traditionally used to help the body manage stress — though the clinical evidence is still building.
Why is there magnesium in a sleep product?
Magnesium plays a role in muscle relaxation and nervous system calm. It's Effective for constipation and indigestion, but in a nighttime blend like this it's more for its theoretical relaxant properties. The dose and form matter, though — we'd need that detail to say more.
Can I take this with my blood pressure medicine?
Not safely without checking with your pharmacist first. Multiple ingredients in this product — L-Theanine, GABA, magnesium, and ashwagandha — can lower blood pressure, and combining them with your medication could drop it too far. Use the checker on this page or call your pharmacy before you start.
What are the side effects I might experience?
Most common are drowsiness, nausea, diarrhea, and gastrointestinal upset — any of which could occur depending on which ingredient your body reacts to most. Headaches, dizziness, and muscle weakness have also been reported with individual ingredients. Rare but serious cases of liver injury have been linked to ashwagandha, though this is uncommon.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Triple Action Stress Shield Nighttime label
Go deeper

The Full Monographs Behind Triple Action Stress Shield Nighttime’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Theanine

Interacts with 565 drugs

Theanine (usually L-theanine) is an amino acid found naturally in tea leaves that many people take to feel calmer and less stressed without strong drowsiness. Early research suggests it may...

Read the full Theanine monograph → Herb & supplement monograph

Magnesium

Interacts with 295 drugs

Magnesium is an essential mineral your body needs for muscles, nerves, blood pressure, and many other functions, and supplements are useful for preventing or correcting deficiency. Some othe...

Read the full Magnesium monograph → Herb & supplement monograph

Pantothenic Acid

Pantothenic acid is vitamin B5, an essential nutrient your body uses to turn food into energy. True deficiency is very rare because it is found in nearly all foods, and most people meet thei...

Read the full Pantothenic Acid monograph → Herb & supplement monograph

Gamma-aminobutyric Acid (gaba)

Interacts with 419 drugs

GABA is a calming chemical messenger (neurotransmitter) that your body makes on its own, and it is sold as a supplement for stress, anxiety, and sleep. The science behind oral GABA supplemen...

Read the full Gamma-aminobutyric Acid (gaba) monograph → Herb & supplement monograph

Ashwagandha

Interacts with 1,372 drugs

Ashwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, though the evidence is still limited. It is generally w...

Read the full Ashwagandha monograph → Herb & supplement monograph

Passion Flower

Interacts with 836 drugs

Passion flower is a traditional calming herb that many people use for anxiety and sleep. Early studies hint it may help with mild anxiety and restlessness, but the evidence is limited and mo...

Read the full Passion Flower monograph →
Sources

Sources & How We Checked

Triple Action Stress Shield Nighttime's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 162 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Theanine 6 references
  1. Yokogoshi H, Kobayashi M. Hypotensive effect of gamma-glutamylethylamide in spontaneously hypertensive rats. Life Sci 1998;62:1065-8.
  2. Haskell, C. F., Kennedy, D. O., Milne, A. L., Wesnes, K. A., and Scholey, A. B. The effects of L-theanine, caffeine and their combination on cognition and mood. Biol.Psychol. 2008;77(2):113-122. PubMed
  3. Yokogoshi, H., Kato, Y., Sagesaka, Y. M., Takihara-Matsuura, T., Kakuda, T., and Takeuchi, N. Reduction effect of theanine on blood pressure and brain 5-hydroxyindoles in spontaneously hypertensive rats. Biosci.Biotechnol.Biochem. 1995;59(4):615-618. PubMed
  4. Lyon MR, Kapoor MP, Juneja LR. The effects of L-theanine (Suntheanine®) on objective sleep quality in boys with attention deficit hyperactivity disorder (ADHD): a randomized, double-blind, placebo-controlled clinical trial. Altern Med Rev. 2011;16(4):348-
  5. Hidese S, Ota M, Wakabayashi C, et al. Effects of chronic l-theanine administration in patients with major depressive disorder: an open-label study. Acta Neuropsychiatr 2017;29(2):72-9.
  6. Tsuchiya T, Honda H, Oikawa M, et al. Oral administration of the amino acids cystine and theanine attenuates the adverse events of S-1 adjuvant chemotherapy in gastrointestinal cancer patients. Int J Clin Oncol 2016;21(6):1085-90. PubMed

See these in context on the Theanine monograph →

Magnesium 82 references
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  4. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
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  6. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride. Washington, DC: National Academy Press, 1999. Available at: http://books.nap.edu/books/0309063507/html/index.html.
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  11. Pfaffenrath V, Wessely P, Meyer C, et al. Magnesium in the prophylaxis of migraine--a double-blind placebo-controlled study. Cephalalgia 1996;16:436-40.. PubMed
  12. Wang F, Van Den Eeden SK, Ackerson LM, et al. Oral magnesium oxide prophylaxis of frequent migrainous headache in children: a randomized, double-blind, placebo-controlled trial. Headache 2003;43:601-10.. PubMed
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See these in context on the Magnesium monograph →

Pantothenic Acid 11 references
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See these in context on the Pantothenic Acid monograph →

Gamma-aminobutyric Acid (gaba) 12 references
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Ashwagandha 32 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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