Interactions on record — worth a quick check against your medications. Based on 2 of 7 ingredients. Check your meds →
Dietary supplement

Ultimate Krill Omega-3 Ingredients & Drug Interactions

by ProCaps Laboratories

Ultimate Krill Omega-3 label
See full label image
Softgel Capsule Category: Fat/fatty Acid
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Ultimate Krill Omega-3 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Ultimate Krill Omega-3 is a dietary supplement by ProCaps Laboratories with 7 active ingredients. Its ingredients are commonly taken for antioxidant support, skin health and aging, eye health.Based on those ingredients, 838 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Astaxanthin, Antarctic Krill Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Ultimate Krill Omega-3 by ProCaps Laboratories

Ask about any prescription or over-the-counter medication and we check it for interactions with Ultimate Krill Omega-3 by ProCaps Laboratories — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Ultimate Krill Omega-3 by ProCaps Laboratories

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 7 of its 7 active ingredients.
  • “Total Omega-3 Fatty Acids” is listed as a grouped ingredient — the label gives one combined amount (400 mg) without saying how much of each component you get.

Ultimate Krill Omega-3 contains 7 active ingredients centered on omega-3 fatty acids from Antarctic krill oil. The product includes eicosapentaenoic acid and docosahexaenoic acid — two omega-3s your body uses for heart and brain health — plus phospholipids that help your body absorb them.

Astaxanthin, a natural antioxidant found in krill, is also included. The softgel capsule also carries a proprietary orange essence flavoring.

The only inactive ingredient listed is the soft-gelatin capsule itself.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Heart health and omega-3 supplementation.
  • We looked for evidence on: Cardiovascular disease (CVD), Hyperlipidemia, Hypertriglyceridemia, Heart failure, Stroke, Hypertension — and 3 related terms.
  • The closest evidence on file: Astaxanthin is rated "Insufficient Reliable Evidence To Rate" for Heart failure (Natural Medicines).
  • Also on file: Astaxanthin is rated "Insufficient Reliable Evidence To Rate" for Hyperlipidemia, Hypertension, Stroke.
  • Also on file: Krill Oil is rated "Insufficient Reliable Evidence To Rate" for Cardiovascular disease (CVD), Hyperlipidemia, Hypertension.

Krill oil in this product is possibly effective for dry eye symptoms. For everything else — including aging skin, Alzheimer disease, cancer, high cholesterol, and cognitive function — the evidence we have isn't strong enough to rate.

Astaxanthin's effectiveness for age-related cognitive decline, macular degeneration, aging skin, and other conditions also lacks reliable evidence to rate, meaning studies haven't shown clear benefits yet.

The evidence, ingredient by ingredient Astaxanthin Krill Oil

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Antarctic Krill Oil is generally well tolerated, but skip this product if you have a shellfish allergy — krill is a shellfish product. If you have a bleeding disorder, use caution and talk to your doctor first.

Gastrointestinal side effects like bloating, diarrhea, fishy burps, heartburn, and nausea are most common, though they tend to be milder with krill oil than with fish oil. Headache, tiredness, and dizziness have been reported rarely.

Astaxanthin is also generally well tolerated, though long-term safety data are limited. Most common side effects are abdominal pain, diarrhea, and red-colored stool.

At very high doses (40 mg daily), severe stomach pain has been reported in a small number of people. For pregnancy and breastfeeding, we don't have enough safety data for either ingredient — talk with your doctor or pharmacist about whether this product is right for you before using it during pregnancy or while nursing.

Side effects, ingredient by ingredient Astaxanthin Krill Oil

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Astaxanthin, Krill Oil.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 839 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before starting Ultimate Krill Omega-3, check with your pharmacist if you take blood thinners or antiplatelet drugs like warfarin or aspirin (Moderate risk of increased bleeding), diabetes medications (Moderate risk of low blood sugar), or drugs broken down by your liver's CYP3A4 or CYP2B6 enzymes — a large group that includes many common medications (Moderate risk of decreased drug levels).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This is a solid krill oil omega-3 supplement that's particularly worth considering if you have dry eyes. If you take blood thinners, diabetes medications, or any drugs your liver breaks down — which is most of them — check your medications with the tool on this page first.

Avoid it if you're allergic to shellfish. Your pharmacist can help you figure out if it fits your routine.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 25, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Ultimate Krill Omega-3, straight from the product label.

Brand ProCaps Laboratories
Net contents 240 Easy To Swallow Capsule(s)
Market status On market
Date entered into DSLD Jan 25, 2017
DSLD ID 69986
Product type Fat/fatty Acid
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Ultimate Krill Omega-3 by ProCaps Laboratories, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Softgel(s)
Maximum serving Sizes:
2 Softgel(s)
Servings per container
120
IngredientAmount% DV
Calories15 Calorie(s)--
Calories from Fat15 Calorie(s)--
Eicosapentaenoic Acid210 mg--
Docosahexaenoic Acid110 mg--
Phospholipids680 mg--
Cholesterol30 mg10%
Total Fat1.5 Gram(s)2%
Astaxanthin150 mcg--
Total Omega-3 Fatty Acids400 mg--
Other Omega-3 Fatty Acids80 mg--
Proprietary Orange essence70 mg--
Antarctic Krill Oil1700 mg--

Other ingredients: Soft-Gelatin Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use Consume two or more capsules daily or as recommended by a health care professional.

General Statements

This product is most effective as part of a healthy diet and active lifestyle, along with one of Andrew Lessman's multi-vitamin-mineral formulas. For answers to questions about the use of this product, call 800.808.7311.

Unsurpassed. Purity. Quality. Integrity. Effectiveness. Andrew Lessman Founder of ProCaps Labs This product is only available from HSN 800.944.9999 www.HSN.com ProCaps Laboratories 800.800.1200

All-Solar Manufacturing

Antarctic Krill are tiny, shrimp-like creatures that live in the oceans near Antarctica and represent one of the most abundant life forms on the planet. Krill Oil provides a unique source of the most important Omege-3 fatty acids EPA and DHA, but in a distinctive and highly absorbable phospholipid form. Another bonus: Krill Oil’s rich reddish color comes from the presence of trace amounts of the protective carotenoids Astaxanthin. Omega-3s are absolutely essential for our good health, yet they cannot be made by the body, so their benefits are only available from cold water fish or an Omega-3 dietary supplement. Research has shown that diets rich in Omega-3s are associated with superior heart, brain, circulatory and general health; yet sadly, the American diet delivers alarmingly low levels of these precious fatty acids.

Formula

Phospholipid-based Omega-3s Higher levels of Krill Oil EPA and DHA

Andrew Lessman’s Ultimate Krill Omega-3 provides Phospholipid-based Omega-3s from Krill oil, but does so without Krill Oil’s normally unpleasant fishy aftertaste.

Our Ultimate Krill Omega-3 provides a unique alternative to fish oil based Omega-3s, delivering higher levels of Omegoa-3s provides a unique alternative to fish oil based Omega-3s, delivering higher levels of Omega-3s per capsule than typical Krill Oil product.

Contains an ingredient derived and purified from shellfish (krill).

FDA Statement of Identity

Dietary Supplement

Formulation

Like all ProCaps’ fish oil Omega-3 formulas, our Ultimate Krill Omega-3 also allows you to enjoy all the benefits of an Omega-3 formula with no mercury, no contaminants, no stomach upset and no unpleasant fishy aftertaste.

Contains no milk, soy, yeast, corn, wheat, gluten, sodium, salt, sugar, color, preservative or manufacturing additives. Contains no additives of any kind.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Contains an ingredient derived and purified from shellfish (krill).

Brand IP Statement(s)

2016 ProCaps Labs

General

605646-02U

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Ultimate Krill Omega-3 by ProCaps Laboratories label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Ultimate Krill Omega-3 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Ultimate Krill Omega-3 by ProCaps Laboratories

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Softgel(s) Dosage formSoftgel Capsule Servings per container120 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Phospholipids

680 mg per serving

Astaxanthin

Interacts with
671 drugs
150 mcg per serving

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise...

Astaxanthin monograph & interactions

Total Omega-3 Fatty Acids

400 mg per serving
  • › Eicosapentaenoic Acid
  • › Docosahexaenoic Acid
  • › Other Omega-3 Fatty Acids

Proprietary Orange essence

70 mg per serving

Antarctic Krill Oil

Interacts with
208 drugs
1700 mg per serving

Krill oil is a source of omega-3 fatty acids (EPA and DHA) bound to phospholipids, which may help absorption. It is most studied for lowering triglyce...

Antarctic Krill Oil monograph & interactions

Other (inactive) ingredients: Soft-Gelatin Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

Ultimate Krill Omega-3 by ProCaps Laboratories Drug Interactions

Want to check YOUR meds against Ultimate Krill Omega-3?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
838Drugs
838 Moderate

Ingredients driving the most interactions

Astaxanthin 671
Antarctic Krill Oil 208

Individual Drug Interactions

The ingredients in Ultimate Krill Omega-3 interact with 838 drugs. Click any drug to see the details.

2 of the 7 ingredients in Ultimate Krill Omega-3 interact with drugs. Each result below shows which ingredient is responsible. Astaxanthin Antarctic Krill Oil

Each ingredient & the kinds of drugs it affects

For each ingredient in Ultimate Krill Omega-3 with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Astaxanthin2 drug types · 671 drugs

Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP2B6.
In vitro research shows that astaxanthin induces cytochrome CYP2B6 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
In vitro research shows that astaxanthin induces CYP3A4 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Astaxanthin full monograph & interactions

Antarctic Krill Oil2 drug types · 208 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, krill oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Taking high doses of omega-3 fatty acids from fish oil can modestly decrease platelet aggregation. Since krill oil also contains these fatty acids, taking high doses of krill oil might also inhibit platelet aggregation. Theoretically, taking high doses of krill oil with antiplatelet or anticoagulant drugs might increase the risk of bleeding. However, the omega-3 content of krill oil is much lower than that of fish oil.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking krill oil with antidiabetes drugs might increase the risk of hypoglycemia.
Some research in animals and humans shows that krill oil might lower blood glucose levels. However, a small study shows that taking krill oil does not reduce blood glucose levels in patients with type 2 diabetes, most of whom were taking antidiabetes drugs.

Likelihood Possible Evidence B
Antarctic Krill Oil full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Ultimate Krill Omega-3, from the product label.

ProCaps Laboratories

See all ProCaps Laboratories products
Name
ProCaps Labs
City
Henderson
State
NV
ZipCode
89011
Phone Number
800-800-1200
Web Address
ProCapsLabs.com
Pharmacist Counseling Corner

Ultimate Krill Omega-3 by ProCaps Laboratories: Common Questions

Does Ultimate Krill Omega-3 by ProCaps Laboratories interact with any medications?
Yes. Based on its ingredients, Ultimate Krill Omega-3 has a known interaction with 838 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Ultimate Krill Omega-3 contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does krill oil actually work for anything?
The strongest evidence we have is for dry eye — krill oil is possibly effective for that. For other conditions like high cholesterol, aging skin, and brain health, the evidence isn't established yet in our data.
Can I take this if I'm pregnant or breastfeeding?
We don't have enough safety data for krill oil or astaxanthin during pregnancy or breastfeeding. Talk with your doctor or pharmacist before using this product if you're pregnant, nursing, or planning to become pregnant — they can weigh the risks and benefits for your situation.
What side effects might I notice?
Most people tolerate krill oil well. The most common side effects are mild gastrointestinal ones: bloating, diarrhea, fishy burps, heartburn, nausea, and stomach discomfort. Headache, tiredness, and dizziness are rare. Astaxanthin may cause abdominal pain, diarrhea, or red-colored stool.
Is it safe if I have a shellfish allergy?
No. Krill is a shellfish product, so this supplement isn't appropriate for you. Talk with your pharmacist about omega-3 alternatives that don't contain shellfish.
What's astaxanthin doing in a krill oil product?
Astaxanthin is a natural antioxidant found in krill itself. It's included because it's part of the krill you're already taking, though we don't yet have strong evidence for specific benefits it provides on its own.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Ultimate Krill Omega-3 is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Ultimate Krill Omega-3 label
Go deeper

The Full Monographs Behind Ultimate Krill Omega-3’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Astaxanthin

Interacts with 671 drugs

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise benefits. Early human studies are promis...

Read the full Astaxanthin monograph → Herb & supplement monograph

Krill Oil

Interacts with 208 drugs

Krill oil is a source of omega-3 fatty acids (EPA and DHA) bound to phospholipids, which may help absorption. It is most studied for lowering triglycerides and supporting heart health, but t...

Read the full Krill Oil monograph →
Sources

Sources & How We Checked

Ultimate Krill Omega-3's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Astaxanthin 3 references
  1. Kupcinskas L, Lafolie P, Lignell A, et al. Efficacy of the natural antioxidant astaxanthin in the treatment of functional dyspepsia in patients with or without Helicobacter pylori infection: A prospective, randomized, double blind, and placebo-controlled
  2. Kistler, A., Liechti, H., Pichard, L., Wolz, E., Oesterhelt, G., Hayes, A., and Maurel, P. Metabolism and CYP-inducer properties of astaxanthin in man and primary human hepatocytes. Arch.Toxicol. 2002;75(11-12):665-675. PubMed
  3. Choi HD, Youn YK, Shin WG. Positive effects of astaxanthin on lipid profiles and oxidative stress in overweight subjects. Plant Foods Hum Nutr. 2011;66:363-369. PubMed

See these in context on the Astaxanthin monograph →

Krill Oil 13 references
  1. Leaf A. On the reanalysis of the GISSI-Prevenzione. Circulation 2002;105:1874-5. PubMed
  2. Connor WE. n-3 Fatty acids from fish and fish oil: panacea or nostrum? Am J Clin Nutr 2001;74;415-6. PubMed
  3. Calder PC. N-3 polyunsaturated fatty acids, inflammation and immunity: pouring oil on troubled waters or another fishy tale? Nutr Res 2001;21:309-41. DOI
  4. Bunea R, El Farrah K, Deutsch L. Evaluation of the effects of Neptune Krill Oil on the clinical course of hyperlipidemia. Altern Med Rev 2004;9:420-8.
  5. Sampalis F, Bunea R, Pelland MF, et al. Evaluation of the effects of Neptune Krill Oil on the management of premenstrual syndrome and dysmenorrhea. Altern Med Rev 2003;8:171-9.
  6. Harris WS, Miller M, Tighe AP, et al. Omega-3 fatty acids and coronary heart disease risk: clinical and mechanistic perspectives. Atherosclerosis 2008;197:12-24. PubMed
  7. Tandy S, Chung RW, Wat E, et al. Dietary krill oil supplementation reduces hepatic steatosis, glycemia, and hypercholesterolemia in high-fat-fed mice. J Agric Food Chem 10-14-2009;57:9339-45. PubMed
  8. Maki, K. C., Reeves, M. S., Farmer, M., Griinari, M., Berge, K., Vik, H., Hubacher, R., and Rains, T. M. Krill oil supplementation increases plasma concentrations of eicosapentaenoic and docosahexaenoic acids in overweight and obese men and women. Nutr.R PubMed
  9. Albert BB, Derraik JG, Brennan CM, et al. Supplementation with a blend of krill and salmon oil is associated with increased metabolic risk in overweight men. Am J Clin Nutr 2015;102(1):49-57.
  10. Berge K, Musa-Veloso K, Harwood M, Hoem N, Burri L. Krill oil supplementation lowers serum triglycerides without increasing low-density lipoprotein cholesterol in adults with borderline high or high triglyceride levels. Nutr Res 2014;34(2):126-33. PubMed
  11. Lobraico JM, DiLello LC, Butler AD, Cordisco ME, Petrini JR, Ahmadi R. Effects of krill oil on endothelial function and other cardiovascular risk factors in participants with type 2 diabetes, a randomized controlled trial. BMJ Open Diabetes Res Care. 2015 PubMed
  12. van der Wurff ISM, von Schacky C, Bergeland T, Zeegers MP, Kirschner PA, de Groot RHM. Krill oil supplementation's effect on school grades in typically developing adolescents. Prostaglandins Leukot Essent Fatty Acids 2023;191:102553. PubMed
  13. van der Wurff ISM, von Schacky C, Bergeland T, et al. Effect of 1 year krill oil supplementation on cognitive achievement of Dutch adolescents: A double-blind randomized controlled trial. Nutrients. 2019;11(6):1230. PubMed

See these in context on the Krill Oil monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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