Interactions on record — worth a quick check against your medications. Based on 2 of 7 ingredients. Check your meds →
Dietary supplement

Ultimate Krill Omega-3 Ingredients & Drug Interactions

by ProCaps Laboratories

Softgel Capsule Category: Fat/fatty Acid
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Ultimate Krill Omega-3 is a dietary supplement by ProCaps Laboratories with 7 active ingredients. Its ingredients are commonly taken for antioxidant support, skin health and aging, eye health.Based on those ingredients, 838 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Astaxanthin, Antarctic Krill Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Ultimate Krill Omega-3 by ProCaps Laboratories

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 7 of its 7 active ingredients.
  • “Total Omega-3 Fatty Acids” is listed as a grouped ingredient — the label gives one combined amount (400 mg) without saying how much of each component you get.

Ultimate Krill Omega-3 contains 7 active ingredients centered on omega-3 fatty acids from Antarctic krill oil. The main omega-3 components are eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), plus astaxanthin, a carotenoid antioxidant naturally found in krill.

The product also includes phospholipids (fat-like compounds in cell membranes) and a proprietary orange essence flavoring. The capsule itself is a soft-gelatin shell, the only inactive ingredient listed.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Phospholipid-based omega-3 support for heart and brain.
  • We looked for evidence on: Cardiovascular disease (CVD), Hyperlipidemia, Hypertriglyceridemia, Age-related cognitive decline, Cognitive function, cholesterol support — and 1 related terms.
  • The closest evidence on file: Astaxanthin is rated "Insufficient Reliable Evidence To Rate" for Age-related cognitive decline (Natural Medicines).
  • Also on file: Astaxanthin is rated "Insufficient Reliable Evidence To Rate" for Hyperlipidemia.
  • Also on file: Krill Oil is rated "Insufficient Reliable Evidence To Rate" for Cardiovascular disease (CVD), Cognitive function, Hyperlipidemia, Hypertriglyceridemia.

Krill oil is rated possibly effective for dry eye symptoms based on available evidence. For astaxanthin, the evidence we hold is insufficient to rate its effectiveness for age-related cognitive decline, macular degeneration, aging skin, Alzheimer's disease, athletic performance, or carpal tunnel syndrome.

Krill oil also has insufficient evidence for aging skin, Alzheimer's disease, cancer prevention, high cholesterol (hyperlipidemia), and cognitive function. The data on these uses isn't established well enough for us to say whether this product will work for you.

The evidence, ingredient by ingredient Astaxanthin Krill Oil

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Both astaxanthin and krill oil are generally well tolerated, though long-term safety data for astaxanthin are limited. The most common side effects from krill oil are digestive — bloating, diarrhea, nausea, heartburn, fishy burps, and stomach discomfort.

Astaxanthin may cause abdominal pain, diarrhea, and red-colored stools; at higher doses, severe stomach pain has been reported in a small number of trial participants. Headache, tiredness, and dizziness have been reported rarely with krill oil.

If you have a shellfish allergy, avoid this product — krill oil comes from crustaceans. If you have a bleeding disorder, use caution.

For pregnancy and breastfeeding, there isn't enough safety data to know either way; talk with your doctor or pharmacist for personalized advice.

Side effects, ingredient by ingredient Astaxanthin Krill Oil

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Astaxanthin, Krill Oil.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 839 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take anticoagulant or antiplatelet drugs (blood thinners like warfarin, clopidogrel, or aspirin) — krill oil may increase bleeding risk. Also double-check if you take antidiabetes medications, since krill oil may theoretically lower blood sugar.

Additionally, if you take medications broken down by your liver (especially those processed by CYP3A4 or CYP2B6 enzymes), astaxanthin may theoretically reduce their effectiveness — your pharmacist can identify these for you.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Ultimate Krill Omega-3 may help with dry eye and provides omega-3 fatty acids from a marine source. If you take blood thinners, diabetes medications, or drugs metabolized by your liver, check with your doctor or pharmacist before starting — the interactions are theoretical but documented.

This product is generally well tolerated, though digestive side effects are common. It's not appropriate during pregnancy or breastfeeding without medical guidance.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 25, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Ultimate Krill Omega-3, straight from the product label.

Brand ProCaps Laboratories
Net contents 240 Easy To Swallow Capsule(s)
Market status On market
Date entered into DSLD Jan 25, 2017
DSLD ID 69986
Product type Fat/fatty Acid
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Ultimate Krill Omega-3 by ProCaps Laboratories, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Softgel(s)
Maximum serving Sizes:
2 Softgel(s)
Servings per container
120
IngredientAmount% DV
Calories15 Calorie(s)--
Calories from Fat15 Calorie(s)--
Eicosapentaenoic Acid210 mg--
Docosahexaenoic Acid110 mg--
Phospholipids680 mg--
Cholesterol30 mg10%
Total Fat1.5 Gram(s)2%
Astaxanthin150 mcg--
Total Omega-3 Fatty Acids400 mg--
Other Omega-3 Fatty Acids80 mg--
Proprietary Orange essence70 mg--
Antarctic Krill Oil1700 mg--

Other ingredients: Soft-Gelatin Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use Consume two or more capsules daily or as recommended by a health care professional.

General Statements

This product is most effective as part of a healthy diet and active lifestyle, along with one of Andrew Lessman's multi-vitamin-mineral formulas. For answers to questions about the use of this product, call 800.808.7311.

Unsurpassed. Purity. Quality. Integrity. Effectiveness. Andrew Lessman Founder of ProCaps Labs This product is only available from HSN 800.944.9999 www.HSN.com ProCaps Laboratories 800.800.1200

All-Solar Manufacturing

Antarctic Krill are tiny, shrimp-like creatures that live in the oceans near Antarctica and represent one of the most abundant life forms on the planet. Krill Oil provides a unique source of the most important Omege-3 fatty acids EPA and DHA, but in a distinctive and highly absorbable phospholipid form. Another bonus: Krill Oil’s rich reddish color comes from the presence of trace amounts of the protective carotenoids Astaxanthin. Omega-3s are absolutely essential for our good health, yet they cannot be made by the body, so their benefits are only available from cold water fish or an Omega-3 dietary supplement. Research has shown that diets rich in Omega-3s are associated with superior heart, brain, circulatory and general health; yet sadly, the American diet delivers alarmingly low levels of these precious fatty acids.

Formula

Phospholipid-based Omega-3s Higher levels of Krill Oil EPA and DHA

Andrew Lessman’s Ultimate Krill Omega-3 provides Phospholipid-based Omega-3s from Krill oil, but does so without Krill Oil’s normally unpleasant fishy aftertaste.

Our Ultimate Krill Omega-3 provides a unique alternative to fish oil based Omega-3s, delivering higher levels of Omegoa-3s provides a unique alternative to fish oil based Omega-3s, delivering higher levels of Omega-3s per capsule than typical Krill Oil product.

Contains an ingredient derived and purified from shellfish (krill).

FDA Statement of Identity

Dietary Supplement

Formulation

Like all ProCaps’ fish oil Omega-3 formulas, our Ultimate Krill Omega-3 also allows you to enjoy all the benefits of an Omega-3 formula with no mercury, no contaminants, no stomach upset and no unpleasant fishy aftertaste.

Contains no milk, soy, yeast, corn, wheat, gluten, sodium, salt, sugar, color, preservative or manufacturing additives. Contains no additives of any kind.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Contains an ingredient derived and purified from shellfish (krill).

Brand IP Statement(s)

2016 ProCaps Labs

General

605646-02U

See for yourself

Ultimate Krill Omega-3 by ProCaps Laboratories label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Ultimate Krill Omega-3 by ProCaps Laboratories

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Softgel(s) Dosage formSoftgel Capsule Servings per container120 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Phospholipids

680 mg per serving

Astaxanthin

Interacts with
671 drugs
150 mcg per serving

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise...

Astaxanthin monograph & interactions

Total Omega-3 Fatty Acids

400 mg per serving
  • › Eicosapentaenoic Acid
  • › Docosahexaenoic Acid
  • › Other Omega-3 Fatty Acids

Proprietary Orange essence

70 mg per serving

Antarctic Krill Oil

Interacts with
208 drugs
1700 mg per serving

Krill oil is a source of omega-3 fatty acids (EPA and DHA) bound to phospholipids, which may help absorption. It is most studied for lowering triglyce...

Antarctic Krill Oil monograph & interactions

Other (inactive) ingredients: Soft-Gelatin Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

Ultimate Krill Omega-3 by ProCaps Laboratories Drug Interactions

Want to check YOUR meds against Ultimate Krill Omega-3?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
838Drugs
838 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Ultimate Krill Omega-3 with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Astaxanthin2 drug types · 671 drugs

Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP2B6.
In vitro research shows that astaxanthin induces cytochrome CYP2B6 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
In vitro research shows that astaxanthin induces CYP3A4 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D

Antarctic Krill Oil2 drug types · 208 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, krill oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Taking high doses of omega-3 fatty acids from fish oil can modestly decrease platelet aggregation. Since krill oil also contains these fatty acids, taking high doses of krill oil might also inhibit platelet aggregation. Theoretically, taking high doses of krill oil with antiplatelet or anticoagulant drugs might increase the risk of bleeding. However, the omega-3 content of krill oil is much lower than that of fish oil.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking krill oil with antidiabetes drugs might increase the risk of hypoglycemia.
Some research in animals and humans shows that krill oil might lower blood glucose levels. However, a small study shows that taking krill oil does not reduce blood glucose levels in patients with type 2 diabetes, most of whom were taking antidiabetes drugs.

Likelihood Possible Evidence B
The maker

Brand information

Manufacturer and brand details for Ultimate Krill Omega-3, from the product label.

ProCaps Laboratories

See all ProCaps Laboratories products
Name
ProCaps Labs
City
Henderson
State
NV
ZipCode
89011
Phone Number
800-800-1200
Web Address
ProCapsLabs.com
Pharmacist Counseling Corner

Ultimate Krill Omega-3 by ProCaps Laboratories: Common Questions

Does Ultimate Krill Omega-3 by ProCaps Laboratories interact with any medications?
Yes. Based on its ingredients, Ultimate Krill Omega-3 has a known interaction with 838 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Ultimate Krill Omega-3 contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I have a shellfish allergy?
No — the data advises against it. Antarctic krill is a crustacean, so if you have a shellfish allergy, avoid this product.
What are the most common side effects?
Digestive side effects from krill oil are most common: bloating, diarrhea, nausea, heartburn, fishy burps, and stomach discomfort. Astaxanthin may cause abdominal pain, diarrhea, and red-colored stools. These effects seem to occur less often or be less severe with krill oil compared to fish oil.
Is this safe to take during pregnancy?
There isn't enough safety data to know either way for both krill oil and astaxanthin. Talk with your doctor or pharmacist for personalized advice before taking it while pregnant.
Is this safe while breastfeeding?
There isn't enough safety data to know either way for both krill oil and astaxanthin. Talk with your doctor or pharmacist for personalized advice before taking it while breastfeeding.
Will this help my dry eyes?
Krill oil is rated possibly effective for dry eye symptoms, so there's some evidence it may help — but it's not guaranteed to work for everyone.
If I have a bleeding disorder, can I take this?
Use caution. Krill oil may increase bleeding risk, especially at higher doses. Talk with your doctor or pharmacist before starting.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Ultimate Krill Omega-3 is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Ultimate Krill Omega-3 label
Sources

Sources & How We Checked

Ultimate Krill Omega-3's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Astaxanthin 3 references
  1. Kupcinskas L, Lafolie P, Lignell A, et al. Efficacy of the natural antioxidant astaxanthin in the treatment of functional dyspepsia in patients with or without Helicobacter pylori infection: A prospective, randomized, double blind, and placebo-controlled
  2. Kistler, A., Liechti, H., Pichard, L., Wolz, E., Oesterhelt, G., Hayes, A., and Maurel, P. Metabolism and CYP-inducer properties of astaxanthin in man and primary human hepatocytes. Arch.Toxicol. 2002;75(11-12):665-675. PubMed
  3. Choi HD, Youn YK, Shin WG. Positive effects of astaxanthin on lipid profiles and oxidative stress in overweight subjects. Plant Foods Hum Nutr. 2011;66:363-369. PubMed

See these in context on the Astaxanthin monograph →

Krill Oil 13 references
  1. Leaf A. On the reanalysis of the GISSI-Prevenzione. Circulation 2002;105:1874-5. PubMed
  2. Connor WE. n-3 Fatty acids from fish and fish oil: panacea or nostrum? Am J Clin Nutr 2001;74;415-6. PubMed
  3. Calder PC. N-3 polyunsaturated fatty acids, inflammation and immunity: pouring oil on troubled waters or another fishy tale? Nutr Res 2001;21:309-41. DOI
  4. Bunea R, El Farrah K, Deutsch L. Evaluation of the effects of Neptune Krill Oil on the clinical course of hyperlipidemia. Altern Med Rev 2004;9:420-8.
  5. Sampalis F, Bunea R, Pelland MF, et al. Evaluation of the effects of Neptune Krill Oil on the management of premenstrual syndrome and dysmenorrhea. Altern Med Rev 2003;8:171-9.
  6. Harris WS, Miller M, Tighe AP, et al. Omega-3 fatty acids and coronary heart disease risk: clinical and mechanistic perspectives. Atherosclerosis 2008;197:12-24. PubMed
  7. Tandy S, Chung RW, Wat E, et al. Dietary krill oil supplementation reduces hepatic steatosis, glycemia, and hypercholesterolemia in high-fat-fed mice. J Agric Food Chem 10-14-2009;57:9339-45. PubMed
  8. Maki, K. C., Reeves, M. S., Farmer, M., Griinari, M., Berge, K., Vik, H., Hubacher, R., and Rains, T. M. Krill oil supplementation increases plasma concentrations of eicosapentaenoic and docosahexaenoic acids in overweight and obese men and women. Nutr.R PubMed
  9. Albert BB, Derraik JG, Brennan CM, et al. Supplementation with a blend of krill and salmon oil is associated with increased metabolic risk in overweight men. Am J Clin Nutr 2015;102(1):49-57.
  10. Berge K, Musa-Veloso K, Harwood M, Hoem N, Burri L. Krill oil supplementation lowers serum triglycerides without increasing low-density lipoprotein cholesterol in adults with borderline high or high triglyceride levels. Nutr Res 2014;34(2):126-33. PubMed
  11. Lobraico JM, DiLello LC, Butler AD, Cordisco ME, Petrini JR, Ahmadi R. Effects of krill oil on endothelial function and other cardiovascular risk factors in participants with type 2 diabetes, a randomized controlled trial. BMJ Open Diabetes Res Care. 2015 PubMed
  12. van der Wurff ISM, von Schacky C, Bergeland T, Zeegers MP, Kirschner PA, de Groot RHM. Krill oil supplementation's effect on school grades in typically developing adolescents. Prostaglandins Leukot Essent Fatty Acids 2023;191:102553. PubMed
  13. van der Wurff ISM, von Schacky C, Bergeland T, et al. Effect of 1 year krill oil supplementation on cognitive achievement of Dutch adolescents: A double-blind randomized controlled trial. Nutrients. 2019;11(6):1230. PubMed

See these in context on the Krill Oil monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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