Major interaction on record — check this product against your medications before combining. Based on 6 of 8 ingredients. Check your meds →
Dietary supplement

Ultra Digestive Enzymes Ingredients & Drug Interactions

by Mason Natural

Ultra Digestive Enzymes label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Ultra Digestive Enzymes against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Ultra Digestive Enzymes is a dietary supplement by Mason Natural with 8 active ingredients. Its ingredients are commonly taken for digestive support for protein digestion, wound cleaning (debridement of dead tissue), sore throat and inflammation.Based on those ingredients, 285 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Calcium, Bromelain, Papain. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Ultra Digestive Enzymes by Mason Natural

Ask about any prescription or over-the-counter medication and we check it for interactions with Ultra Digestive Enzymes by Mason Natural — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Ultra Digestive Enzymes by Mason Natural

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 8 of its 8 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Ultra Digestive Enzymes contains 8 active ingredients designed to help break down food. Amylase, lipase, and acid protease (a type of protease) work on carbohydrates, fats, and proteins respectively — the three main components of what you eat.

Papain comes from papaya and bromelain from pineapple; both are plant enzymes that may also help with protein digestion. Lactase breaks down lactose (milk sugar), and cellulase targets plant fiber.

Calcium rounds out the formula as a mineral. The product also includes inactive ingredients like microcrystalline cellulose (a binder), stearic acid, croscarmellose sodium, silicon dioxide, pharmaceutical glaze, magnesium silicate, and maltodextrin.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Support healthy digestion and reduce bloating.
  • We looked for evidence on: Dyspepsia, Exercise-induced muscle soreness, Lactose intolerance, Postoperative swelling, Sprains, Wound healing — and 4 related terms.
  • The strongest evidence on file: Lactase is rated "Effective" for Lactose intolerance (Natural Medicines).
  • Also on file: Calcium is rated "Effective" for Dyspepsia.
  • Also on file: Papain is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced muscle soreness, Wound healing.

The evidence supporting most of these ingredients is limited. Lactase is the one ingredient with solid support — it's effective for lactose intolerance.

For the others, the data we hold shows insufficient reliable evidence to rate them: papain, bromelain, lipase, acid protease, and amylase don't have established effectiveness for their intended purposes in this context. Calcium itself is effective for several conditions including osteoporosis and low blood calcium, but that's not the role it's playing in a digestive enzyme blend.

Bottom line: if you're looking for enzyme support for digestion, the evidence for most of these ingredients hasn't been well established.

The evidence, ingredient by ingredient Papain Bromelain Lipase Lactase Calcium Proteolytic Enzymes (proteases)

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Papain and bromelain are generally tolerated short-term at normal doses, but high doses may be unsafe. Some people may have allergic reactions — papain can trigger itchy watery eyes, runny nose, sneezing, abdominal cramps, or diarrhea in sensitive individuals, and bromelain may cause similar IgE-mediated allergic reactions.

Both ingredients can also cause mild gastrointestinal upset like diarrhea or gastric discomfort. Calcium is generally well tolerated at recommended amounts, though high doses can lead to constipation, kidney stones, or other problems.

Lipase and lactase have minimal adverse effects reported in adults when used as directed. Acid protease may cause digestive upset or allergic reactions in sensitive people.

For pregnancy, papain and bromelain should be avoided — the data advises against them. Calcium is likely safe at adequate levels during pregnancy.

For lactase, there isn't enough data, so check with your doctor. Bromelain and acid protease should be avoided during breastfeeding due to insufficient safety information.

Side effects, ingredient by ingredient Papain Bromelain Lipase Lactase Calcium Proteolytic Enzymes (proteases)

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 3 of the 6 matched ingredients can interact with medications — Papain, Calcium, Bromelain.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; heart-rhythm medications; lithium.
  • For scale: 285 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check these medication types with your pharmacist, worst severity first: HIV integrase inhibitors (dolutegravir, elvitegravir), intravenous ceftriaxone, blood thinners and antiplatelet drugs (including warfarin), thyroid medications (levothyroxine), heart rhythm and blood pressure drugs (sotalol, diltiazem, raltegravir, calcipotriene), and tetracycline antibiotics. No interactions are documented for amylase and cellulase, which we could not check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This product may help if you have trouble digesting food, particularly lactose intolerance, though evidence for most ingredients is limited. If you take any prescription medications — especially blood thinners, thyroid drugs, HIV medications, or heart rhythm drugs — check them against the interaction tool before starting.

Talk to your pharmacist if you're pregnant, breastfeeding, or have a serious digestive condition.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Ultra Digestive Enzymes, straight from the product label.

Brand Mason Natural
Barcode (UPC) 311845180254
Net contents 60 Tablet(s)
Market status On market
Date entered into DSLD Apr 22, 2021
DSLD ID 244939
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Ultra Digestive Enzymes by Mason Natural, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
60
UPC/BARCODE
311845180254
IngredientAmount% DV
Amylase50 mg--
Papain50 mg--
Bromelain50 mg--
Lipase50 mg--
Lactase50 mg--
Calcium44 mg3%
Cellulase50 mg--
Acid Protease50 mg--

Other ingredients: Microcrystalline Cellulose, Stearic Acid, Croscarmellose Sodium, Silicon Dioxide, Pharmaceutical Glaze, Magnesium Silicate, Maltodextrin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Seals/Symbols

Mason guarantee Laboratory Tested cGMP Certified Good Manufacturing Practice

General Statements

Certified N Mason natural Est. 1967

Please recycle

Formula

Plant-based ultra digestive enzymes with bromelain, lactase, papain & protease

Formulation

May Support healthy digestion & reduce bloating

Guaranteed no added: Sugar, yeast, soy, wheat, dairy, fish, tree nuts, peanuts, egg, fragrance, artificial colors or flavors, preservatives, crustacean shellfish.

Soy free

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Suggested/Recommended/Usage/Directions

Directions: Adults - Take one tablet daily, preferably with food, as a dietary supplement.

Precautions

Caution: If you are pregnant, nursing, taking any medications or have any medical condition, consult your physician before use.

Discontinue use and consult your physician if any adverse reactions occur.

Keep out of reach of children.

Tamper-Evident Seal: Do not use product if seal appears tampered.

Storage

Store in a dry place under controlled room temperature: 20 degrees - 25 degrees C (68 degrees - 77 degrees F).

Brand IP Statement(s)

Mason Natural is a registered trademark and does not refer to any product or ingredient claim.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Ultra Digestive Enzymes by Mason Natural label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Ultra Digestive Enzymes label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Ultra Digestive Enzymes by Mason Natural

These are the 8 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Amylase

50 mg per serving

Papain

Interacts with
2 drugs
50 mg per serving

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food an...

Papain monograph & interactions

Bromelain

Interacts with
141 drugs
50 mg per serving

Bromelain is a group of protein-digesting enzymes from pineapple that people take mainly for inflammation, swelling, and sinus problems. Some early st...

Bromelain monograph & interactions

Lipase

No known
interactions
50 mg per serving

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy fo...

Lipase monograph & interactions

Lactase

No known
interactions
50 mg per serving

Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can red...

Lactase monograph & interactions

Calcium

Interacts with
168 drugs
44 mg per serving Form: Dicalcium Phosphate

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet f...

Calcium monograph & interactions

Cellulase

50 mg per serving

Acid Protease

No known
interactions
50 mg per serving

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...

Acid Protease monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Stearic Acid, Croscarmellose Sodium, Silicon Dioxide, Pharmaceutical Glaze, Magnesium Silicate, Maltodextrin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Ultra Digestive Enzymes by Mason Natural Drug Interactions

Want to check YOUR meds against Ultra Digestive Enzymes?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
285Drugs
7 Major 260 Moderate 18 Minor

Ingredients driving the most interactions

Calcium 168
Bromelain 141
Papain 2

Individual Drug Interactions

The ingredients in Ultra Digestive Enzymes interact with 285 drugs. Click any drug to see the details.

3 of the 8 ingredients in Ultra Digestive Enzymes interact with drugs. Each result below shows which ingredient is responsible. Calcium Bromelain Papain

Each ingredient & the kinds of drugs it affects

For each ingredient in Ultra Digestive Enzymes with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Calcium18 drug types · 168 drugs

Ceftriaxone (Rocephin)

Co-administration of intravenous calcium and ceftriaxone can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys.
Avoid administering intravenous calcium in any form, such as parenteral nutrition or Lactated Ringers, within 48 hours of intravenous ceftriaxone. Case reports in neonates show that administering intravenous ceftriaxone and calcium can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys. In several cases, neonates have died as a result of this interaction. So far there are no reports in adults; however, there is still concern that this interaction might occur in adults.

Likelihood Probable Evidence D
Dolutegravir (Tivicay)

Calcium seems to reduce levels of dolutegravir.
Advise patients to take dolutegravir either 2 hours before or 6 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium carbonate 1200 mg concomitantly with dolutegravir 50 mg reduces plasma levels of dolutegravir by almost 40%. Calcium appears to decrease levels of dolutegravir through chelation.

Likelihood Probable Evidence B
Elvitegravir (Vitekta)

Calcium seems to reduce levels of elvitegravir.
Advise patients to take elvitegravir either 2 hours before or 2 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium along with elvitegravir can reduce blood levels of elvitegravir through chelation.

Likelihood Probable Evidence B
Aluminum

Calcium citrate might increase aluminum absorption and toxicity. Other types of calcium do not increase aluminum absorption.
Calcium citrate can increase the absorption of aluminum when taken with aluminum hydroxide. The increase in aluminum levels may become toxic, particularly in individuals with kidney disease. However, the effect of calcium citrate on aluminum absorption is due to the citrate anion rather than calcium cation. Calcium acetate does not appear to increase aluminum absorption.

Likelihood Possible Evidence B
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Calcium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide and calcium can be taken together if taken with food. However, if taken on an empty stomach, bictegravir/emtricitabine/tenofovir alafenamide should not be taken with, or 2 hours after, calcium containing products.

Likelihood Probable Evidence D
Bisphosphonates

Calcium reduces the absorption of bisphosphonates.
Advise patients to take bisphosphonates at least 30 minutes before calcium, but preferably at a different time of day. Calcium supplements decrease absorption of bisphosphonates.

Likelihood Probable Evidence C
Calcipotriene (Dovonex)

Taking calcipotriene with calcium might increase the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with calcium supplements might increase the risk of hypercalcemia.

Likelihood Possible Evidence B
Digoxin (Lanoxin)

Using intravenous calcium with digoxin might increase the risk of fatal cardiac arrhythmias.
Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. However, one retrospective analysis of clinical data suggests that intravenous calcium does not increase the risk of dysrhythmias or mortality in patients receiving digoxin.

Likelihood Possible Evidence B
Diltiazem (Cardizem, Others)

Theoretically, calcium may reduce the therapeutic effects of diltiazem.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, calcium might increase this risk of hypercalcemia and reduce the effectiveness of diltiazem.

Likelihood Probable Evidence D
Levothyroxine (Synthroid, Others)

Calcium seems to reduce the absorption and effectiveness of levothyroxine.
Advise patients to take levothyroxine and calcium supplements at least 4 hours apart. Calcium reduces levothyroxine absorption, probably by forming insoluble complexes. Calcium carbonate supplements reduce effectiveness of levothyroxine in patients with hypothyroidism.

Likelihood Probable Evidence B
Lithium

Theoretically, concomitant use of calcium and lithium may increase this risk of hypercalcemia.
Clinical research suggests that long-term use of lithium may cause hypercalcemia in 10% to 60% of patients. Theoretically, concomitant use of lithium and calcium supplements may further increase this risk.

Likelihood Possible Evidence B
Quinolone Antibiotics

Calcium seems to reduce the absorption of quinolone antibiotics.
Advise patients to take oral quinolones at least 2 hours before or 4-6 hours after calcium supplements or calcium-fortified foods. Taking calcium at the same time as oral quinolones can reduce quinolone absorption. Calcium binds to quinolones in the gut.

Likelihood Probable Evidence B
Raltegravir (Isentress)

Calcium may reduce levels of raltegravir.
Pharmacokinetic research shows that taking a single dose of calcium carbonate 3000 mg along with raltegravir 400 mg twice daily modestly decreases the mean area under the curve of raltegravir, but the decrease does not necessitate a dose adjustment of raltegravir. However, a case of elevated HIV-1 RNA levels and documented resistance to raltegravir has been reported for a patient taking calcium carbonate 1 gram three times daily plus vitamin D3 (cholecalciferol) 400 IU three times daily in combination with raltegravir 400 mg twice daily for 11 months. It is thought that calcium reduced raltegravir levels by chelation, leading to treatment failure.

Likelihood Possible Evidence B
Sotalol (Betapace)

Calcium seems to reduce the absorption of sotalol.
Advise patients to separate doses by at least 2 hours before or 4-6 hours after calcium. Calcium appears to reduce the absorption of sotalol, probably by forming insoluble complexes.

Likelihood Possible Evidence B
Tetracycline Antibiotics

Calcium seems to reduce the absorption of tetracycline antibiotics.
Advise patients to take oral tetracyclines at least 2 hours before, or 4-6 hours after calcium supplements. Taking calcium at the same time as oral tetracyclines can reduce tetracycline absorption. Calcium binds to tetracyclines in the gut.

Likelihood Probable Evidence C
Thiazide Diuretics

Taking calcium along with thiazides might increase the risk of hypercalcemia and renal failure.
Thiazides reduce calcium excretion by the kidneys. Using thiazides along with moderately large amounts of calcium carbonate increases the risk of milk-alkali syndrome (hypercalcemia, metabolic alkalosis, renal failure). Patients may need to have their serum calcium levels and/or parathyroid function monitored regularly.

Likelihood Probable Evidence C
Verapamil (Calan, Others)

Theoretically, calcium may reduce the therapeutic effects of verapamil.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, use of calcium supplements may increase this risk of hypercalcemia and reduce the effectiveness of verapamil.

Likelihood Probable Evidence D
Calcium Channel Blockers

Intravenous calcium may decrease the effects of calcium channel blockers; oral calcium is unlikely to have this effect.
Intravenous calcium is used to decrease the effects of calcium channel blockers in the management of overdose. Intravenous calcium gluconate has been used before intravenous verapamil (Isoptin) to prevent or reduce the hypotensive effects without affecting the antiarrhythmic effects. But there is no evidence that dietary or supplemental calcium when taken orally interacts with calcium channel blockers.

Likelihood Unlikely Evidence D
Calcium full monograph & interactions

Bromelain2 drug types · 141 drugs

Anticoagulant/Antiplatelet Drugs

Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
There is one case report of a patient experiencing minor bruising while taking bromelain with naproxen. Bromelain is thought to have antiplatelet activity. Whether this interaction is of concern with topical bromelain is unclear. Interference with coagulation of burn wounds has been reported in a patient receiving bromelain-based enzymatic debridement. However, observational research has found that topical bromelain debridement is not associated with increases or decreases in laboratory markers of coagulation when compared with surgical debridement.

Likelihood Possible Evidence D
Tetracycline Antibiotics

Theoretically, bromelain might increase levels of tetracycline antibiotics.
Laboratory research suggests that bromelain might increase the absorption of tetracycline antibiotics. However, a study in healthy adults reported no difference in tetracycline plasma levels when a 500 mg dose was taken with or without bromelain 80 mg.

Likelihood Possible Evidence B
Bromelain full monograph & interactions

Papain1 drug type · 2 drugs

Warfarin (Coumadin)

Theoretically, papain might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.

Likelihood Possible Evidence D
Papain full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Ultra Digestive Enzymes, from the product label.

Mason Natural

See all Mason Natural products
Name
Mason Vitamins, Inc.
City
Miami Lakes
State
FL
ZipCode
33014
Phone Number
1-888-860-5376
Web Address
www.MasonVitamins.com
Pharmacist Counseling Corner

Ultra Digestive Enzymes by Mason Natural: Common Questions

Does Ultra Digestive Enzymes by Mason Natural interact with any medications?
Yes. Based on its ingredients, Ultra Digestive Enzymes has a known interaction with 285 medications, including 7 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Ultra Digestive Enzymes contains 8 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help my digestion?
Lactase — which breaks down milk sugar — has solid evidence behind it, especially if you're lactose intolerant. For the other enzymes (amylase, lipase, papain, bromelain, protease, cellulase), the evidence in our data is insufficient to say whether they actually improve digestion. Talk to your pharmacist about whether this blend makes sense for your specific situation.
Can I take this if I'm pregnant?
Papain and bromelain should be avoided during pregnancy based on safety concerns. Lactase is likely safe. Calcium is important in pregnancy, but stick to recommended amounts. For the other ingredients, there isn't enough data — check with your doctor before taking them regularly while pregnant.
Can I take this while breastfeeding?
Lactase is likely safe and has a rating of 'Likely Safe' during breastfeeding. Papain and bromelain should be avoided due to insufficient safety data. Calcium at recommended amounts is safe. For lipase and acid protease, there's little data, so ask your pharmacist or doctor first.
What are papain and bromelain?
Papain is an enzyme from papaya, and bromelain is an enzyme from pineapple. Both are used in digestive supplements to help break down proteins, though the evidence for how well they work in supplement form is limited. Some people can have allergic reactions to them, and they can affect blood thinners.
Is this product a substitute for a prescription digestive enzyme?
No. Over-the-counter enzyme blends like this are not the same as prescription pancreatic enzymes prescribed for serious digestive conditions. If you have a condition like cystic fibrosis or pancreatitis, talk to your doctor about what you actually need.
What are the inactive ingredients?
The product contains microcrystalline cellulose (a binder), stearic acid, croscarmellose sodium, silicon dioxide, pharmaceutical glaze, magnesium silicate, and maltodextrin. These are standard tablet fillers and binders.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Ultra Digestive Enzymes is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Ultra Digestive Enzymes label
Go deeper

The Full Monographs Behind Ultra Digestive Enzymes’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Papain

Interacts with 2 drugs

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food and laboratory uses, strong human evidence...

Read the full Papain monograph → Herb & supplement monograph

Bromelain

Interacts with 141 drugs

Bromelain is a group of protein-digesting enzymes from pineapple that people take mainly for inflammation, swelling, and sinus problems. Some early studies are promising, but the overall evi...

Read the full Bromelain monograph → Herb & supplement monograph

Lipase

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...

Read the full Lipase monograph → Herb & supplement monograph

Lactase

Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can reduce gas, bloating, cramping, and diarrhe...

Read the full Lactase monograph → Herb & supplement monograph

Calcium

Interacts with 168 drugs

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet falls short. Most people do best getting...

Read the full Calcium monograph → Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph →
Sources

Sources & How We Checked

Ultra Digestive Enzymes's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 97 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Papain 11 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
  3. Shuttleworth D, Hill S, Marks R, Connelly DM. Relief of experimentally induced pruritus with a novel eutectic mixture of local anaesthetic agents. Br J Dermatol 1988;119:535-40.
  4. Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
  5. Martin, T., Uhder, K., Kurek, R., Roeddiger, S., Schneider, L., Vogt, H. G., Heyd, R., and Zamboglou, N. Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial PubMed
  6. Walker-Renard, P. Update on the medicinal management of phytobezoars. Am J Gastroenterol. 1993;88(10):1663-1666.
  7. Tymoszuk D, Wiszniewska M, Walusiak-Skorupa J. Papain-induced occupational rhinoconjunctivitis and asthma - A case report. Med Pr 2016;67(1):109-12. PubMed
  8. Soto-Mera MT, López-Rico MR, Filgueira JF, et al. Occupational allergy to papain. Allergy 2000;55(10):983-4. PubMed
  9. Tarlo SM, Shaikh W, Bell B, et al. Papain-induced allergic reactions. Clin Allergy 1978;8(3):207-15. PubMed
  10. Baur X, König G, Bencze K, Fruhmann G. Clinical symptoms and results of skin test, RAST and bronchial provocation test in thirty-three papain workers: Evidence for strong immunogenic potency and clinically relevant proteolytic e?ects of airborne papain. C
  11. Novey HS, Keenan WJ, Fairshter RD, Wells ID, Wilson AF, Culver BD. Pulmonary disease in workers exposed to papain: clinico-physiological and immunological studies. Clin Allergy 1980;10(6):721-31. PubMed

See these in context on the Papain monograph →

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Lipase 1 reference
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Lactase 1 reference
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Proteolytic Enzymes (proteases) 3 references
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See these in context on the Proteolytic Enzymes (proteases) monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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