Interactions on record — worth a quick check against your medications. Based on 1 of 3 ingredients. Check your meds →
Dietary supplement

Ultra Flora Plus DF Ingredients & Drug Interactions

by Metagenics

Ultra Flora Plus DF label
See full label image
Powder Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Ultra Flora Plus DF against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Ultra Flora Plus DF is a dietary supplement by Metagenics with 3 active ingredients. Its ingredients are commonly taken for digestive health and balance, diarrhea (including antibiotic-related), vaginal yeast and bacterial infections.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lactobacillus acidophilus NCFM. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Ultra Flora Plus DF by Metagenics

Ask about any prescription or over-the-counter medication and we check it for interactions with Ultra Flora Plus DF by Metagenics — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Ultra Flora Plus DF by Metagenics

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 17, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 3 active ingredients.
  • “A 50:50 Blend” is a proprietary blend — the label gives one combined amount (15,000,000,000 Live Organism(s)) without saying how much of each component you get.

Ultra Flora Plus DF is a powder with 3 active ingredients: Lactobacillus acidophilus NCFM (a live probiotic bacterium), Bifidobacterium lactis Bi-07 (another live probiotic bacterium), and Globulin Protein Concentrate. The product also contains inactive ingredients including fructooligosaccharides and concentrate of immunoglobulin proteins.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: digestive health and bacterial balance.
  • We looked for evidence on: Antibiotic-associated diarrhea, Bacterial vaginosis, Clostridioides difficile infection, Colic, Constipation, Helicobacter pylori — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Bacterial vaginosis, Helicobacter pylori, Irritable bowel syndrome (IBS).
  • Also on file: Lactobacillus Acidophilus is rated "Insufficient Reliable Evidence To Rate" for Constipation, Inflammatory bowel disease (IBD), Lactose intolerance.

The Lactobacillus acidophilus in this product is rated possibly effective for irritable bowel syndrome (IBS), Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis. It's rated possibly ineffective for atopic disease (allergic conditions), and there isn't enough reliable evidence to rate it for acute respiratory distress syndrome.

We don't have effectiveness data on file for the other two active ingredients.

The evidence, ingredient by ingredient Lactobacillus Acidophilus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactobacillus acidophilus is generally well tolerated in healthy adults and children. That said, since it contains live, active microorganisms, there's a theoretical concern it could cause infection in some patients — cases of bacteremia, sepsis, and other serious infections have been reported, though most are thought to happen when bacteria move from their normal location in the body.

Gastrointestinal side effects like belly discomfort, bloating, gas, diarrhea, or nausea are uncommon but possible, especially when combined with other probiotics. A small number of trial participants taking a multi-probiotic blend reported rash or itching, though it's unclear whether L. acidophilus was the cause.

Check with your doctor before starting, especially if you have a weakened immune system or are hospitalized.

Side effects, ingredient by ingredient Lactobacillus Acidophilus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lactobacillus Acidophilus.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before combining this product with antibiotic drugs. Taking them at the same time may lower how well the probiotic works — spacing out the doses is usually recommended.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may help with IBS, antibiotic-associated diarrhea, or bacterial vaginosis. If you're on antibiotics, space out the timing with your doctor's guidance — taking them together may reduce the probiotic's benefit.

Talk with your own doctor or pharmacist before starting, particularly if you have any condition affecting your immune system.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Ultra Flora Plus DF, straight from the product label.

Brand Metagenics
Barcode (UPC) 755571031247
Net contents 1.76 oz.; 50 Gram(s)
Market status On market
Date entered into DSLD Nov 25, 2013
DSLD ID 27787
Product type Non-nutrient/non-botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Ultra Flora Plus DF by Metagenics, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.25 tsp
Maximum serving Sizes:
0.25 tsp
Servings per container
67
UPC/BARCODE
755571031247
IngredientAmount% DV
Calories5 {Calories}--
Total Carbohydrates1 Gram(s)1%
Lactobacillus acidophilus NCFM0 NP--
A 50:50 Blend15000000000 Live Organism(s)--
Globulin Protein Concentrate560 mg--
Bifidobacterium lactis Bi-070 NP--

Other ingredients: Fructooligosaccharides, concentrate of immunoglobulin proteins

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Powder

Product is filled by weight, not by volume. Contents will settle during shipping.

Genetic Potential Through Nutrition

15 BILLION ORGANISMS PER SERVING GUARANTEED

LUL072G

F1256B

PROD. UF50

Formula

Contains: milk, soy.

Bifidobacteria & NCFM(R) Acidophilus with Probio-Saccharide(R) Factor & Probio-Protein(R) Factor

Precautions

Contains: milk, soy.

Formulation

Formulated to Exclude: Wheat, corn, nuts, tree nuts, fish, crustacean shellfish, colors, artificial sweeteners, artificial flavors, and preservatives.

Storage

NOTICE: For maximum stability and viability, keep refrigerated. However, product may be stored at room temperature (65-75(0)F) for up to one month without adversely affecting potency. This makes Ultra Flora Plus DF an excellent choice for travelers.

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

U.S. Patent Nos 5,744,134 and 6,241,983 NCFM(R) is a trademark of the North Carolina Dairy Foundation

Ultra Flora Plus(R) provides 15 billion live organisms per serving guaranteed through expiration. This patented probiotic supplement features highly viable, pure strains of Lactobacillus acidophilus (NCFM(R) strain) and Bifidobacterium lactis (formerly known as B. infantis)-"friendly" bacteria that support a healthy intestinal environment. In addition, Ultra Flora Plus supplies the valuable Probio-Saccharide(R) Factor (fructooligosaccharides) along with Probio-Protein(R) Factor, an immunoglobulin protein concentrate from whey.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Suggested/Recommended/Usage/Directions

DIRECTIONS: Mix about 1/4 teaspoon (.75 g) with four to six ounces unchilled water one to two times daily between meals, or as directed by your healthcare practitioner.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Ultra Flora Plus DF by Metagenics label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Ultra Flora Plus DF label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Ultra Flora Plus DF by Metagenics

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size0.25 tsp Dosage formPowder Servings per container67 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

A 50:50 Blend

15000000000 Live Organism(s) per serving

Globulin Protein Concentrate

560 mg per serving

Other (inactive) ingredients: Fructooligosaccharides, Concentrate of immunoglobulin proteins. These complete the product’s ingredient list but are not active constituents.

Interaction report

Ultra Flora Plus DF by Metagenics Drug Interactions

Want to check YOUR meds against Ultra Flora Plus DF?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Lactobacillus acidophilus NCFM 182

Individual Drug Interactions

The ingredients in Ultra Flora Plus DF interact with 182 drugs. Click any drug to see the details.

1 of the 3 ingredients in Ultra Flora Plus DF interact with drugs. Each result below shows which ingredient is responsible. Lactobacillus acidophilus NCFM

Each ingredient & the kinds of drugs it affects

For each ingredient in Ultra Flora Plus DF with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lactobacillus acidophilus NCFM1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus acidophilus NCFM full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Ultra Flora Plus DF, from the product label.

Metagenics

See all Metagenics products
Name
METAGENICS, INC. Makers of Professional Quality Supplements
Street Address
100 Ave. La Pata
City
San Clemente
State
CA
ZipCode
92673
Web Address
www.metagenics.com
Pharmacist Counseling Corner

Ultra Flora Plus DF by Metagenics: Common Questions

Does Ultra Flora Plus DF by Metagenics interact with any medications?
Yes. Based on its ingredients, Ultra Flora Plus DF has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Ultra Flora Plus DF contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while I'm on antibiotics?
You can, but timing matters. Antibiotics can kill off the live organisms in this probiotic, which would reduce how well it works. Talk with your doctor or pharmacist about spacing out your antibiotic and this supplement — they can suggest the best timing for your situation.
Is this safe during pregnancy?
Lactobacillus acidophilus is rated possibly safe in pregnancy based on available data. That said, safety information is limited, so discuss it with your doctor or midwife before starting — they know your individual health picture and can give you personalized advice.
What does this product actually do?
The main active ingredient, Lactobacillus acidophilus, is possibly effective for irritable bowel syndrome, antibiotic-associated diarrhea, certain types of bacterial vaginosis, and Helicobacter pylori infection. We don't have reliable evidence data on the other probiotic or the protein concentrate in this formulation.
Are there any side effects?
Most people tolerate it well, but some experience mild stomach symptoms like bloating, gas, discomfort, or diarrhea — these are uncommon. Very rarely, a rash or itching has been reported. Since it contains live microorganisms, there's a small theoretical risk of infection if your immune system is compromised.
Does it work for allergies?
No — Lactobacillus acidophilus is rated possibly ineffective for allergic conditions (atopic disease). It's not recommended for that use based on current evidence.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Ultra Flora Plus DF is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Ultra Flora Plus DF label
Go deeper

The Full Monographs Behind Ultra Flora Plus DF’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph →
Sources

Sources & How We Checked

Ultra Flora Plus DF's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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