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Dietary supplement

Urinary Bladder Support Ingredients & Drug Interactions

by Hawaii Pharm

Liquid Category: Botanical
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Urinary Bladder Support is a dietary supplement by Hawaii Pharm with 4 active ingredients. Its ingredients are commonly taken for cough and sore throat, dry mouth and throat irritation, digestive upset and heartburn.Based on those ingredients, 2,143 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Marshmallow Leaf Extract, Dry, Uva Ursi Herb Extract, Dry, Corn Silk Extract, Dry. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Urinary Bladder Support by Hawaii Pharm

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 4 active ingredients.
  • “Proprietary Extract Blend” is a proprietary blend — the label gives one combined amount (983 mg) without saying how much of each component you get.

This liquid formula contains four active plant extracts. Marshmallow leaf extract, corn silk extract, couch grass root extract, and uva ursi herb extract are blended together to support urinary tract health.

The product also includes alcohol, water, and glycerin as inactive ingredients that help preserve and deliver the extracts.

Does it work?

Leans against
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Leans against

The strongest graded evidence we hold for the stated purpose leans against a benefit.

Why this rating?
  • The label markets this product for: urinary bladder and kidney support.
  • We looked for evidence on: Urinary tract infections (UTIs), Kidney stones (nephrolithiasis), Nocturnal enuresis, Benign prostatic hyperplasia (BPH), Prostatitis, Urinary discomfort — and 3 related terms.
  • The closest evidence on file: Uva Ursi is rated "Possibly Ineffective" for Urinary tract infections (UTIs) (Natural Medicines).
  • Also on file: Corn Silk is rated "Insufficient Reliable Evidence To Rate" for Kidney stones (nephrolithiasis), Prostatitis, Urinary tract infections (UTIs), Nocturnal enuresis.
  • Also on file: Uva Ursi is rated "Insufficient Reliable Evidence To Rate" for Benign prostatic hyperplasia (BPH).

The evidence for these ingredients is limited. Marshmallow leaf has insufficient evidence to rate for the conditions it's traditionally used for — including vaginal yeast infections, diarrhea, eczema, and respiratory infections.

Corn silk, too, shows insufficient evidence for its proposed uses like heart disease, diabetes, and fatigue. Uva ursi herb extract is rated possibly ineffective for urinary tract infections, the very condition this product seems designed to address — the data we hold doesn't support its use for that purpose.

Couch grass root has no effectiveness ratings in our data.

The evidence, ingredient by ingredient Marshmallow Corn Silk Couch Grass Uva Ursi

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Marshmallow leaf and corn silk are generally well tolerated for short-term use, though human safety data are limited for both. Uva ursi is also generally well tolerated at low doses in the short term, but can be toxic at high doses or with prolonged use — at very high doses (30 grams or more), it may be fatal.

All three have advised against use during pregnancy due to insufficient safety data. Marshmallow and uva ursi should be avoided while breastfeeding; for corn silk, safety while breastfeeding is unknown, so avoid it unless a doctor approves.

Uva ursi may cause nausea, vomiting, diarrhea, and stomach upset, and at high doses can cause serious effects like convulsions and delirium. Couch grass is considered generally well tolerated but should be avoided in pregnancy and breastfeeding due to limited safety data.

Side effects, ingredient by ingredient Marshmallow Corn Silk Couch Grass Uva Ursi

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 4 matched ingredients can interact with medications — Corn Silk, Uva Ursi, Marshmallow.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; lithium.
  • For scale: 2,144 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Urinary Bladder Support, check with your pharmacist if you take blood pressure medications (antihypertensives), diabetes medications, corticosteroids, diuretics, or warfarin — corn silk extract has moderate interactions with all of these. Uva ursi may affect medications metabolized by CYP2C19 or CYP3A4 enzymes, glucuronidated drugs, or lithium, and urinary acidifiers can interfere with uva ursi's function.

Marshmallow leaf may impair absorption of oral medications — space them 30–60 minutes apart. If you're on any regular medication, use the checker on this page with your specific drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with graded evidence leaning against its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product combines four plant extracts aimed at urinary tract support, but the evidence that they work is not established in our data — uva ursi is even rated possibly ineffective for UTIs. If you take blood pressure, diabetes, or blood-thinning medications, or corticosteroids or diuretics, you need to check your exact drugs with the tool below before starting, because corn silk and other ingredients carry documented interactions.

Talk to your pharmacist or doctor about whether this product is right for you and your medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Urinary Bladder Support, straight from the product label.

Brand Hawaii Pharm
Barcode (UPC) 840253664150
Net contents 4 Fluid Ounce(s); 120 mL
Market status On market
Date entered into DSLD Oct 24, 2023
DSLD ID 301953
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Urinary Bladder Support by Hawaii Pharm, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.7 mL
Maximum serving Sizes:
1 mL
Servings per container
120
UPC/BARCODE
840253664150
IngredientAmount% DV
Proprietary Extract Blend983 mg--
Marshmallow Leaf Extract, Dry0 NP--
Corn Silk Extract, Dry0 NP--
Couch Root Extract, Dry0 NP--
Uva Ursi Herb Extract, Dry0 NP--

Other ingredients: Alcohol, Water, Glycerin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Hawaii Pharm Herbal Extract Highest quality since 2008

Suggested/Recommended/Usage/Directions

Suggested use: Shake well before using. For adults add about 20-30 drops (0.7-1 mL, one full squeeze of the dropper bulb) to some juice or water, up to 4 times a day.

Precautions

Warning: We recommend to seek expert medical advice before taking.

Do not use if you are allergic to any ingredients.

Consult your physician before giving to children under 18, during pregnancy, if nursing or taking medications.

Consult your physician before giving to children under 18, during pregnancy, if nursing or taking medications.

May affect the ability to drive and operate machinery. May have contraindications, can cause side effects and adverse reactions. Do not use if seal is broken or missing.

Keep out of the reach of children!

Storage

Store in a cool dry place.

Seals/Symbols

cGMP Made in compliance with cGMP 21 CFR 111 in an FDA registered and inspected facility.

Organic Alcohol Based USA Made in United States of America

FDA Disclaimer Statement

This product has not been evaluated by the FDA and is not intended to diagnose, treat, cure or prevent any disease.

Formulation

Made in USA, Hawaii

Only natural ingredients Purity is laboratory tested and verified

All the raw materials are gluten-free by their nature No artificial colors, flavors, or preservatives

Not tested on animals

Organic Alcohol Based

FDA Statement of Identity

Herbal Supplement

Formula

Organic Alcohol Based

General Statements

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See for yourself

Urinary Bladder Support by Hawaii Pharm label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Urinary Bladder Support by Hawaii Pharm

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size0.7 mL Dosage formLiquid Servings per container120 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Other (inactive) ingredients: Alcohol, Water, Glycerin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Urinary Bladder Support by Hawaii Pharm Drug Interactions

Want to check YOUR meds against Urinary Bladder Support?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
2,143Drugs
971 Moderate 1,172 Minor

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Urinary Bladder Support with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Marshmallow Leaf Extract, Dry3 drug types · 2,040 drugs

Lithium

Theoretically, due to potential diuretic effects, marshmallow might reduce excretion and increase levels of lithium.
Marshmallow is thought to have diuretic properties. To avoid lithium toxicity, the dose of lithium might need to be decreased when used with marshmallow.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, marshmallow flower might have antiplatelet effects.
Animal research suggests that marshmallow flower extract has antiplatelet effects. However, the root and leaf of marshmallow, not the flower, are the plant parts most commonly found in dietary supplements. Theoretically, use of marshmallow flower with anticoagulant/antiplatelet drugs can have additive effects, and might increase the risk for bleeding in some patients.

Likelihood Unlikely Evidence D
Oral Drugs

Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Marshmallow contains mucilage which can affect oral drug absorption. To avoid changes in absorption, take marshmallow 30-60 minutes after oral medications.

Likelihood Possible Evidence D

Uva Ursi Herb Extract, Dry6 drug types · 803 drugs

Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, uva ursi may decrease the metabolism of CYP2C19 substrates.
In vitro, uva ursi appears to inhibit cytochrome CYP2C19. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.
In vitro, uva ursi appears to inhibit CYP3A4. This effect has not been reported in humans.

Likelihood Possible Evidence D
Glucuronidated Drugs

Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
In vitro, uva ursi extract appears to strongly inhibit UDP-glucuronosyltransferase (UGT) 1A1 (UGT1A1). However, uva ursi extract does not appear to inhibit UGT1A1 in animal models. This effect has not been reported in humans.

Likelihood Possible Evidence D
Lithium

Theoretically, uva ursi may increase lithium levels, necessitating a decrease in dose.
Uva ursi may have diuretic properties. Diuretics may increase lithium reabsorption with sodium in the proximal tubule of the kidney. Theoretically, uva ursi might reduce excretion and increase levels of lithium.

Likelihood Probable Evidence D
Urinary Acidifying Agents

Effects of uva ursi in the urinary tract may be reduced by urinary acidifying agents.
Uva ursi seems to work best in alkaline urine. Theoretically, taking uva ursi with medications known to acidify the urine may decrease any effects of uva ursi on the urinary tract.

Likelihood Possible Evidence D
P-Glycoprotein Substrates

Theoretically, uva ursi may alter the levels of drugs transported by P-glycoprotein.
In vitro, uva ursi appears to inhibit the multi-drug transporter protein, P-glycoprotein. This effect has not been reported in humans.

Likelihood Possible Evidence D

Corn Silk Extract, Dry5 drug types · 290 drugs

Antidiabetes Drugs

Theoretically, taking corn silk with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research in diabetic mice shows that taking corn silk extract lowers fasting blood glucose levels.

Likelihood Possible Evidence D
Antihypertensive Drugs

Taking corn silk extract with antihypertensive drugs might increase the risk of hypotension.
Clinical research in both hypertensive and normotensive adults shows that taking corn silk extract lowers systolic and diastolic blood pressure.

Likelihood Possible Evidence D
Corticosteroids

Taking corn silk with corticosteroids might increase the risk of hypokalemia.
Clinical research shows that taking corn silk extract increases the urinary excretion of potassium.

Likelihood Possible Evidence D
Diuretic Drugs

Taking corn silk with diuretic drugs might increase the risk of adverse effects such as hyponatremia and hypokalemia.
Clinical research shows that taking corn silk extract increases urine volume and promotes the urinary excretion of sodium and potassium. Some patients may require electrolyte supplementation.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, suddenly stopping, starting, or changing corn silk treatment may alter the effects of warfarin.
Corn silk contains vitamin K. Individuals taking warfarin should consume a consistent daily amount of corn silk to maintain consistent anticoagulation.

Likelihood Likely Evidence D
The maker

Brand information

Manufacturer and brand details for Urinary Bladder Support, from the product label.

Hawaii Pharm

See all Hawaii Pharm products
Name
Hawaii Pharm LLC
Street Address
510 Sumner St. Ste. 613
City
Honolulu
State
HI
ZipCode
96817
Phone Number
888-854-2924
Web Address
www.hawaiipharm.com
Pharmacist Counseling Corner

Urinary Bladder Support by Hawaii Pharm: Common Questions

Does Urinary Bladder Support by Hawaii Pharm interact with any medications?
Yes. Based on its ingredients, Urinary Bladder Support has a known interaction with 2,143 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Urinary Bladder Support contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while I'm pregnant or breastfeeding?
No — all the ingredients in this product advise against use during pregnancy due to insufficient safety data. For breastfeeding, marshmallow and uva ursi should be avoided, and corn silk's safety is unknown so you'd need a doctor's approval. Talk with your doctor or pharmacist about alternatives.
Does this actually work for urinary tract infections?
The evidence we hold doesn't support it. Uva ursi, one of the main ingredients, is rated possibly ineffective for UTIs, and the other ingredients have insufficient evidence. If you have a UTI, talk to your doctor about proven treatments.
What are the side effects I should watch for?
Uva ursi can cause nausea, vomiting, diarrhea, and stomach upset — at very high doses it can cause serious effects like convulsions and delirium. The other ingredients are generally well tolerated, though human safety data are limited. Stop and contact your doctor if you notice severe symptoms.
Why do I need to space this away from my other medications?
Marshmallow leaf contains a thick substance called mucilage that can coat your stomach and slow or block absorption of oral drugs. Taking marshmallow 30–60 minutes after your medications gives them time to be absorbed first.
I take warfarin — can I use this product?
Corn silk contains vitamin K, which affects how warfarin works. If you take warfarin, you would need to keep your corn silk intake completely consistent — but it's safest to check with your pharmacist or doctor first, since this product also lowers blood pressure and affects blood sugar, which may interact with your other medications.
What's in this product besides the plant extracts?
The liquid formula contains alcohol, water, and glycerin as inactive ingredients. These help preserve and deliver the active extracts.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Urinary Bladder Support is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Urinary Bladder Support label
Sources

Sources & How We Checked

Urinary Bladder Support's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 17 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Marshmallow 5 references
  1. Monographs on the medicinal uses of plant drugs. Exeter, UK: European Scientific Co-op Phytother, 1997.
  2. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  3. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  4. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  5. Hage-Sleiman R, Mroueh M, Daher CF. Pharmacological evaluation of aqueous extract of Althaea officinalis flower grown in Lebanon. Pharm Biol 2011;49(3):327-33.

See these in context on the Marshmallow monograph →

Corn Silk 4 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  3. George GO, Idu FK. Corn silk aqueous extracts and intraocular pressure of systemic and non-systemic hypertensive subjects. Clin Exp Optom. 2015 Mar;98(2):138-49. PubMed
  4. Sheng L, Chen Q, Di L, Li N. Evaluation of anti-diabetic potential of corn silk in high-fat diet/streptozotocin- induced type 2 diabetes mice model. Endocr Metab Immune Disord Drug Targets. 2020. PubMed

See these in context on the Corn Silk monograph →

Uva Ursi 8 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. Terry C. Telger, transl. 3rd ed. Berlin, GER: Springer, 1998.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  4. Wang L, Del Priore LV. Bull's-eye maculopathy secondary to herbal toxicity from uva ursi. Am J Ophthalmol 2004;137:1135-7. PubMed
  5. Beaux, D., Fleurentin, J., and Mortier, F. Effect of extracts of Orthosiphon stamineus Benth, Hieracium pilosella L., Sambucus nigra L. and Arctostaphylos uva-ursi (L.) Spreng. in rats. Phytother.Res 1999;13(3):222-225.
  6. de Arriba SG, Naser B, Nolte KU. Risk assessment of free hydroquinone derived from Arctostaphylos Uva-ursi folium herbal preparations. Int J Toxicol. 2013;32(6):442-453.
  7. Park JB, Kim D, Min JS, et al. Identification and characterization of in vitro inhibitors against UDP-glucuronosyltransferase 1A1 in uva-ursi extracts and evaluation of in vivo uva-ursi-drug interactions. Food Chem Toxicol. 2018;120:651-661. PubMed
  8. Chauhan B, Yu C, Krantis A, et al. In vitro activity of uva-ursi against cytochrome P450 isoenzymes and P-glycoprotein. Can J Physiol Pharmacol. 2007;85(11):1099-107.

See these in context on the Uva Ursi monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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