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Dietary supplement

Uva Ursi (Bearberry Leaf Extract) Ingredients & Drug Interactions

by BulkSupplements.com

Uva Ursi (Bearberry Leaf Extract) label
See full label image
Powder Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Uva Ursi (Bearberry Leaf Extract) against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Uva Ursi (Bearberry Leaf Extract) is a dietary supplement by BulkSupplements.com with 1 active ingredient. Its ingredients are commonly taken for urinary tract infections, urinary discomfort, mild diuretic.Based on those ingredients, 803 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bearberry leaf extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Uva Ursi (Bearberry Leaf Extract) by BulkSupplements.com

Ask about any prescription or over-the-counter medication and we check it for interactions with Uva Ursi (Bearberry Leaf Extract) by BulkSupplements.com — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Uva Ursi (Bearberry Leaf Extract) by BulkSupplements.com

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: bearberry leaf extract (uva ursi), a plant used traditionally for urinary tract support. The powder form is delivered with no inactive fillers or other ingredients listed.

Does it work?

Leans against
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Leans against

The strongest graded evidence we hold for the stated purpose leans against a benefit.

Why this rating?
  • The label markets this product for: urinary tract support.
  • We looked for evidence on: Urinary tract infections (UTIs), urinary discomfort, kidney health.
  • The closest evidence on file: Uva Ursi is rated "Possibly Ineffective" for Urinary tract infections (UTIs) (Natural Medicines).

The evidence for uva ursi is mixed. For urinary tract infections, the data suggests it's possibly ineffective — meaning current evidence points away from it being helpful for that purpose.

For bronchitis and benign prostatic hyperplasia (enlarged prostate), there isn't enough reliable evidence in the data we hold to say whether it works or doesn't.

The evidence, ingredient by ingredient Uva Ursi

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Uva ursi is generally well tolerated in low doses over the short term. The most common side effects are mild: diarrhea, nausea, stomach upset, and vomiting.

However, it can be toxic at high doses or with prolonged use. At very high doses (20 grams or more of the dried herb), serious effects including convulsions, delirium, shortness of breath, and collapse have been reported — and doses of 30 grams or more may be fatal.

The safety data advises against use during pregnancy (it may stimulate the uterus) and while breastfeeding (not enough safety information exists).

Side effects, ingredient by ingredient Uva Ursi

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Uva Ursi.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: lithium.
  • For scale: 804 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, ask your pharmacist to check any medications you take that are processed by your liver (CYP2C19 or CYP3A4 substrates), as well as lithium if you take it for mood stability. Medications that acidify your urine may also interfere with uva ursi's effects.

No interactions are documented for the one ingredient we could check if your medications fall outside these categories, but that doesn't mean interactions don't exist.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with graded evidence leaning against its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Uva ursi may be worth considering if you're exploring natural urinary support, but the evidence for urinary tract infections isn't strong. If you take any prescription medications — especially those for mood, heart rhythm, allergies, or lithium — check them with your pharmacist first.

Stick to short-term, low-dose use and avoid it entirely if you're pregnant or nursing.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Uva Ursi (Bearberry Leaf Extract), straight from the product label.

Brand BulkSupplements.com
Barcode (UPC) X0014BHNG9
Net contents 100 Gram(s); 3.5 Oz(s)
Market status On market
Date entered into DSLD Oct 22, 2021
DSLD ID 254318
Product type Botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Uva Ursi (Bearberry Leaf Extract) by BulkSupplements.com, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
750 mg
Maximum serving Sizes:
750 mg
Servings per container
133
UPC/BARCODE
X0014BHNG9
IngredientAmount% DV
Bearberry leaf extract750 mg--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Clean & pure bulk supplements

New - Bulksupplements Bearberry Leaf Extract (Uva Ursi) Powder (100 grams)

FDA Disclaimer Statement

Warning: This product is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Always consult a physician before taking any dietary supplement.

Keep out of reach of children.

Formulation

Free Of: Added sugar, soy, dairy, yeast, gluten, additives

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take 750 mg (about 1/3 tsp) once or twice daily with food, or as directed by a physician. Not intended for long-term use.

Storage

Store in a dry, cool place

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Uva Ursi (Bearberry Leaf Extract) by BulkSupplements.com label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Uva Ursi (Bearberry Leaf Extract) label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Uva Ursi (Bearberry Leaf Extract) by BulkSupplements.com

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size750 mg Dosage formPowder Servings per container133 Amounts shown are per serving.

Bearberry leaf extract

Interacts with
803 drugs
750 mg per serving

Uva ursi is a traditional herb used mainly for urinary tract infections, and its leaves contain a compound called arbutin that may have antimicrobial...

Bearberry leaf extract monograph & interactions

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

Uva Ursi (Bearberry Leaf Extract) by BulkSupplements.com Drug Interactions

Want to check YOUR meds against Uva Ursi (Bearberry Leaf Extract)?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
803Drugs
740 Moderate 63 Minor

Ingredients driving the most interactions

Bearberry leaf extract 803

Individual Drug Interactions

The ingredients in Uva Ursi (Bearberry Leaf Extract) interact with 803 drugs. Click any drug to see the details.

1 of the 1 ingredient in Uva Ursi (Bearberry Leaf Extract) interact with drugs. Each result below shows which ingredient is responsible. Bearberry leaf extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Uva Ursi (Bearberry Leaf Extract) with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Bearberry leaf extract6 drug types · 803 drugs

Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, uva ursi may decrease the metabolism of CYP2C19 substrates.
In vitro, uva ursi appears to inhibit cytochrome CYP2C19. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.
In vitro, uva ursi appears to inhibit CYP3A4. This effect has not been reported in humans.

Likelihood Possible Evidence D
Glucuronidated Drugs

Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
In vitro, uva ursi extract appears to strongly inhibit UDP-glucuronosyltransferase (UGT) 1A1 (UGT1A1). However, uva ursi extract does not appear to inhibit UGT1A1 in animal models. This effect has not been reported in humans.

Likelihood Possible Evidence D
Lithium

Theoretically, uva ursi may increase lithium levels, necessitating a decrease in dose.
Uva ursi may have diuretic properties. Diuretics may increase lithium reabsorption with sodium in the proximal tubule of the kidney. Theoretically, uva ursi might reduce excretion and increase levels of lithium.

Likelihood Probable Evidence D
Urinary Acidifying Agents

Effects of uva ursi in the urinary tract may be reduced by urinary acidifying agents.
Uva ursi seems to work best in alkaline urine. Theoretically, taking uva ursi with medications known to acidify the urine may decrease any effects of uva ursi on the urinary tract.

Likelihood Possible Evidence D
P-Glycoprotein Substrates

Theoretically, uva ursi may alter the levels of drugs transported by P-glycoprotein.
In vitro, uva ursi appears to inhibit the multi-drug transporter protein, P-glycoprotein. This effect has not been reported in humans.

Likelihood Possible Evidence D
Bearberry leaf extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Uva Ursi (Bearberry Leaf Extract), from the product label.

BulkSupplements.com

See all BulkSupplements.com products
Name
BulkSupplements.com
Street Address
7511 Eastgate Rd
City
Henderson
State
NV
ZipCode
89011
Web Address
BulkSupplements.com
Pharmacist Counseling Corner

Uva Ursi (Bearberry Leaf Extract) by BulkSupplements.com: Common Questions

Does Uva Ursi (Bearberry Leaf Extract) by BulkSupplements.com interact with any medications?
Yes. Based on its ingredients, Uva Ursi (Bearberry Leaf Extract) has a known interaction with 803 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Uva Ursi (Bearberry Leaf Extract) contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take uva ursi while pregnant or breastfeeding?
No — the safety data advises against it during pregnancy because it may stimulate the uterus, and there isn't enough information to use it safely while breastfeeding. Talk with your OB or midwife about safer options.
What are the common side effects?
At low doses over the short term, diarrhea, nausea, stomach upset, and vomiting are the most common. These are usually mild, but if they don't settle, stop taking it and let your pharmacist or doctor know.
Is uva ursi safe to take long-term?
No. It's meant for short-term use only and can be toxic with prolonged or high-dose use. Stick to the label's dosing and duration.
Does uva ursi actually work for urinary tract infections?
The evidence suggests it's likely ineffective for that purpose, so it may not be the best choice if that's your main reason for taking it. Your pharmacist or doctor can suggest other options.
Why is there a warning about urine acidity?
Uva ursi works best in alkaline (less acidic) urine. If you take medications that acidify your urine, they may reduce uva ursi's effects in your urinary tract.
How much uva ursi is too much?
At high doses (20 grams of dried herb or more), serious side effects like convulsions and delirium have been reported. Doses of 30 grams or more may be fatal. Always follow the label's recommended dose.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Uva Ursi (Bearberry Leaf Extract) is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Uva Ursi (Bearberry Leaf Extract) label
Go deeper

The Full Monographs Behind Uva Ursi (Bearberry Leaf Extract)’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Uva Ursi

Interacts with 803 drugs

Uva ursi is a traditional herb used mainly for urinary tract infections, and its leaves contain a compound called arbutin that may have antimicrobial effects in the urine. Evidence in people...

Read the full Uva Ursi monograph →
Sources

Sources & How We Checked

Uva Ursi (Bearberry Leaf Extract)'s label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Uva Ursi 8 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. Terry C. Telger, transl. 3rd ed. Berlin, GER: Springer, 1998.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  4. Wang L, Del Priore LV. Bull's-eye maculopathy secondary to herbal toxicity from uva ursi. Am J Ophthalmol 2004;137:1135-7. PubMed
  5. Beaux, D., Fleurentin, J., and Mortier, F. Effect of extracts of Orthosiphon stamineus Benth, Hieracium pilosella L., Sambucus nigra L. and Arctostaphylos uva-ursi (L.) Spreng. in rats. Phytother.Res 1999;13(3):222-225.
  6. de Arriba SG, Naser B, Nolte KU. Risk assessment of free hydroquinone derived from Arctostaphylos Uva-ursi folium herbal preparations. Int J Toxicol. 2013;32(6):442-453.
  7. Park JB, Kim D, Min JS, et al. Identification and characterization of in vitro inhibitors against UDP-glucuronosyltransferase 1A1 in uva-ursi extracts and evaluation of in vivo uva-ursi-drug interactions. Food Chem Toxicol. 2018;120:651-661. PubMed
  8. Chauhan B, Yu C, Krantis A, et al. In vitro activity of uva-ursi against cytochrome P450 isoenzymes and P-glycoprotein. Can J Physiol Pharmacol. 2007;85(11):1099-107.

See these in context on the Uva Ursi monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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