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Dietary supplement

Uva Ursi Ingredients & Drug Interactions

by Herbal Terra

Uva Ursi label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Uva Ursi against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Uva Ursi is a dietary supplement by Herbal Terra with 1 active ingredient. Its ingredients are commonly taken for urinary tract infections, urinary discomfort, mild diuretic.Based on those ingredients, 804 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are certified organic Uva Ursi (Arctostaphylos uva-ursi) dried herb liquid extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Uva Ursi by Herbal Terra

Ask about any prescription or over-the-counter medication and we check it for interactions with Uva Ursi by Herbal Terra — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Uva Ursi by Herbal Terra

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 24, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: certified organic Uva Ursi (Arctostaphylos uva-ursi) dried herb liquid extract. Uva Ursi is a plant traditionally used for urinary tract support.

The only other ingredient listed is menstruum, which is the liquid used to extract and preserve the herb.

Does it work?

Leans against
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Leans against

The strongest graded evidence we hold for the stated purpose leans against a benefit.

Why this rating?
  • The label markets this product for: urinary tract health support.
  • We looked for evidence on: Urinary tract infections (UTIs), urinary discomfort, kidney stones, bladder health.
  • The closest evidence on file: Uva Ursi is rated "Possibly Ineffective" for Urinary tract infections (UTIs) (Natural Medicines).

The evidence for Uva Ursi's effectiveness is mixed and limited. For urinary tract infections (UTIs), it's rated as possibly ineffective — meaning current data don't support its use for that purpose.

For bronchitis and benign prostatic hyperplasia (enlarged prostate), there simply isn't enough reliable evidence to say whether it works or not. If you're considering it for any of these conditions, talk with your doctor or pharmacist about what the evidence actually shows for your situation.

The evidence, ingredient by ingredient Uva Ursi

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Uva Ursi is generally well tolerated in low doses when used short-term. The most common side effects are diarrhea, nausea, stomach upset, and vomiting.

At high doses — around 20 grams of dried herb or higher — it can cause serious effects including convulsions, delirium, shortness of breath, and tinnitus. Very high doses (30 grams or more) have been reported to be fatal, so staying within recommended amounts is important.

Uva Ursi is not safe in pregnancy — the safety data advises against it because it may stimulate the uterus. There isn't enough information to know whether it's safe while breastfeeding, so avoid it during lactation as well.

Because of the risk of toxicity with prolonged use, this herb is meant for short-term use only.

Side effects, ingredient by ingredient Uva Ursi

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Uva Ursi.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: lithium.
  • For scale: 805 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Uva Ursi, check with your doctor or pharmacist if you take medications broken down by CYP2C19 or CYP3A4 (many common prescriptions use these pathways), drugs metabolized by glucuronidation, lithium, urinary acidifying agents, or P-glycoprotein substrates. The interactions are theoretical based on lab studies, but they could be significant — especially with lithium.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with graded evidence leaning against its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Uva Ursi might be worth considering if you're looking for traditional urinary tract support, but evidence for UTI effectiveness is limited. If you take any prescription medications — especially those processed through your liver, lithium, or urinary-acidifying drugs — check with your doctor or pharmacist before starting.

It's a short-term herb only, not safe in pregnancy or while breastfeeding, and high doses can be dangerous.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Uva Ursi, straight from the product label.

Brand Herbal Terra
Barcode (UPC) 0606595855010
Net contents 4 Fluid Ounce(s); 120 mL
Market status On market
Date entered into DSLD Sep 25, 2020
DSLD ID 234261
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Organic, Gluten Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Uva Ursi by Herbal Terra, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 mL
Maximum serving Sizes:
1 mL
Servings per container
120
UPC/BARCODE
0606595855010
IngredientAmount% DV
certified organic Uva Ursi (Arctostaphylos uva-ursi) dried herb liquid extract970 mg--

Other ingredients: Menstruum

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Origin of plant material: Croatia.

Manufactured in the USA in an FDA registered facility

Sugar free

Dried herb/menstruum ratio: 1:3 Expertly extracted Laboratory tested 330 mg/1 mL Premium product Super concentrated liquid herbal extract

Non GMO

No artificial ingredients, GMO, gluten, color additives, fillers, preservatives or binders. Natural Gluten Free

Suggested/Recommended/Usage/Directions

Direction Shake well before use. Adults take up to 30 drops (1 mL, one full squeeze of the dropper bulb) in 3-4 fl. oz of juice or water up to 4 times a day. We recommend to seek expert medical advice before taking this or any other herbal supplements.

FDA Disclaimer Statement

Notice This product has not been evaluated by the FDA and is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Caution May have contraindications.

Do not use if you are allergic to any ingredients.

Consult a physician before using during pregnancy, if nursing, or if you are on any medications.

Keep out of the reach of children.

Storage

Store in a cool, dry, dark place.

Formula

Arctostaphylos uva-ursi

FDA Statement of Identity

Herbal Supplement

Seals/Symbols

Made in USA Made in an FDA registered facility Natural Gluten Free

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Uva Ursi by Herbal Terra label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Uva Ursi label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Uva Ursi by Herbal Terra

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 mL Dosage formLiquid Servings per container120 Amounts shown are per serving.

Certified organic Uva Ursi (Arctostaphylos uva-ursi) dried herb liquid extract

Interacts with
804 drugs
970 mg per serving

Uva ursi is a traditional herb used mainly for urinary tract infections, and its leaves contain a compound called arbutin that may have antimicrobial...

Certified organic Uva Ursi (Arctostaphylos uva-ursi) dried herb liquid extract monograph & interactions

Other (inactive) ingredients: Menstruum. These complete the product’s ingredient list but are not active constituents.

Interaction report

Uva Ursi by Herbal Terra Drug Interactions

Want to check YOUR meds against Uva Ursi?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
804Drugs
742 Moderate 62 Minor

Ingredients driving the most interactions

certified organic Uva Ursi (Arctostaphylos uva-ursi) dried herb liquid extract 804

Individual Drug Interactions

The ingredients in Uva Ursi interact with 804 drugs. Click any drug to see the details.

1 of the 1 ingredient in Uva Ursi interact with drugs. Each result below shows which ingredient is responsible. certified organic Uva Ursi (Arctostaphylos uva-ursi) dried herb liquid extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Uva Ursi with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

certified organic Uva Ursi (Arctostaphylos uva-ursi) dried herb liquid extract6 drug types · 804 drugs

Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, uva ursi may decrease the metabolism of CYP2C19 substrates.
In vitro, uva ursi appears to inhibit cytochrome CYP2C19. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.
In vitro, uva ursi appears to inhibit CYP3A4. This effect has not been reported in humans.

Likelihood Possible Evidence D
Glucuronidated Drugs

Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
In vitro, uva ursi extract appears to strongly inhibit UDP-glucuronosyltransferase (UGT) 1A1 (UGT1A1). However, uva ursi extract does not appear to inhibit UGT1A1 in animal models. This effect has not been reported in humans.

Likelihood Possible Evidence D
Lithium

Theoretically, uva ursi may increase lithium levels, necessitating a decrease in dose.
Uva ursi may have diuretic properties. Diuretics may increase lithium reabsorption with sodium in the proximal tubule of the kidney. Theoretically, uva ursi might reduce excretion and increase levels of lithium.

Likelihood Probable Evidence D
Urinary Acidifying Agents

Effects of uva ursi in the urinary tract may be reduced by urinary acidifying agents.
Uva ursi seems to work best in alkaline urine. Theoretically, taking uva ursi with medications known to acidify the urine may decrease any effects of uva ursi on the urinary tract.

Likelihood Possible Evidence D
P-Glycoprotein Substrates

Theoretically, uva ursi may alter the levels of drugs transported by P-glycoprotein.
In vitro, uva ursi appears to inhibit the multi-drug transporter protein, P-glycoprotein. This effect has not been reported in humans.

Likelihood Possible Evidence D
certified organic Uva Ursi (Arctostaphylos uva-ursi) dried herb liquid extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Uva Ursi, from the product label.

Herbal Terra

See all Herbal Terra products
Name
Herbal Terra
Pharmacist Counseling Corner

Uva Ursi by Herbal Terra: Common Questions

Does Uva Ursi by Herbal Terra interact with any medications?
Yes. Based on its ingredients, Uva Ursi has a known interaction with 804 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Uva Ursi contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Uva Ursi while pregnant or breastfeeding?
No — Uva Ursi is not safe during pregnancy because it may stimulate the uterus and lacks solid safety data. There also isn't enough information to know if it's safe while breastfeeding, so avoid it during lactation. Talk with your doctor or pharmacist about alternatives if you're pregnant or nursing.
What are the side effects of Uva Ursi?
At low doses and short-term use, the most common side effects are diarrhea, nausea, stomach upset, and vomiting. At very high doses (20 grams or more), rare but serious effects include convulsions, delirium, shortness of breath, and tinnitus. Doses of 30 grams or higher have been reported to be fatal.
How long can I take Uva Ursi?
Uva Ursi is meant for short-term use only because it can be toxic with prolonged use. Don't take it long-term without talking to your doctor or pharmacist first.
Does Uva Ursi actually work for urinary tract infections?
The evidence doesn't support its use for UTIs — it's rated as possibly ineffective based on current data. For bronchitis and enlarged prostate, there simply isn't enough reliable evidence to say whether it works.
Will Uva Ursi interact with my medications?
It may, depending on what you take. Uva Ursi can theoretically slow how your liver metabolizes certain medications and may affect lithium levels. Use the medication checker on this page to see if any of your prescriptions are affected, then discuss the results with your doctor or pharmacist before starting.
What is menstruum in this product?
Menstruum is the liquid used to extract and preserve the Uva Ursi herb in this supplement. It's an inactive ingredient that helps deliver the active plant material.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Uva Ursi label
Go deeper

The Full Monographs Behind Uva Ursi’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Uva Ursi

Interacts with 804 drugs

Uva ursi is a traditional herb used mainly for urinary tract infections, and its leaves contain a compound called arbutin that may have antimicrobial effects in the urine. Evidence in people...

Read the full Uva Ursi monograph →
Sources

Sources & How We Checked

Uva Ursi's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Uva Ursi 8 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. Terry C. Telger, transl. 3rd ed. Berlin, GER: Springer, 1998.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  4. Wang L, Del Priore LV. Bull's-eye maculopathy secondary to herbal toxicity from uva ursi. Am J Ophthalmol 2004;137:1135-7. PubMed
  5. Beaux, D., Fleurentin, J., and Mortier, F. Effect of extracts of Orthosiphon stamineus Benth, Hieracium pilosella L., Sambucus nigra L. and Arctostaphylos uva-ursi (L.) Spreng. in rats. Phytother.Res 1999;13(3):222-225.
  6. de Arriba SG, Naser B, Nolte KU. Risk assessment of free hydroquinone derived from Arctostaphylos Uva-ursi folium herbal preparations. Int J Toxicol. 2013;32(6):442-453.
  7. Park JB, Kim D, Min JS, et al. Identification and characterization of in vitro inhibitors against UDP-glucuronosyltransferase 1A1 in uva-ursi extracts and evaluation of in vivo uva-ursi-drug interactions. Food Chem Toxicol. 2018;120:651-661. PubMed
  8. Chauhan B, Yu C, Krantis A, et al. In vitro activity of uva-ursi against cytochrome P450 isoenzymes and P-glycoprotein. Can J Physiol Pharmacol. 2007;85(11):1099-107.

See these in context on the Uva Ursi monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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