Interactions on record — worth a quick check against your medications. Based on 2 of 5 ingredients. Check your meds →
Dietary supplement

Vagiclear Ingredients & Drug Interactions

by Higher Nature

Vagiclear label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Vagiclear against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Vagiclear is a dietary supplement by Higher Nature with 5 active ingredients. Its ingredients are commonly taken for digestive health and balance, diarrhea (including antibiotic-related), vaginal yeast and bacterial infections.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lactobacillus acidophilus, {Lactobacillus} bulgaricus. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Vagiclear by Higher Nature

Ask about any prescription or over-the-counter medication and we check it for interactions with Vagiclear by Higher Nature — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Vagiclear by Higher Nature

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Vagiclear contains 5 active ingredients, all probiotics — beneficial bacteria meant to support vaginal and digestive health. The main ones are Lactobacillus acidophilus and Lactobacillus bulgaricus, along with Lactobacillus rhamnosus, Lactobacillus plantarum, and Lactobacillus casei.

Each capsule delivers live, active organisms. The inactive ingredients are microcrystalline cellulose (a filler) and a vegetarian capsule shell.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: hi-potency friendly bacteria for female health.
  • We looked for evidence on: Bacterial vaginosis, Vaginal candidiasis, Vulvovaginal health, Vaginal microbiome balance.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Bacterial vaginosis (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Insufficient Reliable Evidence To Rate" for Vaginal candidiasis.
  • Also on file: Lactobacillus Delbrueckii is rated "Insufficient Reliable Evidence To Rate" for Vaginal candidiasis.

The evidence for Lactobacillus acidophilus supports it as possibly effective for irritable bowel syndrome (IBS), Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis. It's rated possibly ineffective for atopic disease and there isn't enough reliable evidence to rate it for acute respiratory distress syndrome.

For Lactobacillus bulgaricus, the data we hold show insufficient reliable evidence to rate it for acne, allergic rhinitis, antibiotic-associated diarrhea, asthma, nonalcoholic fatty liver disease, and the common cold. We don't have established effectiveness ratings for the other three ingredients in this product.

The evidence, ingredient by ingredient Lactobacillus Acidophilus Lactobacillus Delbrueckii

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactobacillus acidophilus is generally well tolerated in healthy adults and children, though gastrointestinal side effects like bloating, gas, abdominal pain, and diarrhea can occur — these are uncommon. There's a theoretical risk of infection in some patients because the live organisms could translocate (move) to other body sites and cause bacteremia, sepsis, or other serious infections, though this is rare and most often happens in people who are already very ill.

Lactobacillus bulgaricus is also generally well tolerated in healthy people but requires caution in those who are very ill or immunocompromised. We hold no pregnancy or breastfeeding data for any of these ingredients, so talk with your doctor or pharmacist before using this product if you're pregnant or nursing.

Side effects, ingredient by ingredient Lactobacillus Acidophilus Lactobacillus Delbrueckii

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Lactobacillus Acidophilus, Lactobacillus Delbrueckii.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist before starting Vagiclear if you take any antibiotic drugs — the probiotics in this product work best when separated in time from antibiotics, which can kill the live organisms.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Vagiclear may help with IBS, antibiotic-associated diarrhea, Helicobacter pylori, and bacterial vaginosis, based on the evidence for its Lactobacillus acidophilus content. If you take antibiotics, you'll need to time this product separately from them.

People who are very ill or have weakened immunity should check with their doctor first. Talk with your pharmacist about whether it's right for you and how to space it around any medications you take.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Vagiclear, straight from the product label.

Brand Higher Nature
Barcode (UPC) 5031013103285
Net contents 10 Capsule(s)
Market status On market
Date entered into DSLD Jan 23, 2015
DSLD ID 41239
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Vegetarian, Adult Female (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Vagiclear by Higher Nature, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
UPC/BARCODE
5031013103285
IngredientAmount% DV
Lactobacillus acidophilus5000000000 {Unit(s)}--
{Lactobacillus} rhamnosus5000000000 {Unit(s)}--
{Lactobacillus} plantarum5000000000 {Unit(s)}--
{Lactobacillus} bulgaricus5000000000 {Unit(s)}--
Lactobacillus casei5000000000 {Unit(s)}--

Other ingredients: Microcrystalline Cellulose, Vegetarian Capsule, Lactobacilli acidophilus, {Lactobacilli} rhamnosus, {Lactobacilli} plantarum, {Lactobacilli} bulgaricus, Lactobacilli casei

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

DOES NOT CONTAIN: sugar, salt, starch, wheat, gluten, maize, corn, lactose, dairy products, artificial preservatives, colours or flavourings.

Suitable for vegetarians.

VEGETARIAN

General Statements

This product is not tested on animals.

This bottle has a UV filter.

Charitable organisations policy: supplements regularly donated

Food supplements should not be used as a substitute for a varied and balanced diet and healthy lifestyle.

Seals/Symbols

Jar {Recycle} 1 PET Lid {Recycle} 5 PP

Formula

hi-potency friendly bacteria for female health

FDA Statement of Identity

FOOD SUPPLEMENT

Suggested/Recommended/Usage/Directions

DIRECTIONS: Insert 1 capsule a day into your vagina before bed, (a vaginal applicator is avaiable to buy for this purpose if required), or as your health professional advises, during and after antibiotic treatment or at times of stress. Can also be taken by mouth; swallow 1-2 capsules a day.

HIGHER NATURE's CANDICLEAR is also recommended.

Precautions

Do not exceed recommended daily intake.

Keep out of reach of children.

Storage

Does not require refrigeration, but keeping in a fridge will extend the life of the friendly bacteria.

Ensure lid is tight and store in a cool, dry, steam-free environment as damp conditions can affect the product quality.

General

VAC010 109 VAC-175-03

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Vagiclear by Higher Nature label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Vagiclear label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Vagiclear by Higher Nature

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Lactobacillus acidophilus

Interacts with
182 drugs
5000000000 {Unit(s)} per serving

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy p...

Lactobacillus acidophilus monograph & interactions

{Lactobacillus} rhamnosus

5000000000 {Unit(s)} per serving

{Lactobacillus} plantarum

5000000000 {Unit(s)} per serving

{Lactobacillus} bulgaricus

Interacts with
182 drugs
5000000000 {Unit(s)} per serving

Lactobacillus delbrueckii is a 'friendly' bacterium used in food fermentation and sold as a probiotic, often as part of multi-strain products. It is g...

{Lactobacillus} bulgaricus monograph & interactions

Lactobacillus casei

5000000000 {Unit(s)} per serving

Other (inactive) ingredients: Microcrystalline Cellulose, Vegetarian Capsule, Lactobacilli acidophilus, {Lactobacilli} rhamnosus, {Lactobacilli} plantarum, {Lactobacilli} bulgaricus, Lactobacilli casei. These complete the product’s ingredient list but are not active constituents.

Interaction report

Vagiclear by Higher Nature Drug Interactions

Want to check YOUR meds against Vagiclear?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Lactobacillus acidophilus 182
{Lactobacillus} bulgaricus 182

Individual Drug Interactions

The ingredients in Vagiclear interact with 182 drugs. Click any drug to see the details.

2 of the 5 ingredients in Vagiclear interact with drugs. Each result below shows which ingredient is responsible. Lactobacillus acidophilus {Lactobacillus} bulgaricus

Each ingredient & the kinds of drugs it affects

For each ingredient in Vagiclear with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Lactobacillus acidophilus1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus acidophilus full monograph & interactions

{Lactobacillus} bulgaricus1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L. delbrueckii.
Lactobacillus delbrueckii preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. delbrueckii preparations by at least two hours.

Likelihood Probable Evidence D
{Lactobacillus} bulgaricus full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Vagiclear, from the product label.

Higher Nature

See all Higher Nature products
Name
Higher Nature
City
Burwash Common
State
East Sussex
ZipCode
TN19 7LX
Web Address
www.highernature.com
Pharmacist Counseling Corner

Vagiclear by Higher Nature: Common Questions

Does Vagiclear by Higher Nature interact with any medications?
Yes. Based on its ingredients, Vagiclear has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Vagiclear contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this with antibiotics?
Not at the same time. Antibiotics can kill the live beneficial bacteria in Vagiclear, making it less effective. Your pharmacist can help you space them apart — usually a few hours or more, depending on the antibiotic.
What are the side effects?
Most people tolerate it well. Uncommon side effects include bloating, gas, abdominal pain, diarrhea, and burping. In rare cases, these probiotics can cause serious infections if they move to other parts of the body, though this mainly happens in people who are already very ill.
Is it safe if I'm immunocompromised or very ill?
No. People with weakened immune systems or serious illness should be cautious and check with their doctor first, since there's a theoretical risk the live organisms could cause infection.
Does Lactobacillus acidophilus actually work for bacterial vaginosis?
The evidence says it's possibly effective, meaning there's reason to think it might help, but it's not proven. Talk with your doctor about whether it's right for your situation.
Can I take this while pregnant or breastfeeding?
We don't have safety data on file for these ingredients in pregnancy or breastfeeding. Check with your doctor or pharmacist — they can give you personalized advice based on your health.
What's in the capsule besides the probiotics?
Microcrystalline cellulose, which is a filler that helps hold the capsule together. The capsule itself is vegetarian.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Vagiclear is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Vagiclear label
Go deeper

The Full Monographs Behind Vagiclear’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph → Herb & supplement monograph

Lactobacillus Delbrueckii

Interacts with 182 drugs

Lactobacillus delbrueckii is a 'friendly' bacterium used in food fermentation and sold as a probiotic, often as part of multi-strain products. It is generally considered safe for healthy peo...

Read the full Lactobacillus Delbrueckii monograph →
Sources

Sources & How We Checked

Vagiclear's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 24 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Lactobacillus Delbrueckii 9 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  3. Ranchal P, Gupta R, Goldberg R, A Lobo S, Pascual A, El Khoury MY. Penicillin-sensitive Lactobacillus jensenii bacteremia. Am J Ther 2021;28(2):e250-e252. PubMed
  4. Grazioli-Gauthier L, Rigamonti E, Leo LA, Martinetti Lucchini G, Lo Priore E, Bernasconi E. Lactobacillus jensenii mitral valve endocarditis: Case report, literature review and new perspectives. IDCases 2022;27:e01401. PubMed
  5. Toprak NU, Bozan T, Yilmaz S, Buyukbayrak EE, Tigen ET. Polymicrobial bacteremia due to Lactobacillus jensenii and Veillonella montpellierensis in a pregnant patient; case report and review of literature. Anaerobe 2022;75:102576. PubMed
  6. Chazan B, Raz R, Shental Y, Sprecher H, Colodner R. Bacteremia and pyelonephritis caused by Lactobacillus jensenii in a patient with urolithiasis. Isr Med Assoc J 2008;10(2):164-5.
  7. Neonakis IK, Skamagkas I, Stafylaki D, Maraki S. Lactobacillus delbrueckii urinary tract infection in a male patient: a case report. Germs 2022;12(2):304-307. PubMed
  8. Maillet F, Passeron A, Podglajen I, Ranque B, Pouchot J. Lactobacillus delbrueckii urinary tract infection in a male patient. Med Mal Infect 2019;49(3):226-228. PubMed
  9. Darbro BW, Petroelje BK, Doern GV. Lactobacillus delbrueckii as the cause of urinary tract infection. J Clin Microbiol 2009;47(1):275-7.

See these in context on the Lactobacillus Delbrueckii monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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