Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

VisionMD Ingredients & Drug Interactions

by 1MD Nutrition

VisionMD label
See full label image
Softgel Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking VisionMD against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

VisionMD is a dietary supplement by 1MD Nutrition with 6 active ingredients. Its ingredients are commonly taken for general antioxidant support, skin and hair care, heart health.Based on those ingredients, 1,079 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Vitamin E, Astaxanthin, Vitamin A. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against VisionMD by 1MD Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with VisionMD by 1MD Nutrition — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of VisionMD by 1MD Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 6 of its 6 active ingredients.
  • “XanMax” is listed as a grouped ingredient — the label gives one combined amount (50 mg) without saying how much of each component you get.
  • “Lyc-O-Mato” is listed as a grouped ingredient — the label gives one combined amount (67 mg) without saying how much of each component you get.

VisionMD contains 6 active ingredients designed to support eye and vision health. Vitamin E is an antioxidant that protects cells from damage.

Lycopene is a carotenoid from tomatoes with antioxidant properties. Lutein and zeaxanthin are carotenoids that concentrate in the eye's retina and macula.

Astaxanthin is another carotenoid with antioxidant effects. Vitamin A supports normal vision and eye tissue.

The product also contains XanMax (a proprietary blend) and Lyc-O-Mato (a lycopene concentrate blend) listed as components, plus inactive ingredients including gelatin, sunflower oil, glycerin, and natural waxes and extracts.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Comprehensive vision and eye health support.
  • We looked for evidence on: Age-related macular degeneration (AMD), Asthenopia (eye strain), Cataracts, Central serous retinopathy, Choroideremia, Corneal abrasion — and 4 related terms.
  • The strongest evidence on file: Lutein is rated "Possibly Effective" for Age-related macular degeneration (AMD) (Natural Medicines).
  • Also on file: Lutein is rated "Possibly Effective" for Cataracts.
  • Also on file: Zeaxanthin is rated "Possibly Effective" for Age-related macular degeneration (AMD).

The evidence for VisionMD's ingredients varies by ingredient and condition. Vitamin A is effective for vitamin A deficiency and possibly effective for aging skin and measles.

Lutein and zeaxanthin are possibly effective for age-related macular degeneration (AMD) and cataracts—two major reasons people take vision supplements. Lycopene is possibly effective for prostate cancer but possibly ineffective for diabetes.

Astaxanthin and zeaxanthin lack reliable evidence for most conditions listed in our data; their effectiveness ratings show insufficient evidence or are not established. The product's overall benefit depends on your specific eye health goal and whether you have an actual deficiency, so talk with your pharmacist about what you're hoping it will do.

The evidence, ingredient by ingredient Vitamin E Astaxanthin Lutein Zeaxanthin Vitamin A Tomato Lycopene

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin E is generally well-tolerated in usual amounts, but long-term high-dose supplements raise the risk of bleeding and, rarely, hemorrhagic stroke. Lycopene supplements can cause gastrointestinal side effects including diarrhea, nausea, and stomach upset.

Astaxanthin is generally well-tolerated but can cause abdominal pain, diarrhea, and red-colored stools; long-term safety data are limited. Lutein and zeaxanthin at typical supplement doses are generally well-tolerated.

Vitamin A at recommended amounts is safe, but high doses are toxic because the body stores it and can cause serious liver damage, headache, and skin problems. For pregnancy: Lutein and zeaxanthin are likely safe.

Vitamin A at recommended amounts is needed, but high doses—especially as retinol—can cause birth defects and must be avoided. Lycopene and astaxanthin have not been well studied in pregnancy; caution is advised.

For breastfeeding: food amounts of all ingredients are fine, but concentrated supplement data are limited. Talk with your doctor or pharmacist about safety if you're pregnant or nursing.

Side effects, ingredient by ingredient Vitamin E Astaxanthin Lutein Zeaxanthin Vitamin A Tomato Lycopene

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 5 of the 6 matched ingredients can interact with medications — Lycopene, Vitamin E, Vitamin A, Astaxanthin, Zeaxanthin.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; cancer treatments; diabetes medications.
  • For scale: 1,080 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking VisionMD, check with your pharmacist if you take retinoids (Major interaction with vitamin A—avoid combining them). Double-check blood thinners or antiplatelet drugs like warfarin, aspirin, clopidogrel, and dabigatran (Moderate, bleeding risk from vitamin E and lycopene).

If you take diabetes medications, cyclosporine, chemotherapy drugs, or any drug broken down by your liver, confirm it's safe with a pharmacist. XanMax and Lyc-O-Mato are blends, so their individual component ingredients are the ones listed above.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

VisionMD is designed to support eye health with lutein, zeaxanthin, and other antioxidants—a reasonable approach for AMD or cataracts if evidence supports those ingredients for you. However, check your medications first, especially if you take blood thinners, retinoids, diabetes drugs, or other prescriptions listed in the med_watch section below.

If you're pregnant, nursing, or taking any medications, talk with your pharmacist before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 23, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about VisionMD, straight from the product label.

Brand 1MD Nutrition
Barcode (UPC) X002YNRZ8R
Net contents 30 Softgel(s)
Market status On market
Date entered into DSLD May 23, 2024
DSLD ID 309827
Product type Other Combinations
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for VisionMD by 1MD Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
30
UPC/BARCODE
X002YNRZ8R
IngredientAmount% DV
Vitamin E121 mg807%
Lycopene10 mg--
Lutein10 mg--
Astaxanthin4 mg--
XanMax50 mg--
Zeaxanthin2 mg--
Vitamin A1530 mcg RAE170%
Lyc-O-Mato67 mg--

Other ingredients: Gelatin, Water, Sunflower Oil, Glycerin, Candelilla Wax, Sunflower Lecithin, Annatto fruit extract

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Manufactured in the USA from globally-sourced ingredients.

GMP Good Manufacturing Practice

Comprehensive vision & eye support Promotes eye health Supports macula function Clinically-tested AREDS2 & CARMIS ingredients

Color may vary.

Non-GMO Shellfish-free Peanut-free Dairy-free Wheat-free

Brand IP Statement(s)

EVTene is a registered trademark of ExcelVite and protected by US Patent: 10,689,594.

XanMax is a registered trademark of Katra Phytochem India Pvt. Ltd.

Lyc-O-Mato is a registered trademark of Lycored Natural Products Ltd., and is protected by U.S. Patent #5,837,311.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, adults take one (1) softgel, once (1x) daily with a meal, or as recommended by a healthcare practitioner.

Precautions

Warning: Consult a healthcare practitioner if you are pregnant or nursing, have a serious medical condition, or use any medications.

Keep out of reach of children.

Do not use if safety seal is damaged or missing.

Storage

Store in a cool, dry place.

General Statements

New

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

VisionMD by 1MD Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

VisionMD label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in VisionMD by 1MD Nutrition

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin E

Interacts with
764 drugs
121 mg per serving Form: D-Alpha-Tocopherol

Vitamin E is an essential fat-soluble vitamin and antioxidant that most people get in adequate amounts from a normal diet. Supplements can help correc...

Vitamin E monograph & interactions

Astaxanthin

Interacts with
671 drugs
4 mg per serving Form: Haematococcus pluvialis Algae Extract

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise...

Astaxanthin monograph & interactions

XanMax

50 mg per serving Form: Marigold flower extract

Vitamin A

Interacts with
387 drugs
1530 mcg RAE per serving Form: EVTene

Vitamin A is an essential nutrient important for vision, skin, immune function, and growth. Most people get enough from a balanced diet, and supplemen...

Vitamin A monograph & interactions

Lyc-O-Mato

No known
interactions
67 mg per serving Form: Tomato Fruit Extract

Tomato is a common food rich in vitamins, potassium, and the antioxidant lycopene, and eating it as part of a balanced diet is healthy for most people...

Lyc-O-Mato monograph & interactions

Other (inactive) ingredients: Gelatin, Water, Sunflower Oil, Glycerin, Candelilla Wax, Sunflower Lecithin, Annatto fruit extract. These complete the product’s ingredient list but are not active constituents.

Interaction report

VisionMD by 1MD Nutrition Drug Interactions

Want to check YOUR meds against VisionMD?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,079Drugs
9 Major 1,070 Moderate

Ingredients driving the most interactions

Vitamin E 764
Astaxanthin 671
Vitamin A 387
Zeaxanthin 86

Individual Drug Interactions

The ingredients in VisionMD interact with 1,079 drugs. Click any drug to see the details.

4 of the 6 ingredients in VisionMD interact with drugs. Each result below shows which ingredient is responsible. Vitamin E Astaxanthin Vitamin A Zeaxanthin

Each ingredient & the kinds of drugs it affects

For each ingredient in VisionMD with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin E8 drug types · 764 drugs

Alkylating Agents

Theoretically, antioxidant effects of vitamin E might reduce the effectiveness of alkylating agents.
There's concern that antioxidants could reduce the activity of chemotherapy drugs which generate free radicals, such as cyclophosphamide, chlorambucil, carmustine, busulfan, and thiotepa. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin E have on chemotherapy. Advise patients to consult their oncologist before using vitamin E supplements, especially in high doses.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Concomitant use of vitamin E and anticoagulant or antiplatelet agents might increase the risk of bleeding.
Vitamin E seems to inhibit of platelet aggregation and antagonize the effects of vitamin K-dependent clotting factors. These effects appear to be dose-dependent, and are probably only likely to be clinically significant with doses of at least 800 units daily. Mixed tocopherols, such as those found in food, might have a greater antiplatelet effect than alpha-tocopherol. RRR alpha-tocopherol (natural vitamin E) 1000 IU daily antagonizes vitamin K-dependent clotting factors. Advise patients to avoid high doses of vitamin E, especially in people with low vitamin K intake or other risk factors for bleeding.

Likelihood Possible Evidence B
Antitumor Antibiotics

Theoretically, antioxidant effects of vitamin E might reduce the effectiveness of antitumor antibiotics.
There's concern that antioxidants could reduce the activity of antitumor antibiotic drugs such as doxorubicin, which generate free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin E have on chemotherapy involving antitumor antibiotics. Advise patients to consult their oncologist before using vitamin E supplements, especially in high doses.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

A specific form of vitamin E might increase absorption and levels of cyclosporine.
There is some evidence that one specific formulation of vitamin E (D-alpha-tocopheryl-polyethylene glycol-1000 succinate, TPGS, tocophersolan, Liqui-E) might increase absorption of cyclosporine. This vitamin E formulation forms micelles which seems to increase absorption of cyclosporine by 40% to 72% in some patients. However, this interaction is unlikely to occur with the usual forms of vitamin E.

Likelihood Unlikely Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.
Vitamin E appears to bind with the nuclear receptor, pregnane X receptor (PXR), which results in increased expression of CYP3A4. Although the clinical significance of this is not known, use caution when considering concomitant use of vitamin E and other drugs affected by these enzymes.

Likelihood Possible Evidence D
Selumetinib (Koselugo)

Taking selumetinib with vitamin E can result in a total daily dose of vitamin E that exceeds safe limits and therefore might increase the risk of bleeding.
Selumetinib contains 48-54 IU vitamin E per capsule. The increased risk of bleeding with vitamin E appears to be dose-dependent. Be cautious when using selumetinib in combination with supplemental vitamin E, especially in patients at higher risk of bleed, such as those with chronic conditions and those taking antiplatelet drugs.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Using vitamin E with warfarin might increase the risk of bleeding.
Due to interference with production of vitamin K-dependent clotting factors, use of more than 400 IU of vitamin E daily with warfarin might increase prothrombin time (PT), INR, and the risk of bleeding,. At a dose of 1000 IU per day, vitamin E can antagonize vitamin K-dependent clotting factors even in people not taking warfarin. Limited clinical evidence suggests that doses up to 1200 IU daily may be used safely by patients taking warfarin, but this may not be applicable in all patient populations.

Likelihood Possible Evidence B
Niacin

Vitamin E might decrease the beneficial effects of niacin on high-density lipoprotein (HDL) cholesterol levels.
A combination of niacin and simvastatin (Zocor) effectively raises high-density lipoprotein (HDL) cholesterol levels in people with coronary disease and low HDL levels. Clinical research shows that taking a combination of antioxidants (vitamin C, vitamin E, beta-carotene, and selenium) along with niacin and simvastatin (Zocor) attenuates this rise in HDL, specifically the HDL-2 and apolipoprotein A1 fractions, by more than 50%. Vitamin E alone combined with a statin does not seem to decrease HDL levels. It is not known whether the adverse effect on HDL is due to one of the other antioxidants or to the combination. It also is not known whether it will occur in other patient populations.

Likelihood Possible Evidence A
Vitamin E full monograph & interactions

Astaxanthin2 drug types · 671 drugs

Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP2B6.
In vitro research shows that astaxanthin induces cytochrome CYP2B6 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
In vitro research shows that astaxanthin induces CYP3A4 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Astaxanthin full monograph & interactions

Vitamin A4 drug types · 387 drugs

Retinoids

Concomitant use of retinoids with vitamin A supplements might produce supratherapeutic vitamin A levels.
Retinoids, which are vitamin A derivatives, could have additive toxic effects when taken with vitamin A supplements.

Likelihood Probable Evidence D
Hepatotoxic Drugs

Theoretically, taking high doses of vitamin A in combination with other potentially hepatotoxic drugs might increase the risk of liver disease.
The tolerable upper intake level (UL) is the highest level of intake that is likely to pose no risk of adverse effects. Doses of vitamin A above the UL can cause hepatotoxicity, ranging from elevated liver enzymes to liver failure.

Likelihood Possible Evidence C
Tetracycline Antibiotics

Theoretically, taking tetracycline antibiotics with high doses of vitamin A can increase the risk of pseudotumor cerebri.
Benign intracranial hypertension (pseudotumor cerebri) can occur with tetracyclines and with acute or chronic vitamin A toxicity. Case reports suggest that taking tetracyclines and vitamin A concurrently can increase the risk of this condition. Avoid high doses of vitamin A in people taking tetracyclines chronically.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, high doses of vitamin A could increase the risk of bleeding with warfarin.
Vitamin A toxicity is associated with hemorrhage and hypoprothrombinemia, possibly due to vitamin K antagonism. Advise patients taking warfarin to avoid doses of vitamin A above the tolerable upper intake level of 10,000 IU/day for adults.

Likelihood Possible Evidence D
Vitamin A full monograph & interactions

Zeaxanthin1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking zeaxanthin with antidiabetes drugs might increase the risk of hypoglycemia.
In an animal diabetic model, zeaxanthin has hypoglycemic effects. However, population research has found that increasing intake of dietary zeaxanthin plus lutein does not decrease the risk of developing type 2 diabetes.

Likelihood Possible Evidence D
Zeaxanthin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for VisionMD, from the product label.

1MD Nutrition

See all 1MD Nutrition products
Name
1MD Nutrition
City
Irvine
State
CA
ZipCode
92618
Phone Number
(888) 393-4030
Web Address
www.1md.org
Pharmacist Counseling Corner

VisionMD by 1MD Nutrition: Common Questions

Does VisionMD by 1MD Nutrition interact with any medications?
Yes. Based on its ingredients, VisionMD has a known interaction with 1,079 medications, including 9 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
VisionMD contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will VisionMD help prevent cataracts or macular degeneration?
Lutein and zeaxanthin are possibly effective for both age-related macular degeneration and cataracts—the main reason people use vision supplements. However, 'possibly effective' means the evidence shows promise but isn't definitive. Talk with your eye doctor about whether VisionMD is right for your specific situation.
What are the most common side effects?
Lycopene can cause gastrointestinal upset including diarrhea, nausea, and stomach discomfort. Astaxanthin may cause abdominal pain, diarrhea, or red-colored stools. Vitamin E and the other ingredients are generally well-tolerated at supplement doses, though vitamin E at very high doses raises bleeding risk over time.
Is it safe to take if I'm pregnant?
Lutein and zeaxanthin are likely safe in pregnancy. Vitamin A at recommended amounts is needed, but high doses can cause birth defects—check the label for vitamin A content and talk with your doctor. Lycopene and astaxanthin haven't been well studied in pregnancy, so use caution and discuss with your clinician before starting.
Can I take this with my blood thinner?
No, not without checking with your pharmacist first. Vitamin E and lycopene both carry a Moderate interaction with blood thinners like warfarin, aspirin, and clopidogrel, raising your bleeding risk. Your pharmacist can tell you if it's safe at this product's dose with your specific medication.
What is lycopene, and why is it in a vision supplement?
Lycopene is a carotenoid (plant pigment) from tomatoes that acts as an antioxidant. It's included because it's possibly effective for prostate cancer and has antioxidant properties that may support overall health, though direct evidence for eye health is limited in our data.
Is there enough data on astaxanthin's long-term safety?
No. Astaxanthin is generally well-tolerated in studies, but long-term safety data are limited. If you're considering taking VisionMD long-term, mention astaxanthin to your pharmacist, especially if you have any liver or bleeding concerns.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

VisionMD label
Go deeper

The Full Monographs Behind VisionMD’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin E

Interacts with 764 drugs

Vitamin E is an essential fat-soluble vitamin and antioxidant that most people get in adequate amounts from a normal diet. Supplements can help correct a true deficiency, but high-dose vitam...

Read the full Vitamin E monograph → Herb & supplement monograph

Astaxanthin

Interacts with 671 drugs

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise benefits. Early human studies are promis...

Read the full Astaxanthin monograph → Herb & supplement monograph

Lutein

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help slow progression of age-related macular...

Read the full Lutein monograph → Herb & supplement monograph

Zeaxanthin

Interacts with 86 drugs

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The strongest evidence relates to slowing progres...

Read the full Zeaxanthin monograph → Herb & supplement monograph

Vitamin A

Interacts with 387 drugs

Vitamin A is an essential nutrient important for vision, skin, immune function, and growth. Most people get enough from a balanced diet, and supplements are mainly useful for correcting a tr...

Read the full Vitamin A monograph → Herb & supplement monograph

Tomato

Tomato is a common food rich in vitamins, potassium, and the antioxidant lycopene, and eating it as part of a balanced diet is healthy for most people. Concentrated tomato or lycopene supple...

Read the full Tomato monograph → Herb & supplement monograph

Lycopene

Interacts with 122 drugs

Lycopene is a red plant pigment and antioxidant found mainly in tomatoes and other red fruits. Eating lycopene-rich foods is linked with possible heart and prostate benefits, but evidence fr...

Read the full Lycopene monograph →
Sources

Sources & How We Checked

VisionMD's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 117 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin E 64 references
  1. Kim JM, White RH. Effect of vitamin E on the anticoagulant response to warfarin. Am J Cardiol 1996;77:545-6. PubMed
  2. Corrigan JJ Jr. The effect of vitamin E on warfarin-induced vitamin K deficiency. Ann N Y Acad Sci 1982;393:361-8. PubMed
  3. Corrigan JJ Jr. Coagulation problems relating to vitamin E. Am J Pediatr Hematol Oncol 1979;1:169-73.
  4. Corrigan JJ Jr, Marcus FI. Coagulopathy associated with vitamin E ingestion. JAMA 1974;230:1300-1. DOI
  5. Labriola D, Livingston R. Possible interactions between dietary antioxidants and chemotherapy. Oncology 1999;13:1003-8.
  6. Chang T, Benet LZ, Hebert MF. The effect of water-soluble vitamin E on cyclosporine pharmacokinetics in healthy volunteers. Clin Pharmacol Ther 1996;59:297-303. PubMed
  7. Pan SH, Lopez RR Jr, Sher LS, et al. Enhanced oral cyclosporine absorption with water-soluble vitamin E early after liver transplantation. Pharmacother 1996;16:59-65. DOI
  8. Anon. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Soprawivenza nell'Infarto miocardico. Lancet 1999;354:447-55. DOI
  9. Chappell LC, Seed PT, Briley AL, et al. Effect of antioxidants on the occurrence of pre-eclampsia in women at increased risk: a randomised trial. Lancet 1999;354:810-6. DOI
  10. Yusuf S, Dagenais G, Pogue J, et al. Vitamin E supplementation and cardiovascular events in high-risk patients. The heart outcomes prevention evaluation study investigators. N Engl J Med 2000;342:154-60. PubMed
  11. Stephens NG, Parsons A, Schofield PM, et al. Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study. Lancet 1996;347:781-6.
  12. The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med 1994;330:1029-35. PubMed
  13. Takahashi O. Haemorrhagic toxicity of a large dose of alpha-, beta-, gamma- and delta-tocopherols, ubiquinone, beta-carotene, retinol acetate and L-ascorbic acid in the rat. Food Chem Toxicol 1995;33:121-8.
  14. Briggs GB, Freeman RK, Yaffe SJ. Drugs in Pregnancy and Lactation. 5th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 1998.
  15. Sano M, Ernesto C, Thomas RG, et al. A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study. N Engl J Med 1997;336:1216-22. PubMed
  16. Liede KE, Haukka JK, Saxen LM, Heinonen OP. Increased tendency towards gingival bleeding caused by joint effect of alpha-tocopherol supplementation and acetylsalicylic acid. Ann Med 1998;30:542-6.
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Lycopene 10 references
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Lutein 2 references
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Astaxanthin 3 references
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Zeaxanthin 4 references
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Vitamin A 31 references
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Tomato 3 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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