Interactions on record — worth a quick check against your medications. Based on 4 of 5 ingredients. Check your meds →
Dietary supplement

Vital Adrenal Cortisol Support Ingredients & Drug Interactions

by Woodstock Vitamins

Vital Adrenal Cortisol Support label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Vital Adrenal Cortisol Support against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Vital Adrenal Cortisol Support is a dietary supplement by Woodstock Vitamins with 5 active ingredients. Its ingredients are commonly taken for anxiety and stress, relaxation and calm, sleep support.Based on those ingredients, 1,436 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Sensoril, Suntheanine, Banaba Leaf Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Vital Adrenal Cortisol Support by Woodstock Vitamins

Ask about any prescription or over-the-counter medication and we check it for interactions with Vital Adrenal Cortisol Support by Woodstock Vitamins — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Vital Adrenal Cortisol Support by Woodstock Vitamins

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains five active ingredients. Relora, Suntheanine (theanine), Banaba Leaf Extract, Maral Root Extract, and Sensoril (ashwagandha) are all herbs and botanical extracts formulated to support adrenal and stress response.

The product also contains inactive ingredients — fillers and binders like microcrystalline cellulose, hydroxypropyl methylcellulose, and silica — that help form and stabilize the capsule.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: resist and recover from everyday stress.
  • We looked for evidence on: Stress, Anxiety, Generalized anxiety disorder (GAD), Fatigue, Psychological well-being, Cortisol regulation — and 2 related terms.
  • The strongest evidence on file: Ashwagandha is rated "Possibly Effective" for Anxiety (Natural Medicines).
  • Also on file: Ashwagandha is rated "Possibly Effective" for Generalized anxiety disorder (GAD), Stress.
  • Also on file: Ashwagandha is rated "Insufficient Reliable Evidence To Rate" for Chemotherapy-related fatigue, Fatigue, Psychological well-being.

The evidence for these ingredients is mixed and mostly limited. Ashwagandha (Sensoril) is possibly effective for insomnia, anxiety, stress, and generalized anxiety disorder based on available data.

Theanine is possibly effective for cognitive function, though its evidence for age-related cognitive decline, anxiety disorders, and other uses rates as insufficient. Banaba Leaf Extract and Maral Root Extract don't have reliable evidence established in our data for their intended uses — Banaba for blood sugar and Maral Root for athletic performance both rate as insufficient.

We hold no effectiveness data for Relora.

The evidence, ingredient by ingredient Theanine Banaba Maral Root Ashwagandha

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Ashwagandha is generally well tolerated short-term in healthy adults, though long-term safety data are limited. It can cause diarrhea, nausea, vomiting, and drowsiness at typical doses, and rare case reports link it to liver damage and thyroid-related problems.

Theanine is generally well tolerated but long-term safety isn't well studied; headaches, drowsiness, and increased dreaming have been reported. Banaba Leaf Extract is generally well tolerated in short studies, though long-term safety is unclear.

Maral Root has limited human safety data. You should not take this product during pregnancy — ashwagandha is traditionally thought to risk miscarriage, and the other ingredients don't have enough safety data.

Avoid it while breastfeeding as well.

Side effects, ingredient by ingredient Theanine Banaba Maral Root Ashwagandha

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Ashwagandha, Theanine, Banaba, Maral Root.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 1,437 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check if you're on blood pressure medications (antihypertensives), diabetes drugs, sedatives or benzodiazepines, blood thinners or antiplatelet drugs like aspirin or Plavix, immunosuppressants, thyroid hormones, or any drug processed by the liver. Ashwagandha and theanine lower blood pressure; ashwagandha and banaba lower blood sugar; ashwagandha and theanine add to sedation; banaba and maral root affect how certain drugs are absorbed or broken down.

Use the medication checker below to verify your specific drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may appeal to people looking for herbal support for stress and sleep, especially if they take ashwagandha or theanine already. However, if you take any medication for blood pressure, blood sugar, anxiety, depression, sleep, immune function, thyroid, or blood thinning, you need to check your exact medications with our tool before starting.

Talk to your pharmacist or doctor first — the interactions here are real, and some ingredients have liver safety concerns.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 20, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Vital Adrenal Cortisol Support, straight from the product label.

Brand Woodstock Vitamins
Barcode (UPC) 669439821244
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Jun 20, 2024
DSLD ID 310332
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Vital Adrenal Cortisol Support by Woodstock Vitamins, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
669439821244
IngredientAmount% DV
Relora250 mg--
Suntheanine100 mg--
Banaba Leaf Extract50 mg--
Maral Root Extract50 mg--
Sensoril150 mg--

Other ingredients: Hydroxypropyl Methylcellulose, L-Leucine, Ascorbyl Palmitate, Medium Chain Triglyceride Oil, Silica, Microcrystalline Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: Take one capsules twice daily, or as directed by your healthcare practitioner.

Precautions

Consult your healthcare practitioner prior to use.

Individuals taking medication should discuss potential interactions with their healthcare practitioner.

Do not use if tamper seal is damaged.

Storage: Keep closed in a cool, dry place out of reach of children.

Professional use only

Formulation

Vital Adrenal Cortisol Support helps your body resist and recover from the effect of everyday stress. Components of this multifunctional formula have been shown to support healthy cortisol levels, help alleviate occasional fatigue, promote mental clarity, and support relaxation and restful sleep.

Does not contain: Wheat, gluten, yeast, soy, dairy products, fish, shellfish, peanuts, tree nuts, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, or artificial preservatives.

Natural stress buster

Manufactured in a GMP compliant facility.

Vegetarian Caps

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Storage

Storage: Keep closed in a cool, dry place out of reach of children.

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Suntheanine Suntheanine is a registered trademark of Taiyo International, Inc. U.S. and International Patents Pending. U.S. Patents Nos. 6831103, 6589566, 6297280. Relora Relora is a registered trademark of NPI, LLC U.S. Patent No. US 6,582,735

Sensoril is a trademark of Natreon, Inc. and is protected under US patents 6,153,198 and 7,318,938.

General Statements

This package is completely recyclable.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Vital Adrenal Cortisol Support by Woodstock Vitamins label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Vital Adrenal Cortisol Support label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Vital Adrenal Cortisol Support by Woodstock Vitamins

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Relora

250 mg per serving Form: Magnolia officinalis bark extract, Phellodendron amurense bark extract

Suntheanine

Interacts with
565 drugs
100 mg per serving Form: L-Theanine

Theanine (usually L-theanine) is an amino acid found naturally in tea leaves that many people take to feel calmer and less stressed without strong dro...

Suntheanine monograph & interactions

Banaba Leaf Extract

Interacts with
299 drugs
50 mg per serving Form: Corosolic Acid

Banaba is a leaf extract most often used to help support healthy blood sugar, and small early studies suggest its active compound corosolic acid may m...

Banaba Leaf Extract monograph & interactions

Maral Root Extract

Interacts with
122 drugs
50 mg per serving

Maral Root (Rhaponticum carthamoides) is a Siberian herb used as an 'adaptogen' and is popular among athletes for stamina and muscle building, largely...

Maral Root Extract monograph & interactions

Sensoril

Interacts with
1,372 drugs
150 mg per serving Form: Ashwagandha Leaf, Root Extract

Ashwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, though the evid...

Sensoril monograph & interactions

Other (inactive) ingredients: Hydroxypropyl Methylcellulose, L-Leucine, Ascorbyl Palmitate, Medium Chain Triglyceride Oil, Silica, Microcrystalline Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Vital Adrenal Cortisol Support by Woodstock Vitamins Drug Interactions

Want to check YOUR meds against Vital Adrenal Cortisol Support?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,436Drugs
1,016 Moderate 420 Minor

Ingredients driving the most interactions

Sensoril 1,372
Suntheanine 565
Banaba Leaf Extract 299
Maral Root Extract 122

Individual Drug Interactions

The ingredients in Vital Adrenal Cortisol Support interact with 1,436 drugs. Click any drug to see the details.

4 of the 5 ingredients in Vital Adrenal Cortisol Support interact with drugs. Each result below shows which ingredient is responsible. Sensoril Suntheanine Banaba Leaf Extract Maral Root Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Vital Adrenal Cortisol Support with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Sensoril10 drug types · 1,372 drugs

Antidiabetes Drugs

Theoretically, taking ashwagandha with antidiabetes drugs might increase the risk of hypoglycemia.
There is preliminary clinical evidence suggesting that ashwagandha might lower blood glucose levels. Theoretically, ashwagandha might have additive effects when used with antidiabetes drugs and increase the risk of hypoglycemia.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Animal research suggests that ashwagandha might lower systolic and diastolic blood pressure. Theoretically, ashwagandha might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.

Likelihood Possible Evidence D
Benzodiazepines

Theoretically, taking ashwagandha might increase the sedative effects of benzodiazepines.
There is preliminary evidence that ashwagandha might have an additive effect with diazepam (Valium) and clonazepam (Klonopin). This may also occur with other benzodiazepines.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Ashwagandha seems to have sedative effects. Theoretically, this may potentiate the effects of barbiturates, other sedatives, and anxiolytics.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Ashwagandha has been linked to cases of acute hepatitis, liver failure, hepatic encephalopathy, autoimmune hepatitis, the need for liver transplantation, and death due to liver failure.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Ashwagandha has demonstrated immunostimulant effects in humans. Animal research has shown that ashwagandha can attenuate the immunosuppression caused by cyclophosphamide.

Likelihood Possible Evidence D
Thyroid Hormone

Ashwagandha might increase the effects and adverse effects of thyroid hormone.
Concomitant use of ashwagandha with thyroid hormones may cause additive therapeutic and adverse effects. Preliminary clinical research and animal studies suggest that ashwagandha boosts thyroid hormone synthesis and secretion. In one clinical study, ashwagandha increased triiodothyronine (T3) and thyroxine (T4) levels by 41.5% and 19.6%, respectively, and reduced serum TSH levels by 17.4% from baseline in adults with subclinical hypothyroidism.

Likelihood Probable Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that ashwagandha extract induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that ashwagandha extract induces CYP3A4 enzymes.

Likelihood Possible Evidence D
Serotonergic Drugs

Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors. However, there is no evidence to suggest that ashwagandha increases the risk of serotonin-related effects, and there have been no published case reports of serotonin syndrome when combined with other serotonergic drugs. Nevertheless, due to the lack of extensive studies on the matter and the fact that ashwagandha appears to affect serotonergic pathways, it would be prudent to exercise caution when combining it with drugs that affect serotonin. [References: - Effects of Withania somnifera (Ashwaga ndha) on Stress and the Stress-Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia. Curr Neuropharmacol. 2021 Sep 14; 19: 1468–1495. - A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573577/]

Likelihood Possible Evidence C
Sensoril full monograph & interactions

Suntheanine3 drug types · 565 drugs

Antihypertensive Drugs

Theanine might lower blood pressure, potentiating the effects of antihypertensive drugs.
Animal research shows that theanine can lower blood pressure in spontaneously hypertensive animals. Theoretically, concomitant use of theanine and antihypertensive drugs might potentiate the antihypertensive activity.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, theanine might have additive sedative effects when used in conjunction with CNS depressants. However, it is unclear if this concern is clinically relevant.
Theoretically, theanine may compete with glutamate and/or increase plasma gamma-aminobutyric acid (GABA) levels, which could cause CNS depression. In one clinical study, some subjects taking oral theanine reported drowsiness.

Likelihood Unlikely Evidence D
Serotonergic Drugs

Clinical studies regarding the effects of L-theanine on serotonin levels are conflicting. Some studies suggest it can increase serotonin levels in the brain while others report that it may decrease them. Nevertheless, there have been no reports of l-theanine being a causative agent in serotonergic-related side effects or serotonin syndrome.

Likelihood Unlikely Evidence C
Suntheanine full monograph & interactions

Banaba Leaf Extract3 drug types · 299 drugs

Antidiabetes Drugs

Theoretically, concomitant use of banaba and hypoglycemic drugs might have additive effects.
Human and animal research suggests that banaba can lower blood glucose levels.

Likelihood Probable Evidence B
Antihypertensive Drugs

Theoretically, concomitant use of banaba and antihypertensive drugs might cause additive effects.
Human and animal research suggests that banaba can lower blood pressure.

Likelihood Probable Evidence B
Organic Anion-Transporting Polypeptide Substrates (Oatp)

Theoretically, concomitant use of banaba with substrates of OATP might reduce the bioavailability of the OATP substrate.
In vitro research shows that banaba inhibits OATP, particularly OATP2B1. OATPs are expressed in the small intestine and liver and are responsible for the absorption of drugs and other compounds.

Likelihood Possible Evidence D
Banaba Leaf Extract full monograph & interactions

Maral Root Extract1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

In vitro research shows that maral root tincture can reduce platelet aggregation. Theoretically, maral root might increase the risk of bleeding when used concomitantly with anticoagulant/antiplatelet drugs. Some of these drugs include aspirin, clopidogrel (Plavix), nonsteroidal anti-inflammatory drugs (NSAIDs) such as diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.

Likelihood Possible Evidence D
Maral Root Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Vital Adrenal Cortisol Support, from the product label.

Woodstock Vitamins

See all Woodstock Vitamins products
Name
Village Vitality LLC
Street Address
79 Tinker Street Fl 2
City
Woodstock
State
NY
ZipCode
12498
Phone Number
(845) 521-7455
Web Address
www.WoodstockVitamins.com
Pharmacist Counseling Corner

Vital Adrenal Cortisol Support by Woodstock Vitamins: Common Questions

Does Vital Adrenal Cortisol Support by Woodstock Vitamins interact with any medications?
Yes. Based on its ingredients, Vital Adrenal Cortisol Support has a known interaction with 1,436 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Vital Adrenal Cortisol Support contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant or breastfeeding?
No, the safety data advises against it. Ashwagandha is traditionally thought to raise the risk of miscarriage. The other ingredients — theanine, banaba, and maral root — don't have enough safety data during pregnancy or breastfeeding either. Talk with your doctor or pharmacist about whether it's right for you.
What is ashwagandha (Sensoril) in this product supposed to do?
Ashwagandha is included for its possibly effective benefits for insomnia, anxiety, stress, and generalized anxiety disorder. It appears to have mild sedative effects and may help with relaxation and sleep.
What's theanine and why is it here?
Theanine (Suntheanine) is an amino acid from tea leaves. The data we hold shows it as possibly effective for cognitive function. It's often used in stress and relaxation formulas because of its calming reputation, though evidence for anxiety and other uses is limited.
What side effects should I watch for?
Ashwagandha may cause diarrhea, nausea, vomiting, or drowsiness. Theanine may cause headaches, drowsiness, or increased dream activity. Banaba may cause dizziness, headache, stomach upset, or weakness, though these were reported in a product containing other herbs too so the exact cause isn't clear. If you develop yellowing of the skin or eyes, severe stomach pain, or unusual bruising, stop and contact your doctor immediately.
I'm on a blood pressure medication. Is this product safe for me?
Not without checking with your pharmacist first. Both ashwagandha and theanine in this product may lower blood pressure, so taking them with blood pressure medications could cause your pressure to drop too far. Use the medication checker on this page with your specific drug name, or call your pharmacist to be sure.
Will this work for adrenal fatigue or low cortisol?
We hold no effectiveness data in our records showing these ingredients work for those conditions. The product is branded for adrenal support, but the scientific evidence we have covers stress, anxiety, sleep, and cognitive function instead. Talk to your doctor about whether these ingredients match what you actually need.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Vital Adrenal Cortisol Support is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Vital Adrenal Cortisol Support label
Go deeper

The Full Monographs Behind Vital Adrenal Cortisol Support’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Theanine

Interacts with 565 drugs

Theanine (usually L-theanine) is an amino acid found naturally in tea leaves that many people take to feel calmer and less stressed without strong drowsiness. Early research suggests it may...

Read the full Theanine monograph → Herb & supplement monograph

Banaba

Interacts with 299 drugs

Banaba is a leaf extract most often used to help support healthy blood sugar, and small early studies suggest its active compound corosolic acid may modestly lower glucose. The overall evide...

Read the full Banaba monograph → Herb & supplement monograph

Maral Root

Interacts with 122 drugs

Maral Root (Rhaponticum carthamoides) is a Siberian herb used as an 'adaptogen' and is popular among athletes for stamina and muscle building, largely because it contains plant compounds cal...

Read the full Maral Root monograph → Herb & supplement monograph

Ashwagandha

Interacts with 1,372 drugs

Ashwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, though the evidence is still limited. It is generally w...

Read the full Ashwagandha monograph →
Sources

Sources & How We Checked

Vital Adrenal Cortisol Support's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 47 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Theanine 6 references
  1. Yokogoshi H, Kobayashi M. Hypotensive effect of gamma-glutamylethylamide in spontaneously hypertensive rats. Life Sci 1998;62:1065-8.
  2. Haskell, C. F., Kennedy, D. O., Milne, A. L., Wesnes, K. A., and Scholey, A. B. The effects of L-theanine, caffeine and their combination on cognition and mood. Biol.Psychol. 2008;77(2):113-122. PubMed
  3. Yokogoshi, H., Kato, Y., Sagesaka, Y. M., Takihara-Matsuura, T., Kakuda, T., and Takeuchi, N. Reduction effect of theanine on blood pressure and brain 5-hydroxyindoles in spontaneously hypertensive rats. Biosci.Biotechnol.Biochem. 1995;59(4):615-618. PubMed
  4. Lyon MR, Kapoor MP, Juneja LR. The effects of L-theanine (Suntheanine®) on objective sleep quality in boys with attention deficit hyperactivity disorder (ADHD): a randomized, double-blind, placebo-controlled clinical trial. Altern Med Rev. 2011;16(4):348-
  5. Hidese S, Ota M, Wakabayashi C, et al. Effects of chronic l-theanine administration in patients with major depressive disorder: an open-label study. Acta Neuropsychiatr 2017;29(2):72-9.
  6. Tsuchiya T, Honda H, Oikawa M, et al. Oral administration of the amino acids cystine and theanine attenuates the adverse events of S-1 adjuvant chemotherapy in gastrointestinal cancer patients. Int J Clin Oncol 2016;21(6):1085-90. PubMed

See these in context on the Theanine monograph →

Banaba 7 references
  1. Judy WV, Hari SP, Stogsdill WW, et al. Antidiabetic activity of a standardized extract (Glucosol) from Lagerstroemia speciosa leaves in Type II diabetics. A dose-dependence study. J Ethnopharmacol 2003;87:115-7. PubMed
  2. Kakuda T, Sakane I, Takihara T, et al. Hypoglycemic effect of extracts from Lagerstroemia speciosa L. leaves in genetically diabetic KK-AY mice. Biosci Biotechnol Biochem 1996;60:204-8.
  3. Fukushima, M., Matsuyama, F., Ueda, N., Egawa, K., Takemoto, J., Kajimoto, Y., Yonaha, N., Miura, T., Kaneko, T., Nishi, Y., Mitsui, R., Fujita, Y., Yamada, Y., and Seino, Y. Effect of corosolic acid on postchallenge plasma glucose levels. Diabetes Res C PubMed
  4. Yamaguchi, Y., Yamada, K., Yoshikawa, N., Nakamura, K., Haginaka, J., and Kunitomo, M. Corosolic acid prevents oxidative stress, inflammation and hypertension in SHR/NDmcr-cp rats, a model of metabolic syndrome. Life Sci 11-25-2006;79(26):2474-2479. PubMed
  5. Fuchikami H, Satoh H, Tsujimoto M, Ohdo S, Ohtani H, Sawada Y. Effects of herbal extracts on the function of human organic anion-transporting polypeptide OATP-B. Drug Metab Dispos 2006;34:577-82. PubMed
  6. Manaf A, Tjandrawinata RR, Malinda D. Insulin sensitizer in prediabetes: a clinical study with DLBS3233, a combined bioactive fraction of Cinnamomum burmanii and Lagerstroemia speciosa. Drug Des Devel Ther. 2016;10:1279-89. PubMed
  7. Tjokroprawiro A, Murtiwi S, Tjandrawinata RR. DLBS3233, a combined bioactive fraction of Cinnamomum burmanii and Lagerstroemia speciosa, in type-2 diabetes mellitus patients inadequately controlled by metformin and other oral antidiabetic agents. J Comple

See these in context on the Banaba monograph →

Maral Root 2 references
  1. Koleckar V, Brojerova E, Rehakova Z, et al. In vitro antiplatelet activity of flavonoids from Leuzea carthamoides. Drug Chem Toxicol 2008;31(1):27-35.
  2. Ryan ED, Gerstner GR, Mota JA, et al. The Acute Effects of a Multi-Ingredient Herbal Supplement on Performance Fatigability: A Double-Blind, Randomized, and Placebo-Controlled Trial. J Diet Suppl 2021;18(5):507-516. PubMed

See these in context on the Maral Root monograph →

Ashwagandha 32 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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