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Dietary supplement

Vitalica Ingredients & Drug Interactions

by CS Health

Vitalica label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Vitalica against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Vitalica is a dietary supplement by CS Health with 2 active ingredients. Its ingredients are commonly taken for antioxidant support, general cellular health, detoxification support.Based on those ingredients, 723 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Sulforaphane Glucosinolate, Broccoli seed raffinate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Vitalica by CS Health

Ask about any prescription or over-the-counter medication and we check it for interactions with Vitalica by CS Health — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Vitalica by CS Health

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 24, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Vitalica contains 2 active ingredients: sulforaphane glucosinolate (a compound from broccoli) and broccoli seed raffinate (a broccoli extract). Both are plant-derived compounds thought to support cellular health.

The capsule also contains inactive ingredients — a vegetable capsule shell, calcium ascorbate, and microcrystalline cellulose — which serve as binders and fillers.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Moderate

Some clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Prostate cancer — rated "Possibly Effective" (Sulforaphane) (Natural Medicines).
  • On file: Colorectal cancer — rated "Possibly Effective" (Broccoli) (Natural Medicines).

Sulforaphane is possibly effective for prostate cancer based on the evidence we hold, though it's rated possibly ineffective for H. pylori infection. For other uses — hay fever, asthma, and general cancer support — the evidence isn't established enough to rate.

Broccoli is possibly effective for colorectal cancer; for bladder cancer, breast cancer, fibromyalgia, and stomach cancer, evidence is insufficient to make a claim. Neither ingredient has strong evidence across a wide range of conditions, so talk with your doctor about whether this product fits your health goals.

The evidence, ingredient by ingredient Sulforaphane Broccoli

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Sulforaphane from food is generally well tolerated, though concentrated supplements haven't been studied as thoroughly for long-term use. Common side effects in trials included bowel discomfort, heartburn, stomach upset, vomiting, headache, insomnia, and irritability.

A small number of trial participants — all with autism or a history of seizure — experienced seizures after taking sulforaphane; if you have a seizure disorder, check with your doctor before using this product. One study noted increased weight gain in adolescent and young adult males.

Broccoli as food is safe, but concentrated seed extracts can cause loose stools, diarrhea, and abdominal pain, especially at high doses. The safety data advises against concentrated sulforaphane supplements in pregnancy; for breastfeeding, there isn't enough information about supplement-level doses, so talk with your doctor or pharmacist for personalized advice.

Side effects, ingredient by ingredient Sulforaphane Broccoli

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Sulforaphane, Broccoli.
  • The most serious interaction on file is rated Moderate.
  • For scale: 724 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Vitalica, check with your pharmacist or doctor if you take any medications metabolized by CYP1A2, CYP3A4, CYP2E1, or CYP2A6 enzymes — a list that spans hundreds of common drugs. Sulforaphane may increase or decrease drug levels depending on the enzyme, and broccoli may speed up metabolism of certain medications.

Severity is Moderate across all these enzyme interactions, meaning the effect on your drug could be clinically meaningful. Use the medication checker on this page, or ask your pharmacist to review your specific prescriptions before you start.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Vitalica may be worth considering if you're interested in plant compounds studied for cancer support and your medications don't interact with the enzyme systems sulforaphane and broccoli affect — but that's a significant 'if'. Anyone taking prescription medications, especially those for the heart, blood pressure, or mood, needs to check with their own pharmacist or doctor before starting, because the interaction potential is real and widespread.

If you're pregnant, breastfeeding, or have a history of seizures, talk with your healthcare provider first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 23, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Vitalica, straight from the product label.

Brand CS Health
Net contents 100 Vegan Capsule(s)
Market status On market
Date entered into DSLD Oct 23, 2019
DSLD ID 207071
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Vitalica by CS Health, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
IngredientAmount% DV
Sulforaphane Glucosinolate34.7 mg--
Broccoli seed raffinate560 mg--

Other ingredients: Vegetable Capsule, Calcium Ascorbate, Microcrystalline Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

The seed makes the difference. This product contains BroccoRaphanin, the original sulforaphane glucosinolate (glucoraphanin) derived from CS Health LLC's proprietary broccoli seed variety. Our seed was bred by natural selection (non-GMO) and contains the highest concentration of sulforaphane glucosinolate available. On ingestion, Vitalica converts to sulforaphane in the body, activates Phase II enzymes, protects DNA from free radicals and promotes immune system health.

Formulation

Our seed was bred by natural selection (non-GMO) and contains the highest concentration of sulforaphane glucosinolate available.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

The Original Sulforaphane Glucosinolate Supplement

General Statements

Mom was right!

Suggested/Recommended/Usage/Directions

Directions: For adults, take one or two capsules daily on an empty stomach.

Brand IP Statement(s)

Sulforaphane glucosinolate branded as BroccoRaphanin Patents: This product is protected by seed patent (PVP) for proprietary broccoli seed (Brassica oleracea italica Hopkins) and U.S. Patents 7,303,770; 5,725,895; 5,968,567; 6,177,122; 6,242,018 and other patents pending.

Precautions

To report an adverse event or reaction, call 866.291.7908.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Vitalica by CS Health label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Vitalica label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Vitalica by CS Health

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sulforaphane Glucosinolate

Interacts with
722 drugs
34.7 mg per serving

Sulforaphane is a natural compound found in broccoli and other cruciferous vegetables that has shown promising antioxidant and anti-inflammatory effec...

Sulforaphane Glucosinolate monograph & interactions

Broccoli seed raffinate

Interacts with
187 drugs
560 mg per serving

Broccoli is a nutritious cruciferous vegetable rich in fiber, vitamins, and plant compounds like sulforaphane that have drawn scientific interest for...

Broccoli seed raffinate monograph & interactions

Other (inactive) ingredients: Vegetable Capsule, Calcium Ascorbate, Microcrystalline Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Vitalica by CS Health Drug Interactions

Want to check YOUR meds against Vitalica?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
723Drugs
723 Moderate

Ingredients driving the most interactions

Sulforaphane Glucosinolate 722
Broccoli seed raffinate 187

Individual Drug Interactions

The ingredients in Vitalica interact with 723 drugs. Click any drug to see the details.

2 of the 2 ingredients in Vitalica interact with drugs. Each result below shows which ingredient is responsible. Sulforaphane Glucosinolate Broccoli seed raffinate

Each ingredient & the kinds of drugs it affects

For each ingredient in Vitalica with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Sulforaphane Glucosinolate3 drug types · 722 drugs

Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, sulforaphane might alter the levels and clinical effects of CYP1A2 substrates.
Animal and in vitro research shows that sulforaphane inhibits CYP1A2 enzyme activity. However, its precursor glucoraphanin also appears to increase the expression of the CYP1A2 enzyme, which could lead to increased metabolism of CYP1A2 substrates. These effects have not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Theoretically, sulforaphane might increase the levels and effects of CYP2E1 substrates.
In vitro evidence shows that sulforaphane inhibits CYP2E1 enzymes. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, sulforaphane might increase the levels and effects of CYP3A4 substrates.
Animal and in vitro research shows that sulforaphane inhibits CYP3A4 enzyme activity and downregulates its expression. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Sulforaphane Glucosinolate full monograph & interactions

Broccoli seed raffinate2 drug types · 187 drugs

Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP1A2.
Pharmacokinetic research in humans shows that eating 500 grams of fresh broccoli daily for 6-12 days can increase CYP1A2 activity by 10% to 200%. Induction of CYP1A2 activity by broccoli is attributed to its glucosinolate constituents.

Likelihood Possible Evidence B
Cytochrome P450 2A6 (Cyp2A6) Substrates

Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP2A6.
Pharmacokinetic research in humans shows that eating 500 grams of broccoli daily for 6 days increases CYP2A6 activity by 135% to 550%. Induction of CYP2A6 activity is attributed to its glucosinolate constituents.

Likelihood Possible Evidence B
Broccoli seed raffinate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Vitalica, from the product label.

CS Health

See all CS Health products
Name
CS Health, LLC
Street Address
1402 W. Main Street
City
Louisville
State
KY
ZipCode
40203
Phone Number
866.747.0990
Web Address
www.cs-health.com
Pharmacist Counseling Corner

Vitalica by CS Health: Common Questions

Does Vitalica by CS Health interact with any medications?
Yes. Based on its ingredients, Vitalica has a known interaction with 723 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Vitalica contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help prevent cancer?
Sulforaphane is possibly effective for prostate cancer specifically, and broccoli is possibly effective for colorectal cancer. For other cancers, the evidence we hold isn't strong enough to say. Talk with your doctor about whether this fits into your broader cancer prevention or management plan.
What are the most common side effects?
The most common effects reported in trials were digestive — bowel discomfort, heartburn, stomach upset, and diarrhea — plus headache, insomnia, and irritability in some people. Broccoli extracts at high doses are particularly linked to loose stools and abdominal cramping. Most people tolerate it well, but if your stomach is sensitive, take note.
Is it safe to take while pregnant or breastfeeding?
Concentrated sulforaphane supplements haven't been proven safe in pregnancy, so the data advises against them — stick to broccoli as food if you're pregnant. For breastfeeding, there isn't enough information about supplement doses, so talk with your doctor or pharmacist before using it and they can give you personalized advice.
Can I take this if I have a seizure disorder?
A small number of people with autism or a seizure history experienced seizures after taking sulforaphane in clinical trials. If you have a seizure disorder or take seizure medication, check with your doctor before starting this product.
What is broccoli seed raffinate?
It's a concentrated extract from broccoli seeds — a more potent form than eating broccoli as food. Like sulforaphane, it can affect how your liver metabolizes medications and may cause digestive upset, especially at higher doses.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Vitalica label
Go deeper

The Full Monographs Behind Vitalica’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sulforaphane

Interacts with 722 drugs

Sulforaphane is a natural compound found in broccoli and other cruciferous vegetables that has shown promising antioxidant and anti-inflammatory effects in lab studies, but strong human evid...

Read the full Sulforaphane monograph → Herb & supplement monograph

Broccoli

Interacts with 187 drugs

Broccoli is a nutritious cruciferous vegetable rich in fiber, vitamins, and plant compounds like sulforaphane that have drawn scientific interest for health benefits. Eating broccoli as food...

Read the full Broccoli monograph →
Sources

Sources & How We Checked

Vitalica's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 21 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sulforaphane 16 references
  1. Park EJ, Pezzuto JM. Botanicals in cancer chemoprevention. Cancer Metastasis Rev 2002;21:231-55. PubMed
  2. Barcelo S, Mace K, Pfeifer AM, Chipman JK. Production of DNA strand breaks by N-nitrosodimethylamine and 2-amino-3-methylimidazo[4,5-f]quinoline in THLE cells expressing human CYP isoenzymes and inhibition by sulforaphane. Mutat Res 1998;402:111-20. PubMed
  3. Cipolla BG, Mandron E, Lefort JM, et al. Effect of sulforaphane in men with biochemical recurrence after radical prostatectomy. Cancer Prev Res (Phila). 2015;8(8):712-9. PubMed
  4. Fahey JW, Wade KL, Wehage SL, et al. Stabilized sulforaphane for clinical use: Phytochemical delivery efficiency. Mol Nutr Food Res. 2017 Apr;61(4). PubMed
  5. Alumkal JJ, Slottke R, Schwartzman J, et al. A phase II study of sulforaphane-rich broccoli sprout extracts in men with recurrent prostate cancer. Invest New Drugs. 2015;33(2):480-9. PubMed
  6. Heber D, Li Z, Garcia-Lloret M, et al. Sulforaphane-rich broccoli sprout extract attenuates nasal allergic response to diesel exhaust particles. Food Funct. 2014;5(1):35-41. PubMed
  7. Singh K, Connors SL, Macklin EA, et al. Sulforaphane treatment of autism spectrum disorder (ASD). Proc Natl Acad Sci U S A. 2014;111(43):15550-5. PubMed
  8. Wise RA, Holbrook JT, Criner G, et al. Lack of effect of oral sulforaphane administration on Nrf2 expression in COPD: A randomized, double-blind, placebo controlled trial. PLoS One. 2016;11(11):e0163716. PubMed
  9. Bent S, Lawton B, Warren T, et al. Identification of urinary metabolites that correlate with clinical improvements in children with autism treated with sulforaphane from broccoli. Mol Autism. 2018;9:35. PubMed
  10. Momtazmanesh S, Amirimoghaddam-Yazdi Z, Moghaddam HS, Mohammadi MR, Akhondzadeh S. Sulforaphane as an adjunctive treatment for irritability in children with autism spectrum disorder: A randomized, double-blind, placebo-controlled clinical trial. Psychiatr PubMed
  11. Fimognari C, Lenzi M, Hrelia P. Interaction of the isothiocyanate sulforaphane with drug disposition and metabolism: pharmacological and toxicological implications. Curr Drug Metab. 2008;9(7):668-78. PubMed
  12. Chinnappan SM, George A, Evans M, Anthony J. Efficacy of Labisia pumila and Eurycoma longifolia standardised extracts on hot flushes, quality of life, hormone and lipid profile of peri-menopausal and menopausal women: a randomised, placebo-controlled stud
  13. Mahéo K, Morel F, Langouët S, et al. Inhibition of cytochromes P-450 and induction of glutathione S-transferases by sulforaphane in primary human and rat hepatocytes. Cancer Res. 1997;57(17):3649-52.
  14. Yoxall V, Kentish P, Coldham N, Kuhnert N, Sauer MJ, Ioannides C. Modulation of hepatic cytochromes P450 and phase II enzymes by dietary doses of sulforaphane in rats: Implications for its chemopreventive activity. Int J Cancer. 2005;117(3):356-62. PubMed
  15. Zimmerman AW, Singh K, Connors SL, et al. Randomized controlled trial of sulforaphane and metabolite discovery in children with Autism Spectrum Disorder. Mol Autism 2021;12(1):38.
  16. Yusin J, Wang V, Henning SM, et al. The effect of broccoli sprout extract on seasonal grass pollen-induced allergic rhinitis. Nutrients 2021;13(4):1337. PubMed

See these in context on the Sulforaphane monograph →

Broccoli 5 references
  1. Kristal AR, Lampe JW. Brassica vegetables and prostate cancer risk: a review of the epidemiological evidence. Nutr Cancer 2002;42:1-9. PubMed
  2. Chakrabarti A, Prais L, Foulds IS. Allergic contact dermatitis to broccoli. Br J Dermatol 2003;148:172-3. PubMed
  3. Hakooz, N. and Hamdan, I. Effects of dietary broccoli on human in vivo caffeine metabolism: a pilot study on a group of Jordanian volunteers. Curr Drug Metab 2007;8(1):9-15. PubMed
  4. Kall MA, Vang O, Clausen J. Effects of dietary broccoli on human drug metabolising activity. Cancer Lett. 1997;114(1-2):169-70. PubMed
  5. Bauman JE, Hsu CH, Centuori S, et al. Randomized Crossover Trial Evaluating Detoxification of Tobacco Carcinogens by Broccoli Seed and Sprout Extract in Current Smokers. Cancers (Basel). 2022;14(9):2129. Published 2022 Apr 24. PubMed

See these in context on the Broccoli monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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