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Dietary supplement

Vitalica Plus Ingredients & Drug Interactions

by CS Health

Vitalica Plus label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Vitalica Plus against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Vitalica Plus is a dietary supplement by CS Health with 1 active ingredient. Its ingredients are commonly taken for general nutrition and antioxidant support, heart and digestive health, detoxification support.Based on those ingredients, 723 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Broccoli seed raffinate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Vitalica Plus by CS Health

Ask about any prescription or over-the-counter medication and we check it for interactions with Vitalica Plus by CS Health — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Vitalica Plus by CS Health

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 24, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • “Broccoli seed raffinate” is listed as a grouped ingredient — the label gives one combined amount (228 mg) without saying how much of each component you get.

Vitalica Plus has one active ingredient: sulforaphane glucosinolate, a compound from broccoli seeds that your body converts to sulforaphane. The capsules also contain inactive ingredients — vegetable capsule material, calcium ascorbate, and microcrystalline cellulose — that serve as fillers and binders.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Sulforaphane's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: cellular health, immune support, and antioxidant protection.
  • We looked for evidence on: Exercise-induced muscle damage, Exercise-induced muscle soreness, Liver disease, Hypercholesterolemia, Hypertension, Oxidative stress — and 3 related terms.
  • The closest evidence on file: Sulforaphane is rated "Insufficient Reliable Evidence To Rate" for Liver disease (Natural Medicines).
  • Also on file: Sulforaphane is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced muscle soreness, Pregnancy-induced hypertension, Exercise-induced muscle damage.

Research suggests sulforaphane may be possibly effective for prostate cancer, though the evidence is still early. It appears possibly ineffective for Helicobacter pylori (a stomach bacteria).

For hay fever, asthma, and cancer more broadly, there isn't enough reliable evidence yet to say whether it helps.

The evidence, ingredient by ingredient Broccoli Sulforaphane

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Sulforaphane from food sources is considered safe, but concentrated supplements like this one haven't been studied long-term the way whole foods have. The most common side effects are bowel discomfort, heartburn, stomach upset, and vomiting.

Some people have reported headache, insomnia, and irritability in clinical trials. Weight gain was seen in one study of young males with autism.

Because concentrated supplements haven't been proven safe in pregnancy, the safety data advises against them — stick to normal food amounts during pregnancy. There isn't enough information on supplement-level doses while breastfeeding; use caution and prefer dietary amounts, and talk with your doctor or pharmacist for personalized advice.

Side effects, ingredient by ingredient Broccoli Sulforaphane

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Sulforaphane.
  • The most serious interaction on file is rated Moderate.
  • For scale: 723 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start Vitalica Plus, check your medications against these enzyme groups: CYP3A4 substrates (Moderate risk), CYP1A2 substrates (Moderate risk), and CYP2E1 substrates (Moderate risk). If you're unsure which enzymes your drugs use, ask your doctor or pharmacist, or use the medication checker below with your exact prescription list.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

If you're interested in sulforaphane for prostate cancer support and you take no medications that run through your liver's CYP3A4, CYP1A2, or CYP2E1 pathways, this might be worth discussing with your doctor or pharmacist. If you do take medications metabolized by those enzymes — and many people do — check your specific prescriptions with the tool on this page before adding this supplement.

Pregnant individuals should avoid concentrated sulforaphane supplements.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 24, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Vitalica Plus, straight from the product label.

Brand CS Health
Net contents 30 Capsule(s)
Market status On market
Date entered into DSLD Mar 24, 2020
DSLD ID 216136
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Vitalica Plus by CS Health, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
IngredientAmount% DV
Sulforaphane Glucosinolate11.4 mg--
Broccoli seed raffinate228 mg--

Other ingredients: Vegetable Capsule, Calcium Ascorbate, Microcrystalline Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Vitalica Plus converts to sulforaphane in the body.

Enzyme-activated broccoli

Formulation

Sulforphane promotes cellular and immune system health. Natural life support Liver detox Anti-oxidant Immune system support Brain function Digestive health Joint/artery health Post exercise recovery Skin Appearance

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

General Statements

Mom was right!

Suggested/Recommended/Usage/Directions

Directions: Take one capsule on an empty stomach, or 30 minutes after last meal, with water.

Brand IP Statement(s)

Sulforaphane glucosinolate branded as BroccoRaphanin Patents: This product is protected by USPVP0 200700022 and 201200459 for proprietary broccoli seed varieties and the following patents: US2012/0213890A1, CN103458921A, EP2678029B1, JP2014-506597A, and W02012/116018A1.

Precautions

To report an adverse event or reaction, call 866.291.7908.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Vitalica Plus by CS Health label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Vitalica Plus label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Vitalica Plus by CS Health

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Broccoli seed raffinate

Interacts with
187 drugs
228 mg per serving

Broccoli is a nutritious cruciferous vegetable rich in fiber, vitamins, and plant compounds like sulforaphane that have drawn scientific interest for...

Broccoli seed raffinate monograph & interactions

Other (inactive) ingredients: Vegetable Capsule, Calcium Ascorbate, Microcrystalline Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Vitalica Plus by CS Health Drug Interactions

Want to check YOUR meds against Vitalica Plus?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
723Drugs
723 Moderate

Ingredients driving the most interactions

Broccoli seed raffinate 187

Individual Drug Interactions

The ingredients in Vitalica Plus interact with 723 drugs. Click any drug to see the details.

1 of the 1 ingredient in Vitalica Plus interact with drugs. Each result below shows which ingredient is responsible. Broccoli seed raffinate

Each ingredient & the kinds of drugs it affects

For each ingredient in Vitalica Plus with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Broccoli seed raffinate2 drug types · 187 drugs

Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP1A2.
Pharmacokinetic research in humans shows that eating 500 grams of fresh broccoli daily for 6-12 days can increase CYP1A2 activity by 10% to 200%. Induction of CYP1A2 activity by broccoli is attributed to its glucosinolate constituents.

Likelihood Possible Evidence B
Cytochrome P450 2A6 (Cyp2A6) Substrates

Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP2A6.
Pharmacokinetic research in humans shows that eating 500 grams of broccoli daily for 6 days increases CYP2A6 activity by 135% to 550%. Induction of CYP2A6 activity is attributed to its glucosinolate constituents.

Likelihood Possible Evidence B
Broccoli seed raffinate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Vitalica Plus, from the product label.

CS Health

See all CS Health products
Name
CS Health, LLC
Street Address
1402 W. Main Street
City
Louisville
State
KY
ZipCode
40203
Phone Number
866.747.0990
Web Address
www.cs-health.com
Pharmacist Counseling Corner

Vitalica Plus by CS Health: Common Questions

Does Vitalica Plus by CS Health interact with any medications?
Yes. Based on its ingredients, Vitalica Plus has a known interaction with 723 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Vitalica Plus contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is sulforaphane glucosinolate and what does it do?
It's a compound from broccoli seeds that your body converts into sulforaphane, an active plant chemical. Research suggests it may help with prostate cancer, though more evidence is needed for other conditions.
Can I take this while pregnant?
No — concentrated sulforaphane supplements haven't been proven safe during pregnancy. Stick to normal food amounts of broccoli and other cruciferous vegetables, and talk with your doctor or pharmacist about whether dietary sources are right for you.
What are the most common side effects?
Bowel discomfort, heartburn, stomach upset, and vomiting are the most frequently reported. Some people have also experienced headache, insomnia, and irritability.
Is this safe to take long-term?
Sulforaphane from food is well-studied and safe over time, but concentrated supplements like this one haven't been studied as thoroughly for long-term use — that's why the data recommends caution.
Can I take this while breastfeeding?
There isn't enough information on supplement-level doses while breastfeeding. Use caution, prefer dietary amounts, and talk with your doctor or pharmacist for personalized advice.
Does it work for hay fever or asthma?
There isn't enough reliable evidence yet to say whether sulforaphane helps with either condition. If you're considering it for those purposes, discuss the evidence with your doctor or pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Vitalica Plus is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Vitalica Plus label
Go deeper

The Full Monographs Behind Vitalica Plus’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Broccoli

Interacts with 187 drugs

Broccoli is a nutritious cruciferous vegetable rich in fiber, vitamins, and plant compounds like sulforaphane that have drawn scientific interest for health benefits. Eating broccoli as food...

Read the full Broccoli monograph → Herb & supplement monograph

Sulforaphane

Interacts with 722 drugs

Sulforaphane is a natural compound found in broccoli and other cruciferous vegetables that has shown promising antioxidant and anti-inflammatory effects in lab studies, but strong human evid...

Read the full Sulforaphane monograph →
Sources

Sources & How We Checked

Vitalica Plus's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 21 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sulforaphane 16 references
  1. Park EJ, Pezzuto JM. Botanicals in cancer chemoprevention. Cancer Metastasis Rev 2002;21:231-55. PubMed
  2. Barcelo S, Mace K, Pfeifer AM, Chipman JK. Production of DNA strand breaks by N-nitrosodimethylamine and 2-amino-3-methylimidazo[4,5-f]quinoline in THLE cells expressing human CYP isoenzymes and inhibition by sulforaphane. Mutat Res 1998;402:111-20. PubMed
  3. Cipolla BG, Mandron E, Lefort JM, et al. Effect of sulforaphane in men with biochemical recurrence after radical prostatectomy. Cancer Prev Res (Phila). 2015;8(8):712-9. PubMed
  4. Fahey JW, Wade KL, Wehage SL, et al. Stabilized sulforaphane for clinical use: Phytochemical delivery efficiency. Mol Nutr Food Res. 2017 Apr;61(4). PubMed
  5. Alumkal JJ, Slottke R, Schwartzman J, et al. A phase II study of sulforaphane-rich broccoli sprout extracts in men with recurrent prostate cancer. Invest New Drugs. 2015;33(2):480-9. PubMed
  6. Heber D, Li Z, Garcia-Lloret M, et al. Sulforaphane-rich broccoli sprout extract attenuates nasal allergic response to diesel exhaust particles. Food Funct. 2014;5(1):35-41. PubMed
  7. Singh K, Connors SL, Macklin EA, et al. Sulforaphane treatment of autism spectrum disorder (ASD). Proc Natl Acad Sci U S A. 2014;111(43):15550-5. PubMed
  8. Wise RA, Holbrook JT, Criner G, et al. Lack of effect of oral sulforaphane administration on Nrf2 expression in COPD: A randomized, double-blind, placebo controlled trial. PLoS One. 2016;11(11):e0163716. PubMed
  9. Bent S, Lawton B, Warren T, et al. Identification of urinary metabolites that correlate with clinical improvements in children with autism treated with sulforaphane from broccoli. Mol Autism. 2018;9:35. PubMed
  10. Momtazmanesh S, Amirimoghaddam-Yazdi Z, Moghaddam HS, Mohammadi MR, Akhondzadeh S. Sulforaphane as an adjunctive treatment for irritability in children with autism spectrum disorder: A randomized, double-blind, placebo-controlled clinical trial. Psychiatr PubMed
  11. Fimognari C, Lenzi M, Hrelia P. Interaction of the isothiocyanate sulforaphane with drug disposition and metabolism: pharmacological and toxicological implications. Curr Drug Metab. 2008;9(7):668-78. PubMed
  12. Chinnappan SM, George A, Evans M, Anthony J. Efficacy of Labisia pumila and Eurycoma longifolia standardised extracts on hot flushes, quality of life, hormone and lipid profile of peri-menopausal and menopausal women: a randomised, placebo-controlled stud
  13. Mahéo K, Morel F, Langouët S, et al. Inhibition of cytochromes P-450 and induction of glutathione S-transferases by sulforaphane in primary human and rat hepatocytes. Cancer Res. 1997;57(17):3649-52.
  14. Yoxall V, Kentish P, Coldham N, Kuhnert N, Sauer MJ, Ioannides C. Modulation of hepatic cytochromes P450 and phase II enzymes by dietary doses of sulforaphane in rats: Implications for its chemopreventive activity. Int J Cancer. 2005;117(3):356-62. PubMed
  15. Zimmerman AW, Singh K, Connors SL, et al. Randomized controlled trial of sulforaphane and metabolite discovery in children with Autism Spectrum Disorder. Mol Autism 2021;12(1):38.
  16. Yusin J, Wang V, Henning SM, et al. The effect of broccoli sprout extract on seasonal grass pollen-induced allergic rhinitis. Nutrients 2021;13(4):1337. PubMed

See these in context on the Sulforaphane monograph →

Broccoli 5 references
  1. Kristal AR, Lampe JW. Brassica vegetables and prostate cancer risk: a review of the epidemiological evidence. Nutr Cancer 2002;42:1-9. PubMed
  2. Chakrabarti A, Prais L, Foulds IS. Allergic contact dermatitis to broccoli. Br J Dermatol 2003;148:172-3. PubMed
  3. Hakooz, N. and Hamdan, I. Effects of dietary broccoli on human in vivo caffeine metabolism: a pilot study on a group of Jordanian volunteers. Curr Drug Metab 2007;8(1):9-15. PubMed
  4. Kall MA, Vang O, Clausen J. Effects of dietary broccoli on human drug metabolising activity. Cancer Lett. 1997;114(1-2):169-70. PubMed
  5. Bauman JE, Hsu CH, Centuori S, et al. Randomized Crossover Trial Evaluating Detoxification of Tobacco Carcinogens by Broccoli Seed and Sprout Extract in Current Smokers. Cancers (Basel). 2022;14(9):2129. Published 2022 Apr 24. PubMed

See these in context on the Broccoli monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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