Interactions on record — worth a quick check against your medications. Based on 5 of 6 ingredients. Check your meds →
Dietary supplement

VitalMax+ Ingredients & Drug Interactions

by Herbs SRA

VitalMax+ label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking VitalMax+ against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

VitalMax+ is a dietary supplement by Herbs SRA with 6 active ingredients. Its ingredients are commonly taken for bodybuilding and testosterone support, anxiety and stress, anti-inflammatory.Based on those ingredients, 1,002 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are DHEA, Chrysin, Cnidium Fruit Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against VitalMax+ by Herbs SRA

Ask about any prescription or over-the-counter medication and we check it for interactions with VitalMax+ by Herbs SRA — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of VitalMax+ by Herbs SRA

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 6 of its 6 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

VitalMax+ contains six active ingredients. D-Aspartic Acid is included, though we cannot check its interaction data.

Chrysin is a natural compound from plants, studied for various health purposes. DHEA is a hormone precursor your body naturally makes, which plays a role in hormone balance.

Cnidium Fruit Extract and Longjack Root Extract (from Eurycoma longifolia) are herbal extracts traditionally used for sexual function and vitality. Muira Puama Extract is another herbal ingredient with a history of traditional use.

The product also contains cellulose as an inactive ingredient (capsule filler).

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Strong

Strong clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Vaginal atrophy — rated "Likely Effective" (Dhea) (Natural Medicines).
  • On file: Aging skin — rated "Possibly Effective" (Dhea) (Natural Medicines).
  • On file: Depression — rated "Possibly Effective" (Dhea) (Natural Medicines).
  • On file: Infertility — rated "Possibly Effective" (Dhea) (Natural Medicines).
  • On file: Sexual desire — rated "Possibly Effective" (Eurycoma Longifolia) (Natural Medicines).

The evidence for VitalMax+'s ingredients is mixed and often limited. DHEA is rated Likely Effective for vaginal atrophy and Possibly Effective for infertility, aging skin, and depression.

Longjack Root Extract is Possibly Effective for sexual desire, though it's rated Possibly Ineffective for athletic performance — the evidence doesn't support that claim. Chrysin, Cnidium Fruit Extract, and Muira Puama Extract have insufficient reliable evidence in our data to rate their effectiveness for the conditions they're marketed for, including sexual function and athletic performance.

For most of the conditions this product addresses, the science isn't yet established.

The evidence, ingredient by ingredient Chrysin Dhea Cnidium Eurycoma Longifolia Muira Puama

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

DHEA is generally well tolerated at typical doses short-term, but long-term safety raises concerns — there's some worry it may be linked to higher cancer risk with extended use. Common side effects include acne, headache, insomnia, mood changes, and nausea.

In women, it can cause masculinization effects like voice deepening, facial hair, and irregular periods. In men, aggression and breast enlargement have been reported.

DHEA can also trigger mood changes, anxiety, and mania. Because DHEA is a hormone, it requires medical guidance.

Chrysin and Cnidium appear generally well tolerated short-term, though long-term safety data are sparse. Longjack Root Extract is generally tolerated in studies short-term, but long-term safety is uncertain.

If longjack raises testosterone beyond normal, testosterone-related side effects — acne, insulin resistance, liver problems — are possible. Muira Puama has limited human safety data.

None of these ingredients should be used during pregnancy; there isn't enough safety information for breastfeeding either.

Side effects, ingredient by ingredient Chrysin Dhea Cnidium Eurycoma Longifolia Muira Puama

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 5 matched ingredients can interact with medications — Dhea, Chrysin, Cnidium, Eurycoma Longifolia.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 1,003 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking VitalMax+, check with your pharmacist if you're on antidepressants (especially SSRIs), blood thinners like warfarin or aspirin, estrogen therapy or birth control pills, cancer medications (aromatase inhibitors, tamoxifen, fulvestrant), the beta-blocker propranolol, diclofenac, the seizure drug mephenytoin, the sleep aid triazolam, or sedatives and anti-anxiety drugs. These have Moderate-severity interactions.

Also flag any drugs metabolized by the liver enzymes CYP3A4, CYP1A2, CYP2C19, or CYP2A6, or the tuberculosis vaccine — interactions are documented with one or more ingredients in this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

VitalMax+ is a multi-ingredient supplement with significant documented interactions, especially with antidepressants, blood thinners, estrogen-based medications, and cancer drugs. If you take any prescription medication — particularly psychiatric drugs, heart or blood medications, or hormone therapies — talk with your pharmacist before starting this product.

The evidence for effectiveness is strongest for DHEA and sexual function; for most other claims, the science is still unclear.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about VitalMax+, straight from the product label.

Brand Herbs SRA
Net contents 120 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Aug 22, 2024
DSLD ID 316218
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for VitalMax+ by Herbs SRA, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
60
IngredientAmount% DV
D-Aspartic Acid40 mg--
Chrysin100 mg--
DHEA4 mg--
Cnidium Fruit Extract104 mg--
Longjack Root Extract40 mg--
Muira Puama Extract104 mg--

Other ingredients: Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, take two (2) capsules twice daily. For best results, take capsules in the morning and the afternoon with 8oz. of water.

Precautions

Caution: Do not exceed recommended dose. Do not use if safety seal is damaged or missing.

Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement.

Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement. Keep out of the reach of children.

Storage

Store in a cool, dry place.

General Statements

Follow us: Facebook Herbs SRA

Herbs SRA Let the herbs improve your health

FDA Disclaimer Statement

These statements have not been evaluated by the FDA (Food and Drug Administration). This product is not intended to diagnose, treat, cure, mitigate or prevent any disease or health condition.

FDA Statement of Identity

Dietary Supplement

Formulation

Promotes healthy sexual vitality Supports libido & stamina

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

VitalMax+ by Herbs SRA label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

VitalMax+ label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in VitalMax+ by Herbs SRA

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

D-Aspartic Acid

40 mg per serving

Chrysin

Interacts with
358 drugs
100 mg per serving

Chrysin is a plant flavonoid sold mainly as a bodybuilding supplement claimed to raise testosterone or block estrogen, but human studies have not show...

Chrysin monograph & interactions

DHEA

Interacts with
776 drugs
4 mg per serving

DHEA is a natural hormone that the body makes and that declines with age, and it is sold as a supplement claiming many benefits. The evidence is mixed...

DHEA monograph & interactions

Cnidium Fruit Extract

Interacts with
351 drugs
104 mg per serving Form: Cnidium monnieri fruit extract

Cnidium is the dried fruit of an Asian plant long used in traditional Chinese medicine, mostly for skin problems and sexual health. Modern human evide...

Cnidium Fruit Extract monograph & interactions

Longjack Root Extract

Interacts with
248 drugs
40 mg per serving

Eurycoma longifolia (tongkat ali) is a Southeast Asian herb most popular for supporting testosterone, libido, and male fertility, with some small huma...

Longjack Root Extract monograph & interactions

Muira Puama Extract

No known
interactions
104 mg per serving Form: Tannins

Muira puama is a Brazilian plant traditionally used as an aphrodisiac and general tonic, often nicknamed 'potency wood.' Human research is very limite...

Muira Puama Extract monograph & interactions

Other (inactive) ingredients: Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

VitalMax+ by Herbs SRA Drug Interactions

Want to check YOUR meds against VitalMax+?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,002Drugs
928 Moderate 74 Minor

Ingredients driving the most interactions

DHEA 776
Chrysin 358
Cnidium Fruit Extract 351
Longjack Root Extract 248

Individual Drug Interactions

The ingredients in VitalMax+ interact with 1,002 drugs. Click any drug to see the details.

4 of the 6 ingredients in VitalMax+ interact with drugs. Each result below shows which ingredient is responsible. DHEA Chrysin Cnidium Fruit Extract Longjack Root Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in VitalMax+ with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

DHEA10 drug types · 776 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, DHEA might increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Human and laboratory research show that DHEA and DHEA-S can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidepressant Drugs

Theoretically, DHEA might increase the risk of psychiatric adverse events when used with antidepressants.
In a human case report, the use of a selective serotonin reuptake inhibitor (SSRI) with DHEA caused a manic episode. Concern for this interaction may be greater in younger individuals with higher baseline DHEA levels.

Likelihood Possible Evidence D
Aromatase Inhibitors

Theoretically, DHEA might interfere with the clinical effects of aromatase inhibitors.
DHEA is a potent estrogen agonist, which may antagonize the anti-estrogen activity of aromatase inhibitors.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Some preliminary evidence shows that DHEA may inhibit CYP3A4; however, the clinical significance of this potential interaction is not known.

Likelihood Possible Evidence D
Fulvestrant (Faslodex)

Theoretically, DHEA might interfere with the anti-estrogen effects of fulvestrant.
DHEA is a potent estrogen agonist. Some research shows that it can overcome the estrogen receptor antagonist action of fulvestrant in estrogen-receptor positive cancer cells.

Likelihood Possible Evidence D
Tamoxifen (Nolvadex)

Theoretically, DHEA might interfere with the anti-estrogen effects of tamoxifen.
DHEA is a potent estrogen agonist. Some research shows that it can overcome the estrogen receptor antagonist activity of tamoxifen in estrogen-receptor positive cancer cells.

Likelihood Possible Evidence D
Triazolam (Halcion)

DHEA can increase blood levels of triazolam.
Administration of DHEA 200 mg daily for two weeks was shown to inhibit the cytochrome P450 3A4 (CYP3A4) metabolism of triazolam. This inhibition appears to be due to DHEA-S, rather than DHEA.

Likelihood Probable Evidence D
Tuberculosis Vaccine

DHEA might reduce the effectiveness of the tuberculosis vaccine.
Animal research shows that high doses of DHEA can reduce the efficacy of the Bacillus Calmette-Guérin (BCG) tuberculosis vaccine.

Likelihood Possible Evidence D
Estrogens

Theoretically, DHEA might increase the effects and adverse effects of estrogen therapy.
DHEA is a precursor to estrogen and androgen and is metabolized into those substances. In clinical research, DHEA supplements increase the levels of these hormones. Also, in clinical research, estrogen-progestin oral contraceptives and conjugated estrogens reduce blood levels of DHEA and DHEA-S. The clinical significance of these findings is unclear.

Likelihood Possible Evidence D
Testosterone

Theoretically, DHEA might increase the effects and side effects of testosterone therapy.
DHEA is a precursor to estrogen and androgen and is metabolized into those substances. In clinical research, DHEA supplements increase the levels of these hormones. The clinical significance of these findings is unclear.

Likelihood Possible Evidence D
DHEA full monograph & interactions

Chrysin9 drug types · 358 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, chrysin might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro evidence suggests that chrysin might inhibit platelet aggregation.

Likelihood Possible Evidence D
Aromatase Inhibitors

Theoretically, chrysin might increase the effects and adverse effects of aromatase inhibitors.
In vitro research suggests that chrysin might decrease estrogen synthesis by acting as an aromatase (estrogen synthetase) inhibitor..

Likelihood Possible Evidence D
Contraceptive Drugs

Theoretically, chrysin might reduce the efficacy of estrogen-containing contraceptive drugs.
In vitro research suggests that chrysin might have antiestrogenic activity.

Likelihood Possible Evidence D
Diclofenac (Voltaren, Others)

Theoretically, chrysin might increase the effects and adverse effects of diclofenac.
In vitro research suggests that chrysin and its sulfate conjugate inhibit diclofenac metabolism. It is speculated that chrysin and its sulfate conjugate reduce the metabolism of diclofenac by inhibiting cytochrome P450 2C9. This effect has not been reported in humans.

Likelihood Possible Evidence D
Estrogens

Theoretically, chrysin might decrease the effects of estrogen therapy.
In vitro research suggests that chrysin might have antiestrogenic activity.

Likelihood Possible Evidence D
Mephenytoin (Mesantoin)

Theoretically, chrysin might increase the effects and adverse effects of mephenytoin.
In vitro research suggests that chrysin and its sulfate and glucuronide conjugates inhibit S-mephenytoin metabolism. It is speculated that chrysin and its conjugates reduce the metabolism of S-mephenytoin by inhibiting cytochrome P450 2C19. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, chrysin might increase levels of drugs metabolized by CYP1A2.
In vitro research suggests that chrysin inhibits CYP1A2 isozymes. However, chrysin does not appear to inhibit CYP1A2-dependent caffeine metabolism in animals. Due to chrysin's low bioavailability and rapid metabolism to glucuronide and sulfate conjugates, this interaction is unlikely.

Likelihood Unlikely Evidence D
Glucuronidated Drugs

Theoretically, chrysin might increase the clearance of drugs that are UGT1A1 substrates, thereby reducing their effectiveness.
In vitro research suggests that chrysin might induce UDP-glucuronosyltransferase 1A1 (UGT1A1).

Likelihood Unlikely Evidence D
Testosterone

Theoretically, chrysin might increase the effects and adverse effects of testosterone.
In vitro research suggests that chrysin and its sulfate conjugate inhibit testosterone metabolism. It is speculated that chrysin and its sulfate conjugate reduce the metabolism of testosterone by inhibiting cytochrome P450 3A4. This effect has not been reported in humans.

Likelihood Possible Evidence D
Chrysin full monograph & interactions

Cnidium Fruit Extract2 drug types · 351 drugs

Anticoagulant/Antiplatelet Drugs

Laboratory research shows that osthol, a constituent of cnidium, inhibits blood clotting and the activity of platelets. Theoretically, cnidium might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Some anticoagulant or antiplatelet drugs include aspirin, clopidogrel (Plavix), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, ticlopidine (Ticlid), warfarin (Coumadin), and others.

Likelihood Possible Evidence D
Cns Depressants

In laboratory research, cnidium has been shown to have sedative and hypnotic effects, possibly related to constituent coumarins. Theoretically, cnidium may potentiate the effects of barbiturates, other sedatives, and anxiolytics.

Likelihood Possible Evidence D
Cnidium Fruit Extract full monograph & interactions

Longjack Root Extract5 drug types · 248 drugs

Propranolol (Inderal)

Eurycoma longifolia can reduce the levels and clinical effects of propranolol.
A small clinical study in healthy persons shows that taking a single dose of a water-based Eurycoma longifolia extract 200 mg, in combination with a single dose of propranolol 80 mg, reduces the propranolol area under the curve (AUC) by 29%, reduces the peak concentration by 42%, and increases time to peak concentration by 86% when compared with control. Since the elimination half-life of propranolol did not change, it seems that Eurycoma longifolia alters the kinetics of propranolol by decreasing its absorption in the gut, and not by altering its metabolism. It is not known if separating administration will prevent this interaction.

Likelihood Probable Evidence A
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP1A2 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2A6 (Cyp2A6) Substrates

Theoretically, Eurycoma longifolia might increase levels of CYP2A6 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2A6 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, Eurycoma longifolia might increase levels of CYP2C19 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2C19 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Testosterone

Theoretically, Eurycoma longifolia may further increase levels of testosterone.
A clinical study in aging males with testosterone levels below 300 ng/dL shows that taking a specific water extract of Eurycoma longifolia roots (Physta; Biotropics Malaysia) 100-200 mg daily with breakfast for 12 weeks increases total testosterone levels by 8% to 11% when compared with placebo. It is unclear whether this increase would occur in individuals with normal testosterone levels.

Likelihood Possible Evidence D
Longjack Root Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for VitalMax+, from the product label.

Herbs SRA

See all Herbs SRA products
Name
Herbs SRA
City
Houston
State
TX
ZipCode
77083-4865
Pharmacist Counseling Corner

VitalMax+ by Herbs SRA: Common Questions

Does VitalMax+ by Herbs SRA interact with any medications?
Yes. Based on its ingredients, VitalMax+ has a known interaction with 1,002 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
VitalMax+ contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take VitalMax+ if I'm on an antidepressant?
Not without checking with your pharmacist first. DHEA in this product has a documented Moderate interaction with antidepressants, especially SSRIs — it may increase the risk of mood side effects including mania. Your pharmacist needs to review your specific medication.
Is it safe to take VitalMax+ while I'm on blood thinners?
No, not without your doctor's approval. Three ingredients here — DHEA, Chrysin, and Cnidium — interact with blood thinners (anticoagulants and antiplatelets) and may raise your bleeding risk. Talk to your pharmacist or doctor before adding this product.
Can I use VitalMax+ if I'm on birth control pills?
You should check with your pharmacist. Chrysin in this product may theoretically reduce the effectiveness of estrogen-containing contraceptives. It's a Moderate interaction, so professional guidance is important.
What are the most common side effects of VitalMax+?
DHEA, the main ingredient with established safety data, most commonly causes acne, headache, insomnia, and mood changes. In women, it can trigger facial hair growth, voice changes, and irregular periods; in men, aggression and breast enlargement have been reported. Other ingredients have limited human safety data.
Is VitalMax+ safe during pregnancy or breastfeeding?
No. DHEA affects hormone levels and should not be used in pregnancy, and there isn't enough safety information for any of the ingredients while breastfeeding. Talk with your doctor if you're pregnant or nursing and interested in this product.
Does VitalMax+ actually work for sexual function?
DHEA is rated Possibly Effective for infertility, and Longjack Root Extract is Possibly Effective for sexual desire — meaning some evidence supports them, but it's not definitive. Muira Puama and Chrysin don't have enough reliable evidence in our data to rate their effectiveness for sexual function.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

VitalMax+ label
Go deeper

The Full Monographs Behind VitalMax+’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Chrysin

Interacts with 358 drugs

Chrysin is a plant flavonoid sold mainly as a bodybuilding supplement claimed to raise testosterone or block estrogen, but human studies have not shown these benefits, largely because the bo...

Read the full Chrysin monograph → Herb & supplement monograph

Dhea

Interacts with 776 drugs

DHEA is a natural hormone that the body makes and that declines with age, and it is sold as a supplement claiming many benefits. The evidence is mixed and limited for most uses, and because...

Read the full Dhea monograph → Herb & supplement monograph

Cnidium

Interacts with 351 drugs

Cnidium is the dried fruit of an Asian plant long used in traditional Chinese medicine, mostly for skin problems and sexual health. Modern human evidence for these uses is very limited, with...

Read the full Cnidium monograph → Herb & supplement monograph

Eurycoma Longifolia

Interacts with 248 drugs

Eurycoma longifolia (tongkat ali) is a Southeast Asian herb most popular for supporting testosterone, libido, and male fertility, with some small human studies suggesting possible benefits....

Read the full Eurycoma Longifolia monograph → Herb & supplement monograph

Muira Puama

Muira puama is a Brazilian plant traditionally used as an aphrodisiac and general tonic, often nicknamed 'potency wood.' Human research is very limited, so its benefits are not well proven,...

Read the full Muira Puama monograph →
Sources

Sources & How We Checked

VitalMax+'s label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 128 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Chrysin 23 references
  1. Galijatovic A, Otake Y, Walle UK, Walle T. Extensive metabolism of the flavonoid chrysin by human Caco-2 and Hep G2 cells. Xenobiotica 1999;29:1241-56. PubMed
  2. Lee H, Yeom H, Kim YG, et al. Structure-related inhibition of human hepatic caffeine N3-demethylation by naturally occurring flavonoids. Biochem Pharmacol 1998;55:1369-75. PubMed
  3. Galijatovic A, Walle UK, Walle T. Induction of UDP-glucuronosyltransferase by the flavonoids chrysin and quercetin in Caco-2 cells. Pharm Res 2000;17:21-6.
  4. Walle UK, Galijatovic A, Walle T. Transport of the flavonoid chrysin and its conjugated metabolites by the human intestinal cell line Caco-2. Biochem Pharmacol 1999;58:431-8. PubMed
  5. Kao YC, Zhou C, Sherman M, et al. Molecular basis of the inhibition of human aromatase (estrogen synthetase) by flavone and isoflavone phytoestrogens: A site-directed mutagenesis study. Environ Health Perspect 1998;106:85-92. PubMed
  6. Jeong HJ, Shin YG, Kim IH, Pezzuto JM. Inhibition of aromatase activity by flavonoids. Arch Pharm Res 1999;22:309-12. PubMed
  7. Walle T, Otake Y, Galijatovic A, et al. Induction of UDP-glucuronosyltransferase UGT1A1 by the flavonoid chrysin in the human hepatoma cell line hep G2. Drug Metab Dispos 2000;28:1077-82. DOI
  8. Walle T, Otake Y, Brubaker JA, et al. Disposition and metabolism of the flavonoid chrysin in normal volunteers. Br J Clin Pharmacol 2001;51:143-6. DOI
  9. Galijatovic A, Otake Y, Walle UK, Walle T. Induction of UDP-glucuronosyltransferase UGT1A1 by the flavonoid chrysin in Caco-2 cells--potential role in carcinogen bioinactivation. Pharm Res 2001;18:374-9. PubMed
  10. Lautraite S, Musonda AC, Doehmer J, et al. Flavonoids inhibit genetic toxicity produced by carcinogens in cells expressing CYP1A2 and CYP1A1. Mutagenesis 2002;17:45-53. PubMed
  11. Han, D. H., Denison, M. S., Tachibana, H., and Yamada, K. Relationship between estrogen receptor-binding and estrogenic activities of environmental estrogens and suppression by flavonoids. Biosci.Biotechnol.Biochem 2002;66(7):1479-1487. PubMed
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Eurycoma Longifolia 4 references
  1. Salman SA, Amrah S, Wahab MS, et al. Modification of propranolol's bioavailability by Eurycoma longifolia water-based extract. J Clin Pharm Ther 2010;35:691-6. PubMed
  2. Tambi MI, Imran MK, Henkel RR. Standardised water-soluble extract of Eurycoma longifolia, Tongkat ali, as testosterone booster for managing men with late-onset hypogonadism? Andrologia 2011 Jun 15. doi: 10.1111/j.1439-0272.2011.01168.x. [Epub ahead of pri PubMed
  3. Han YM, Kim IS, Rehman SU, Choe K, Yoo HH. In vitro evaluation of the effects of Eurycoma longifolia extract on CYP-mediated drug metabolism. Evid Based Complement Alternat Med 2015;2015:631329.
  4. Chinnappan SM, George A, Pandey P, Narke G, Choudhary YK. Effect of Eurycoma longifolia standardised aqueous root extract-Physta ® on testosterone levels and quality of life in ageing male subjects: a randomised, double-blind, placebo-controlled multicent

See these in context on the Eurycoma Longifolia monograph →

Muira Puama 2 references
  1. Waynberg, J. and Brewer, S. Effects of Herbal vX on libido and sexual activity in premenopausal and postmenopausal women. Adv Ther 2000;17(5):255-262. PubMed
  2. Nguyen S, Rajfer J, Shaheen M. Safety and efficacy of daily Revactin in men with erectile dysfunction: a 3-month pilot study. Transl Androl Urol. 2018;7(2):266-73. PubMed

See these in context on the Muira Puama monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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