Vitamin D3 Gummies 50 mcg Ingredients & Drug Interactions
by Nature Made
What is this page for?
First and foremost: checking Vitamin D3 Gummies 50 mcg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Vitamin D3 Gummies 50 mcg is a dietary supplement by Nature Made with 2 active ingredients. Its ingredients are commonly taken for bone health and osteoporosis, correcting vitamin d deficiency, immune system support.Based on those ingredients, 715 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin D3. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Vitamin D3 Gummies 50 mcg by Nature Made
Ask about any prescription or over-the-counter medication and we check it for interactions with Vitamin D3 Gummies 50 mcg by Nature Made — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Vitamin D3 Gummies 50 mcg by Nature Made
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: vitamin D3, a form of vitamin D your body uses to absorb calcium, support bone health, and maintain immune function. The gummy also has inactive ingredients like glucose syrup, gelatin, natural flavors, and wax coating—the typical stuff that makes a gummy a gummy.
Does it work?
Strong evidence
Vitamin D3 is established as effective for treating specific medical conditions: rickets (soft bones from vitamin D deficiency), osteomalacia (weak adult bones), familial hypophosphatemia (a rare genetic disorder), renal osteodystrophy (bone disease from kidney failure), and hypoparathyroidism (low parathyroid hormone). If you're taking this for general bone health or immune support beyond these conditions, the evidence in our data doesn't speak to that—talk with your doctor about whether this dose suits your needs.
How safe is it?
Well-documented data
Vitamin D is generally well tolerated at recommended doses, but very high doses over time can cause toxicity with symptoms like high blood calcium, bone loss, and in children, slowed growth. The product facts note that serious side effects are rare when taken as directed.
During pregnancy, vitamin D at recommended amounts is likely safe, though the facts also note a possibly unsafe rating—meaning the data is mixed—so use it only under your doctor's guidance. Breastfeeding at recommended doses is considered likely safe, but check with your doctor before taking higher amounts.
Meds to double-check
Moderate interaction found
Before taking this gummy, double-check with your doctor or pharmacist if you take digoxin or other heart medications like verapamil or diltiazem (Major risk from calcium buildup), thiazide diuretics, atorvastatin, calcipotriene (vitamin D skin cream), aluminum-containing supplements, or any enzyme-dependent drugs—vitamin D3 can change how some of these work. The dose here is modest, but combined with other vitamin D sources or high doses, the risk climbs.
The bottom line
Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This gummy is a straightforward, well-tolerated way to get vitamin D3 at a modest dose, especially if you have a diagnosed deficiency or a condition like rickets or osteomalacia. If you take digoxin, heart rhythm medications, thiazide diuretics, atorvastatin, or any topical vitamin D product, mention this gummy to your doctor or pharmacist first so they can watch your calcium levels and adjust if needed.
Pregnant or breastfeeding? Talk it over with your healthcare provider before starting.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 22, 2022.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Vitamin D3 Gummies 50 mcg, straight from the product label.
| Brand | Nature Made |
|---|---|
| Barcode (UPC) | 031604028442 |
| Net contents | 90 Gummy(ies) |
| Market status | On market |
| Date entered into DSLD | Sep 22, 2022 |
| DSLD ID | 271651 |
| Product type | Vitamin |
| Supplement form | Gummy Or Jelly |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Vitamin D3 Gummies 50 mcg by Nature Made, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 15 Calorie(s) | -- |
| Total Carbohydrates | 4 Gram(s) | 1% |
| Sugar | 2 Gram(s) | -- |
| Vitamin D3 | 50 mcg | 250% |
| added Sugars | 2 Gram(s) | 4% |
Other ingredients: Glucose Syrup, Water, Gelatin, Citric Acid, Palm Oil, Natural flavors, Malic Acid, Tartaric Acid, Carnauba Wax, Colors added
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Formulation
#1 pharmacist recommended
Supports bone, teeth, muscle & immune health
No artificial flavors - Natural fruit flavors No synthetic dyes - Colors derived from natural sources No high fructose corn syrup No artificial sweeteners Gluten free
USP has tested and verified ingredients, potency and manufacturing process. USP sets official standards for dietary supplements. www.uspverified.org Based on Pharmacy Times Survey of pharmacists recommending Letter Vitamin Supplements.
Formula
Natural fruit flavors Strawberry, peach & mango with other natural flavors
50 mcg of vitamin D3 is equivalent to 2000 IU.
Seals/Symbols
USP Dietary Supplement Verified
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Suggested use: Adults, chew 2 gummies daily.
Storage
Store tightly closed, in a cool, dry place, out of reach of children.
Precautions
Store tightly closed, in a cool, dry place, out of reach of children.
Do not use if imprinted seal under cap is broken or missing.
Caution: If you are taking medication, consult your physician before use.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Vitamin D3 Gummies 50 mcg by Nature Made label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Vitamin D3 Gummies 50 mcg by Nature Made
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Gummie(s) Dosage formGummy Or Jelly Servings per container45 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Sugar
Vitamin D3
Interacts with715 drugs
Vitamin D is a fat-soluble vitamin that helps your body absorb calcium and is important for healthy bones, muscles, and immune function. Many people,...
Vitamin D3 monograph & interactionsOther (inactive) ingredients: Glucose Syrup, Water, Gelatin, Citric Acid, Palm Oil, Natural flavors, Malic Acid, Tartaric Acid, Carnauba Wax, Colors added. These complete the product’s ingredient list but are not active constituents.
Vitamin D3 Gummies 50 mcg by Nature Made Drug Interactions
HelloPharmacist Interaction Report
Nature Made Vitamin D3 Gummies at 50 mcg per serving interact with several medication types, most seriously through vitamin D3's potential to raise blood calcium levels (hypercalcemia).
The most serious risk is with digoxin, a heart medication where high-dose vitamin D can trigger dangerous irregular heartbeats. Moderate concerns also involve thiazide diuretics, calcium-channel blockers (verapamil and diltiazem), cholesterol drugs like atorvastatin, and calcipotriene (a vitamin D-like skin medication for psoriasis)—all affected by vitamin D3's effects on calcium metabolism or drug absorption.
Vitamin D3 may also increase aluminum absorption in people with kidney failure, and could theoretically weaken certain enzyme-dependent drugs through CYP3A4 induction, though that risk is minor. Altogether, these interactions span 716 individual medications.
Read the full breakdown — every affected drug type, severity by severity
The key with most of these is DOSE: the gummy you're holding contains 50 mcg (2,000 IU), which is below the recommended upper limit of 4,000 IU daily for adults. But if you're taking any of these medications—especially digoxin, heart rhythm drugs, or thiazide water pills—you'll want to mention this gummy to your doctor or pharmacist before starting, so they can monitor your blood calcium and make sure it doesn't interfere with how your medication works.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Vitamin D3 Gummies 50 mcg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Vitamin D3 Gummies 50 mcg interact with 715 drugs. Click any drug to see the details.
1 of the 2 ingredients in Vitamin D3 Gummies 50 mcg interact with drugs. Each result below shows which ingredient is responsible. Vitamin D3
Chlorothiazide, MethyldopaAldochlor, Aldoclor 150, Aldoclor 250
How Chlorothiazide, Methyldopa interacts with Vitamin D3 Gummies 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Chlorothiazide, Methyldopa interactionChlorothiazide, ReserpineDiupres
How Chlorothiazide, Reserpine interacts with Vitamin D3 Gummies 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Chlorothiazide, Reserpine interactionChlorthalidoneHygroton, Thalitone
How Chlorthalidone interacts with Vitamin D3 Gummies 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Chlorthalidone interactionChlorthalidone, ClonidineClorpres, Combipres
How Chlorthalidone, Clonidine interacts with Vitamin D3 Gummies 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Chlorthalidone, Clonidine interactionCryptenamine, MethyclothiazideDiutensen
How Cryptenamine, Methyclothiazide interacts with Vitamin D3 Gummies 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Cryptenamine, Methyclothiazide interactionCyclothiazideAnhydron, Fluidil
How Cyclothiazide interacts with Vitamin D3 Gummies 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Cyclothiazide interactionDeserpidine, HydrochlorothiazideOreticyl, Oreticyl Forte
How Deserpidine, Hydrochlorothiazide interacts with Vitamin D3 Gummies 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Deserpidine, Hydrochlorothiazide interactionDeserpidine, MethyclothiazideEnduronyl, Enduronyl Forte
How Deserpidine, Methyclothiazide interacts with Vitamin D3 Gummies 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Deserpidine, Methyclothiazide interactionDigoxinDigitek, Lanoxicaps, Lanoxin
How Digoxin interacts with Vitamin D3 Gummies 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Digoxin (lanoxin) Moderate
Interaction Summary
Theoretically, hypercalcemia induced by high-dose vitamin D can increase the risk of arrhythmia from digoxin.
Read the full Vitamin D3 + Digoxin interactionDihydroxyaluminum Sodium CarbonateRolaids
How Dihydroxyaluminum Sodium Carbonate interacts with Vitamin D3 Gummies 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Aluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D3 + Dihydroxyaluminum Sodium Carbonate interactionDiltiazemAdizem-SR, Adizem-XL, Angitil SR, Angitil XL, Calcicard CR, Cardizem +23 more
How Diltiazem interacts with Vitamin D3 Gummies 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Diltiazem (cardizem, Others), Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of diltiazem for arrhythmia.
Read the full Vitamin D3 + Diltiazem interactionDiltiazem, EnalaprilTeczem
How Diltiazem, Enalapril interacts with Vitamin D3 Gummies 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Cytochrome P450 3a4 (cyp3a4) Substrates, Diltiazem (cardizem, Others) Moderate
Interaction Summary
Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
Read the full Vitamin D3 + Diltiazem, Enalapril interactionEnalapril Maleate, HydrochlorothiazideVaseretic
How Enalapril Maleate, Hydrochlorothiazide interacts with Vitamin D3 Gummies 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Enalapril Maleate, Hydrochlorothiazide interactionEzetimibe, AtorvastatinLiptruzet
How Ezetimibe, Atorvastatin interacts with Vitamin D3 Gummies 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Atorvastatin (lipitor), Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Vitamin D might reduce absorption of atorvastatin.
Read the full Vitamin D3 + Ezetimibe, Atorvastatin interactionFish Oil TriglyceridesOmegaven
How Fish Oil Triglycerides interacts with Vitamin D3 Gummies 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Aluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D3 + Fish Oil Triglycerides interactionFosinopril, HydrochlorothiazideMonopril HCT
How Fosinopril, Hydrochlorothiazide interacts with Vitamin D3 Gummies 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Fosinopril, Hydrochlorothiazide interactionGuanethidine, HydrochlorothiazideEsimil
How Guanethidine, Hydrochlorothiazide interacts with Vitamin D3 Gummies 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Guanethidine, Hydrochlorothiazide interactionHydralazine, HydrochlorothiazideApresazide, Apresoline-Esidrix
How Hydralazine, Hydrochlorothiazide interacts with Vitamin D3 Gummies 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Hydralazine, Hydrochlorothiazide interactionHydralazine, Hydrochlorothiazide, ReserpineSer-Ap-Es, Unipres, Uniserp
How Hydralazine, Hydrochlorothiazide, Reserpine interacts with Vitamin D3 Gummies 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Hydralazine, Hydrochlorothiazide, Reserpine interactionHydrochlorothiazideAquazide, Aquazide H, Esidrix, HCTZ, Hydro, Hydro-D +3 more
How Hydrochlorothiazide interacts with Vitamin D3 Gummies 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Hydrochlorothiazide interactionHydrochlorothiazide, IrbesartanAvalide
How Hydrochlorothiazide, Irbesartan interacts with Vitamin D3 Gummies 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Hydrochlorothiazide, Irbesartan interactionHydrochlorothiazide, LabetalolTrandate HCT
How Hydrochlorothiazide, Labetalol interacts with Vitamin D3 Gummies 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Hydrochlorothiazide, Labetalol interactionHydrochlorothiazide, LisinoprilPrinzide, Zestoretic
How Hydrochlorothiazide, Lisinopril interacts with Vitamin D3 Gummies 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Hydrochlorothiazide, Lisinopril interactionHydrochlorothiazide, Losartan PotassiumHyzaar
How Hydrochlorothiazide, Losartan Potassium interacts with Vitamin D3 Gummies 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Hydrochlorothiazide, Losartan Potassium interactionHydrochlorothiazide, MethyldopaAldoril 15, Aldoril 25, Aldoril D30, Methazide
How Hydrochlorothiazide, Methyldopa interacts with Vitamin D3 Gummies 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Hydrochlorothiazide, Methyldopa interactionHydrochlorothiazide, MetoprololLopressor HCT
How Hydrochlorothiazide, Metoprolol interacts with Vitamin D3 Gummies 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Hydrochlorothiazide, Metoprolol interactionHydrochlorothiazide, MoexiprilUniretic
How Hydrochlorothiazide, Moexipril interacts with Vitamin D3 Gummies 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Hydrochlorothiazide, Moexipril interactionHydrochlorothiazide, PindololViskazide
How Hydrochlorothiazide, Pindolol interacts with Vitamin D3 Gummies 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Hydrochlorothiazide, Pindolol interactionHydrochlorothiazide, PropranololInderide
How Hydrochlorothiazide, Propranolol interacts with Vitamin D3 Gummies 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Hydrochlorothiazide, Propranolol interactionHydrochlorothiazide, QuinaprilAccuretic
How Hydrochlorothiazide, Quinapril interacts with Vitamin D3 Gummies 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Hydrochlorothiazide, Quinapril interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Vitamin D3 Gummies 50 mcg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Vitamin D3
Aluminum
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
The protein that transports calcium across the intestinal wall can also bind and transport aluminum. This protein is stimulated by vitamin D, which may therefore increase aluminum absorption. This mechanism may contribute to increased aluminum levels and toxicity in people with renal failure, when they take vitamin D and aluminum-containing phosphate binders chronically.
Atorvastatin (Lipitor)
Vitamin D might reduce absorption of atorvastatin.
A small, low-quality clinical study shows that taking vitamin D reduces levels of atorvastatin and its active metabolites by up to 55%. However, while atorvastatin levels decreased, total cholesterol, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol levels did not substantially change. Atorvastatin is metabolized in the gut by CYP3A4 enzymes, and researchers theorized that vitamin D might induce CYP3A4, causing reduced levels of atorvastatin. However, this proposed mechanism was not specifically studied.
Calcipotriene (Dovonex)
Taking calcipotriene with vitamin D increases the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with vitamin D supplements might increase the risk of hypercalcemia.
Digoxin (Lanoxin)
Theoretically, hypercalcemia induced by high-dose vitamin D can increase the risk of arrhythmia from digoxin.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and digoxin concurrently.
Diltiazem (Cardizem, Others)
Theoretically, hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of diltiazem for arrhythmia.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically this could also occur with diltiazem. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and diltiazem concurrently.
Thiazide Diuretics
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Thiazide diuretics decrease urinary calcium excretion, which could lead to hypercalcemia if vitamin D supplements are taken concurrently. This has been reported in people being treated with vitamin D for hypoparathyroidism, and also in elderly people with normal parathyroid function who were taking a thiazide, vitamin D, and calcium-containing antacids daily.
Verapamil (Calan, Others)
Hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of verapamil for arrhythmia.
Hypercalcemia due to high doses of vitamin D can reduce the effectiveness of verapamil in atrial fibrillation. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and verapamil concurrently.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
There is some concern that vitamin D might induce CYP3A4. In vitro research suggests that vitamin D induces CYP3A4 transcription. Additionally, observational research has found that increased UV light exposure and serum vitamin D levels are associated with decreased serum levels of CYP3A4 substrates such as tacrolimus and sirolimus, while no association between UV light exposure or vitamin D levels and levels of mycophenolic acid, a non-CYP3A4 substrate, was found. A small, low-quality clinical study shows that taking vitamin D reduces levels of the CYP3A4 substrate atorvastatin and its active metabolites by up to 55%; however, the clinical effects of atorvastatin were not reduced. While researchers theorized that vitamin D might induce CYP3A4, this proposed mechanism was not specifically studied.
Brand information
Manufacturer and brand details for Vitamin D3 Gummies 50 mcg, from the product label.
Nature Made
See all Nature Made products- Name
- Nature Made Nutritional Products
- City
- West Hills
- State
- CA
- ZipCode
- 91309-9903
- Phone Number
- 1-800-276-2878
- Web Address
- www.NatureMade.com
Vitamin D3 Gummies 50 mcg by Nature Made: Common Questions
Does Vitamin D3 Gummies 50 mcg by Nature Made interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is this safe to take if I'm pregnant?
What does vitamin D3 actually do in my body?
Can I take this with my heart or blood pressure medication?
What happens if I take too much vitamin D?
Is it okay to breastfeed while taking this?
Does this work for general bone health, or just specific conditions?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Vitamin D3 Gummies 50 mcg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Vitamin D3 Gummies 50 mcg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Vitamin D3 Gummies 50 mcg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 26 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Vitamin D 26 references
- McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
- Tatro DS, ed. Drug Interactions Facts. Facts and Comparisons Inc., St. Louis, MO. 1999.
- Koutkia P, Chen TC, Holick MF. Vitamin D intoxication associated with an over-the-counter supplement. N Engl J Med 2001;345:66-7. PubMed
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