Interactions on record — worth a quick check against your medications. Based on 2 of 3 ingredients. Check your meds →
Dietary supplement

VolcaNO Pre-Workout Ingredients & Drug Interactions

by Force Factor

VolcaNO Pre-Workout label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking VolcaNO Pre-Workout against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

VolcaNO Pre-Workout is a dietary supplement by Force Factor with 3 active ingredients. Its ingredients are commonly taken for morning sickness in pregnancy, premenstrual syndrome (pms), preventing or treating b6 deficiency.Based on those ingredients, 303 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin B6. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against VolcaNO Pre-Workout by Force Factor

Ask about any prescription or over-the-counter medication and we check it for interactions with VolcaNO Pre-Workout by Force Factor — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of VolcaNO Pre-Workout by Force Factor

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 8 active ingredients.
  • “Nitric Oxide Muscle Matrix” is a proprietary blend — the label gives one combined amount (1,520 mg) without saying how much of each component you get.
  • “Vein-Annihilating Energy Blend” is a proprietary blend — the label doesn't break down how much of each component you get.
  • “Creatine Strength Complex” is a proprietary blend — the label doesn't break down how much of each component you get.

VolcaNO Pre-Workout contains 8 active ingredients designed to support muscle pump and athletic performance. The formula includes Vitamin B6 (a B vitamin), Agmatine Sulfate and AgmaPure (both forms of agmatine, a compound derived from an amino acid), L-Glycine, L-Methionine, L-Citrulline, L-Norvaline, and two forms of creatine — CON-CRET Creatine HCl and creatine within a proprietary blend.

These are combined with standard inactive ingredients: gelatin capsules, silica, microcrystalline cellulose, magnesium stearate, titanium dioxide, and colorants.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: boost strength, energy, muscle mass, and workout performance.
  • We looked for evidence on: Athletic performance, Muscle strength, Muscle breakdown, Cognitive function, exercise endurance, muscle recovery — and 2 related terms.
  • The strongest evidence on file: Creatine is rated "Possibly Effective" for Athletic performance (Natural Medicines).
  • Also on file: Creatine is rated "Possibly Effective" for Muscle strength.
  • Also on file: L-citrulline is rated "Possibly Effective" for Athletic performance.

The evidence base for VolcaNO's ingredients varies. Creatine is possibly effective for muscle strength and athletic performance, and possibly effective for sarcopenia (muscle wasting).

L-Citrulline is possibly effective for athletic performance. Vitamin B6 has established effectiveness for treating vitamin B6 deficiency and certain types of anemia, and is possibly effective for pregnancy-related nausea — but the product provides B6 at supplemental doses, not therapeutic ones.

The effectiveness of Agmatine Sulfate, L-Glycine, L-Methionine, and L-Norvaline for athletic performance or pre-workout support has not been established in the data we hold.

The evidence, ingredient by ingredient Vitamin B6 Creatine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin B6 is well tolerated at doses under 100 mg daily, but high doses over time can cause nerve damage (sensory neuropathy). Agmatine appears well tolerated for short-term use, though long-term safety in humans hasn't been well studied.

L-Glycine is generally well tolerated at typical doses, and L-Methionine is safe in food amounts. Creatine is generally well tolerated in healthy adults but may cause water retention, gastrointestinal upset, muscle cramps, and dehydration.

L-Citrulline is generally well tolerated; the most common side effects are gastrointestinal discomfort and heartburn. All ingredients lack sufficient safety data during pregnancy and breastfeeding — check with your doctor before use if you're pregnant or nursing.

Side effects, ingredient by ingredient Vitamin B6 Creatine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 6 matched ingredients can interact with medications — Vitamin B6, Glycine, L-citrulline, Agmatine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications; Parkinson's medications.
  • For scale: 303 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking VolcaNO, check with your pharmacist or doctor if you take any antihypertensive drugs (blood pressure medications) — Vitamin B6, Agmatine, and L-Citrulline may lower blood pressure further. Also double-check if you take antidiabetes drugs (blood sugar medication), seizure medications like phenobarbital or phenytoin, the antipsychotic clozapine, or phosphodiesterase-5 inhibitors for erectile dysfunction.

No interactions are documented for L-Methionine or creatine.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

VolcaNO is a multi-ingredient pre-workout with creatine and amino acids aimed at muscle pump and performance. If you take blood pressure medication, diabetes medication, seizure medication, an antipsychotic like clozapine, or drugs for erectile dysfunction, you'll need to check your specific medications with the tool below before starting.

Talk to your pharmacist or doctor, especially if you have kidney issues, are pregnant, or are nursing.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 7 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about VolcaNO Pre-Workout, straight from the product label.

Brand Force Factor
Barcode (UPC) 818594011759
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Feb 23, 2022
DSLD ID 260303
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for VolcaNO Pre-Workout by Force Factor, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
4 Capsule(s)
Servings per container
60
UPC/BARCODE
818594011759
IngredientAmount% DV
Vitamin B61 mg50%
Agmatine Sulfate0 NP--
L-Glycine0 NP--
L-Methionine0 NP--
L-Citrulline0 NP--
L-Norvaline0 NP--
CON-CRET Creatine HCl0 NP--
AgmaPure0 NP--
Nitric Oxide Muscle Matrix1520 mg--
Vein-Annihilating Energy Blend0 NP--
Creatine Strength Complex0 NP--

Other ingredients: Gelatin, Silica, Microcrystalline Cellulose, Magnesium Stearate, Titanium Dioxide, FD&C Red #40, FD&C Blue #1

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Unleash the force At first glance, a volcano looks like nothing more than a harmless mountain. But deep inside, it's full of raging hot magma that's ready to erupt with destructive force. VolcaNO from Force Factor is no different. It's an unassuming little capsule that can deliver the energy, power, and strength you need to destroy even your most punishing workouts. Like an oncoming tidal wave of lava, nothing will stand in your way when you're fueled by VolcaNO.

Amplify energy & power Boost strength & endurance Improve muscle mass & recovery Pre-Workout Muscle Builder

Formula

The secret is three time-tested ingredients: L-citrulline, creatine, and agmatine. On their own, they're nothing special. But when fused together into one earth-shattering pre-workout formula, they unleash a monstrous volcanic fury that will help you finally build the rock-solid body you've been craving. VolcaNO is one of the first supplements ever to include this explosive triad, and once you experience the seismic power, you won't be able to imagine a workout without it.

Explosive nitric oxide booster

For adult use only.

Suggested/Recommended/Usage/Directions

Directions Workout Days: Take 2-4 capsules with breakfast and 2-4 capsules 30 minutes before working out. Rest Days: Take 2-4 capsules with breakfast and 2-4 capsules with dinner.

Seals/Symbols

Made In The USA

FDA Statement of Identity

Dietary Supplement

Precautions

Keep out of reach of children.

Allergen Warning: Manufactured by equipment which processes products containing milk, eggs, soybeans, wheat, shellfish, fish oil, tree nuts, and peanut flavor.

Precautions: Use only as directed.

Consult a healthcare professional before starting any new diet and exercise program, if you are pregnant or nursing, have a medical condition, or use prescription medications.

Storage

Store in a cool, dry place. Protect from heat, light, and moisture.

Brand IP Statement(s)

Agmapure is a trademark of Shanghal Yongyi Biotechnology Co., Ltd. Con-Cret and Con-Cret Reinforced are registered trademarks of ProMera Health, LLC. Con-Cret is covered by one or more of U.S. Patent Nos. 8,354,450, 8,026,385, and 7,608,641.

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, prevent, or cure any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

VolcaNO Pre-Workout by Force Factor label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

VolcaNO Pre-Workout label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in VolcaNO Pre-Workout by Force Factor

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin B6

Interacts with
210 drugs
1 mg per serving Form: Pyridoxine Hydrochloride

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is b...

Vitamin B6 monograph & interactions

Nitric Oxide Muscle Matrix

1520 mg per serving

Other (inactive) ingredients: Gelatin, Silica, Microcrystalline Cellulose, Magnesium Stearate, Titanium Dioxide, FD&C Red #40, FD&C Blue #1. These complete the product’s ingredient list but are not active constituents.

Interaction report

VolcaNO Pre-Workout by Force Factor Drug Interactions

Want to check YOUR meds against VolcaNO Pre-Workout?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
303Drugs
298 Moderate 5 Minor

Ingredients driving the most interactions

Vitamin B6 210

Individual Drug Interactions

The ingredients in VolcaNO Pre-Workout interact with 303 drugs. Click any drug to see the details.

1 of the 3 ingredients in VolcaNO Pre-Workout interact with drugs. Each result below shows which ingredient is responsible. Vitamin B6

Each ingredient & the kinds of drugs it affects

For each ingredient in VolcaNO Pre-Workout with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin B65 drug types · 210 drugs

Amiodarone (Cordarone)

Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Despite initial case reports suggesting that pyridoxine may have a protective effect against amiodarone-induced photosensitivity, preliminary clinical research suggests that pyridoxine may actually exacerbate this adverse effect.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Research in hypertensive rats shows that vitamin B6 can decrease systolic blood pressure. Similarly, clinical research in patients with hypertension shows that taking high doses of vitamin B6 may reduce systolic and diastolic blood pressure, possibly by reducing plasma levels of epinephrine and norepinephrine.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenobarbital, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenobarbital to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

High doses of vitamin B6 may reduce the levels and clinical effects of phenytoin.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenytoin, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenytoin to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Levodopa

Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Vitamin B6 (pyridoxine) enhances the metabolism of levodopa, reducing its clinical effects. However, this interaction does not occur when carbidopa is used concurrently with levodopa (Sinemet). Therefore, it is not likely to be a problem in most people.

Likelihood Unlikely Evidence D
Vitamin B6 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for VolcaNO Pre-Workout, from the product label.

Force Factor

Name
Force Factor, LLC
City
Boston
State
MA
ZipCode
02108
Phone Number
1-866-443-6723
Pharmacist Counseling Corner

VolcaNO Pre-Workout by Force Factor: Common Questions

Does VolcaNO Pre-Workout by Force Factor interact with any medications?
Yes. Based on its ingredients, VolcaNO Pre-Workout has a known interaction with 303 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
VolcaNO Pre-Workout contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this have caffeine or other stimulants?
The product facts provided don't list caffeine or other stimulants as ingredients. If you're sensitive to stimulants, check the label or contact the manufacturer for a complete ingredient breakdown.
Can I take this if I'm pregnant or breastfeeding?
The safety data we have advises against use during pregnancy and breastfeeding for most of the ingredients here. Only L-Methionine is rated Likely Safe in pregnancy; the others lack adequate safety data. Talk with your doctor or pharmacist before taking it.
What are the common side effects?
The most common side effects reported are gastrointestinal — diarrhea, nausea, heartburn, and stomach discomfort. Creatine may also cause water retention, muscle cramps, or dehydration. Vitamin B6 at high doses can cause headache or nerve damage with long-term use.
Is creatine in this safe for my kidneys?
Creatine is generally well tolerated in healthy adults, but if you have kidney problems or kidney disease, you should talk to your doctor before taking it. The data advises caution for anyone with kidney issues.
How does this help with athletic performance?
Creatine and L-Citrulline in this product are possibly effective for athletic performance. Creatine helps muscle cells produce energy during intense exercise, and L-Citrulline supports blood flow. The other ingredients haven't been shown in our data to improve performance specifically.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if VolcaNO Pre-Workout is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

VolcaNO Pre-Workout label
Go deeper

The Full Monographs Behind VolcaNO Pre-Workout’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin B6

Interacts with 210 drugs

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is best known for helping with pregnancy-rel...

Read the full Vitamin B6 monograph → Herb & supplement monograph

Creatine

Creatine is one of the most studied sports supplements, with solid evidence that it can boost strength and performance during short, high-intensity activities like weightlifting and sprintin...

Read the full Creatine monograph →
Sources

Sources & How We Checked

VolcaNO Pre-Workout's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 146 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin B6 32 references
  1. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Geerling BJ, Dagnelie PC, Badart-Smook A, et al. Diet as a risk factor for the development of ulcerative colitis. Am J Gastroenterol 2000;95:1008-13. PubMed
  4. South M. Neonatal seizures after pyridoxine use -- reply. Lancet 1999;354:2083. PubMed
  5. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  6. Baxter P, Aicardi J. Neonatal seizures after pyridoxine use. Lancet 1999;354:2082-3. PubMed
  7. Bendich A, Cohen M. Vitamin B6 safety issues. Ann N Y Acad Sci 1990;585:321-30.
  8. Schaumburg H, Kaplan J, Windebank A. Sensory neuropathy from pyridoxine abuse. A new megavitamin syndrome. N Engl J Med 1983;309:445-8. PubMed
  9. Gordon N. Pyridoxine dependency: an update. Dev Med Child Neurol 1997;39:63-5. PubMed
  10. Lewis PJ. Pain in the hand and wrist. Pyridoxine supplements may help patients with carpal tunnel syndrome. BMJ 1995;310:1534. PubMed
  11. Kaufman G. Pyridoxine against amiodarone-induced photosensitivity (letter). Lancet 1984;1:51-2. PubMed
  12. Mulrow JP, Mulrow CD, McKenna WJ. Pyridoxine and amiodarone-induced photosensitivity. Ann Intern Med 1985;103:68-9. PubMed
  13. Kawada A, Kashima A, Shiraishi H, et al. Pyridoxine-induced photosensitivity and hypophosphatasia. Dermatology 2000;201:356-60.. PubMed
  14. Vasile A, Goldberg R, Kornberg B. Pyridoxine toxicity: report of a case. J Am Osteopath Assoc 1984;83:790-1. DOI
  15. Hansson O, Sillanpaa M. Pyridoxine and serum concentration of phenytoin and phenobarbitone. Lancet 1976;1:256. DOI
  16. Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
  17. Chittumma P, Kaewkiattikun K, Wiriyasiriwach B. Comparison of the effectiveness of ginger and vitamin B6 for treatment of nausea and vomiting in early pregnancy: a randomized double-blind controlled trial. J Med Assoc Thai 2007;90:15-20.
  18. Hatzitolios, A., Iliadis, F., Katsiki, N., and Baltatzi, M. Is the anti-hypertensive effect of dietary supplements via aldehydes reduction evidence based? A systematic review. Clin Exp.Hypertens. 2008;30(7):628-639. PubMed
  19. Vasdev, S., Ford, C. A., Parai, S., Longerich, L., and Gadag, V. Dietary vitamin B6 supplementation attenuates hypertension in spontaneously hypertensive rats. Mol.Cell Biochem. 1999;200(1-2):155-162.
  20. de, Vogel S., Dindore, V., van, Engeland M., Goldbohm, R. A., van den Brandt, P. A., and Weijenberg, M. P. Dietary folate, methionine, riboflavin, and vitamin B-6 and risk of sporadic colorectal cancer. J Nutr 2008;138(12):2372-2378. PubMed
  21. Hagen, I., Nesheim, B. I., and Tuntland, T. No effect of vitamin B-6 against premenstrual tension. A controlled clinical study. Acta Obstet.Gynecol.Scand. 1985;64(8):667-670. PubMed
  22. Aybak, M., Sermet, A., Ayyildiz, M. O., and Karakilcik, A. Z. Effect of oral pyridoxine hydrochloride supplementation on arterial blood pressure in patients with essential hypertension. Arzneimittelforschung. 1995;45(12):1271-1273.
  23. Lal, K. J., Dakshinamurti, K., and Thliveris, J. The effect of vitamin B6 on the systolic blood pressure of rats in various animal models of hypertension. J Hypertens. 1996;14(3):355-363. PubMed
  24. Lauritzen CH, Reuter HD, Repges R, Bohnert K, and Schmidt U. Treatment of premenstrual tension syndrome with Vitex agnus castus. Controlled, double-blind study versus pyridoxine. Phytomed 1997;4(3):183-189. PubMed
  25. Fonseca VA, Lavery LA, Thethi TK, et al. Metanx in type 2 diabetes with peripheral neuropathy: A randomized trial. Am J Med 2013;126(2):141-9. PubMed
  26. Hankey GJ, Eikelboom JW, Yi Q, et al. Treatment with B vitamins and incidence of cancer in patients with previous stroke or transient ischemic attack: Results of a randomized placebo-controlled trial. Stroke 2012;43(6):1572-7. PubMed
  27. Hoyer-Kuhn H, Kohbrok S, Volland R, Franklin J, Hero B, Beck BB, Hoppe B. Vitamin B6 in primary hyperoxaluria I: first prospective trial after 40 years of practice. Clin J Am Soc Nephrol. 2014 Mar;9(3):468-77. PubMed
  28. Mahmoud A, Tabassum S, Al Enazi S, et al. Amelioration of levetiracetam-induced behavioral side effects by pyridoxine. A randomized double blind controlled study. Pediatr Neurol 2021;119:15-21. PubMed
  29. Gupta M, Gallante B, Bamberger JN, et al. Prospective randomized evaluation of idiopathic hyperoxaluria treatments. J Endourol 2021;35(12):1844-1851. PubMed
  30. Li H, Chen M, Liang S, et al. Excessive vitamin B6 during treatment is related to poor prognosis of patients with nasopharyngeal carcinoma: A U-shaped distribution suggests low dose supplement. Clin Nutr 2021;40(4):2293-2300. PubMed
  31. Tanigawa J, Nabatame S, Tominaga K, et al. High-dose pyridoxine treatment for inherited glycosylphosphatidylinositol deficiency. Brain Dev 2021;43(6):680-687. PubMed
  32. Committee on Practice Bulletins-Obstetrics. ACOG Practice Bulletin No. 189: Nausea And Vomiting Of Pregnancy. Obstet Gynecol. 2018;131(1):e15-e30. PubMed

See these in context on the Vitamin B6 monograph →

Agmatine 3 references
  1. Piletz JE, Aricioglu F, Cheng JT, et al. Agmatine: clinical applications after 100 years in translation. Drug Discov Today 2013;18(17-18):880-93. PubMed
  2. Keynan O, Mirovsky Y, Dekel S, Gilad VH, Gilad GM. Safety and efficacy of dietary agmatine sulfate in lumbar disc-associated radiculopathy. An open-label, dose-escalating study followed by a randomized, double-blind, placebo-controlled trial. Pain Med 201 PubMed
  3. Shopsin B. The clinical antidepressant effect of exogenous agmatine is not reversed by parachlorophenylalanine: a pilot study. Acta Neuropsychiatr 2013;25(2):113-8. PubMed

See these in context on the Agmatine monograph →

Glycine 5 references
  1. Heresco-Levy U, Javitt DC, Ermilov M, et al. Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia. Arch Gen Psychiatry 1999;56:29-36.. PubMed
  2. Potkin SG, Jin Y, Bunney BG, Costa J, Gulasekaram B. Effect of clozapine and adjunctive high-dose glycine in treatment-resistant schizophrenia. Am J Psychiatry 1999;156:145-7.. PubMed
  3. Gusev EI, Skvortsova VI, Dambinova SA, et al. Neuroprotective effects of glycine for therapy of acute ischaemic stroke. Cerebrovasc Dis 2000;10:49-60. PubMed
  4. Inagawa K, Kawai N, Ono K, Sukegawa E, Tsubuku S, Takahashi M. Assessment of acute adverse effects of glycine ingestion at a high dose in human volunteers. Seikatsu Eisei. 2006; 50:27-32.
  5. Woods SW, Walsh BC, Hawkins KA, Miller TJ, Saksa JR, D'Souza DC, Pearlson GD, Javitt DC, McGlashan TH, Krystal JH. Glycine treatment of the risk syndrome for psychosis: report of two pilot studies. Eur Neuropsychopharmacol. 2013 Aug;23(8):931-40. PubMed

See these in context on the Glycine monograph →

Methionine 12 references
  1. La Vecchia C, Negri E, Franceschi S, Decarli A. Case-control study on influence of methionine, nitrite, and salt on gastric carcinogenesis in northern Italy. Nutr Cancer 1997;27:65-8. PubMed
  2. Btaiche IF, Khalidi N. Parenteral nutrition-associated liver complications in children. Pharmacotherapy 2002;22:188-211.. PubMed
  3. Cottington EM, LaMantia C, Stabler SP, et al. Adverse event associated with methionine loading test: a case report. Arterioscler Thromb Vasc Biol 2002;22:1046-50.. PubMed
  4. Anon. Should methionine be added to paracetamol formulations? Drug Ther Perspect 1997;10:11-3. DOI
  5. Smulders, Y. M., Rakic, M., Slaats, E. H., Treskes, M., Sijbrands, E. J., Odekerken, D. A., Stehouwer, C. D., and Silberbusch, J. Fasting and post-methionine homocysteine levels in NIDDM. Determinants and correlations with retinopathy, albuminuria, and c
  6. McAuley, D. F., Hanratty, C. G., McGurk, C., Nugent, A. G., and Johnston, G. D. Effect of methionine supplementation on endothelial function, plasma homocysteine, and lipid peroxidation. J.Toxicol.Clin.Toxicol. 1999;37(4):435-440. PubMed
  7. Hanratty, C. G., McGrath, L. T., McAuley, D. F., Young, I. S., and Johnston, G. D. The effects of oral methionine and homocysteine on endothelial function. Heart 2001;85(3):326-330. PubMed
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