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Dietary supplement

White Mulberry Leaf Extract 1,000 mg Ingredients & Drug Interactions

by Bio Nutrition

White Mulberry Leaf Extract 1,000 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking White Mulberry Leaf Extract 1,000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

White Mulberry Leaf Extract 1,000 mg is a dietary supplement by Bio Nutrition with 1 active ingredient. Its ingredients are commonly taken for blood sugar support, high cholesterol, weight management.Based on those ingredients, 87 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are White Mulberry Leaf Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against White Mulberry Leaf Extract 1,000 mg by Bio Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with White Mulberry Leaf Extract 1,000 mg by Bio Nutrition — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of White Mulberry Leaf Extract 1,000 mg by Bio Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: white mulberry leaf extract at 1,000 mg per capsule. The extract comes from the leaves of the white mulberry plant and is traditionally used in botanical medicine.

The capsule also holds inactive ingredients — silica, vegetable stearate, and vegetable cellulose — which are fillers and binders that help hold the supplement together.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see White Mulberry's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: support healthy blood sugar levels.
  • We looked for evidence on: Diabetes, Impaired glucose tolerance (prediabetes), Glycemic control, Metabolic health.
  • The closest evidence on file: White Mulberry is rated "Insufficient Reliable Evidence To Rate" for Diabetes (Natural Medicines).
  • Also on file: White Mulberry is rated "Insufficient Reliable Evidence To Rate" for Impaired glucose tolerance (prediabetes).

The evidence for white mulberry leaf extract isn't established in the data we hold. The product has been studied for androgenic alopecia (hair loss), osteoporosis, common cold, diabetes, and high cholesterol, but current research doesn't provide reliable evidence to rate how well it works for any of these conditions.

The evidence, ingredient by ingredient White Mulberry

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

White mulberry leaf is generally well tolerated when taken by mouth. In a clinical trial, participants taking 4.6 grams three times daily experienced bloating and flatulence (about half), loose stools (about a quarter), and constipation (about one-fifth), but these side effects often improved over time.

The safety data in pregnancy and lactation isn't sufficient — the facts advise against medicinal amounts during pregnancy and breastfeeding. If you're pregnant or nursing and considering this supplement, talk with your pharmacist or doctor for personalized guidance.

Side effects, ingredient by ingredient White Mulberry

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — White Mulberry.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 87 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, check with your pharmacist if you're on diabetes medications (risk of low blood sugar) or OCT2 substrate drugs like metformin (the extract may slow their elimination and increase side effects). Altogether, these interactions span 86 individual medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

If you're interested in white mulberry leaf extract, the main thing is to check your blood sugar medication and any OCT2 substrate drugs with your pharmacist first — that's where the documented interactions live. Monitor your glucose if you take diabetes medications.

Be aware that the effectiveness for any condition hasn't been clearly established yet.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 25, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about White Mulberry Leaf Extract 1,000 mg, straight from the product label.

Brand Bio Nutrition
Barcode (UPC) 854936003556
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Apr 25, 2019
DSLD ID 200796
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Halal, Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for White Mulberry Leaf Extract 1,000 mg by Bio Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Vegetarian Capsule(s)
Maximum serving Sizes:
2 Vegetarian Capsule(s)
UPC/BARCODE
854936003556
IngredientAmount% DV
White Mulberry Leaf Extract1000 mg--

Other ingredients: Silica, Vegetable Stearate, Vegetable Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: Take two (2) capsules once daily with meals or as recommended by a health care professional.

Formula

Description: Bio Nutrition uses the finest White Mulberry Leaf Extract designed to support healthy blood sugar levels and contributes to overall health.

Halal

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

Recycle

Made in USA

Seals/Symbols

Halal Food Council Halal USA

Vegetarian

Formulation

Vegetarian

Free of gluten, yeast, corn, dairy, salt, sugar, wheat, soy and preservatives

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

White Mulberry Leaf Extract 1,000 mg by Bio Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

White Mulberry Leaf Extract 1,000 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in White Mulberry Leaf Extract 1,000 mg by Bio Nutrition

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Vegetarian Capsule(s) Dosage formCapsule Amounts shown are per serving.

White Mulberry Leaf Extract

Interacts with
87 drugs
1000 mg per serving

White mulberry leaf is most studied for helping blunt the rise in blood sugar after meals, but the human evidence is limited and not strong. It is gen...

White Mulberry Leaf Extract monograph & interactions

Other (inactive) ingredients: Silica, Vegetable Stearate, Vegetable Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

White Mulberry Leaf Extract 1,000 mg by Bio Nutrition Drug Interactions

Want to check YOUR meds against White Mulberry Leaf Extract 1,000 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
87Drugs
87 Moderate

Ingredients driving the most interactions

White Mulberry Leaf Extract 87

Individual Drug Interactions

The ingredients in White Mulberry Leaf Extract 1,000 mg interact with 87 drugs. Click any drug to see the details.

1 of the 1 ingredient in White Mulberry Leaf Extract 1,000 mg interact with drugs. Each result below shows which ingredient is responsible. White Mulberry Leaf Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in White Mulberry Leaf Extract 1,000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

White Mulberry Leaf Extract2 drug types · 87 drugs

Antidiabetes Drugs

Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Clinical research shows that white mulberry leaf can lower blood glucose levels. Advise patients to monitor glucose levels closely.

Likelihood Possible Evidence D
Organic Cation Transporter 2 (Oct2) Substrates

Theoretically, white mulberry leaf might slow the elimination and increase the adverse effects of drugs which are OCT2 substrates.
Animal research shows that coadministration of white mulberry leaf extract with metformin, an OCT2 substrate, slows the renal elimination of metformin via inhibition of OCT2 activity. OCT2 is expressed in the kidneys and is responsible for transporting cationic drugs into tubular epithelial cells in order to be excreted in the urine.

Likelihood Possible Evidence D
White Mulberry Leaf Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for White Mulberry Leaf Extract 1,000 mg, from the product label.

Bio Nutrition

See all Bio Nutrition products
Name
Bio Nutrition, Inc.
City
Island Park
State
NY
ZipCode
11558
Phone Number
516-432-1590
Web Address
www.bionutritioninc.com
Pharmacist Counseling Corner

White Mulberry Leaf Extract 1,000 mg by Bio Nutrition: Common Questions

Does White Mulberry Leaf Extract 1,000 mg by Bio Nutrition interact with any medications?
Yes. Based on its ingredients, White Mulberry Leaf Extract 1,000 mg has a known interaction with 87 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
White Mulberry Leaf Extract 1,000 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help with my blood sugar or diabetes?
The evidence isn't established in the data we hold. White mulberry leaf extract has been studied for diabetes, but current research doesn't provide reliable evidence to rate how well it works for blood sugar control.
What side effects might I notice?
Most people tolerate it well. The most common side effects are bloating, flatulence, loose stools, and constipation — but these often improve over time. In one trial, about half of participants experienced bloating or gas, a quarter had loose stools, and one-fifth had constipation.
Is it safe to take if I'm pregnant or breastfeeding?
The safety data isn't sufficient to know either way. The facts advise against medicinal amounts during pregnancy and breastfeeding. Talk with your pharmacist or doctor for personalized advice based on your situation.
Why do I need to check my diabetes and blood pressure medications?
White mulberry leaf extract can lower blood glucose levels, which may increase the risk of low blood sugar if you're on diabetes medications. It can also slow how your kidneys clear certain drugs (like metformin), allowing them to build up — that's why a conversation with your pharmacist matters.
Does this product contain any fillers?
It has three inactive ingredients: silica, vegetable stearate, and vegetable cellulose. These are standard binders and fillers that help the capsule hold together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if White Mulberry Leaf Extract 1,000 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

White Mulberry Leaf Extract 1,000 mg label
Go deeper

The Full Monographs Behind White Mulberry Leaf Extract 1,000 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

White Mulberry

Interacts with 87 drugs

White mulberry leaf is most studied for helping blunt the rise in blood sugar after meals, but the human evidence is limited and not strong. It is generally well tolerated as a food and tea,...

Read the full White Mulberry monograph →
Sources

Sources & How We Checked

White Mulberry Leaf Extract 1,000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

White Mulberry 6 references
  1. Andallu B, Suryakantham V, Lakshmi Srikanthi B, Reddy GK. Effect of mulberry (Morus indica L.) therapy on plasma and erythrocyte membrane lipids in patients with type 2 diabetes. Clin Chim Acta 2001;314:47-53. PubMed
  2. Mudra M, Ercan-Fang N, Zhong L, et al. Influence of mulberry leaf extract on the blood glucose and breath hydrogen response to ingestion of 75 g sucrose by type 2 diabetic and control subjects. Diabetes Care 2007;30:1272-4. PubMed
  3. Kimura T, Nakagawa K, Kubota H, et al. Food-grade mulberry powder enriched with 1-deoxynojirimycin suppresses the elevation of postprandial blood glucose in humans. J Agric Food Chem 2007;55:5869-74. PubMed
  4. Huh HW, Na YG, Bang KH, et al. Extended intake of mulberry leaf extract delayed metformin elimination via inhibiting the organic cation transporter 2. Pharmaceutics. 2020;12(1):49. PubMed
  5. Thaipitakwong T, Supasyndh O, Rasmi Y, Aramwit P. A randomized controlled study of dose-finding, efficacy, and safety of mulberry leaves on glycemic profiles in obese persons with borderline diabetes. Complement Ther Med. 2020;49:102292. PubMed
  6. Thondre PS, Lightowler H, Ahlstrom L, Gallagher A. Mulberry leaf extract improves glycaemic response and insulaemic response to sucrose in healthy subjects: results of a randomized, double blind, placebo-controlled study. Nutr Metab (Lond) 2021;18(1):41. PubMed

See these in context on the White Mulberry monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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