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Dietary supplement

Wild Yam 220 mg Ingredients & Drug Interactions

by Nature's Answer

Wild Yam 220 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Wild Yam 220 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Wild Yam 220 mg is a dietary supplement by Nature's Answer with 2 active ingredients. Its ingredients are commonly taken for menopausal symptoms, menstrual cramps, hormone balance (popular belief).Based on those ingredients, 41 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Wild Yam (Dioscorea villosa) root extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Wild Yam 220 mg by Nature's Answer

Ask about any prescription or over-the-counter medication and we check it for interactions with Wild Yam 220 mg by Nature's Answer — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Wild Yam 220 mg by Nature's Answer

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: wild yam root extract at 220 mg per capsule. Wild yam has a long history in traditional medicine, though modern evidence for most of its claimed uses is limited or absent.

The capsule also contains inactive ingredients — rice flour, vegetable cellulose, and calcium silicate — which are common fillers and binders.

Does it work?

Leans against
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Leans against

The strongest graded evidence we hold for the stated purpose leans against a benefit.

Why this rating?
  • The label markets this product for: Menopause Support.
  • We looked for evidence on: Menopausal symptoms, Postmenopausal conditions, Hormone balance, Hot flashes.
  • The closest evidence on file: Wild Yam is rated "Possibly Ineffective" for Menopausal symptoms (Natural Medicines).
  • Also on file: Wild Yam is rated "Insufficient Reliable Evidence To Rate" for Postmenopausal conditions.

The evidence for wild yam is thin across most uses we have data on. For menopausal symptoms, it's rated possibly ineffective, meaning the research doesn't support it for that purpose.

For gallbladder disease, sexual dysfunction, painful periods, and infertility, there isn't enough reliable evidence to know whether it works — the data we hold doesn't establish effectiveness for any of these.

The evidence, ingredient by ingredient Wild Yam

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Wild yam is generally well tolerated when taken by mouth in the short term. The most common side effects are fever, headache, upset stomach, and vomiting — especially at higher doses.

Serious adverse effects are rare, though anaphylaxis (a severe allergic reaction) has been reported. There isn't enough safety data to recommend it during pregnancy or while breastfeeding, so those are best avoided.

Long-term safety hasn't been well studied, so caution applies if you're thinking of using it for months at a time.

Side effects, ingredient by ingredient Wild Yam

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Wild Yam.
  • The most serious interaction on file is rated Moderate.
  • For scale: 41 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take estrogens or hormone therapies (birth control, hormone replacement therapy, and similar medications), check your exact drugs with the tool on this page before starting wild yam. The interaction is Moderate — wild yam may increase or decrease how your hormones work.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with graded evidence leaning against its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Wild yam may be worth a try if you're exploring natural options, but understand that evidence for most uses is absent or weak. If you take any estrogen-based medication — birth control, hormone therapy, or anything else — check with us or your doctor first; wild yam may interfere.

Keep it short-term, and don't use it in pregnancy or while nursing.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 7, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Wild Yam 220 mg, straight from the product label.

Brand Nature's Answer
Barcode (UPC) 083000164491
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Jan 7, 2019
DSLD ID 184960
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult Female (18 - 50 Years), Menopause, Seniors/Mature (>50 Years) - Women ONLY, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Wild Yam 220 mg by Nature's Answer, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
UPC/BARCODE
083000164491
IngredientAmount% DV
Wild Yam (Dioscorea villosa) root extract200 mg--
Wild Yam20 mg--

Other ingredients: Rice Flour, Vegetable Cellulose, Calcium Silicate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Discover Nature's Answer and trust the Difference... The True Nature of Our Standards goes way beyond the herb...

Discover Nature's Answer

2017 Nature's Answer

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Storage

Store in a cool, dry place.

Seals/Symbols

Gluten Free

General Statements

Since 1972

Formula

Menopause Support

Dioscorea villosa

FDA Statement of Identity

Dietary Supplement

Formulation

Gluten-Free

Vegan

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take one (1) capsule daily with food or water.

Precautions

Warning: Keep out of reach of children.

Do not use if safety seal is damaged or missing.

Do not use if you are pregnant or nursing. If you are taking any medications, planning any medical procedure or have a medical condition, consult with your healthcare practitioner before use.

General

18449 Rev. 417

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Wild Yam 220 mg by Nature's Answer label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Wild Yam 220 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Wild Yam 220 mg by Nature's Answer

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Wild Yam (Dioscorea villosa) root extract

Interacts with
41 drugs
200 mg per serving Form: Diosgenin

Wild yam is a root traditionally used for menopausal symptoms, cramps, and as a so-called 'natural' hormone supplement, but solid human evidence for t...

Wild Yam (Dioscorea villosa) root extract monograph & interactions

Wild Yam

Interacts with
41 drugs
20 mg per serving

Wild yam is a root traditionally used for menopausal symptoms, cramps, and as a so-called 'natural' hormone supplement, but solid human evidence for t...

Wild Yam monograph & interactions

Other (inactive) ingredients: Rice Flour, Vegetable Cellulose, Calcium Silicate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Wild Yam 220 mg by Nature's Answer Drug Interactions

Want to check YOUR meds against Wild Yam 220 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
41Drugs
41 Moderate

Ingredients driving the most interactions

Wild Yam (Dioscorea villosa) root extract 41

Individual Drug Interactions

The ingredients in Wild Yam 220 mg interact with 41 drugs. Click any drug to see the details.

1 of the 2 ingredients in Wild Yam 220 mg interact with drugs. Each result below shows which ingredient is responsible. Wild Yam (Dioscorea villosa) root extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Wild Yam 220 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Wild Yam (Dioscorea villosa) root extract1 drug type · 41 drugs

Estrogens

Theoretically, wild yam might increase or decrease the effects of estrogen.
Wild yam root shows estrogenic and anti-estrogenic effects in vitro. Theoretically, wild yam might interfere with hormone therapy.

Likelihood Possible Evidence D
Wild Yam (Dioscorea villosa) root extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Wild Yam 220 mg, from the product label.

Nature's Answer

See all Nature's Answer products
Name
Nature's Answer
Street Address
85 Commerce Drive
City
Hauppauge
State
NY
ZipCode
11788
Phone Number
(800) 439-2324
Web Address
www.naturesanswer.com
Pharmacist Counseling Corner

Wild Yam 220 mg by Nature's Answer: Common Questions

Does Wild Yam 220 mg by Nature's Answer interact with any medications?
Yes. Based on its ingredients, Wild Yam 220 mg has a known interaction with 41 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Wild Yam 220 mg contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does wild yam actually help with hot flashes and night sweats?
The research we have rates it as possibly ineffective for menopausal symptoms, so evidence doesn't support it for that use. If you're looking for relief, talk with your doctor about options with stronger evidence behind them.
Can I take this if I'm on birth control or HRT?
Not without checking first. Wild yam may interfere with how estrogen medications work — it could make them stronger or weaker. Search your exact medications with our tool on this page, then run it by your pharmacist or doctor before you start.
What side effects should I watch for?
Most people tolerate it fine, but watch for fever, headache, upset stomach, or vomiting — especially if you take a higher dose. A severe allergic reaction is very rare but possible. Stop and call your doctor if you have unusual symptoms.
Is it safe to take long-term?
The data we have suggests it's likely okay for short-term use in healthy adults, but long-term safety hasn't been well studied. If you're thinking of using it for months, talk with your pharmacist about what we don't know.
Can I take this while I'm pregnant or breastfeeding?
No — there isn't enough safety data to recommend it during pregnancy or while nursing. Skip it during both of those times, and talk with your doctor if you're looking for support during pregnancy.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Wild Yam 220 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Wild Yam 220 mg label
Go deeper

The Full Monographs Behind Wild Yam 220 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Wild Yam

Interacts with 41 drugs

Wild yam is a root traditionally used for menopausal symptoms, cramps, and as a so-called 'natural' hormone supplement, but solid human evidence for these uses is lacking. Despite popular cl...

Read the full Wild Yam monograph →
Sources

Sources & How We Checked

Wild Yam 220 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Wild Yam 7 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Eagon PK, Elm MS, Hunter DS, et al. Medicinal herbs: modulation of estrogen action. Era of Hope Mtg, Dept Defense; Breast Cancer Res Prog, Atlanta, GA 2000;Jun 8-11.
  3. Cheong JL, Bucknall R. Retinal vein thrombosis associated with a herbal phytoestrogen preparation in a susceptible patient. Postgrad Med J 2005;81:266-7.. PubMed
  4. Rosenberg Zand, R. S., Jenkins, D. J., and Diamandis, E. P. Effects of natural products and nutraceuticals on steroid hormone-regulated gene expression. Clin Chim.Acta 2001;312(1-2):213-219. PubMed
  5. Araghiniknam M, Chung S, Nelson-White T, and et al. Antioxidant activity of Dioscorea and dehydroepiandrosterone (DHEA) in older humans. Life Sciences 1996;59:L147-L157.
  6. Zeng M, Zhang L, Li M, et al. Estrogenic effects of the extracts from the Chinese Yam (Dioscorea opposite Thunb.) and its effective compounds in vitro and in vivo. Molecules. 2018 Jan 23;23(2). Pii: E11. PubMed
  7. Lu J, Wong RN, Zhang L, et al. Comparative analysis of proteins with stimulating activity on ovarian estradiol biosynthesis from four different Dioscorea species in vitro using both phenotypic and target-based approaches: implication for treating menopaus

See these in context on the Wild Yam monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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