Wild Yam & Chaste Tree Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Wild Yam & Chaste Tree against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Wild Yam & Chaste Tree is a dietary supplement by Nature's Sunshine with 2 active ingredients. Its ingredients are commonly taken for menopausal symptoms, menstrual cramps, hormone balance (popular belief).Based on those ingredients, 121 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Chaste Tree berries concentrate, Wild Yam root extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Wild Yam & Chaste Tree by Nature's Sunshine
Ask about any prescription or over-the-counter medication and we check it for interactions with Wild Yam & Chaste Tree by Nature's Sunshine — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Wild Yam & Chaste Tree by Nature's Sunshine
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
This product contains 2 active ingredients: wild yam root extract and chaste tree berries concentrate, both in a proprietary blend. Wild yam has been used traditionally for women's health, while chaste tree (also called vitex) is included for hormone-related concerns.
The capsules also contain inactive ingredients like cellulose, magnesium stearate, and stearic acid as binders and fillers.
Does it work?
Moderate evidence
The evidence for what this product can do is mixed and often limited. For chaste tree, the research is most solid: it's considered possibly effective for premenstrual syndrome (PMS) and breast tenderness (mastalgia).
Wild yam, on the other hand, is rated possibly ineffective for menopausal symptoms—the condition many people think it helps with. For other uses listed here—gallbladder disease, sexual dysfunction, irregular periods, infertility with wild yam, and aging skin or premenstrual dysphoric disorder with chaste tree—the evidence isn't established enough to rate.
Talk to your doctor or pharmacist about whether this product makes sense for what you're hoping to address.
How safe is it?
Well-documented data
Both ingredients are generally well tolerated in the short term, though long-term safety data for wild yam is sparse. The most common side effects are mild: wild yam may cause headache, fever, upset stomach, or vomiting, especially at higher doses; chaste tree may cause diarrhea, fatigue, headache, insomnia, nausea, stomach pain, skin irritation, or irregular menstruation.
A rare but serious reaction to wild yam is anaphylaxis (a severe allergic reaction). Chaste tree can also trigger skin problems like rashes, acne, or itching, and may cause prolonged or heavy menstrual bleeding.
During pregnancy, the safety data advises against both ingredients—wild yam and chaste tree have not been studied enough to know they're safe. The same goes for breastfeeding: there isn't enough data to know either way, and chaste tree may influence hormones related to milk production.
Talk with your doctor or pharmacist before taking this product if you're pregnant, breastfeeding, or planning either.
Meds to double-check
Moderate interaction found
Before taking Wild Yam & Chaste Tree, check with your doctor or pharmacist if you're on estrogen-containing medications—that includes birth control and hormone replacement therapy, since both ingredients may interfere with their effects. Also flag any antipsychotic drugs, dopamine agonists (for Parkinson's or restless legs), or metoclopramide (Reglan), all of which chaste tree may affect.
No interactions are documented in our data for other major medication categories.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Wild Yam & Chaste Tree is mainly worth considering if you're dealing with PMS or breast tenderness, since chaste tree has research backing for those. It's not well supported for menopausal symptoms.
The biggest caution is if you're on hormonal birth control, hormone replacement therapy, antipsychotic medications, or dopamine-related drugs—you'll want to check with your doctor or pharmacist first, because this product may interfere with how those work. Pregnant or breastfeeding?
This one's best avoided.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2022.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Wild Yam & Chaste Tree, straight from the product label.
| Brand | Nature's Sunshine |
|---|---|
| Barcode (UPC) | 099904011083 |
| Net contents | 100 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Nov 22, 2022 |
| DSLD ID | 278317 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Kosher, Adult Female (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Wild Yam & Chaste Tree by Nature's Sunshine, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Proprietary Blend | 420 mg | -- |
| Wild Yam root extract | 0 NP | -- |
| Chaste Tree berries concentrate | 0 NP | -- |
Other ingredients: Capsules, Cellulose, Vegetable Magnesium Stearate, Stearic Acid
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
General Statements
Bottle made from 100% post consumer recycled material. We are committed to you and our planet. Scan to learn more.
New look! Same great product
Formula
This wild yam and chaste tree combination is unique to Nature's Sunshine. Wild yam root and chaste tree berries have long been used for female health.
Ko Kosher Service Pareve
With herbal extracts
Traditionally used to support women's health
Precautions
Pregnant or lactating women should consult their health care professional prior to taking this supplement.
Do not use if inner seal is missing or damaged.
Seals/Symbols
Ko Kosher Service Pareve
Formulation
Female glandular system support
Guaranteed pure
FDA Statement of Identity
Dietary Supplement
Brand IP Statement(s)
Natures Sunshine Herbal experts since 1972
Suggested/Recommended/Usage/Directions
Recommended use: Take 1 or 2 capsules with a meal twice daily. Drink one glass (8 ounces) of water with the capsules.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Wild Yam & Chaste Tree by Nature's Sunshine label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Wild Yam & Chaste Tree by Nature's Sunshine
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container50 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Proprietary Blend
Other (inactive) ingredients: Capsules, Cellulose, Vegetable Magnesium Stearate, Stearic Acid. These complete the product’s ingredient list but are not active constituents.
Wild Yam & Chaste Tree by Nature's Sunshine Drug Interactions
HelloPharmacist Interaction Report
Wild Yam & Chaste Tree by Nature's Sunshine does interact with medications—through both its wild yam and chaste tree ingredients.
The most serious concern is with estrogen-containing drugs like hormone replacement therapy and birth control: wild yam may theoretically increase or decrease estrogen effects, while chaste tree may interfere with their efficacy. Altogether, these interactions span 121 individual medications.
Read the full breakdown — every affected drug type, severity by severity
Chaste tree also affects dopamine-related medications. It may interfere with metoclopramide (Reglan, used for nausea and reflux) and antipsychotic drugs, and it could potentiate dopamine agonists—medications used for Parkinson's disease and restless leg syndrome.
Both moderate-severity interactions mean the herb's dopamine activity could change how these drugs work.
Wild yam carries a rare but serious adverse effect: one case report documented temporary vision loss from a blood clot in the eye after taking a multi-herb product containing wild yam, though it's unclear whether wild yam alone was responsible. Neither ingredient has documented interactions we could confirm with other major drug categories.
Check your exact medications with the search tool on this page before starting.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Wild Yam & Chaste Tree?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Wild Yam & Chaste Tree interact with 121 drugs. Click any drug to see the details.
2 of the 2 ingredients in Wild Yam & Chaste Tree interact with drugs. Each result below shows which ingredient is responsible. Chaste Tree berries concentrate Wild Yam root extract
AcepromazineAtravet
How Acepromazine interacts with Wild Yam & Chaste Tree — through 1 ingredient. Tap an ingredient for the detail:
Chaste Tree Berries ConcentrateAntipsychotic Drugs Moderate
Interaction Summary
Theoretically, vitex agnus-castus could interfere with the activity of antipsychotic drugs.
Read the full Chaste Tree Berries Concentrate + Acepromazine interactionAcetophenazineTindal
How Acetophenazine interacts with Wild Yam & Chaste Tree — through 1 ingredient. Tap an ingredient for the detail:
Chaste Tree Berries ConcentrateAntipsychotic Drugs Moderate
Interaction Summary
Theoretically, vitex agnus-castus could interfere with the activity of antipsychotic drugs.
Read the full Chaste Tree Berries Concentrate + Acetophenazine interactionAmitriptyline, PerphenazineEtrafon, Etrafon-A, Etrafon-Forte, Triavil
How Amitriptyline, Perphenazine interacts with Wild Yam & Chaste Tree — through 1 ingredient. Tap an ingredient for the detail:
Chaste Tree Berries ConcentrateAntipsychotic Drugs Moderate
Interaction Summary
Theoretically, vitex agnus-castus could interfere with the activity of antipsychotic drugs.
Read the full Chaste Tree Berries Concentrate + Amitriptyline, Perphenazine interactionApomorphineAPO-go, APO-go Pen, APO-go PFS, Apokyn, Uprima
How Apomorphine interacts with Wild Yam & Chaste Tree — through 1 ingredient. Tap an ingredient for the detail:
Chaste Tree Berries ConcentrateDopamine Agonists Moderate
Interaction Summary
Theoretically, vitex agnus-castus could interfere with dopamine agonists.
Read the full Chaste Tree Berries Concentrate + Apomorphine interactionApomorphine HydrochlorideKynmobi
How Apomorphine Hydrochloride interacts with Wild Yam & Chaste Tree — through 1 ingredient. Tap an ingredient for the detail:
Chaste Tree Berries ConcentrateDopamine Agonists Moderate
Interaction Summary
Theoretically, vitex agnus-castus could interfere with dopamine agonists.
Read the full Chaste Tree Berries Concentrate + Apomorphine Hydrochloride interactionAripiprazoleAbilify, Abilify Maintena, Abilify Mycite
How Aripiprazole interacts with Wild Yam & Chaste Tree — through 1 ingredient. Tap an ingredient for the detail:
Chaste Tree Berries ConcentrateAntipsychotic Drugs Moderate
Interaction Summary
Theoretically, vitex agnus-castus could interfere with the activity of antipsychotic drugs.
Read the full Chaste Tree Berries Concentrate + Aripiprazole interactionAripiprazole LauroxilAristada, Aristada Initio Kit
How Aripiprazole Lauroxil interacts with Wild Yam & Chaste Tree — through 1 ingredient. Tap an ingredient for the detail:
Chaste Tree Berries ConcentrateAntipsychotic Drugs Moderate
Interaction Summary
Theoretically, vitex agnus-castus could interfere with the activity of antipsychotic drugs.
Read the full Chaste Tree Berries Concentrate + Aripiprazole Lauroxil interactionArmodafinilNuvigil
How Armodafinil interacts with Wild Yam & Chaste Tree — through 1 ingredient. Tap an ingredient for the detail:
Chaste Tree Berries ConcentrateDopamine Agonists Moderate
Interaction Summary
Theoretically, vitex agnus-castus could interfere with dopamine agonists.
Read the full Chaste Tree Berries Concentrate + Armodafinil interactionAsenapineSaphris, Secuado
How Asenapine interacts with Wild Yam & Chaste Tree — through 1 ingredient. Tap an ingredient for the detail:
Chaste Tree Berries ConcentrateAntipsychotic Drugs Moderate
Interaction Summary
Theoretically, vitex agnus-castus could interfere with the activity of antipsychotic drugs.
Read the full Chaste Tree Berries Concentrate + Asenapine interactionBazedoxifene Acetate, Conjugated EstrogensDuavee
How Bazedoxifene Acetate, Conjugated Estrogens interacts with Wild Yam & Chaste Tree — through 2 ingredients. Tap an ingredient for the detail:
Chaste Tree Berries ConcentrateEstrogens Moderate
Interaction Summary
Theoretically, vitex agnus-castus could interfere with the activity of estrogens.
Read the full Chaste Tree Berries Concentrate + Bazedoxifene Acetate, Conjugated Estrogens interactionWild Yam Root ExtractEstrogens Moderate
Interaction Summary
Theoretically, wild yam might increase or decrease the effects of estrogen.
Read the full Wild Yam Root Extract + Bazedoxifene Acetate, Conjugated Estrogens interactionBenserazide, LevodopaMadopar, Prolopa
How Benserazide, Levodopa interacts with Wild Yam & Chaste Tree — through 1 ingredient. Tap an ingredient for the detail:
Chaste Tree Berries ConcentrateDopamine Agonists Moderate
Interaction Summary
Theoretically, vitex agnus-castus could interfere with dopamine agonists.
Read the full Chaste Tree Berries Concentrate + Benserazide, Levodopa interactionBirth Control PillsBirth control pills
How Birth Control Pills interacts with Wild Yam & Chaste Tree — through 1 ingredient. Tap an ingredient for the detail:
Chaste Tree Berries ConcentrateContraceptive Drugs Moderate
Interaction Summary
Theoretically, vitex agnus-castus could interfere with oral contraceptives.
Read the full Chaste Tree Berries Concentrate + Birth Control Pills interactionBrexpiprazoleRexulti
How Brexpiprazole interacts with Wild Yam & Chaste Tree — through 1 ingredient. Tap an ingredient for the detail:
Chaste Tree Berries ConcentrateAntipsychotic Drugs, Dopamine Agonists Moderate
Interaction Summary
Theoretically, vitex agnus-castus could interfere with the activity of antipsychotic drugs.
Read the full Chaste Tree Berries Concentrate + Brexpiprazole interactionBromocriptineParlodel
How Bromocriptine interacts with Wild Yam & Chaste Tree — through 1 ingredient. Tap an ingredient for the detail:
Chaste Tree Berries ConcentrateDopamine Agonists Moderate
Interaction Summary
Theoretically, vitex agnus-castus could interfere with dopamine agonists.
Read the full Chaste Tree Berries Concentrate + Bromocriptine interactionButaperazineRepoise
How Butaperazine interacts with Wild Yam & Chaste Tree — through 1 ingredient. Tap an ingredient for the detail:
Chaste Tree Berries ConcentrateAntipsychotic Drugs Moderate
Interaction Summary
Theoretically, vitex agnus-castus could interfere with the activity of antipsychotic drugs.
Read the full Chaste Tree Berries Concentrate + Butaperazine interactionCarbidopa, LevodopaDhivy, Rytary, Sinemet, Sinemet CR
How Carbidopa, Levodopa interacts with Wild Yam & Chaste Tree — through 1 ingredient. Tap an ingredient for the detail:
Chaste Tree Berries ConcentrateDopamine Agonists Moderate
Interaction Summary
Theoretically, vitex agnus-castus could interfere with dopamine agonists.
Read the full Chaste Tree Berries Concentrate + Carbidopa, Levodopa interactionCarbidopa, Levodopa, EntacaponeStalevo
How Carbidopa, Levodopa, Entacapone interacts with Wild Yam & Chaste Tree — through 1 ingredient. Tap an ingredient for the detail:
Chaste Tree Berries ConcentrateDopamine Agonists Moderate
Interaction Summary
Theoretically, vitex agnus-castus could interfere with dopamine agonists.
Read the full Chaste Tree Berries Concentrate + Carbidopa, Levodopa, Entacapone interactionCariprazine HydrochlorideVraylar
How Cariprazine Hydrochloride interacts with Wild Yam & Chaste Tree — through 1 ingredient. Tap an ingredient for the detail:
Chaste Tree Berries ConcentrateAntipsychotic Drugs Moderate
Interaction Summary
Theoretically, vitex agnus-castus could interfere with the activity of antipsychotic drugs.
Read the full Chaste Tree Berries Concentrate + Cariprazine Hydrochloride interactionCarphenazineProketazin
How Carphenazine interacts with Wild Yam & Chaste Tree — through 1 ingredient. Tap an ingredient for the detail:
Chaste Tree Berries ConcentrateAntipsychotic Drugs Moderate
Interaction Summary
Theoretically, vitex agnus-castus could interfere with the activity of antipsychotic drugs.
Read the full Chaste Tree Berries Concentrate + Carphenazine interactionChlorpromazineThorazine, Thorazine Spansules
How Chlorpromazine interacts with Wild Yam & Chaste Tree — through 1 ingredient. Tap an ingredient for the detail:
Chaste Tree Berries ConcentrateAntipsychotic Drugs Moderate
Interaction Summary
Theoretically, vitex agnus-castus could interfere with the activity of antipsychotic drugs.
Read the full Chaste Tree Berries Concentrate + Chlorpromazine interactionChlorprothixeneTaractan
How Chlorprothixene interacts with Wild Yam & Chaste Tree — through 1 ingredient. Tap an ingredient for the detail:
Chaste Tree Berries ConcentrateAntipsychotic Drugs Moderate
Interaction Summary
Theoretically, vitex agnus-castus could interfere with the activity of antipsychotic drugs.
Read the full Chaste Tree Berries Concentrate + Chlorprothixene interactionClozapineClozaril, Versacloz
How Clozapine interacts with Wild Yam & Chaste Tree — through 1 ingredient. Tap an ingredient for the detail:
Chaste Tree Berries ConcentrateAntipsychotic Drugs Moderate
Interaction Summary
Theoretically, vitex agnus-castus could interfere with the activity of antipsychotic drugs.
Read the full Chaste Tree Berries Concentrate + Clozapine interactionConjugated EstrogensCenestin, Enjuvia, Premarin, Premarin Vaginal Cream
How Conjugated Estrogens interacts with Wild Yam & Chaste Tree — through 2 ingredients. Tap an ingredient for the detail:
Chaste Tree Berries ConcentrateEstrogens Moderate
Interaction Summary
Theoretically, vitex agnus-castus could interfere with the activity of estrogens.
Read the full Chaste Tree Berries Concentrate + Conjugated Estrogens interactionWild Yam Root ExtractEstrogens Moderate
Interaction Summary
Theoretically, wild yam might increase or decrease the effects of estrogen.
Read the full Wild Yam Root Extract + Conjugated Estrogens interactionConjugated Estrogens, Medroxyprogesterone AcetatePremplus, Prempro
How Conjugated Estrogens, Medroxyprogesterone Acetate interacts with Wild Yam & Chaste Tree — through 2 ingredients. Tap an ingredient for the detail:
Chaste Tree Berries ConcentrateEstrogens Moderate
Interaction Summary
Theoretically, vitex agnus-castus could interfere with the activity of estrogens.
Read the full Chaste Tree Berries Concentrate + Conjugated Estrogens, Medroxyprogesterone Acetate interactionWild Yam Root ExtractEstrogens Moderate
Interaction Summary
Theoretically, wild yam might increase or decrease the effects of estrogen.
Read the full Wild Yam Root Extract + Conjugated Estrogens, Medroxyprogesterone Acetate interactionConjugated Estrogens, MeprobamatePMB 200, PMB 400
How Conjugated Estrogens, Meprobamate interacts with Wild Yam & Chaste Tree — through 2 ingredients. Tap an ingredient for the detail:
Chaste Tree Berries ConcentrateEstrogens Moderate
Interaction Summary
Theoretically, vitex agnus-castus could interfere with the activity of estrogens.
Read the full Chaste Tree Berries Concentrate + Conjugated Estrogens, Meprobamate interactionWild Yam Root ExtractEstrogens Moderate
Interaction Summary
Theoretically, wild yam might increase or decrease the effects of estrogen.
Read the full Wild Yam Root Extract + Conjugated Estrogens, Meprobamate interactionConjugated Estrogens, MethyltestosteronePremarin with Methyltestosterone
How Conjugated Estrogens, Methyltestosterone interacts with Wild Yam & Chaste Tree — through 2 ingredients. Tap an ingredient for the detail:
Chaste Tree Berries ConcentrateEstrogens Moderate
Interaction Summary
Theoretically, vitex agnus-castus could interfere with the activity of estrogens.
Read the full Chaste Tree Berries Concentrate + Conjugated Estrogens, Methyltestosterone interactionWild Yam Root ExtractEstrogens Moderate
Interaction Summary
Theoretically, wild yam might increase or decrease the effects of estrogen.
Read the full Wild Yam Root Extract + Conjugated Estrogens, Methyltestosterone interactionCyamemazineTercian
How Cyamemazine interacts with Wild Yam & Chaste Tree — through 1 ingredient. Tap an ingredient for the detail:
Chaste Tree Berries ConcentrateAntipsychotic Drugs Moderate
Interaction Summary
Theoretically, vitex agnus-castus could interfere with the activity of antipsychotic drugs.
Read the full Chaste Tree Berries Concentrate + Cyamemazine interactionCyproterone Acetate, Ethinyl EstradiolDiane-35, Dianette
How Cyproterone Acetate, Ethinyl Estradiol interacts with Wild Yam & Chaste Tree — through 2 ingredients. Tap an ingredient for the detail:
Chaste Tree Berries ConcentrateEstrogens Moderate
Interaction Summary
Theoretically, vitex agnus-castus could interfere with the activity of estrogens.
Read the full Chaste Tree Berries Concentrate + Cyproterone Acetate, Ethinyl Estradiol interactionWild Yam Root ExtractEstrogens Moderate
Interaction Summary
Theoretically, wild yam might increase or decrease the effects of estrogen.
Read the full Wild Yam Root Extract + Cyproterone Acetate, Ethinyl Estradiol interactionDesogestrel, Ethinyl EstradiolDesogen, Marvelon, Marvelon 21, Marvelon 28, Mircette, Ortho-Cept +2 more
How Desogestrel, Ethinyl Estradiol interacts with Wild Yam & Chaste Tree — through 2 ingredients. Tap an ingredient for the detail:
Chaste Tree Berries ConcentrateContraceptive Drugs, Estrogens Moderate
Interaction Summary
Theoretically, vitex agnus-castus could interfere with oral contraceptives.
Read the full Chaste Tree Berries Concentrate + Desogestrel, Ethinyl Estradiol interactionWild Yam Root ExtractEstrogens Moderate
Interaction Summary
Theoretically, wild yam might increase or decrease the effects of estrogen.
Read the full Wild Yam Root Extract + Desogestrel, Ethinyl Estradiol interactionDopamineIntropin
How Dopamine interacts with Wild Yam & Chaste Tree — through 1 ingredient. Tap an ingredient for the detail:
Chaste Tree Berries ConcentrateDopamine Agonists Moderate
Interaction Summary
Theoretically, vitex agnus-castus could interfere with dopamine agonists.
Read the full Chaste Tree Berries Concentrate + Dopamine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Wild Yam & Chaste Tree with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Chaste Tree berries concentrate
Antipsychotic Drugs
Theoretically, vitex agnus-castus could interfere with the activity of antipsychotic drugs.
Vitex agnus-castus might interfere with the action of dopamine antagonists such as antipsychotic drugs due to its dopamine agonist effects.
Contraceptive Drugs
Theoretically, vitex agnus-castus could interfere with oral contraceptives.
Vitex agnus-castus might interfere with the efficacy of oral contraceptives due to possible hormone modulating activity.
Dopamine Agonists
Theoretically, vitex agnus-castus could interfere with dopamine agonists.
Vitex agnus-castus might potentiate the actions of dopaminergic agonists due to possible dopaminergic effects.
Estrogens
Theoretically, vitex agnus-castus could interfere with the activity of estrogens.
Vitex agnus-castus has hormone modulating activity that can interfere with the efficacy of hormone replacement therapy.
Metoclopramide (Reglan)
Theoretically, dopaminergic effects of vitex agnus-castus could interfere with metoclopramide.
Vitex agnus-castus might interfere with the action of dopamine antagonists such as metoclopramide due to its possible dopaminergic effects.
Wild Yam root extract
Estrogens
Theoretically, wild yam might increase or decrease the effects of estrogen.
Wild yam root shows estrogenic and anti-estrogenic effects in vitro. Theoretically, wild yam might interfere with hormone therapy.
Brand information
Manufacturer and brand details for Wild Yam & Chaste Tree, from the product label.
Nature's Sunshine
See all Nature's Sunshine products- Name
- Nature's Sunshine Products, Inc.
- City
- Spanish Fork
- State
- UT
- ZipCode
- 84660
- Phone Number
- (800) 223-8225
- Web Address
- www.naturessunshine.com
Wild Yam & Chaste Tree by Nature's Sunshine: Common Questions
Does Wild Yam & Chaste Tree by Nature's Sunshine interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is Wild Yam & Chaste Tree safe if I'm trying to get pregnant?
Will this help my hot flashes?
What's the most common side effect I might notice?
Can I take this with my birth control?
What exactly is chaste tree, and why is it in this product?
Is this safe to take long-term?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Wild Yam & Chaste Tree is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Wild Yam & Chaste Tree’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Wild Yam
Interacts with 41 drugsWild yam is a root traditionally used for menopausal symptoms, cramps, and as a so-called 'natural' hormone supplement, but solid human evidence for these uses is lacking. Despite popular cl...
Read the full Wild Yam monograph → Herb & supplement monographVitex Agnus-castus
Interacts with 121 drugsVitex (chasteberry) is an herbal remedy most often used for PMS and menstrual cycle problems, and the strongest evidence is for easing some PMS symptoms. It is generally well tolerated by ma...
Read the full Vitex Agnus-castus monograph →Sources & How We Checked
Wild Yam & Chaste Tree's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 30 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Wild Yam 7 references
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Eagon PK, Elm MS, Hunter DS, et al. Medicinal herbs: modulation of estrogen action. Era of Hope Mtg, Dept Defense; Breast Cancer Res Prog, Atlanta, GA 2000;Jun 8-11.
- Cheong JL, Bucknall R. Retinal vein thrombosis associated with a herbal phytoestrogen preparation in a susceptible patient. Postgrad Med J 2005;81:266-7.. PubMed
- Rosenberg Zand, R. S., Jenkins, D. J., and Diamandis, E. P. Effects of natural products and nutraceuticals on steroid hormone-regulated gene expression. Clin Chim.Acta 2001;312(1-2):213-219. PubMed
- Araghiniknam M, Chung S, Nelson-White T, and et al. Antioxidant activity of Dioscorea and dehydroepiandrosterone (DHEA) in older humans. Life Sciences 1996;59:L147-L157.
- Zeng M, Zhang L, Li M, et al. Estrogenic effects of the extracts from the Chinese Yam (Dioscorea opposite Thunb.) and its effective compounds in vitro and in vivo. Molecules. 2018 Jan 23;23(2). Pii: E11. PubMed
- Lu J, Wong RN, Zhang L, et al. Comparative analysis of proteins with stimulating activity on ovarian estradiol biosynthesis from four different Dioscorea species in vitro using both phenotypic and target-based approaches: implication for treating menopaus
Vitex Agnus-castus 23 references
- Wuttke W. Dopaminergic action of extracts of Agnus Castus. Forschende Komplementarmedizen 1996;3:329-30.
- Jarry H, Leonhardt S., Gorkow C, Wuttke W. In vitro prolactin but not LH and FSH release is inhibited by compounds in extracts of Agnus Castus: direct evidence for a dopaminergic principle by the dopamine receptor assay. Exp Clin Endocrinol 1994;102:448- PubMed
- Schellenberg R. Treatment for the premenstrual syndrome with agnus castus fruit extract: prospective, randomised, placebo-controlled study. BMJ 2001;322:134-7. PubMed
- Lauritzen CH, Reuter HD, Repges R, et al. Treatment of premenstrual tension syndrome with Vitex agnus castus: Controlled-double blind versus pyridoxine. Phytomedicine 1997;4:183-9.
- Berger D, Schaffner W, Schrader E, et al. Efficacy of Vitex agnus castus L. extract Ze 440 in patients with premenstrual syndrome (PMS). Arch Gynecol Obstet 2000;264:150-3.
- Loch EG, Selle H, Boblitz N. Treatment of premenstrual syndrome with a phytopharmaceutical formulation containing Vitex agnus castus. J Womens Health Gend Based Med 2000;9:315-20. PubMed
- Meier B, Berger D, Hoberg E, et al. Pharmacological activities of Vitex agnus-castus extracts in vitro. Phytomedicine 2000;7:373-81. PubMed
- Liu J, Burdette JE, Xu H, et al. Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms. J Agric Food Chem 2001;49:2472-9.. PubMed
- Wuttke W, Jarry H, Christoffel V, et al. Chaste tree (Vitex agnus-castus)--pharmacology and clinical indications. Phytomedicine 2003;10:348-57. PubMed
- Atmaca M, Kumru S, Tezcan E. Fluoxetine versus Vitex agnus castus extract in the treatment of premenstrual dysphoric disorder. Hum Psychopharmacol 2003;18:191-5..
- Daniele C, Thompson Coon J, Pittler MH, Ernst E. Vitex agnus castus: a systematic review of adverse events. Drug Saf 2005;28:319-32..
- Halaska M, Beles P, Gorkow C, Sieder C. Treatment of cyclical mastalgia with a solution containing a Vitex agnus castus extract: results of a placebo-controlled double-blind study. Breast 1999;8:175-81. PubMed
- Prilepskaya VN, Ledina AV, Tagiyeva AV, Revazova FS. Vitex agnus castus: Successful treatment of moderate to severe premenstrual syndrome. Maturitas 2006;55 Suppl 1:S55-63. DOI
- Ma, L., Lin, S., Chen, R., and Wang, X. Treatment of moderate to severe premenstrual syndrome with Vitex agnus castus (BNO 1095) in Chinese women. Gynecol.Endocrinol. 2010;26(8):612-616. PubMed
- Ma, L., Lin, S., Chen, R., Zhang, Y., Chen, F., and Wang, X. Evaluating therapeutic effect in symptoms of moderate-to-severe premenstrual syndrome with Vitex agnus castus (BNO 1095) in Chinese women. Aust.N.Z.J Obstet.Gynaecol. 2010;50(2):189-193. PubMed
- Dinç T, Coskun F. Comparison of fructus agni casti and flurbiprofen in the treatment of cyclic mastalgia in premenopausal women. Ulus Cerrahi Derg. 2014 Mar 1;30(1):34-8 PubMed
- Momoeda M, Sasaki H, Tagashira E, Ogishima M, Takano Y, Ochiai K. Efficacy and safety of Vitex agnus-castus extract for treatment of premenstrual syndrome in Japanese patients: a prospective, open-label study. Adv Ther. 2014 Mar;31(3):362-73. PubMed
- Yavarikia P, Shahnazi M, Hadavand Mirzaie S, Javadzadeh Y, Lutfi R. Comparing the effect of mefenamic Acid and vitex agnus on intrauterine device induced bleeding. J Caring Sci. 2013 Aug 31;2(3):245-54.
- Van Die MD, Burger HC, Teede HG, Bone KM. Vitex agnus castus extracts for female reproductive disorders: a systematic review of clinical trials. Planta Med 2013:79:562-575. PubMed
- Ooi SL, Watts S, McClean R, Pak SC. Vitex agnus-castus for the treatment of cyclic mastalgia: A systematic review and meta-analysis. J Womens Health (Larchmt). 2020;29(2):262-278. PubMed
- Mollazadeh S, Mirghafourvand M, Abdollahi NG. The effects of Vitex agnus-castus on menstrual bleeding: A systematic review and meta-analysis. J Complement Integr Med. 2019;17(1). pii: /j/jcim.2019.17.issue-1/jcim-2018-0053/jcim-2018-0053.xml.
- Najib FS, Poordast T, Mahmudi MS, Shiravani Z, Namazi N, Omrani GR. Does Vitex Agnus-Castus L. Have Deleterious Effect on Fertility and Pregnancy Outcome? An Experimental Study on Rats for Prediction of Its Safety. J Pharmacopuncture 2022;25(2):106-113. PubMed
- Somuncu E, Solak IHA. Colonic Obstruction Secondary to Phytobezoar Caused by Vitex Agnus-Castus Seeds: A Case Report. J Coll Physicians Surg Pak 2022;32(8):S115-S117. PubMed
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