Interactions on record — worth a quick check against your medications. Based on 2 of 4 ingredients. Check your meds →
Dietary supplement

Wild Yam Root Ingredients & Drug Interactions

by Mountain Meadow Herbs

Wild Yam Root label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Wild Yam Root against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Wild Yam Root is a dietary supplement by Mountain Meadow Herbs with 4 active ingredients. Its ingredients are commonly taken for constipation (laxative), dry skin (moisturizer), dry, irritated eyes.Based on those ingredients, 41 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Wild Yam root extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Wild Yam Root by Mountain Meadow Herbs

Ask about any prescription or over-the-counter medication and we check it for interactions with Wild Yam Root by Mountain Meadow Herbs — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Wild Yam Root by Mountain Meadow Herbs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 4 active ingredients.

This liquid contains four ingredients. The active ones are glycerin (a naturally derived humectant and laxative agent), wild yam root extract (the main botanical), grain alcohol (a solvent and preservative), and distilled water.

There are no inactive fillers listed.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Strong

Strong clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Constipation — rated "Likely Effective" (Glycerol) (Natural Medicines).
  • On file: Athletic performance — rated "Possibly Effective" (Glycerol) (Natural Medicines).
  • On file: Ichthyosis — rated "Possibly Effective" (Glycerol) (Natural Medicines).

The evidence for wild yam root's effectiveness is sparse. For menopausal symptoms, the data suggests it's likely ineffective.

For other conditions like sexual dysfunction, dysmenorrhea, infertility, and gallbladder disease, we don't have enough reliable evidence to know either way. Glycerin, the other active ingredient here, is rated likely effective for constipation, but that's not what this product is marketed for.

The evidence, ingredient by ingredient Glycerol Wild Yam

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Orally, wild yam is generally well tolerated, though headache, fever, upset stomach, and vomiting can happen — especially at higher doses. A rare case of anaphylaxis has been reported.

Glycerin can cause bloating, nausea, vomiting, diarrhea, dizziness, and headache at larger doses, and may cause dehydration. Both ingredients have limited long-term safety data, so don't use medicinal doses without talking to your doctor first.

During pregnancy, there isn't enough data on wild yam to know whether it's safe — avoid it and stick with your doctor's advice. The same goes for breastfeeding.

Glycerin's pregnancy and lactation safety information isn't on file here.

Side effects, ingredient by ingredient Glycerol Wild Yam

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Wild Yam.
  • The most serious interaction on file is rated Moderate.
  • For scale: 41 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you're on any estrogen-based medication — hormone replacement therapy, birth control pills, or other hormonal drugs — double-check with your pharmacist before adding this product. Wild yam could theoretically strengthen or weaken how your estrogen works.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Wild yam root is heavily marketed for menopausal symptoms, but the data shows it's likely not effective for that. If you take estrogen-based medications or hormonal birth control, this product could interfere with how they work — check with us before you start.

For other uses, the evidence just isn't there yet.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 11, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Wild Yam Root, straight from the product label.

Brand Mountain Meadow Herbs
Barcode (UPC) 813086014010
Net contents 2 Fluid Ounce(s); 60 mL
Market status On market
Date entered into DSLD Apr 11, 2022
DSLD ID 267597
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Children 4 or More Years of Age, Vegan, Vegetarian, Adult Female (18 - 50 Years), Menopause, Seniors/Mature (>50 Years) - Women ONLY
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Wild Yam Root by Mountain Meadow Herbs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.25 Teaspoon(s)
Maximum serving Sizes:
0.25 Teaspoon(s)
Servings per container
48
UPC/BARCODE
813086014010
IngredientAmount% DV
Glycerin0 NP--
Grain Alcohol0 NP--
Wild Yam root extract1.25 mL--
Water, Distilled0 NP--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formula

Dioscorea villosa

Enhance your overall female health and wellness

Formulation

Hand-made extract

GF (Gluten free) Sugar free

Vegan

Enhance your overall female health and wellness Plant-based estrogen source Menopause symptom support Comfortable mentruation support

FDA Statement of Identity

Herbal Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: 12+ yrs: 1/4 tsp. Take in water 1-3 times daily.

Shake well.

Precautions

Caution: If you are pregnant, nursing, have a medical condition, or are taking a prescription, consult your health care provider before using this product.

Keep out of reach of children.

Storage

Store in a cool, dry place out of sunlight.

Seals/Symbols

Made in Montana USA

General Statements

1 dropperful = approx. 1/8 tsp.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Wild Yam Root by Mountain Meadow Herbs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Wild Yam Root label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Wild Yam Root by Mountain Meadow Herbs

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size0.25 Teaspoon(s) Dosage formLiquid Servings per container48 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Glycerin

No known
interactions
0 NP per serving

Glycerol (glycerin) is a sweet, syrupy compound made naturally in the body and widely used in foods, skin products, and medicines. It is well establis...

Glycerin monograph & interactions

Grain Alcohol

0 NP per serving

Wild Yam root extract

Interacts with
41 drugs
1.25 mL per serving

Wild yam is a root traditionally used for menopausal symptoms, cramps, and as a so-called 'natural' hormone supplement, but solid human evidence for t...

Wild Yam root extract monograph & interactions

Water, Distilled

0 NP per serving
Interaction report

Wild Yam Root by Mountain Meadow Herbs Drug Interactions

Want to check YOUR meds against Wild Yam Root?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
41Drugs
41 Moderate

Ingredients driving the most interactions

Wild Yam root extract 41

Individual Drug Interactions

The ingredients in Wild Yam Root interact with 41 drugs. Click any drug to see the details.

1 of the 4 ingredients in Wild Yam Root interact with drugs. Each result below shows which ingredient is responsible. Wild Yam root extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Wild Yam Root with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Wild Yam root extract1 drug type · 41 drugs

Estrogens

Theoretically, wild yam might increase or decrease the effects of estrogen.
Wild yam root shows estrogenic and anti-estrogenic effects in vitro. Theoretically, wild yam might interfere with hormone therapy.

Likelihood Possible Evidence D
Wild Yam root extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Wild Yam Root, from the product label.

Mountain Meadow Herbs

See all Mountain Meadow Herbs products
Name
Mountain Meadow Herbs, Inc.
Street Address
1019 Hard Rock Rd
City
Somers
State
MT
ZipCode
59932
Phone Number
888.528.8615
Web Address
www.mmherbs.com
Pharmacist Counseling Corner

Wild Yam Root by Mountain Meadow Herbs: Common Questions

Does Wild Yam Root by Mountain Meadow Herbs interact with any medications?
Yes. Based on its ingredients, Wild Yam Root has a known interaction with 41 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Wild Yam Root contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help with hot flashes and night sweats?
The evidence suggests wild yam is likely not effective for menopausal symptoms. There are other options worth discussing with your doctor.
Is it safe to take this long-term?
Wild yam has a good short-term safety profile in healthy adults, but long-term safety hasn't been well studied. Talk to your doctor before using it regularly.
Can I take this while I'm pregnant or breastfeeding?
No — there isn't enough safety data on wild yam for pregnancy or breastfeeding. Avoid it during both and discuss alternatives with your doctor.
What side effects might I notice?
Most commonly, headache, fever, upset stomach, and vomiting — especially at higher doses. Glycerin in the formula can also cause bloating, nausea, and diarrhea.
What's the grain alcohol in here for?
It's used as a solvent to extract the active compounds and as a preservative to keep the liquid fresh.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Wild Yam Root is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Wild Yam Root label
Go deeper

The Full Monographs Behind Wild Yam Root’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Glycerol

Glycerol (glycerin) is a sweet, syrupy compound made naturally in the body and widely used in foods, skin products, and medicines. It is well established as a laxative and a skin and eye moi...

Read the full Glycerol monograph → Herb & supplement monograph

Wild Yam

Interacts with 41 drugs

Wild yam is a root traditionally used for menopausal symptoms, cramps, and as a so-called 'natural' hormone supplement, but solid human evidence for these uses is lacking. Despite popular cl...

Read the full Wild Yam monograph →
Sources

Sources & How We Checked

Wild Yam Root's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glycerol 8 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Wagner DR. Hyperhydrating with glycerol: implications for athletic performance. J Am Diet Assoc 1999;99:207-12. PubMed
  3. Yu YL, Kumana CR, Lauder IJ, et al. Treatment of acute cortical infarct with intravenous glycerol. A double-blind, placebo-controlled randomized trial. Stroke 1993;24:1119-24. PubMed
  4. Frei A, Cottier C, Wunderlich P, Ludin E. Glycerol and dextran combined in the therapy of acute stroke. A placebo-controlled, double-blind trial with a planned interim analysis. Stroke 1987;18:373-9. PubMed
  5. Balaskas E, Szepietowski JC, Bessis D, Ioannides D, Ponticelli C, Ghienne C, Taberly A, Dupuy P. Randomized, double-blind study with glycerol and paraffin in uremic xerosis. Clin J Am Soc Nephrol. 2011 Apr;6(4):748-52. PubMed
  6. Blanchet-Bardon C, Tadini G, Machado Matos M, Delarue A. Association of glycerol and paraffin in the treatment of ichthyosis in children: an international, multicentric, randomized, controlled, double-blind study. J Eur Acad Dermatol Venereol. 2012 Aug;26 PubMed
  7. Kajita N, Kanamori K, Yamamoto S, Yoshida K. Generalized Urticaria Caused by a Glycerin Enema in an Infant. J Investig Allergol Clin Immunol 2022;32(4):318-319. PubMed
  8. Suzuki R, Fukuyama K, Miyazaki Y, Namiki T. Contact urticaria syndrome and protein contact dermatitis caused by glycerin enema. JAAD Case Reports. 2016;2:108-10. PubMed

See these in context on the Glycerol monograph →

Wild Yam 7 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Eagon PK, Elm MS, Hunter DS, et al. Medicinal herbs: modulation of estrogen action. Era of Hope Mtg, Dept Defense; Breast Cancer Res Prog, Atlanta, GA 2000;Jun 8-11.
  3. Cheong JL, Bucknall R. Retinal vein thrombosis associated with a herbal phytoestrogen preparation in a susceptible patient. Postgrad Med J 2005;81:266-7.. PubMed
  4. Rosenberg Zand, R. S., Jenkins, D. J., and Diamandis, E. P. Effects of natural products and nutraceuticals on steroid hormone-regulated gene expression. Clin Chim.Acta 2001;312(1-2):213-219. PubMed
  5. Araghiniknam M, Chung S, Nelson-White T, and et al. Antioxidant activity of Dioscorea and dehydroepiandrosterone (DHEA) in older humans. Life Sciences 1996;59:L147-L157.
  6. Zeng M, Zhang L, Li M, et al. Estrogenic effects of the extracts from the Chinese Yam (Dioscorea opposite Thunb.) and its effective compounds in vitro and in vivo. Molecules. 2018 Jan 23;23(2). Pii: E11. PubMed
  7. Lu J, Wong RN, Zhang L, et al. Comparative analysis of proteins with stimulating activity on ovarian estradiol biosynthesis from four different Dioscorea species in vitro using both phenotypic and target-based approaches: implication for treating menopaus

See these in context on the Wild Yam monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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