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Dietary supplement

Yellow Sweetclover Ingredients & Drug Interactions

by Herbalist & Alchemist

Yellow Sweetclover label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Yellow Sweetclover against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Yellow Sweetclover is a dietary supplement by Herbalist & Alchemist with 1 active ingredient. Its ingredients are commonly taken for varicose veins and poor circulation, leg swelling (edema), hemorrhoids.Based on those ingredients, 480 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are fresh Yellow Sweetclover flowering tops extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Yellow Sweetclover by Herbalist & Alchemist

Ask about any prescription or over-the-counter medication and we check it for interactions with Yellow Sweetclover by Herbalist & Alchemist — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Yellow Sweetclover by Herbalist & Alchemist

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 24, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: fresh yellow sweetclover flowering tops extract in liquid form. Sweetclover has been used traditionally for circulation and swelling, though the evidence for its effectiveness is limited.

The liquid is made with distilled water and ethyl alcohol as inactive ingredients.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Sweet Clover's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Supports capillary tonicity and muscle relaxation.
  • We looked for evidence on: Chronic venous insufficiency (CVI), Hemorrhoids, Bruises, Postoperative swelling, Varicose veins, Poor circulation — and 1 related terms.
  • The closest evidence on file: Sweet Clover is rated "Insufficient Reliable Evidence To Rate" for Chronic venous insufficiency (CVI) (Natural Medicines).
  • Also on file: Sweet Clover is rated "Insufficient Reliable Evidence To Rate" for Hemorrhoids, Bruises, Postoperative swelling.

The evidence for yellow sweetclover isn't established. Our data shows insufficient reliable evidence to rate it for chronic venous insufficiency (poor circulation in the legs), diabetic nerve pain, hemorrhoids, or post-operative pain — the conditions it's most commonly used for.

That doesn't mean it doesn't work; it means the clinical trials backing it up aren't solid enough yet for us to make a confident claim.

The evidence, ingredient by ingredient Sweet Clover

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Sweetclover is generally used in small amounts, but its coumarin content — which gives it anticoagulant and liver-affecting properties — means you should use it cautiously. Large doses can cause transient liver injury in susceptible people and in rare cases headache.

One case report linked a multi-herb tea containing sweetclover to bleeding problems after two months of use, though it's unclear if sweetclover alone was responsible. The safety data advises against use during pregnancy and breastfeeding because there isn't enough information to know it's safe.

Side effects, ingredient by ingredient Sweet Clover

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Sweet Clover.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 481 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist if you take blood thinners (like warfarin or clopidogrel) or antiplatelet drugs (like aspirin) — sweetclover may increase bleeding risk. Also flag any medications that can harm the liver, since sweetclover's coumarin content can theoretically add to that risk.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

If you take blood thinners, medications that affect your liver, or you're pregnant or breastfeeding, this product isn't for you. Anyone else considering it should check their exact medications with your doctor or pharmacist before starting — and if you're taking it for a specific condition, know that the evidence supporting it is still limited.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 31, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Yellow Sweetclover, straight from the product label.

Brand Herbalist & Alchemist
Barcode (UPC) 667056127077
Net contents 2 fl. Oz.; 60 mL
Market status On market
Date entered into DSLD Aug 31, 2018
DSLD ID 179901
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Yellow Sweetclover by Herbalist & Alchemist, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1.5 mL
Maximum serving Sizes:
2 mL
Servings per container
30
UPC/BARCODE
667056127077
IngredientAmount% DV
fresh Yellow Sweetclover flowering tops extract2 mL--

Other ingredients: distilled Water, Ethyl Alcohol

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Melilotus officinalis

OK

General Statements

Supports Capillary Tonicity and Promotes Muscle Relaxation

Botanical Preparation Ratio 1:2.5

FDA Statement of Identity

Herbal Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: 30-40 drops (1.5-2 mL) in juice or water. Take 3 times per day. Shake well before using.

Precautions

Contraindications: Do not use during pregnancy.

Keep out of children's reach

FDA Disclaimer Statement

This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

General

NO. SML-2 1802TU

Seals/Symbols

OK

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Yellow Sweetclover by Herbalist & Alchemist label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Yellow Sweetclover label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Yellow Sweetclover by Herbalist & Alchemist

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1.5 mL Dosage formLiquid Servings per container30 Amounts shown are per serving.

Fresh Yellow Sweetclover flowering tops extract

Interacts with
480 drugs
2 mL per serving

Sweet clover is a traditional European herb most often promoted for vein problems and leg swelling, but high-quality human evidence is limited. It con...

Fresh Yellow Sweetclover flowering tops extract monograph & interactions

Other (inactive) ingredients: Distilled Water, Ethyl Alcohol. These complete the product’s ingredient list but are not active constituents.

Interaction report

Yellow Sweetclover by Herbalist & Alchemist Drug Interactions

Want to check YOUR meds against Yellow Sweetclover?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
480Drugs
480 Moderate

Ingredients driving the most interactions

fresh Yellow Sweetclover flowering tops extract 480

Individual Drug Interactions

The ingredients in Yellow Sweetclover interact with 480 drugs. Click any drug to see the details.

1 of the 1 ingredient in Yellow Sweetclover interact with drugs. Each result below shows which ingredient is responsible. fresh Yellow Sweetclover flowering tops extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Yellow Sweetclover with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

fresh Yellow Sweetclover flowering tops extract2 drug types · 480 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, fresh sweet clover might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Fresh sweet clover contains coumarinic acids, which are converted to free coumarins during drying. Dicoumarol, which has anticoagulant activity, also has been found in some sweet clover preparations and can be formed if fresh sweet clover is allowed to spoil.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, concomitant use of sweet clover with hepatoxic drugs might increase the risk of hepatotoxicity.
Orally, large amounts of sweet clover can cause transient liver injury in susceptible individuals, possibly due to coumarin content. In one case report, a patient with multiple sclerosis developed jaundiced palms and a slight elevation in serum alanine aminotransferase (ALT) after taking sweet clover containing coumarin 10 mg daily for 3 years. Two weeks after starting therapy with subcutaneous interferon (IFN)-beta 1b, aspartate transaminase (AST) and ALT levels increased to 7 and 17 times the upper limit of normal, respectively. Levels normalized after discontinuation of both products. Subsequent use of IFN-beta 1a alone, without sweet clover, resulted in only a very slight increase in AST.

Likelihood Possible Evidence D
fresh Yellow Sweetclover flowering tops extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Yellow Sweetclover, from the product label.

Herbalist & Alchemist

See all Herbalist & Alchemist products
Name
Herbalist & Alchemist, Inc.
City
Washington
State
NJ
ZipCode
07882
Phone Number
800-611-8235
Web Address
www.herbalist-alchemist.com
Pharmacist Counseling Corner

Yellow Sweetclover by Herbalist & Alchemist: Common Questions

Does Yellow Sweetclover by Herbalist & Alchemist interact with any medications?
Yes. Based on its ingredients, Yellow Sweetclover has a known interaction with 480 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Yellow Sweetclover contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
No. The safety data advises against use during pregnancy and breastfeeding because there isn't enough information to know it's safe. Talk with your doctor or pharmacist about other options if you're pregnant, trying to conceive, or breastfeeding.
What is the coumarin in sweetclover, and why does it matter?
Coumarin is a natural compound in sweetclover that acts like a blood thinner. It's why the product can increase bleeding risk with blood thinners and potentially add stress to your liver — especially at large doses.
What side effects should I watch for?
Headache is rare but has been reported. At large doses, sweetclover can cause liver injury or even stupor. If you notice yellowing of the skin or palms, unusual bruising or bleeding, or severe headache, stop taking it and contact your doctor.
Does this actually work for circulation or swelling?
We don't have enough reliable evidence yet to say whether it works for chronic venous insufficiency, hemorrhoids, diabetic nerve pain, or post-operative pain. Traditional use doesn't guarantee effectiveness.
Why is the interaction count so high?
The 481 interactions reflect the combined effect of sweetclover's coumarin compounds on blood thinners and liver-affecting medications — two very broad drug categories with many individual members. Your actual risk depends on your specific medications, which is why checking with your pharmacist matters.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Yellow Sweetclover label
Go deeper

The Full Monographs Behind Yellow Sweetclover’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sweet Clover

Interacts with 480 drugs

Sweet clover is a traditional European herb most often promoted for vein problems and leg swelling, but high-quality human evidence is limited. It contains coumarin, which can become dangero...

Read the full Sweet Clover monograph →
Sources

Sources & How We Checked

Yellow Sweetclover's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sweet Clover 6 references
  1. Monographs on the medicinal uses of plant drugs. Exeter, UK: European Scientific Co-op Phytother, 1997.
  2. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  3. Wichtl MW. Herbal Drugs and Phytopharmaceuticals. Ed. N.M. Bisset. Stuttgart: Medpharm GmbH Scientific Publishers, 1994.
  4. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  5. Hogan RP III. Hemorrhagic diathesis caused by drinking an herbal tea. JAMA 1983;249:2679-80. DOI
  6. Tamura S, Warabi Y, Matsubara S. Severe liver dysfunction possibly caused by the combination of interferon beta-1b therapy and melilot (sweet clover) supplement. J Clin Pharm Ther 2012;37(6):724-5. PubMed

See these in context on the Sweet Clover monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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