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Dietary supplement

Youth Guard Pregnenolone 50 mg Ingredients & Drug Interactions

by Vitamin World

Youth Guard Pregnenolone 50 mg label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Youth Guard Pregnenolone 50 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Youth Guard Pregnenolone 50 mg is a dietary supplement by Vitamin World with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, anxiety and stress, anti-aging.Based on those ingredients, 82 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pregnenolone. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Youth Guard Pregnenolone 50 mg by Vitamin World

Ask about any prescription or over-the-counter medication and we check it for interactions with Youth Guard Pregnenolone 50 mg by Vitamin World — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Youth Guard Pregnenolone 50 mg by Vitamin World

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Oct 1, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Youth Guard Pregnenolone 50 mg is a single-ingredient supplement: pregnenolone, a steroid hormone precursor your body naturally produces. The capsule also contains inactive ingredients (rice flour, gelatin, vegetable magnesium stearate, and silica) as fillers and binders.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Pregnenolone's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: support pregnenolone levels naturally declining with age.
  • We looked for evidence on: Aging, Memory, Fatigue, Stress, cognitive function, energy — and 2 related terms.
  • The closest evidence on file: Pregnenolone is rated "Insufficient Reliable Evidence To Rate" for Fatigue (Natural Medicines).
  • Also on file: Pregnenolone is rated "Insufficient Reliable Evidence To Rate" for Memory, Stress, Aging.

The evidence for pregnenolone is not established for any of the conditions listed in our data — which include alcohol use disorder, Alzheimer disease, autism spectrum disorder, back pain, and bipolar disorder. Each of these is rated as having insufficient reliable evidence to rate its effectiveness.

If you're considering this supplement for a specific health concern, talk it over with your doctor to see what the research actually supports.

The evidence, ingredient by ingredient Pregnenolone

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pregnenolone is generally well tolerated orally, but it is a hormone with limited human safety data, so use only under guidance from your healthcare professional. The most common side effects reported are acne, agitation, diarrhea, drowsiness, excitement, hair loss, skin abscess, sweating, and tremor.

Less often, it has caused skin rashes (possibly related to sun sensitivity), depressive mood, and changes in appetite; however, it's not always certain these were directly caused by pregnenolone. The safety data advises against pregnenolone during pregnancy due to unknown risks.

There isn't enough information to know whether it's safe while breastfeeding, so avoid it at that time as well.

Side effects, ingredient by ingredient Pregnenolone

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Pregnenolone.
  • The most serious interaction on file is rated Moderate.
  • For scale: 82 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this supplement, double-check with your doctor or pharmacist if you take estrogens, progestins, testosterone, progesterone medications, or benzodiazepines (sedatives or anti-anxiety drugs). Pregnenolone may intensify the effects of hormones or reduce how well benzodiazepines work.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Pregnenolone is a hormone supplement with Moderate interactions with estrogens, progestins, testosterone, progesterone, and benzodiazepines — it may strengthen some hormone drugs and weaken sedatives. The evidence for its effectiveness for common health conditions isn't established in our data.

Because it's a hormone with limited safety research, this is one to discuss with your doctor or pharmacist before you start, especially if you take any hormonal or anxiety medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 26, 2011.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Youth Guard Pregnenolone 50 mg, straight from the product label.

Brand Vitamin World
Barcode (UPC) 766443551461
Net contents 90 Rapid Release Capsule(s)
Market status On market
Date entered into DSLD Oct 26, 2011
DSLD ID 1324
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Youth Guard Pregnenolone 50 mg by Vitamin World, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
UPC/BARCODE
766443551461
IngredientAmount% DV
Pregnenolone50 mg--

Other ingredients: Rice Flour, Gelatin, Vegetable Magnesium Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

©2009 Vitamin World, Inc.

FDA Disclaimer Statement

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Formula

Pregnenolone Levels Can Naturally Decline With Age

Formulation

No Artificial Color, Flavor or Sweetener, No Preservatives, No Sugar, No Starch, No Milk, No Lactose, No Soy, No Gluten, No Wheat, No Yeast, No Fish. Sodium Free.

Precautions

KEEP OUT OF REACH OF CHILDREN.

WARNING: NOT FOR USE BY INDIVIDUALS UNDER THE AGE OF 18 YEARS. DO NOT USE IF YOU ARE PREGNANT, NURSING OR ARE A WOMAN OF CHILDBEARING AGE. Consult a physician or licensed qualified health care professional before using this product if you have, or have a family history of, prostate cancer, prostate enlargement, heart disease, low "good" cholesterol (HDL), breast, uterine or ovarian cancer, high blood pressure, seizures or if you are using any other dietary supplement, prescription drug, including MAO inhibitors or anti-seizure medication, or over-the-counter drug. Do not exceed recommended serving. Exceeding recommended serving may cause serious adverse health effects. Possible side effects include acne, hair loss, hair growth on the face (in women), aggressiveness, irritability, and increased levels of estrogen. Discontinue use and call a physician or licensed qualified health care professional immediately if you experience rapid heartbeat, dizziness, blurred vision, allergic reaction, rash, gastrointestinal discomfort, diarrhea, headache, heart palpitations, nervousness, anxiety, depression, insomnia, high blood pressure, muscle weakness, changes in appetite, breast pain, menstrual changes or other similar symptoms.

Storage

STORE IN A DRY PLACE AND AVOID EXCESSIVE HEAT. TAMPER RESISTANT: DO NOT USE IF SEAL UNDER CAP IS BROKEN OR MISSING.

General

PROD. #55146 B28174 01B

General Statements

From the moment raw ingredients reach our facilities to the time a finished supplement is packaged, stringent analysis confirms the potency, purity, and nutritional content of every nutritional product that bears the Vitamin World name. We guarantee it!

Healthy Aging Formula*

Get healthy.

To report any adverse reactions call 1-800-332-1088.

Seals/Symbols

QUALITY ASSURED

Suggested/Recommended/Usage/Directions

DIRECTIONS: For adults, take one (1) capsule in the morning before a meal.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Youth Guard Pregnenolone 50 mg by Vitamin World label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Youth Guard Pregnenolone 50 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Youth Guard Pregnenolone 50 mg by Vitamin World

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Pregnenolone

Interacts with
82 drugs
50 mg per serving

Pregnenolone is a hormone your body makes naturally and a building block for other hormones like cortisol, DHEA, estrogen, and testosterone. It is sol...

Pregnenolone monograph & interactions

Other (inactive) ingredients: Rice Flour, Gelatin, Vegetable Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Youth Guard Pregnenolone 50 mg by Vitamin World Drug Interactions

Want to check YOUR meds against Youth Guard Pregnenolone 50 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
82Drugs
82 Moderate

Ingredients driving the most interactions

Pregnenolone 82

Individual Drug Interactions

The ingredients in Youth Guard Pregnenolone 50 mg interact with 82 drugs. Click any drug to see the details.

1 of the 1 ingredient in Youth Guard Pregnenolone 50 mg interact with drugs. Each result below shows which ingredient is responsible. Pregnenolone

Each ingredient & the kinds of drugs it affects

For each ingredient in Youth Guard Pregnenolone 50 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Pregnenolone5 drug types · 82 drugs

Benzodiazepines

Concomitant use of pregnenolone may reduce the effects of benzodiazepines.
Very preliminary clinical research shows that chronic use of pregnenolone reduces sedative effects of diazepam when compared with chronic use of placebo. This effect may be related to the activity of pregnenolone at GABAA receptors.

Likelihood Probable Evidence B
Estrogens

Theoretically, taking pregnenolone might enhance the effects of estrogens.
Pregnenolone is a precursor for several steroid hormones, including estrogens.

Likelihood Possible Evidence D
Progesterone

Theoretically, taking pregnenolone might enhance the effects of progesterone.
In humans, some research shows that oral administration of pregnenolone can increase levels of progesterone. However, other research shows no effect on progesterone levels. It is possible the impact of pregnenolone on progesterone levels may be dose dependent.

Likelihood Possible Evidence D
Progestin

Theoretically, taking pregnenolone might enhance the effects of progestin.
Pregnenolone is a precursor for several steroid hormones, including progestin.

Likelihood Possible Evidence D
Testosterone

Theoretically, taking pregnenolone might enhance the effects of testosterone.
Pregnenolone is a precursor for several steroid hormones, including testosterone. However, preliminary clinical research shows that taking pregnenolone 30-500 mg orally daily for up to 8 weeks does not affect testosterone levels.

Likelihood Possible Evidence D
Pregnenolone full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Youth Guard Pregnenolone 50 mg, from the product label.

Vitamin World

See all Vitamin World products
Phone Number
1-800-228-4533
Web Address
www.vitaminworld.com
Pharmacist Counseling Corner

Youth Guard Pregnenolone 50 mg by Vitamin World: Common Questions

Does Youth Guard Pregnenolone 50 mg by Vitamin World interact with any medications?
Yes. Based on its ingredients, Youth Guard Pregnenolone 50 mg has a known interaction with 82 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Youth Guard Pregnenolone 50 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take pregnenolone if I'm pregnant or breastfeeding?
No — the safety data advises against pregnenolone during pregnancy because the risks are unknown. There also isn't enough information to know if it's safe while breastfeeding. Talk with your doctor or pharmacist about whether this supplement is right for you.
What are the common side effects?
The most common ones reported are acne, agitation, diarrhea, drowsiness, excitement, hair loss, skin abscess, sweating, and tremor. Skin rashes and changes in mood or appetite have also been reported, though it's not always clear they were caused by pregnenolone itself.
Does pregnenolone really work for Alzheimer disease or bipolar disorder?
The evidence isn't established for either condition in our data — we rate it as having insufficient reliable evidence for Alzheimer disease, bipolar disorder, and several other conditions listed. If you're considering it for a specific health goal, ask your doctor what the research actually shows.
Will this boost my hormone levels?
Pregnenolone is a precursor to several steroid hormones, so theoretically it could raise levels of estrogen, progesterone, progestin, and testosterone. However, research on testosterone shows it doesn't actually increase levels, and the effects on progesterone are mixed — so the picture is unclear and may depend on dose.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Youth Guard Pregnenolone 50 mg label
Go deeper

The Full Monographs Behind Youth Guard Pregnenolone 50 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Pregnenolone

Interacts with 82 drugs

Pregnenolone is a hormone your body makes naturally and a building block for other hormones like cortisol, DHEA, estrogen, and testosterone. It is sold as a supplement for memory, mood, and...

Read the full Pregnenolone monograph →
Sources

Sources & How We Checked

Youth Guard Pregnenolone 50 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pregnenolone 6 references
  1. Devlin TM, ed. Textbook of Biochemistry With Clinical Correlations. third ed. New York: Wiley-Liss Inc., 1992.
  2. Fung LK, Libove RA, Phillips J, Haddad F, Hardan AY.Brief report: an open-label study of the neurosteroid pregnenolone in adults with autism spectrum disorder. J Autism Dev Disord 2014;44(11):2971-7. PubMed
  3. Brown ES, Park J, Marx CE, et al. A randomized, double-blind, placebo-controlled trial of pregnenolone for bipolar depression. Neuropsychopharmacology 2014;39(12):2867-73. PubMed
  4. Ritsner MS, Gibel A, Shleifer T, et al. Pregnenolone and dehydroepiandrosterone as an adjunctive treatment in schizophrenia and schizoaffective disorder: an 8-week, double-blind, randomized, controlled, 2-center, parallel-group trial. J Clin Psychiatry 20 PubMed
  5. Meieran SE, Reus VI, Webster R, Shafton R, Wolkowitz OM. Chronic pregnenolone effects in normal humans: attenuation of benzodiazepine-induced sedation. Psychoneuroendocrinology 2004;29(4):486-500. PubMed
  6. Marx CE, Keefe RS, Buchanan RW, et al. Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia. Neuropsychopharmacology 2009;34(8):1885-903. PubMed

See these in context on the Pregnenolone monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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