Interactions on record — worth a quick check against your medications. Based on 2 of 8 ingredients. Check your meds →
Dietary supplement

Zypan Ingredients & Drug Interactions

by SP Standard Process

Zypan label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Zypan against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Zypan is a dietary supplement by SP Standard Process with 8 active ingredients. Its ingredients are commonly taken for low stomach acid (hypochlorhydria), bloating and gas, indigestion.Based on those ingredients, 36 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Betaine Hydrochloride. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Zypan by SP Standard Process

Ask about any prescription or over-the-counter medication and we check it for interactions with Zypan by SP Standard Process — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Zypan by SP Standard Process

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 8 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (600 mg) without saying how much of each component you get.

Zypan contains 8 ingredients, most of them digestive-support compounds. Betaine Hydrochloride increases stomach acid production.

Pepsin is a protein-digesting enzyme. The product also includes animal-derived extracts — Bovine and Ovine (sheep) spleen, and Bovine pancreas — along with Pancreatin, another enzyme blend.

Stearic Acid and Ammonium Chloride round out the formula. The tablets also contain cellulose and calcium stearate as inactive ingredients (binders and flow agents).

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Digestive support and enzyme supplementation.
  • We looked for evidence on: Dyspepsia, Diarrhea, Indigestion, Bloating.
  • The closest evidence on file: Betaine Hydrochloride is rated "Insufficient Reliable Evidence To Rate" for Diarrhea (Natural Medicines).
  • Also on file: Betaine Hydrochloride is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia.

The evidence for Betaine Hydrochloride is insufficient to rate its effectiveness for indigestion, low thyroid hormone (hypothyroidism), diarrhea, rheumatoid arthritis, food allergies, or hay fever. We hold no effectiveness ratings for the other active ingredients in this product.

If you're considering Zypan for a specific condition, talk with your pharmacist or doctor about whether the evidence supports its use for your situation.

The evidence, ingredient by ingredient Betaine Hydrochloride Proteolytic Enzymes (proteases)

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Betaine Hydrochloride may irritate the stomach and is not safe if you have ulcers, gastritis, or true acid reflux — the extra acid it produces could worsen these conditions or cause heartburn. It is not safe in pregnancy and should be avoided during breastfeeding.

Pepsin is generally well tolerated for most adults but may cause digestive upset or, rarely, allergic reactions. It should be avoided in pregnancy unless prescribed, and use during breastfeeding is not recommended without medical advice.

Occupational exposure to pepsin has rarely triggered allergic reactions and asthma.

Side effects, ingredient by ingredient Betaine Hydrochloride Proteolytic Enzymes (proteases)

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Betaine Hydrochloride.
  • The most serious interaction on file is rated Minor.
  • For scale: 36 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take H2-blockers (like famotidine), antacids, or proton pump inhibitors (like omeprazole, lansoprazole, or ranitidine), check your exact medications with the tool on this page before using Zypan. All three interactions are Minor, but they may reduce how well your acid-reducing drug works.

No interactions are documented for the other active ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Only minor medication interactions are documented, and safety information is well characterized.

Zypan is a digestive enzyme and acid-support product meant for stomach function, but it's not right for everyone. If you take acid-reducing medications (H2-blockers, antacids, or PPIs), this product could reduce their effectiveness.

Anyone with ulcers, gastritis, or acid reflux should avoid it. Check with your pharmacist before starting, especially if you're pregnant, breastfeeding, or on any medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 26, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Zypan, straight from the product label.

Brand SP Standard Process
Barcode (UPC) 812122013529
Net contents 330 Tablet(s)
Market status On market
Date entered into DSLD Dec 26, 2020
DSLD ID 239724
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Zypan by SP Standard Process, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Tablet(s)
Maximum serving Sizes:
2 Tablet(s)
Servings per container
165
UPC/BARCODE
812122013529
IngredientAmount% DV
Stearic Acid0 NP--
Proprietary Blend600 mg--
Betaine Hydrochloride0 NP--
Ammonium Chloride0 NP--
Pepsin0 NP--
Bovine Spleen0 NP--
Ovine Spleen0 NP--
Bovine Pancreas Cytosol extract0 NP--
Pancreatin (3X)0 NP--

Other ingredients: Cellulose, Calcium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested use: Two tablets with each meal, or as directed.

Formulation

Non-dairy formula Gluten free

General Statements

Whole Food Supplements Since 1929

Precautions

Caution: Chewing this product is not recommended.

This product is processed in a facility that manufactures other products containing soy, milk, egg, wheat, peanut, tree nuts, fish, and shellfish.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Zypan by SP Standard Process label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Zypan label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Zypan by SP Standard Process

These are the 8 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Tablet(s) Dosage formTablet Or Pill Servings per container165 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

600 mg per serving
  • › Stearic Acid
  • › Betaine Hydrochloride
  • › Ammonium Chloride
  • › Pepsin
  • › Bovine Spleen
  • › Ovine Spleen
  • › Bovine Pancreas Cytosol extract
  • › Pancreatin (3X)

Other (inactive) ingredients: Cellulose, Calcium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Zypan by SP Standard Process Drug Interactions

Want to check YOUR meds against Zypan?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
36Drugs
36 Minor

Ingredients driving the most interactions

Betaine Hydrochloride 36

Individual Drug Interactions

The ingredients in Zypan interact with 36 drugs. Click any drug to see the details.

1 of the 8 ingredients in Zypan interact with drugs. Each result below shows which ingredient is responsible. Betaine Hydrochloride

Each ingredient & the kinds of drugs it affects

For each ingredient in Zypan with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Betaine Hydrochloride3 drug types · 36 drugs

Antacids

Betaine hydrochloride increases stomach acidity and could decrease the effects of antacids.
In human research, betaine hydrochloride increases stomach acidity. Antacids are taken to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with antacids might decrease the effects of the antacids.

Likelihood Possible Evidence D
H2-Blockers

Betaine hydrochloride increases stomach acidity and could decrease the effects of H2-blockers.
In human research, betaine hydrochloride increases stomach acidity. H2-blockers are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with H2-blockers might decrease the effects of H2-blockers.

Likelihood Possible Evidence D
Proton Pump Inhibitors (Ppis)

Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.
In human research, betaine hydrochloride increases stomach acidity. PPIs are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with PPIs might decrease the effects of PPIs

Likelihood Possible Evidence D
Betaine Hydrochloride full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Zypan, from the product label.

SP Standard Process

See all SP Standard Process products
Name
Standard Process Inc.
Street Address
1200 West Royal Lee Drive
City
Palmyra
State
WI
ZipCode
53156
Pharmacist Counseling Corner

Zypan by SP Standard Process: Common Questions

Does Zypan by SP Standard Process interact with any medications?
Yes. Based on its ingredients, Zypan has a known interaction with 36 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Zypan contains 8 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Zypan if I have acid reflux?
No. Betaine Hydrochloride increases stomach acid, which can irritate and worsen acid reflux. If you have true acid reflux, gastritis, or ulcers, this product is not safe for you.
Will Zypan work with my acid-reducing medication?
Probably not as well as you'd want. Betaine Hydrochloride increases stomach acid and can weaken the effects of H2-blockers, antacids, and PPIs. If you take any of these, talk with your pharmacist about timing or whether this product is right for you.
Is Zypan safe during pregnancy?
No. Betaine Hydrochloride is not safe in pregnancy. Safety data is insufficient for the other ingredients as well, so it's best avoided. Talk with your doctor before taking it if you're pregnant or planning to become pregnant.
Can I take Zypan while breastfeeding?
No. Betaine Hydrochloride should be avoided during breastfeeding. Pepsin also is not recommended while breastfeeding without medical advice, so this product is not a good choice. Ask your pharmacist about safer alternatives.
What does Zypan actually do?
It's designed to support stomach function and digestion through a blend of enzymes and stomach-acid-promoting compounds. However, the evidence for how well it works is insufficient for most conditions. Talk with your doctor about whether it's the right choice for your digestive needs.
Can Zypan cause side effects?
Betaine Hydrochloride may cause heartburn or stomach irritation. Pepsin is generally well tolerated but can cause digestive upset or, very rarely, allergic reactions. Stop taking it and call your pharmacist if you have unusual symptoms.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Zypan label
Go deeper

The Full Monographs Behind Zypan’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Betaine Hydrochloride

Interacts with 36 drugs

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is limited and mostly based on tradition rat...

Read the full Betaine Hydrochloride monograph → Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph →
Sources

Sources & How We Checked

Zypan's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Betaine Hydrochloride 2 references
  1. Yago MR, Frymoyer A, Benet LZ, Smelick GS, Frassetto LA, Ding X, Dean B, Salphati L, Budha N, Jin JY, Dresser MJ, Ware JA. The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria. AAPS J. 2014 PubMed
  2. Yago MR, Frymoyer AR, Smelick GS, Frassetto LA, Budha NR, Dresser MJ, Ware JA, Benet LZ. Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. Mol Pharm. 2013 Nov 4;10(11):4032-7. PubMed

See these in context on the Betaine Hydrochloride monograph →

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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