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REFRESH PLUS carboxymethylcellulose sodium 5 mg/mL Solution/ Drops, 70 vials — NDC 00023-0403-70 package photo
Label image from the product's FDA listing (DailyMed) — may show a different pack size or an older label revision.

REFRESH PLUS carboxymethylcellulose sodium 5 mg/mL Solution/ Drops, 70 vials — NDC 0023-0403-70 (Billing 00023-0403-70)

by Allergan, Inc. · 70 VIAL, SINGLE-USE in 1 CARTON / .4 mL in 1 VIAL, SINGLE-USE

This is a package of 70 vials of REFRESH PLUS carboxymethylcellulose sodium 5 mg/mL Solution/ Drops from Allergan, Inc., marketed since Oct 1996 and currently FDA-listed; retail pharmacies pay about $0.2596 per vial (NADAC).

NDC 00023-0403-70
🏷️ FDA NDC (as labeled) 0023-0403-70 billing pads the labeler segment with a zero
This package
Contains70 vials Cost per ea$0.2596 NADAC Per package$18.17 / 70 vials Pack sizes5 compare ↓
Also priced by: Medicaid pays $0.8446/unit — full pricing hub ↓
Product page 00023-0403-30 Also comes in: 5 vials 0023-0403-05 30 vials 0023-0403-30 50 vials 0023-0403-50 100 vials 0023-0403-10
OTC On market Non-controlled ⇄ Compare with another NDC
🗂️ FDA directory synced Oct 1, 2026 · this listing last changed Aug 13, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →

This page is curated, coded, and maintained by

Compiled from public FDA, CMS, DailyMed, NADAC, and related drug data sources. Editorial policy

NDC database record

One package, one record: these facts belong to NDC 0023-0403-70 alone.

Record
FDA NDC Directory package listing · Human OTC drug
Code segments
0023 labeler · 0403 product · 70 package
Package marketed since
Oct 9, 1996
Sample package
No — commercial package
Listing certified through
Dec 31, 2027
Billing quantity
70 EA per package
Barcode (UPC-A, from the NDC)
3 0023040370 2
Medicaid fills, this package
33,108 prescriptions in the last four reported quarters
FDA record last changed
Aug 13, 2026
⚠️
Other active recalls for Carboxymethylcellulose Sodium (different manufacturers) — 6 · tap to view
These affect other manufacturers’ products for the same ingredient — not necessarily the exact NDC on this page.
Class II · Apr 23, 2025 — cGMP deviations and lack of assurance of sterility. (BRS Analytical Services, LLC) · FDA recall D-0406-2025
Class III · Dec 18, 2024 — LABELING: LABEL MIX-UP (AvKARE) · FDA recall D-0175-2025
Class I · Nov 13, 2023 — Non-Sterility (Kilitch Healthcare India Limited) · FDA recall D-0291-2024
Class I · Nov 13, 2023 — Non-Sterility (Kilitch Healthcare India Limited) · FDA recall D-0299-2024
Class I · Oct 31, 2023 — Non-Sterility: FDA found insanitary conditions and positive bacterial test results from environmental sampling at the manufacturing facility. (Cardinal Health Inc.) · FDA recall D-0134-2024
Class I · Oct 31, 2023 — Non-Sterility: FDA found insanitary conditions and positive bacterial test results from environmental sampling at the manufacturing facility. (Cardinal Health Inc.) · FDA recall D-0132-2024
Each entry is an official FDA enforcement report — look up any recall number in the FDA recall database ↗

Identity & classification

Regulatory identifiers FDA, NLM and CMS codes for this package

FDA NDC (as labeled) 0023-0403-70
Product NDC 0023-0403
11-digit billing NDC 00023040370
NCPDP billing unit EA — each (per item)
RxCUI 1188426
UNII K679OBS311
Application # M018
SPL Set ID 0f6a4b4b-cde6-4518-84b5-ce997f1154a7
DEA schedule Non-controlled
Marketing category OTC MONOGRAPH DRUG
Marketing status On market
FDA listing status Listed (active directory)
Marketing start 1996-10-09
Route OPHTHALMIC
Dosage form SOLUTION/ DROPS
Substance CARBOXYMETHYLCELLULOSE SODIUM

Drug-database identifiers Medi-Span GPI and First Databank GCN / HICL / AHFS classification

GCN Seq No 030011
GCN 37384
HICL code 003843
Ingredient (HICL) Carboxymethylcellulose Sodium
HIC1 code Q
Therapeutic class — broad (HIC1) Ear/Eye/Nose/Rectum/Topical/Vagina/Other
HIC2 code Q6
Therapeutic class — intermediate (HIC2) Ophthalmic Preparations
HIC3 code Q6T
Therapeutic class — specific (HIC3) Artificial Tears
AHFS code 52:92.00.00
AHFS class Eent Drugs, Miscellaneous
FDB label name REFRESH PLUS 0.5% EYE DROPS
FDB brand name Refresh Plus
Legend status O — Over-the-counter (OTC) drug or device
Quick answers
  • GSN (GCN sequence number): 030011
  • GCN: 37384
  • HICL (First Databank): 003843
  • AHFS class code: 52:92.00.00
  • RxCUI (RxNorm): 1188426
Why two NDCs? The FDA registers this code as 0023-0403-70 — a 4-4-2 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the labeler segment → 00023-0403-70. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.

Clinical

Label name REFRESH PLUS 0.5% EYE DROPS Ingredient Carboxymethylcellulose Sodium
🧪 What is this product?

Refresh Plus is an over-the-counter eye drop solution containing carboxymethylcellulose sodium, a lubricating agent. This OTC monograph product is applied directly to the eye and is typically used to help relieve dry eye discomfort by providing moisture and forming a protective layer on the eye surface. Carboxymethylcellulose sodium functions as an artificial tear substitute that helps restore the eye's natural moisture balance.

Supplement & herbal interactions

🌿 Drug–supplement interaction checker →
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.

Pricing

A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.

Price systemPer eaPer package
Retail pharmacies payNADAC · weekly $0.260 $18.17 / 70 vials
Medicaid paysCMS SDUD · 12 mo $0.8446 $59.12 / 70 vials
Medicare drug plans payPart D · quarterly No Part D plan price is available for this NDC in our data.
NADAC price history (per ea) — tap or hover for the price & month
Dec 2025 Jan 2026 Mar 2026 May 2026 $0.260 $0.260
Flat over the last 4 months.
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.

Packaging — all sizes for this product

Package NDCDescription Per unit Per pack Marketing startMarketing endStatus
00023-0403-05 0023-0403-05 5 VIAL, SINGLE-USE in 1 CARTON / .4 mL in 1 VIAL, SINGLE-USE Sample — — 1996-10-09 — Active
00023-0403-10 0023-0403-10 100 VIAL, SINGLE-USE in 1 CARTON / .4 mL in 1 VIAL, SINGLE-USE — — 1996-10-09 — Active
00023-0403-30 0023-0403-30 Main listing 30 VIAL, SINGLE-USE in 1 CARTON / .4 mL in 1 VIAL, SINGLE-USE $0.2968 / ea $8.90 1996-10-09 — Active
00023-0403-50 0023-0403-50 50 VIAL, SINGLE-USE in 1 CARTON / .4 mL in 1 VIAL, SINGLE-USE $0.2764 / ea $13.82 1996-10-09 — Active
00023-0403-70 You're viewing this 70 VIAL, SINGLE-USE in 1 CARTON / .4 mL in 1 VIAL, SINGLE-USE $0.2596 / ea $18.17 1996-10-09 — Active

This pack has the lowest per-ea cost of the 3 priced pack sizes ($0.2596 NADAC).

This pack accounts for about 17% of this product's recent Medicaid fills; most go to a different pack size. See all packs ↓

Pack size FAQ

What quantity is in this package?
This package contains 70 vials — 70 vial, single-use in 1 carton / .4 ml in 1 vial, single-use.
How does this package differ from NDC 00023-0403-05?
Both are REFRESH PLUS carboxymethylcellulose sodium 5 mg/mL Solution/ Drops — the drug itself is identical. This page's package is the 70 vials one, while NDC 00023-0403-05 is the 5 vials package.
What NDC number is used to bill for this package of REFRESH PLUS carboxymethylcellulose sodium 5 mg/mL Solution/ Drops?
Use the 11-digit billing form listed in the identifiers section of this page. Pharmacy and medical claims use the 11-digit form; the FDA label may print a shorter form of the same code.

Prices are the latest CMS NADAC pharmacy acquisition cost per NDC; per-pack figures are per-unit × pack quantity, shown only when the pack is denominated in the same measure NADAC prices.

Therapeutic equivalents

ProductLabelerPackNADAC/unitTEStatusPrice vs. this
Leader Lubricant Eye Drops .5 g/100mL 70000-0012-01 Cardinal 70 vials $0.163 — Availability likely save 37%
Rugby Lubricant Eye Drops .5 g/100mL 00536-1387-92 Rugby 30 vials $0.227 — Availability likely save 13%
Good Neighbor Pharmacy Lubricant Eye Drops .5 g/100mL 46122-0756-56 Amerisource 30 vials $0.227 — Availability likely save 13%
carboxymethylcellulose sodium 5 mg/mL 50268-0067-30 AvPAK 30 vials $0.227 — Availability likely save 13%
Foster and Thrive Lubricant Eye Drops .5 g/100mL 70677-1190-01 Strategic 30 vials $0.227 — Availability likely save 13%
Refresh Plus 5 mg/mLthis 00023-0403-70 Allergan, 70 vials $0.260 — Availability likely —
Carboxymethylcellulose Sodium Eye Lubricant 5 mg/mL 42494-0448-05 Cameron 2 bottles $0.275 — Discontinued +6%
Rugby Carboxymethylcellulose Sodium 0.5% Eye Drops .5 g/100mL 00536-1386-35 Rugby 2 bottles $0.280 — Availability likely +8%
carboxymethylcellulose sodium 5 mg/mL 50268-0068-15 AvPAK 1 bottle $0.324 — Availability likely +25%
Leader Lubricant Eye Drops Soothing Relief .5 g/100mL 70000-0705-01 LEADER/Cardinal 1 bottle $0.324 — Availability likely +25%
Refresh Tears 5 mg/mL 00023-0798-01 Allergan, 2 bottles $0.412 — Availability likely +59%
Lubricant Drops 5 mg/mL 70000-0090-01 CARDINAL 1 bottle $0.498 — FDA listed +92%
Refresh Tears 00023-0795-65 Allergan, 1 kit — — FDA listed —
Walgreens Lubricant Eye Drops Preservative Free .5 g/100mL 00363-8800-01 Walgreen 30 vials — — FDA listed —
Walgreens Lubricant Eye Drops 5 mg/mL 00363-8832-15 Walgreen 2 bottles — — FDA listed —
Walgreens Lubricant Eye Drops 5 mg/mL 00363-8833-15 Walgreen 1 bottle — — FDA listed —
Lubricant Eye 5 mg/mL 00536-1476-92 Rugby 30 ampules — — FDA listed —
Lubricant Eye Drops Preservative Free .5 g/100mL 11673-0150-01 Target 70 vials — — FDA listed —
Up and Up Dry Eye Relief Lubricant Eye Drops 5 mg/mL 11673-0771-01 Target 2 bottles — — FDA listed —
Up and Up Dry Eye Relief Lubricant Eye Drops 5 mg/mL 11716-0771-01 Hanlim 2 bottles — — FDA listed —
Auro-Cmc 5 mg/mL 16030-0401-10 Aurolab 10 ml — — FDA listed —
Carboxymethylcellulose Sodium Eye Drops 0.5% 5 mg/mL 16030-0501-05 Aurolab 5 ml — — FDA listed —
Gentle Eyes Lubricant Eye Drops 5 mg/mL 17312-0430-15 TRP 1 bottle — — FDA listed —
Signature Care Lubricant Eye Drops .5 g/100mL 21130-0705-01 Better 30 vials — — FDA listed —
Kroger Lubricant Eye .5 g/100mL 30142-0373-33 The 30 vials — — FDA listed —
HEB Lubricant Eye Drops .5 g/100mL 37808-0100-01 HEB 30 vials — — FDA listed —
Medi-First Lubricant Eye Drops .5 g/100mL 47682-0193-83 Unifirst 30 ampules — — FDA listed —
Green Guard Lubricant Eye Drops .5 g/100mL 47682-0194-83 UniFirst 30 ampules — — FDA listed —
Equate Lubricant Eye Drops Preservative-Free .5 g/100mL 49035-0245-01 Wal-Mart 25 vials — — FDA listed —
Equate Restore Plus Lubricant Eye Drops .5 g/100mL 49035-0389-01 Walmart, 70 vials — — FDA listed —
Good Sense Lubricating Plus Lubricant Eye Drops .5 g/100mL 50804-0700-01 GoodSense 30 bottles — — FDA listed —
Carboxymethylcellulose Sodium 0.5% 5 mg/mL 51407-0945-30 Golden 3 pouches — — Discontinued —
Discount Drug Mart Lubricant Eye Drops 5 mg/mL 53943-0510-01 Discount 5 bottles — — FDA listed —
Retaine CMC 5 mg/mL 54799-0460-30 OCuSOFT 30 vials — — FDA listed —
Medics Choice Lubricant Eye Drops .5 g/100mL 55651-0030-01 K.C. 5 ampules — — FDA listed —
Lubricant Eye Drops 5 mg/mL 55651-0105-05 KC 5 bottles — — FDA listed —
Lubricant Eye Drops 5 mg/mL 55651-0510-01 KC 5 bottles — — FDA listed —
Publix Moisturizing Relief Eye Drops .5 g/100mL 56062-0789-01 Publix 30 vials — — FDA listed —
TheraTears Dry and Tired 5 mg/mL 58790-0013-30 MEDTECH 6 pouches — — FDA listed —
Family Care Single Use Lubricant Eye Drop 0.4mL 5ct 5 mg/mL 65923-0575-05 United 1 vial — — FDA listed —
Family Care Single Use Lubricant Eye Drop 0.4mL 30ct 5 mg/mL 65923-0576-30 United 30 vials — — FDA listed —
Refresh Tears 5 mg/mL 66715-1073-00 Lil' 1 bottle — — Discontinued —
Refresh Tears Lubricant 5 mg/mL 67751-0130-01 Navajo 3 ml — — Discontinued —
Lubricating Tears 5 mg/mL 69618-0076-55 Reliable 1 bottle — — FDA listed —
CVS Lubricant Eye Drops .5 g/100mL 69842-0804-01 CVS 70 vials — — FDA listed —
CVS Lubricant Eye Drops 30 ct .5 g/100mL 69842-0993-01 CVS 30 vials — — FDA listed —
Lubricant Eye 5 mg/mL 70000-0751-01 CARDINAL 30 ampules — — FDA listed —
Lubricant Eye Drops 5 mg/mL 71105-0105-05 Redicare 5 bottles — — FDA listed —
TopCare Health Lubricant Eye Drops .5 g/100mL 76162-0089-30 Topcare 30 vials — — FDA listed —
Meijer Lubricant Eye Drops .5 g/100mL 79481-0066-01 Meijer 30 vials — — FDA listed —
Rain Renewal Eye Drops .5 g/100mL 79662-0001-30 Rain 30 bottles — — FDA listed —
Equate Moisturizing Comfort Lubricant Eye Drops .5 g/100mL 79903-0264-05 Walmart 1 bottle — — FDA listed —
Focus Tears PF 5 mg/mL 82724-0009-20 Covalent 30 vials — — FDA listed —
Eyes Alive Lubricating 5 mg/mL 83291-0200-00 RIVIERA 100 ampules — — FDA listed —
About this product: other versions of the same ingredient, strength and form are listed above, least expensive first, with FDA equivalence ratings where available.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.

Availability & generic status

🏛️
1996
On the market since
Oct 1996
📍
2026
Currently FDA-listed
30 years listed
🔒
·
No generic listed yet
brand only
ℹ️No FDA-approved generic found

We did not find an FDA-approved generic match for this exact strength, form and route.

Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.

Inactive Ingredients / Excipients

Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.

💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.

  • UNII M4I0D6VV5M
    Calcium chloride is a salt compound that acts as a firming agent and source of calcium ions in medications. It's used in formulations to help maintain tablet structure, improve texture, or serve as a buffering agent.
  • UNII QTT17582CB
    A strong acid used to adjust and maintain the proper pH level in liquid medicines, ensuring stability and preventing breakdown of active ingredients.
  • UNII 02F3473H9O
    A mineral salt used in medications as a source of magnesium. It helps bind ingredients together, improve texture, and maintain the product's stability during storage.
  • UNII 660YQ98I10
    Potassium chloride is a mineral salt used in medicines as a buffer and to help maintain the proper pH balance and stability of the formulation during storage and use.
  • UNII 451W47IQ8X
    Sodium chloride is common table salt. It's used in medicines as a buffer to maintain proper pH, as a filler to add bulk, or to adjust the osmotic balance in liquid formulations.
  • UNII 55X04QC32I
    A strong alkaline chemical used to adjust and maintain the pH balance of liquid medicines. It helps keep the medicine stable and ensures it stays effective during storage.
  • UNII TU7HW0W0QT
    A salt derived from lactic acid, sodium lactate acts as a buffer and pH stabilizer in medicines. It helps maintain the product's acidity level and can also serve as a humectant to retain moisture.
  • UNII 059QF0KO0R
    Water is a liquid solvent that dissolves and mixes ingredients together in liquid medicines, syrups, and injections. It helps distribute the active drug evenly throughout the product.

8 inactive ingredients listed in the exact product block matched to this NDC.

The official label also statesCalcium chloride dihydrate; magnesium chloride hexahydrate; potassium chloride; purified water; sodium chloride; and sodium lactate. May contain hydrochloric acid and/or sodium hydroxide (to adjust pH).

Label-section wording can be broader than the structured product block and may mention additional formulation ingredients.

Where does this data come from?
Data sourced from official FDA Structured Product Labeling (SPL) via DailyMed — ingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.

Inactive ingredient FAQ

Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.

Manufacturer & labeler

LabelerAllergan, Inc.
FDA applicationM018 (OTC MONOGRAPH DRUG)
Labeler code00023
First marketedOct 1996
Product typeHuman Otc Drug
Portfolio188 products on file

More NDCs from Allergan, Inc. labeler code 00023

The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.

FDA label — Drug Facts FDA SPL

The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage ⏱️ Dosage and Administration ⚠️ Warnings 🧪 Active Ingredient 🧪 Inactive Ingredients 🎯 Purpose 📄 Stop Use and Ask a Doctor If 📄 Keep Out of Reach of Children 📄 Other Information 📄 Questions or Comments 📄 Package Label / Principal Display Panel
🎯 Indications and Usage 31 words ▾

Uses For the temporary relief of burning, irritation, and discomfort due to dryness of the eye or exposure to wind or sun. May be used as a protectant against further irritation.

⏱️ Dosage and Administration 47 words ▾

Directions To open, TWIST AND PULL TAB TO REMOVE . Instill 1 or 2 drops in the affected eye(s) as needed and discard container. *Follow your eye doctor’s instructions if you are using this product after an eye surgery (e.g., LASIK) to relieve eye dryness and discomfort.

⚠️ Warnings 92 words ▾

Warnings For external use only. To avoid contamination, do not touch tip of container to any surface. Do not reuse.

Once opened, discard. Do not touch unit-dose tip to eye. If solution changes color or becomes cloudy, do not use.

Stop use and ask a doctor if you experience eye pain, changes in vision, continued redness or irritation of the eye, or if the condition worsens or persists for more than 72 hours. Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.

🧪 Active Ingredient 5 words ▾

Active ingredient Carboxymethylcellulose sodium 0.5%

🧪 Inactive Ingredients 27 words ▾

Inactive ingredients Calcium chloride dihydrate; magnesium chloride hexahydrate; potassium chloride; purified water; sodium chloride; and sodium lactate. May contain hydrochloric acid and/or sodium hydroxide (to adjust pH).

🎯 Purpose 3 words ▾

Purpose Eye lubricant

📄 Stop Use and Ask a Doctor If 33 words ▾

Stop use and ask a doctor if you experience eye pain, changes in vision, continued redness or irritation of the eye, or if the condition worsens or persists for more than 72 hours.

📄 Keep Out of Reach of Children 19 words ▾

Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.

📄 Other Information 26 words ▾

Other information Use only if single-use container is intact. Use before expiration date marked on container. Store at 59°-77°F (15°-25°C). RETAIN THIS CARTON FOR FUTURE REFERENCE.

📄 Questions or Comments 9 words ▾

Questions or comments? 1.800. 678.1605 refreshbrand.com v1.0DFL0403 Phone icon

📄 Package Label / Principal Display Panel 205 words ▾

PRINCIPAL DISPLAY PANEL NDC 0023-0403-30 Preservative-free Refresh Plus ® Lubricant Eye Drops For Eye Dryness MOISTURIZING RELIEF Original Strength Lubricates & Moisturizes Recommended for Sensitive Eyes 30 Single-Use Containers 0.01 fl oz (0.4 mL) each Sterile NDC 0023-0403-30 Preservative-free Refresh Plus® Lubricant Eye Drops For Eye Dryness MOISTURIZING RELIEF Original Strength Lubricates & Moisturizes Recommended for Sensitive Eyes 30 Single-Use Containers 0.01 fl oz (0.4 mL) each Sterile

PRINCIPAL DISPLAY PANEL NDC 0023-0403-50 VALUE SIZE 50 Vials Preservative-free Refresh Plus ® Lubricant Eye Drops For Eye Dryness MOISTURIZING RELIEF Original Strength Lubricates & Moisturizes Recommended for Sensitive Eyes 50 Single-Use Containers 0.01 fl oz (0.4 mL) each Sterile NDC 0023-0403-50 VALUE SIZE 50 Vials Preservative-free Refresh Plus® Lubricant Eye Drops For Eye Dryness MOISTURIZING RELIEF Original Strength Lubricates & Moisturizes Recommended for Sensitive Eyes 50 Single-Use Containers 0.01 fl oz (0.4 mL) each Sterile

PRINCIPAL DISPLAY PANEL NDC 0023-0403-70 VALUE SIZE 7 0 Vials Preservative-free Refresh Plus ® Lubricant Eye Drops ORIGINAL STRENGTH Moisturizing Relief Great for Sensitive Eyes 70 Vials 0.01 fl oz (0.4mL) each Sterile NDC 0023-0403-70 VALUE SIZE 70 Vials Preservative-free Refresh Plus® Lubricant Eye Drops ORIGINAL STRENGTH Moisturizing Relief Great for Sensitive Eyes 70 Vials 0.01 fl oz (0.4mL) each Sterile

Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA. Prefer the government’s original formatting? View this label on DailyMed ↗

Medicaid utilization & spend

📍 This exact package only: Medicaid data is reported per full 11-digit NDC — labeler, product and pack size — so every number here is for this package alone, not the drug overall. Other pack sizes report separately.
💊 Pharmacy benefit only: These are Medicaid outpatient pharmacy claims, billed by NDC. They exclude the medical benefit — clinic- or hospital-administered drugs billed under HCPCS J-codes — so drugs used mostly that way (e.g. Avastin, Lucentis, Keytruda) can look low or missing here. That’s expected, not an error.
📅 Q1 2025 – Q1 2026 · 5 quarters of data
ⓘ The newest quarter is usually incomplete when first published; states restate recent quarters in later CMS releases, so the latest figures typically revise upward. State coverage-policy changes can also shift quarter-to-quarter totals.
Prescriptions last 4 qtrs
33.1K
Units reimbursed last 4 qtrs
934.9K
Gross reimbursed last 4 qtrs
$789.7K
Avg / prescription
$23.85
Avg / unit
$0.8446
Latest quarter Q1 2026
8.9KRx
Medicaid pays / ea
$0.8446
gross reimbursed
vs
NADAC / ea
$0.2596
acquisition cost
=
Spread
+$0.5850
+225% vs cost
What Medicaid paid per ea (before rebates; includes the pharmacy’s dispensing fee) compared with NADAC — the average price pharmacies pay to buy the drug. A positive spread means Medicaid reimbursed more than the purchase price, before manufacturer rebates.
Fee-for-service vs managed care ⓘ
96% FFS
Fee-for-service · 31,842 Rx Managed care · 1,266 Rx
State Medicaid map
Alaska: no data reported AK Maine: 2,856 units · 205 per 100k residents ME Washington: no data reported WA Idaho: no data reported ID Montana: no data reported MT North Dakota: no data reported ND Minnesota: 19,683 units · 343 per 100k residents MN Wisconsin: 12,472 units · 211 per 100k residents WI Michigan: 5,480 units · 54.6 per 100k residents MI New York: 869,007 units · 4,440 per 100k residents NY Vermont: no data reported VT New Hampshire: no data reported NH Oregon: no data reported OR Nevada: 578 units · 18.1 per 100k residents NV Wyoming: no data reported WY South Dakota: no data reported SD Iowa: no data reported IA Illinois: no data reported IL Indiana: no data reported IN Ohio: 7,840 units · 66.5 per 100k residents OH Pennsylvania: 10,447 units · 80.6 per 100k residents PA New Jersey: no data reported NJ Massachusetts: no data reported MA California: 5,317 units · 13.6 per 100k residents CA Utah: no data reported UT Colorado: no data reported CO Nebraska: 804 units · 40.6 per 100k residents NE Missouri: no data reported MO Kentucky: no data reported KY West Virginia: no data reported WV Virginia: 440 units · 5.0 per 100k residents VA Maryland: no data reported MD Connecticut: no data reported CT Rhode Island: no data reported RI Arizona: no data reported AZ New Mexico: no data reported NM Kansas: no data reported KS Arkansas: no data reported AR Tennessee: no data reported TN North Carolina: no data reported NC South Carolina: no data reported SC Delaware: no data reported DE Oklahoma: no data reported OK Louisiana: no data reported LA Mississippi: no data reported MS Alabama: no data reported AL Georgia: no data reported GA D.C.: no data reported DC Hawaii: no data reported HI Texas: no data reported TX Florida: no data reported FL
Units reimbursed · per 100k residents
5.04,440
gray = no data reported ⓘ
Colors are per 100,000 residents, so big states don’t automatically dominate. Tap or hover a state for its actual totals.
Tap or hover a state
…for its Medicaid breakdown
🏆 Top states by units · per 100k residents
1 New York 4,440 /100k
2 Minnesota 343 /100k
3 Wisconsin 211 /100k
4 Maine 205 /100k
5 Pennsylvania 80.6 /100k
6 Ohio 66.5 /100k
7 Michigan 54.6 /100k
8 Nebraska 40.6 /100k
National units — by quarter
💵 About the dollar figures: “reimbursed” is what Medicaid paid pharmacies before confidential manufacturer rebates, so the program’s real net cost is lower than these numbers. Fee-for-service and managed-care claims are combined unless split above. Source: CMS State Drug Utilization Data; per-100k rates use 2023 Census population estimates.

Medicaid utilization by pack size

Medicaid (SDUD) totals over the four most recent reported quarters for every package size of this drug — handy when a specific package (e.g. a starter/titration pack) carries little or no Medicaid volume on its own.
30 vials00023-0403-30 150,987 Rx · $3,301,183
70 vials this page00023-0403-70 33,108 Rx · $789,683
50 vials00023-0403-50 8,857 Rx · $244,576
5 vials00023-0403-05 No Medicaid data
100 vials00023-0403-10 No Medicaid data
Drug total (last 4 qtrs): 192,952 Rx · 3,834,836 units · $4,335,441 gross reimbursed
Tap a pack size to open its page. Source: CMS State Drug Utilization Data, last 4 quarters.

Reported adverse events (FAERS)

Read carefully: FAERS reports are voluntary and unverified. Counts are not incidence, do not establish causation, are subject to reporting bias, and cannot be used to compare one drug to another. Shown for signal context only. Reports for REFRESH PLUS (this brand).

Top reported reactions

Macular Degeneration392
Nausea303
Eye Irritation268
Pain236
Weight Decreased225
Malaise206
Eye Pain199

Age at onset

Child1
Adolescent2
Adult160
Elderly347

Reporter sex

2,548 reports
Male · 23%
Female · 76%
Unknown · 0%

Serious outcomes

Hospitalization721
Death133
Disabling48
Life-threatening45
Reports over time (by year) — tap or hover for the count & year
2019 2021 2023 2026 411 0
Most recent year is provisional (FAERS lags ~3 months).
Where does this data come from?
Adverse-event reports from the FDA Adverse Event Reporting System (FAERS) via openFDA. FAERS reports are voluntary and unverified — counts are not incidence and don’t establish causation.
← 00023-0312-04 · Allergan, 00023-0506-01 · Allergan, →
For educational and professional reference only — not medical advice. Pricing reflects published NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.