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Bupivacaine Hydrochloride Injection shortage

Bupivacaine Hydrochloride Injection is currently listed in shortage by the FDA. The FDA lists 62 affected products. The reported reason: Discontinuation of the manufacture of the drug; Demand increase for the drug; Other. This page was last refreshed from FDA data on Oct 1, 2026.

Current ⚠ Supply risk: Low Anesthesia 62 products 8 manufacturers 3,145 days · 8.6 yr First posted Feb 20, 2018 Updated Sep 22, 2026
Here’s the bottom line

One specific strength of bupivacaine hydrochloride injection — 0.75% (15 mg/2 mL) mixed with 8.25% dextrose — currently has no available source. Most other strengths remain available from multiple manufacturers that have not reported a shortage.

Don’t stop or change your therapy on your own — talk with your prescriber about the plan that fits you, and ask your pharmacist what’s actually available (see options).

Do you take this drug? See the ‘What to do’ recommendation from Dr. Brian Staiger, PharmD →
62
Affected NDCs
8
Reporting manufacturers
7/8
Reporting mfrs supplying
18/19
Affected strengths supplied
7%
NDCs unavailable
3,145
Days in shortage
127,041
Medicaid Rx (2025)
Source: FDA Drug Shortages Database API (openFDA). Last refreshed Oct 1, 2026 · yesterday

What’s in shortage — at a glance

These figures count only the manufacturers that reported this shortage to the FDA — not every company that makes Bupivacaine Hydrochloride Injection. Other makers that haven’t reported a problem are shown in the green card below.

Availability of affected NDCs
From the FDA shortage report
62 NDCs
Available 47 Limited 6 Unavailable 4 To be discontinued 5
Affected strengths still supplied
Among manufacturers reporting this shortage
18/19 strengths
Sourceable 18 No supply 1
FDA-reporting manufacturers with supply
Among manufacturers reporting this shortage
7/8 makers
With supply 7 No supply 1
✓ Other manufacturers not reporting a shortage
Still-marketed Bupivacaine Hydrochloride Injection from companies that have not filed an FDA shortage — these are not counted in the figures above. Stock can still vary by pharmacy.
Hikma Pharmaceuticals USA Inc. B. Braun Medical Inc. Hospira, Inc. Camber Pharmaceuticals, Inc.
Plus 6 alternative dosage forms of Bupivacaine Hydrochloride.
See all other options & details →
Shortage timeline
  1. Sep 22, 2026
    Currently in shortage
    62 of 62 products affected.
  2. Sep 18, 2026
    FDA refreshed this shortage record
    1 product updated.
  3. Sep 17, 2026
    FDA refreshed this shortage record
    8 products updated.
  4. Sep 15, 2026
    FDA refreshed this shortage record
    10 products updated.
  5. Sep 11, 2026
    FDA refreshed this shortage record
    6 products updated.
  6. Jul 30, 2026
    FDA refreshed this shortage record
    1 product updated.
  7. Jul 17, 2026
    FDA refreshed this shortage record
    6 products updated.
  8. May 5, 2026
    FDA refreshed this shortage record
    10 products updated.
  9. May 5, 2026
    More presentations reported
    5 more products added to the shortage.
  10. Feb 20, 2018
    First reported to the FDA
    57 products first listed.

Built from FDA posting and update dates. The end date FDA publishes is the posting/update date, not a true resolution date, so durations are approximate.

What exactly is on backorder — by manufacturer

Manufacturer: Aspiro Pharma Limited 📞 732-529-0430, [email protected] 6 NDCS click to expand
Status NDC / product Strength Availability Related information Reason
Current Bupivacaine Hydrochloride, Injection, 5 mg/1 mL (NDC 31722-276-34) NDC 31722-0276-34 — Available — —
Current Bupivacaine Hydrochloride, Injection, 2.5 mg/1 mL (NDC 31722-275-34) NDC 31722-0275-34 — Available — —
Current Bupivacaine Hydrochloride, Injection, 2.5 mg/1 mL (NDC 31722-275-32) NDC 31722-0275-32 — Available — —
Current Bupivacaine Hydrochloride, Injection, 7.5 mg/1 mL (NDC 31722-277-34) NDC 31722-0277-34 — Available — —
Current Bupivacaine Hydrochloride, Injection, 5 mg/1 mL (NDC 31722-276-32) NDC 31722-0276-32 — Available — —
Current Bupivacaine Hydrochloride, Injection, 7.5 mg/1 mL (NDC 31722-277-32) NDC 31722-0277-32 — Available — —
Manufacturer: Eugia US LLC 📞 888-238-7880 8 NDCS click to expand
Status NDC / product Strength Availability Related information Reason
Current Bupivacaine Hydrochloride, Injection, 5 mg/1 mL (NDC 55150-170-30) NDC 55150-0170-30 — Available Check wholesalers for inventory —
Current Bupivacaine Hydrochloride, Injection, 5 mg/1 mL (NDC 55150-169-10) NDC 55150-0169-10 — Available Check wholesalers for inventory —
Current Bupivacaine Hydrochloride, Injection, 7.5 mg/1 mL (NDC 55150-172-30) NDC 55150-0172-30 — Available Check wholesalers for inventory —
Current Bupivacaine Hydrochloride, Injection, 5 mg/1 mL (NDC 55150-250-50) NDC 55150-0250-50 — Available Check wholesalers for inventory —
Current Bupivacaine Hydrochloride, Injection, 2.5 mg/1 mL (NDC 55150-168-30) NDC 55150-0168-30 — Available Check wholesalers for inventory —
Current Bupivacaine Hydrochloride, Injection, 2.5 mg/1 mL (NDC 55150-167-10) NDC 55150-0167-10 — Available Check wholesalers for inventory —
Current Bupivacaine Hydrochloride, Injection, 2.5 mg/1 mL (NDC 55150-249-50) NDC 55150-0249-50 — Available Check wholesalers for inventory —
Current Bupivacaine Hydrochloride, Injection, 7.5 mg/1 mL (NDC 55150-171-10) NDC 55150-0171-10 — Available Check wholesalers for inventory —
Manufacturer: Fresenius Kabi USA, LLC 📞 888-386-1300 10 NDCS click to expand
Status NDC / product Strength Availability Related information Reason
Current Sensorcaine, Injection, 5 mg/1 mL (NDC 63323-466-17) NDC 63323-0466-17 — Available Check wholesalers for inventory —
Current Sensorcaine, Injection, 5 mg/1 mL (NDC 63323-466-31) NDC 63323-0466-31 — Unavailable Estimated recovery: TBD Delay in shipping of the drug
Current Sensorcaine, Injection, 5 mg/1 mL (NDC 63323-467-57) NDC 63323-0467-57 — Available Check wholesalers for inventory —
Current Sensorcaine, Injection, 7.5 mg/1 mL (NDC 63323-472-17) NDC 63323-0472-17 — Available Check wholesalers for inventory —
Current Sensorcaine, Injection, 2.5 mg/1 mL (NDC 63323-464-31) NDC 63323-0464-31 — Unavailable Estimated recovery: TBD Demand increase for the drug
Current Sensorcaine, Injection, 2.5 mg/1 mL (NDC 63323-464-37) NDC 63323-0464-37 — Available Check wholesalers for inventory —
Current Sensorcaine, Injection, 2.5 mg/1 mL (NDC 63323-464-17) NDC 63323-0464-17 — Available Check wholesalers for inventory —
Current Sensorcaine, Injection, 5 mg/1 mL (NDC 63323-466-37) NDC 63323-0466-37 — Available Check wholesalers for inventory —
Current Sensorcaine, Injection, 7.5 mg/1 mL (NDC 63323-472-37) NDC 63323-0472-37 — Available Check wholesalers for inventory —
Current Sensorcaine, Injection, 2.5 mg/1 mL (NDC 63323-465-57) NDC 63323-0465-57 — Available Check wholesalers for inventory —
Manufacturer: Hospira, Inc., a Pfizer Company 📞 844-646-4398 20 NDCS click to expand
Status NDC / product Strength Availability Related information Reason
Current Marcaine, Injection, Marcaine 125 mg/50 mL (2.5 mg/mL) (NDC 0409-1160-01) NDC 00409-1160-01 — Available — —
Current Bupivacaine Hydrochloride, Injection, Bupivacaine Spinal 15 mg/2 mL (7.5 mg/mL in 8.25% dextrose) (NDC 0409-3613-01) NDC 00409-3613-01 — Limited Availability Limited Supply Available. Next Delivery: May 2027; Estimated Recovery: June 2027 Demand increase for the drug
Current Marcaine, Injection, 150 mg/30 mL (5 mg/mL) (NDC 0409-1530-01) NDC 00409-1530-01 — Available — —
Current Marcaine, Injection, 225 mg/30 mL (NDC 0409-2253-25) NDC 00409-2253-25 — Available Historical NDC: 0409-1582-29 —
Current Bupivacaine Hydrochloride, Injection, 50 mg/10 mL (5 mg/mL) (NDC 0409-1162-01) NDC 00409-1162-01 — Available — —
Current Marcaine, Injection, 250 mg/50 mL (NDC 0409-0525-25) NDC 00409-0525-25 — Available Historical NDC: 0409-1610-50 —
Current Marcaine, Injection, Marcaine 225 mg/30 mL (7.5 mg/mL) (NDC 0409-2253-01) NDC 00409-2253-01 — Available Historical NDC: 0409-1582-29 —
Current Bupivacaine Hydrochloride, Injection, 7.5 mg/1 mL (NDC 0409-1165-01) NDC 00409-1165-01 — Available — —
Current Bupivacaine Hydrochloride, Injection, 125 mg/50 mL (2.5 mg/mL) (NDC 0409-1160-01) NDC 00409-1160-01 — Available — —
Current Marcaine, Injection, 0.75% 15 mg/2 mL (NDC 0409-1761-62) NDC 00409-1761-62 — Available — —
Current Marcaine, Injection, 0.75% 15 mg/2 mL (7.5 mg/mL) in Dextrose 8.25% (NDC 0409-1761-10) NDC 00409-1761-10 — Unavailable Next Delivery: November 2026; Estimated Recovery: December 2026; Shortage per Manufacturer: Manufacturing Delay Other
Current Bupivacaine Hydrochloride, Injection, 150 mg/30 mL (5 mg/mL) (NDC 0409-1162-02) NDC 00409-1162-02 — Available — —
Current Marcaine, Injection, 75 mg/30 mL (2.5 mg/mL) (NDC 0409-7535-01) NDC 00409-7535-01 — Available — —
Current Bupivacaine Hydrochloride, Injection, 25 mg/10 mL (2.5 mg/mL) (NDC 0409-1159-01) NDC 00409-1159-01 — Available — —
Current Bupivacaine Hydrochloride, Injection, 75 mg/30 mL (2.5 mg/mL) (NDC 0409-1159-02) NDC 00409-1159-02 — Available — —
Current Marcaine, Injection, 25 mg/10 mL (2.5 mg/mL) (NDC 0409-2510-01) NDC 00409-2510-01 — Available — —
Current Bupivacaine Hydrochloride, Injection, 225 mg/30 mL (7.5 mg/mL) (NDC 0409-1165-02) NDC 00409-1165-02 — Available — —
Current Marcaine, Injection, Marcaine 75 mg/10 mL (7.5 mg/mL) (NDC 0409-1165-01) NDC 00409-1165-01 — Available — —
Current Bupivacaine Hydrochloride, Injection, 250 mg/50 mL (5 mg/mL) (NDC 0409-1163-01) NDC 00409-1163-01 — Available — —
Current Marcaine, Injection, 50 mg/10 mL (5 mg/mL) (NDC 0409-5010-01) NDC 00409-5010-01 — Available — —
Manufacturer: Huons Co., Ltd 📞 +82-2-854-4700 or via email [email protected] 1 NDC click to expand
Status NDC / product Strength Availability Related information Reason
Current Bupivacaine Hydrochloride, Injection, 7.5 mg/1 mL (NDC 73293-0002-2) NDC 73293-0002-02 — Unavailable Estimated recovery: TBD Demand increase for the drug
Manufacturer: Kindos Pharmaceuticals Co. Ltd. 📞 844-824-8426 10 NDCS click to expand
Status NDC / product Strength Availability Related information Reason
To Be Discontinued Bupivacaine Hydrochloride, Injection, 7.5 mg/1 mL (NDC 71288-728-32) NDC 71288-0728-32 — — Discontinuation of the manufacture of the drug —
Current Bupivacaine Hydrochloride, Injection, 2.5 mg/1 mL (NDC 71288-722-32) NDC 71288-0722-32 — Limited Availability Meitheal Pharmaceuticals is distributor/labeler Discontinuation of the manufacture of the drug
Current Bupivacaine Hydrochloride, Injection, 7.5 mg/1 mL (NDC 71288-728-32) NDC 71288-0728-32 — Limited Availability Meitheal Pharmaceuticals is distributor/labeler Discontinuation of the manufacture of the drug
To Be Discontinued Bupivacaine Hydrochloride, Injection, 5 mg/1 mL (NDC 71288-726-52) NDC 71288-0726-52 — — Discontinuation of the manufacture of the drug —
To Be Discontinued Bupivacaine Hydrochloride, Injection, 5 mg/1 mL (NDC 71288-725-32) NDC 71288-0725-32 — — Discontinuation of the manufacture of the drug —
To Be Discontinued Bupivacaine Hydrochloride, Injection, 2.5 mg/1 mL (NDC 71288-722-32) NDC 71288-0722-32 — — Discontinuation of the manufacture of the drug —
Current Bupivacaine Hydrochloride, Injection, 2.5 mg/1 mL (NDC 71288-723-52) NDC 71288-0723-52 — Limited Availability Meitheal Pharmaceuticals is distributor/labeler Discontinuation of the manufacture of the drug
To Be Discontinued Bupivacaine Hydrochloride, Injection, 2.5 mg/1 mL (NDC 71288-723-52) NDC 71288-0723-52 — — Discontinuation of the manufacture of the drug —
Current Bupivacaine Hydrochloride, Injection, 5 mg/1 mL (NDC 71288-726-52) NDC 71288-0726-52 — Limited Availability Meitheal Pharmaceuticals is distributor/labeler Discontinuation of the manufacture of the drug
Current Bupivacaine Hydrochloride, Injection, 5 mg/1 mL (NDC 71288-725-32) NDC 71288-0725-32 — Limited Availability Meitheal Pharmaceuticals is distributor/labeler Discontinuation of the manufacture of the drug
Manufacturer: ONESOURCE SPECIALTY PTE LTD 📞 888-217-8103 1 NDC click to expand
Status NDC / product Strength Availability Related information Reason
Current Bupivacaine Hydrochloride PRESERVATIVE FREE, Injection, 2.5 mg/1 mL 5mg / 1mL (NDC 72266-263-10) NDC 72266-0263-10 — Available Distributed by Fosun Pharma USA Inc. —
Manufacturer: Somerset Therapeutics, LLC 📞 732-554-1037 6 NDCS click to expand
Status NDC / product Strength Availability Related information Reason
Current Bupivacaine Hydrochloride, Injection, 2.5 mg/1 mL (NDC 70069-752-01) NDC 70069-0752-01 — Available — —
Current Bupivacaine Hydrochloride, Injection, 2.5 mg/1 mL (NDC 70069-752-10) NDC 70069-0752-10 — Available — —
Current Bupivacaine Hydrochloride, Injection, 5 mg/1 mL (NDC 70069-753-01) NDC 70069-0753-01 — Available — —
Current Bupivacaine Hydrochloride, Injection, 2.5 mg/1 mL (NDC 70069-752-25) NDC 70069-0752-25 — Available — —
Current Bupivacaine Hydrochloride, Injection, 5 mg/1 mL (NDC 70069-753-10) NDC 70069-0753-10 — Available — —
Current Bupivacaine Hydrochloride, Injection, 5 mg/1 mL (NDC 70069-753-25) NDC 70069-0753-25 — Available — —

These rows are manufacturer reports to the FDA for Bupivacaine Hydrochloride Injection — they do not necessarily cover every manufacturer that makes this drug. A company appears here only if it told the FDA it has a supply problem, so other makers may still have stock. That’s the basis for the Where else can I get Bupivacaine Hydrochloride Injection? options further down this page.

Why is Bupivacaine Hydrochloride Injection in shortage?

Bupivacaine hydrochloride injection is on the FDA shortage list for a few different reasons, depending on which manufacturer and product you're looking at. The biggest issue involves Kindos Pharmaceuticals (whose products are distributed by Meitheal Pharmaceuticals) — they are permanently stopping production of their 2.5 mg/mL, 5 mg/mL, and 7.5 mg/mL versions, and those are now only in limited supply with no confirmed recovery date. Fresenius Kabi's Sensorcaine 2.5 mg/mL (one specific package size) is also currently unavailable because more people need it than usual, and they haven't given a firm date for when it will be back. There's also a separate product — bupivacaine 0.75% with dextrose (7.5 mg/mL in dextrose 8.25%) — that has a factory production delay, with the next delivery expected around November 2026 and a full recovery estimated for December 2026.

It's worth knowing that several other manufacturers — including Hospira/Pfizer, Eugia, Somerset Therapeutics, and Aspiro Pharma — are reporting their versions as currently available, though some notes suggest checking with wholesalers for inventory. This shortage reflects a complicated mix of one company permanently stopping certain products, higher-than-normal demand, and a manufacturing hold-up affecting a specific formulation.

FDA reason code(s): Discontinuation of the manufacture of the drug; Demand increase for the drug; Other; Delay in shipping of the drug

Based on the manufacturer-reported reason(s) and notes on file with the FDA for Bupivacaine Hydrochloride Injection, summarized in plain English by HelloPharmacist. A drug can be short for more than one reason, and the FDA updates these as manufacturers report changes.

What should I do if I take Bupivacaine Hydrochloride Injection?

Bupivacaine Hydrochloride Injection, a local anesthetic used during procedures, is currently on the FDA shortage list. Because this is a hospital and clinic injectable, your care team usually manages its supply, but I want you to understand what the data shows.

Most strengths still have an available source. These include the common concentrations such as 2.5 mg/mL, 5 mg/mL, and 7.5 mg/mL products, along with Marcaine and Sensorcaine presentations. The one strength with no available source right now is the 0.75% 15 mg/2 mL (7.5 mg/mL) in Dextrose 8.25%, with the manufacturer reporting an estimated recovery around December 2026.

The reported reasons include some manufacturers discontinuing certain products, higher demand, and shipping delays. The reassuring part is that 7 of 8 manufacturers are still reporting available supply, so most forms remain obtainable even though this shortage has lasted over a year.

  • Do not stop, skip, or change your care plan on your own.
  • If your strength still has supply, your pharmacy or clinic can order it by checking wholesalers and other manufacturers.
  • The same medicine is made by other companies (such as Hikma, B. Braun, Camber, and Hospira); your pharmacy may be able to source one of these, though it may not be in local stock.
  • If your exact strength is discontinued or cannot be found, ask your prescriber or pharmacist about options, such as a clinician-chosen alternative.
  • Manufacturer contact numbers are listed on this page for reference; pharmacies usually handle these calls.

This is general, national information and may not match your local stock.

See “Where else can I get Bupivacaine Hydrochloride Injection?” below ↓ The same medicine from manufacturers not reporting a shortage, alternative dosage forms, and therapeutic equivalents with pricing.
If you are a patient:
  • Don’t stop or change the medication on your own — talk to your prescriber first.
  • If this is part of an ongoing or essential regimen (for example HIV treatment or prevention, seizure, heart, transplant, diabetes or mental-health medicines), do not skip or ration doses — contact your pharmacist or prescriber right away to arrange continued supply before you run out.
  • Ask your pharmacy to check other manufacturers, strengths, package sizes, and nearby stores.
  • Ask your prescriber whether a different strength, formulation, or the brand/generic version is appropriate.
Keep reading
Our full Bupivacaine guide

Uses, dosing, side effects, prices, and the complete FDA label — written in plain English and pharmacist-reviewed.

Read the Bupivacaine guide →

Where else can I get Bupivacaine Hydrochloride Injection?

FDA shortages are manufacturer-reported — a company only shows up on the shortage list if it told the FDA it has a supply problem, so not every maker of Bupivacaine Hydrochloride Injection is necessarily short. Below we pull together the other still-marketed options that are not reported in shortage: the same medicine from manufacturers that haven’t reported a problem, and alternative dosage forms. These may still be out of stock at your pharmacy, and only your prescriber or pharmacist can decide what’s right for you.

Same medicine, other manufacturers (not reported short)

Same active ingredient, dosage form & route as the shortage (matched on the FDB HICL ingredient code), from makers that have not filed a shortage with the FDA:

ProductStrengthForm / routeManufacturerNDC
Bupivacaine Hydrochloride BUPIVACAINE HYDROCHLORIDE 2.5 mg/mL Injection, Solution · Infiltration, Perineural Hikma Pharmaceuticals USA Inc. 00143-9328-10
Bupivacaine Hydrochloride BUPIVACAINE HYDROCHLORIDE 5 mg/mL Injection, Solution · Perineural Hikma Pharmaceuticals USA Inc. 00143-9329-10
Bupivacaine Hydrochloride BUPIVACAINE HYDROCHLORIDE 7.5 mg/mL Injection, Solution · Epidural, Retrobulbar Hikma Pharmaceuticals USA Inc. 00143-9332-10
Bupivacaine Hydrochloride With Dextrose BUPIVACAINE HYDROCHLORIDE 7.5 mg/mL Injection · Subarachnoid B. Braun Medical Inc. 00264-9379-88
Bupivacaine Hydrochloride BUPIVACAINE HYDROCHLORIDE 2.5 mg/mL Injection, Solution · Epidural, Infiltration, Intracaudal, Perineural Hospira, Inc. 00409-1159-10
Bupivacaine Hydrochloride BUPIVACAINE HYDROCHLORIDE 5 mg/mL Injection, Solution · Epidural, Intracaudal, Perineural Hospira, Inc. 00409-1162-10
Marcaine BUPIVACAINE HYDROCHLORIDE 150 mg/30mL Injection, Solution · Epidural, Intracaudal, Perineural Hospira, Inc. 00409-1530-25
Marcaine BUPIVACAINE HYDROCHLORIDE 7.5 mg/mL Injection, Solution · Epidural, Retrobulbar Hospira, Inc. 00409-1582-10
Marcaine BUPIVACAINE HYDROCHLORIDE 25 mg/10mL Injection, Solution · Epidural, Infiltration, Intracaudal, Perineural Hospira, Inc. 00409-2510-25
Marcaine BUPIVACAINE HYDROCHLORIDE 50 mg/10mL Injection, Solution · Epidural, Intracaudal, Perineural Hospira, Inc. 00409-5010-25
Marcaine BUPIVACAINE HYDROCHLORIDE 75 mg/30mL Injection, Solution · Epidural, Infiltration, Intracaudal, Perineural Hospira, Inc. 00409-7535-25
Bupivacaine Hydrochloride BUPIVACAINE HYDROCHLORIDE 2.5 mg/mL Injection, Solution · Epidural, Infiltration, Intracaudal, Perineural Camber Pharmaceuticals, Inc. 31722-0275-31

Alternative dosage forms of Bupivacaine Hydrochloride

A different form of the same drug (for example a solution when capsules are short). A form change is a clinical decision — ask your prescriber:

Therapeutic equivalents & pricing 30 productsclick to expand

Orange Book–rated equivalents of the affected strengths, with the latest NADAC price (a federal retail-acquisition benchmark, not your copay) and an evidence-based availability label. Cheapest first.

ProductManufacturerPackageNADAC $/unitAB ratingAvailability
Sensorcaine Mpf 5 mg/mLNDC 63323-0466-17 Fresenius 25 vials — AP FDA listed
Bupivacaine HCl 5 mg/mLNDC 70594-0117-02 Xellia 10 vials — AP FDA listed
Bupivacaine HCl 5 mg/mLNDC 70594-0118-01 Xellia 30 ml — AP FDA listed
Bupivacaine Hydrochloride 5 mg/mLNDC 76420-0561-10 Asclemed 10 ml — AP FDA listed
Bupivacaine Hydrochloride 5 mg/mLNDC 76420-0579-10 Asclemed 10 ml — AP FDA listed
Bupivacaine Hydrochloride 5 mg/mLNDC 72603-0602-25 NorthStar 25 vials — AP FDA listed
Bupivacaine Hydrochloride 5 mg/mLNDC 84549-0162-02 ProPharma 30 ml — AP FDA listed
Bupivacaine Hydrochloride 5 mg/mLNDC 31722-0276-34 Camber 25 vials — AP FDA listed
Bupivacaine Hydrochloride 5 mg/mLNDC 00143-9334-10 Hikma 10 vials — AP FDA listed
Bupivacaine Hydrochloride 5 mg/mLNDC 85766-0013-10 Sportpharm 10 ml — AP FDA listed
Bupivacaine Hydrochloride 5 mg/mLNDC 00143-9331-10 Hikma 10 vials — AP FDA listed
Bupivacaine Hydrochloride 5 mg/mLNDC 72603-0506-10 NorthStar 10 vials — AP FDA listed
bupivacaine hydrochloride 5 mg/mLNDC 71288-0725-32 Meitheal 1 vial — — Discontinued
Bupivacaine Hydrochloride 5 mg/mLNDC 00409-1162-10 Hospira, 25 vials — AP Discontinued
Sensorcaine MPF 5 mg/mLNDC 00404-9946-10 Henry 1 vial — AP FDA listed
Marcaine 5 mg/mLNDC 00404-9779-10 Henry 1 vial — AP FDA listed
Sensorcaine Mpf 2.5 mg/mLNDC 63323-0464-17 Fresenius 25 vials — AP FDA listed
Bupivacaine Hydrochloride 2.5 mg/mLNDC 72603-0415-25 NorthStar 25 vials — AP FDA listed
Bupivacaine Hydrochloride 2.5 mg/mLNDC 00143-9330-10 Hikma 10 vials — AP FDA listed
Bupivacaine Hydrochloride 2.5 mg/mLNDC 84549-0259-02 ProPharma 30 ml — AP FDA listed
Bupivacaine Hydrochloride 2.5 mg/mLNDC 31722-0275-34 Camber 25 vials — AP FDA listed
Bupivacaine Hydrochloride 2.5 mg/mLNDC 55154-6970-05 Cardinal 5 vials — AP FDA listed
bupivacaine hydrochloride 2.5 mg/mLNDC 71288-0722-32 Meitheal 1 vial — — Discontinued
Bupivacaine Hydrochloride 2.5 mg/mLNDC 83854-0004-10 Anthea 10 vials — AP FDA listed
Bupivacaine Hydrochloride 2.5 mg/mLNDC 85766-0074-01 Sportpharm 25 vials — AP FDA listed
Bupivacaine Hydrochloride 2.5 mg/mLNDC 00409-1159-10 Hospira, 25 vials — AP FDA listed
Marvona-25 SUIK 2.5 mg/mLNDC 87063-0079-01 Asclemed 1 vial — — FDA listed
Bupivacaine Hydrochloride 2.5 mg/mLNDC 00143-9333-10 Hikma 10 vials — AP FDA listed
Marcaine 2.5 mg/mLNDC 00404-9770-10 Henry 1 vial — AP FDA listed
Bupivacaine Hydrochloride 2.5 mg/mLNDC 72603-0327-10 NorthStar 10 vials — AP FDA listed

Equivalents share the same ingredient, strength, dosage form and route; an AB rating means the FDA considers them substitutable. NADAC is a national retail-pharmacy acquisition benchmark from CMS — not what you pay. Availability is inferred from recent pricing, not a stock check.

Other drugs in the same treatment class

These are different medicines — not other versions of Bupivacaine Hydrochloride Injection — that fall in the same broad treatment class (local anesthetics) . They are not automatic substitutes: they can differ in how they work, dosing, effectiveness, side effects and what they’re approved to treat. Do not switch on your own. This list is for information only — ask your prescriber or pharmacist whether any of them is appropriate for you.

Identity & classification

GCN Seq No 052194
GCN 19758
HICL code 025243
Ingredient (HICL) Bupivacaine Hcl/Pf
HIC1 code H
Therapeutic class — broad (HIC1) Nervous System (Except Autonomic)
HIC2 code H0
Therapeutic class — intermediate (HIC2) Act On Non-Autonomic Nervous System
HIC3 code H0A
Therapeutic class — specific (HIC3) Local Anesthetics
AHFS code 72:00.00.00
AHFS class Local Anesthetics
FDB label name BUPIVACAINE 0.5% 150MG/30ML VL
FDB brand name Bupivacaine Hcl
Legend status F — Federal legend — prescription drug or device
GPI-1469100010102012
Where does this data come from?
Identity codes come from First Databank (FDB) (HICL ingredient, HIC1–3 therapeutic-class hierarchy, GCN, AHFS class, legend status) and Medi-Span GPI, mapped from a representative affected NDC. Licensed reference data — for identification only.

Other anesthesia shortages

Bupivacaine Hydrochloride Injection shortage FAQs

Is Bupivacaine Hydrochloride Injection in shortage?
Yes — the FDA currently lists Bupivacaine Hydrochloride Injection in shortage (status: “Current”, first reported Feb 20, 2018). 62 of 62 products are affected. This is national, manufacturer-reported data, so your pharmacy may still have stock.
Why is Bupivacaine Hydrochloride Injection in shortage?
The manufacturer-reported reason on file with the FDA: Discontinuation of the manufacture of the drug; Demand increase for the drug; Other. Limited Supply Available. Next Delivery: May 2027; Estimated Recovery: June 2027.
Which products are affected?
Bupivacaine Hydrochloride, Injection, 5 mg/1 mL (NDC 31722-276-34) (NDC 31722-0276-34); Bupivacaine Hydrochloride, Injection, 2.5 mg/1 mL (NDC 31722-275-34) (NDC 31722-0275-34); Bupivacaine Hydrochloride, Injection, 2.5 mg/1 mL (NDC 31722-275-32) (NDC 31722-0275-32). The full per-NDC list (availability, manufacturer and status) is in the table above — each NDC links to its own page.
When will Bupivacaine Hydrochloride Injection be available again?
The manufacturer reports: Limited Supply Available. Next Delivery: May 2027; Estimated Recovery: June 2027. The FDA does not publish a single guaranteed restock date — confirm with your pharmacy.
Can I still get Bupivacaine Hydrochloride somewhere?
Other manufacturers (Hikma Pharmaceuticals USA Inc., B. Braun Medical Inc., Hospira, Inc. and others) still market it and have not reported a shortage. 6 alternative dosage forms of Bupivacaine Hydrochloride are also listed. See “Where else can I get Bupivacaine Hydrochloride Injection?” above — stock still varies by pharmacy.
What should I do if I take Bupivacaine Hydrochloride Injection?
Don’t stop or change it on your own. Ask your pharmacist whether they can order it from another manufacturer or a different strength/package size, and ask your prescriber about a long-term plan before your supply runs out.

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How to read the Supply-Risk rating
Low (1–2)Multiple manufacturers still supplying and most strengths or pack sizes sourceable.
Medium (3)Some constraint — fewer suppliers or a notable share of NDCs unavailable.
High (4–5)Down to a single source, most strengths or pack sizes unsourceable, or a long-running outage.
Where does this data come from?
Shortage records come from the FDA Drug Shortages Database API via openFDA (/drug/shortages) — drug, manufacturer & contact, NDC/product, status, availability, reason, therapeutic category and posting/update dates. Current / To Be Discontinued = active; Resolved is kept for history. The Supply-Risk rating is assessed per active ingredient and adds the FDA NDC Directory (still-marketed manufacturers by ingredient & form); same-medicine and equivalent products use First Databank classification + CMS NADAC pricing; Medicaid use + most-affected states come from CMS Medicaid State Drug Utilization Data. Reference only — confirm current status with the manufacturer or FDA before acting on it.
Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD.
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