Claritin With Advil interaction Details
In our latest question and answer, the pharmacist discusses the combined use of Claritin (loratadine) and Advil (ibuprofen)

Question
Is it ok to take Claritin with Advil?

Answered by Dr. Brian Staiger, PharmD
Medical Content Reviewed By HelloPharmacist
Staff
Last updated Apr 24, 2025
Key points
- There is no drug interaction between Claritin (loratadine) and Advil (ibuprofen). They are considered safe to take together.
There is no known interaction between Claritin, which contains the antihistamine loratadine, and Advil, which contains the NSAID (non-steroidal anti-inflammatory drug) ibuprofen. They are considered safe to take together.
Combining NSAIDs and Antihistamine
The combination of an antihistamine, like Claritin (loratadine), and an NSAID, like Advil (ibuprofen), is commonly used.
In fact, while there aren't any products on the market that contain both loratadine and ibuprofen in a single pill, there are plenty of other products that contain both an antihistamine and an NSAID. Examples of these products are:
- Advil PM (ibuprofen; diphenhydramine)
- Motrin PM (ibuprofen; diphenhydramine)
- Aleve PM (naproxen; diphenhydramine)
You don't see products containing a once-daily antihistamine, like Claritin and an NSAID together for the simple reason that antihistamines are often taken continuously to help treat and prevent both allergies. NSAIDs on the other hand, are generally only recommended to be taking intermittently, on an as needed basis.
Final Words
As talked about in the sections above, you can feel safe taking Claritin and Advil together.
Thanks so much for reaching out and please do so again anytime.
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Dr. Brian Staiger, PharmD
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