Is Amoxicillin Safe With Pepcid Dual Action Complete?

In our latest question and answer, our pharmacist discusses whether or not it is safe to combine amoxicillin with Pepcid Dual Action Complete.

2 min read Updated Jun 2026 Read by 5,405 people
Is Amoxicillin Safe With Pepcid Dual Action Complete?
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Pinky asked

Amoxicillin with Equate Dual action Acid Reducer Complete? Safety?

Sep 25, 2022
The quick answer
  • Amoxicillin is safe to take with Pepcid Dual Action Complete with no drug interactions to worry about.
  • Pepcid Dual Action Complete works by both neutralizing existing stomach acid and reducing future acid production in the stomach.
  • Amoxicillin is an antibiotic used to treat bacterial infections like ear, throat, and urinary tract infections.
A quick summary of Dr. Brian Staiger, PharmD's full answer below, condensed by AI from that answer only (not from any outside source). The pharmacist's answer is the source of record.

Answer

Thanks for reaching out! Yes, amoxicillin is safe to take with Pepcid Dual Action Complete (which is the brand name equivalent to the drug you stated in your question, Wal-Mart generic brand Equate Dual Action Complete). There is no drug interaction to be concerned about.

What Is Pepcid Dual Action Complete?

Pepcid Dual Action Complete (and Equate Dual Action Complete) contains the following drugs:

  • Famotidine
  • Calcium Carbonate
  • Magnesium Hydroxide

Famotidine is classified as an 'H2-blocker' and is the drug in the brand name product Pepcid. It works by decreasing the amount of acid made in the stomach by binding to 'H2' receptors in the stomach, which reduces overall acid secretion.

Calcium carbonate and magnesium hydroxide work as antacids and are the ingredients you find in Tums. They neutralize pre-existing stomach acid.

Together, famotidine and calcium carbonate/magnesium hydroxide work together to both neutralize stomach acid (so it works quickly) and reduces subsequent acid secretion.

Drugs that alter the acidity of the stomach can certainly interact with a number of drugs, but fortunately, amoxicillin is not one of them.

What Is Amoxicillin?

Amoxicillin is used to treat certain infections caused by bacteria, such as pneumonia; bronchitis (infection of the airway tubes leading to the lungs); and infections of the ears, nose, throat, urinary tract, and skin. It is also used in combination with other medications to eliminate H. pylori, a bacteria that causes ulcers.

Amoxicillin is in a class of medications called penicillin-like antibiotics. It works by stopping the growth of bacteria.

Pepcid Complete With Amoxicillin

As stated, there is no drug interaction between amoxicillin and Pepcid Complete (i.e. Equate Dual Action Complete). They can be taken together.

Final Words

Thanks for your question! Reach back out anytime.

References & sources
  1. Famotidine Monograph — PubChem
  2. Calcium Carbonate Monograph — PubChem
  3. Magnesium Hydroxide Monograph — PubChem
Glossary — Terms in This Answer
H2-blocker
A type of medication that reduces stomach acid production by blocking H2 receptors in the stomach.
Famotidine
An H2-blocker medication that decreases the amount of acid made in the stomach.
Antacids
Medications that neutralize stomach acid that has already been produced.
Calcium carbonate
An antacid ingredient that neutralizes existing stomach acid.
Magnesium hydroxide
An antacid ingredient that neutralizes existing stomach acid.
Amoxicillin
A penicillin-like antibiotic used to treat bacterial infections by stopping bacteria growth.
H. pylori
A type of bacteria that lives in the stomach and can cause ulcers.
Drug interaction
A situation where two medications affect each other's effectiveness or safety when taken together.
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Dr. Brian Staiger, PharmD
About the pharmacist

Dr. Brian Staiger, PharmD

Clinical Pharmacy

Doctor of Pharmacy, board certified clinical pharmacist (BCPS), American Herbalist Guild, Medication Therapy Management certified

Brian Staiger, PharmD, BCPS, is a licensed pharmacist with more than 13 years of experience across retail pharmacy, clinical pharmacy, medication safety, pharmacy program development, and healthcare administration. He is the founder of HelloPharmacist.com, where he helps patients...

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