Amobarbital
31 interactions 3 explained in plain English
Also sold as:
Amytal
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Acetaminophen And Codeine
Midazolam Nasal Spray
Levonorgestrel Intrauterine System
Butorphanol Injection
Butorphanol Nasal Spray
Nalbuphine Injection
Major
Amobarbital Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of respiratory and CNS depression Details Amobarbital Amitriptyline Elavil Explained Reduced tricyclic antidepressant exposure and possible additive adverse effects Details Amobarbital Buprenorphine Belbuca Explained An increased risk of respiratory depression and CNS depression Details Amobarbital Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Amobarbital Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Amobarbital Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Amobarbital Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Amobarbital Diazepam Nasal Spray Valtoco An increased risk of CNS and respiratory depression Details Amobarbital Diazepam Rectal Diastat An increased risk of CNS and respiratory depression Details Amobarbital Doxorubicin Adriamycin Reduced DOXOrubicin exposure Details Amobarbital Doxycycline Injection Acticlate Reduced doxycycline exposure and reduced efficacy of doxycycline Details Amobarbital Esketamine Nasal Spray Spravato Increased risk of sedation Details Amobarbital Fentanyl Transdermal Patch Duragesic® Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Amobarbital Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression Details Amobarbital Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression Details Amobarbital Lacosamide Injection Motpoly An increased risk of CNS depression Details Amobarbital Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Amobarbital Levonorgestrel After banger Reduced levonorgestrel exposure, reduced efficacy of levonorgestrel and an increased risk of breakthrough bleeding or contraceptiv... Details Amobarbital Levonorgestrel Intrauterine System Kyleena Reduced levonorgestrel exposure, reduced efficacy of levonorgestrel and an increased risk of breakthrough bleeding or contraceptiv... Details Amobarbital Metoclopramide Injection Gimoti Increased risk of CNS depression Details Amobarbital Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Amobarbital Midazolam Nasal Spray Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Amobarbital Midazolam Injection Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Amobarbital Morphine Injection Astramorph® PF Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Amobarbital Nalbuphine Injection Nubain® Increased risk of respiratory and CNS depression DetailsModerate
Amobarbital Capsaicin Arthricare for Women Moisturizing Increased or decreased effectiveness of barbiturates Details Amobarbital Capsaicin Topical Aspercreme Warming® Increased or decreased effectiveness of barbiturates Details Amobarbital Capsaicin Transdermal Patch Aspercreme Warming® Patch Increased or decreased effectiveness of barbiturates Details Amobarbital Clonidine Transdermal Patch Catapres An increased risk of sedation and somnolence Details Amobarbital Folic Acid Folacin Reduced folic acid exposure, reduced barbiturates exposure and reduced efficacy of barbiturate Details Amobarbital Ospemifene Osphena Decreased ospemifene exposure and efficacy DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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