Avanafil

113 interactions 1 explained in plain English 299 cited references
Also sold as: Stendra Stendra®
About Avanafil

Avanafil is used to treat erectile dysfunction (ED: impotence; inability to get or keep an erection in men). Avanafil is in a class of medications called phosphodiesterase (PDE) inhibitors. It works by increasing blood flow to the penis during sexual stimulation. This increased blood flow can cause an erection. Avanafi… Read the full Avanafil drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Nitroglycerin Transdermal Patch Isosorbide Mononitrate Amyl Nitrite Isosorbide Dinitrate Isosorbide Erythrityl Tetranitrate
17 Contraindicated 60 Major 36 Moderate
All (113) Contraindicated (17) Major (60) Moderate (36)

Contraindicated

Avanafil Amyl Nitrite Potentiation of hypotensive effects Details Avanafil Ensitrelvir Increased CYP3A substrates exposure and an increased risk of CYP3A substrates-related adverse effects Details Avanafil Erythrityl Tetranitrate Potentiation of hypotensive effects Details Avanafil Isosorbide Dilatrate®-SR Potentiation of hypotensive effects Details Avanafil Isosorbide Dinitrate Isochron Potentiation of hypotensive effects Details Avanafil Isosorbide Mononitrate Potentiation of hypotensive effects Details Avanafil Itraconazole Sporanox Increased avanafil exposure and an increased risk of avanafil-related adverse effects Details Avanafil Levoketoconazole Recorlev Increased CYP3A4 substrate exposure and an increased risk of sensitive CYP3A4 substrate-related adverse reaction Details Avanafil Nitroglycerin Gonitro Potentiation of hypotensive effects Details Avanafil Pentaerythritol Tetranitrate Potentiation of hypotensive effects Details Avanafil Propatyl Nitrate Potentiation of hypotensive effects Details Avanafil Riociguat Adempas Increased risk of hypotension Details Avanafil Vericiguat Verquvo Increased risk of hypotension Details Avanafil Nitroglycerin Spray Nitrolingual Potentiation of hypotensive effects Details Avanafil Nitroglycerin Sublingual Nitrostat Potentiation of hypotensive effects Details Avanafil Nitroglycerin Topical Nitro-Bid Potentiation of hypotensive effects Details Avanafil Nitroglycerin Transdermal Patch Minitran® Patch Potentiation of hypotensive effects Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.