Ethinyl Estradiol

102 interactions 3 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Isotretinoin Demeclocycline Penicillin V Potassium Bexarotene Topical Cyclosporine Injection Desonide

83 Major 19 Moderate

All (102) Major (83) Moderate (19)

Major

Ethinyl Estradiol Isotretinoin Absorica Explained Decreased effectiveness of hormonal contraceptives Details Ethinyl Estradiol Amoxicillin Amoxi Drop Reduced efficacy of oral contraceptive Details Ethinyl Estradiol Ampicillin Amcill® Decreased contraceptive effectiveness Details Ethinyl Estradiol Ampicillin Injection Omnipen-N® Decreased contraceptive effectiveness Details Ethinyl Estradiol Avapritinib Ayvakit Increased ethinyl estradiol exposure and an increased risk of ethinyl estradiol-related adverse reactions Details Ethinyl Estradiol Anagrelide Agrylin Increased anagrelide exposure Details Ethinyl Estradiol Beclomethasone Nasal Spray Beconase Increased corticosteroid exposure Details Ethinyl Estradiol Beclomethasone Oral Inhalation Beclovent® Increased corticosteroid exposure Details Ethinyl Estradiol Bexarotene Targretin Decreased contraceptive effectiveness Details Ethinyl Estradiol Bexarotene Topical Targretin Decreased contraceptive effectiveness Details Ethinyl Estradiol Budesonide Entocort Increased corticosteroid exposure Details Ethinyl Estradiol Budesonide Nasal Spray Rhinocort Increased corticosteroid exposure Details Ethinyl Estradiol Budesonide Oral Inhalation Pulmicort Increased corticosteroid exposure Details Ethinyl Estradiol Cefaclor Ceclor® Decreased contraceptive effectiveness Details Ethinyl Estradiol Cefadroxil Duricef® Decreased contraceptive effectiveness Details Ethinyl Estradiol Cefdinir Omnicef® Decreased contraceptive effectiveness Details Ethinyl Estradiol Cefixime Suprax Decreased contraceptive effectiveness Details Ethinyl Estradiol Cefprozil Cefzil® Decreased contraceptive effectiveness Details Ethinyl Estradiol Ceftazidime Injection Fortaz Decreased contraceptive effectiveness Details Ethinyl Estradiol Cefuroxime Injection Kefurox® Decreased contraceptive effectiveness Details Ethinyl Estradiol Ciclesonide Nasal Spray Omnaris Increased corticosteroid exposure Details Ethinyl Estradiol Ciclesonide Oral Inhalation Alvesco Increased corticosteroid exposure Details Ethinyl Estradiol Clobetasol Byqlovi Increased corticosteroid exposure Details Ethinyl Estradiol Clobetasol Topical Clobex® Increased corticosteroid exposure Details Ethinyl Estradiol Colesevelam Welchol Decreased contraceptive effectiveness Details Ethinyl Estradiol Cyclosporine Injection Atopica Increased cycloSPORINE exposure and an increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details Ethinyl Estradiol Cyclosporine Ophthalmic Cequa Increased cycloSPORINE exposure and an increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details Ethinyl Estradiol Deflazacort Emflaza Increased corticosteroid exposure Details Ethinyl Estradiol Demeclocycline Declomycin® Reduced ethinyl estradiol exposure, reduced efficacy of ethinyl estradiol and an increased risk of breakthrough bleeding and/or co... Details Ethinyl Estradiol Desonide Desowen Increased corticosteroid exposure Details Ethinyl Estradiol Desonide Topical Desonate® Increased corticosteroid exposure Details Ethinyl Estradiol Desoximetasone Topicort Increased corticosteroid exposure Details Ethinyl Estradiol Desoximetasone Topical Topicort Increased corticosteroid exposure Details Ethinyl Estradiol Dexamethasone Injection Decadron Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive, increased risk of breakthrough bleeding and/o... Details Ethinyl Estradiol Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive, increased risk of breakthrough bleeding and/o... Details Ethinyl Estradiol Diflorasone Topical Apexicon Increased corticosteroid exposure Details Ethinyl Estradiol Difluprednate Ophthalmic Durezol Increased corticosteroid exposure Details Ethinyl Estradiol Doxycycline Injection Acticlate Reduced efficacy of oral contraceptive Details Ethinyl Estradiol Enasidenib Idhifa Reduced hormonal contraceptive exposure and reduced efficacy of hormonal contraceptive and an increased risk of breakthrough bleed... Details Ethinyl Estradiol Encorafenib Braftovi Reduced hormonal contraceptives exposure and reduced efficacy of hormonal contraceptives Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.