Frovatriptan

21 interactions 4 explained in plain English
Also sold as: Frova
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Dihydroergotamine Nasal Spray Methylergonovine Dihydroergotamine Injection Sertraline Palonosetron Injection Lithium Carbonate
3 Contraindicated 18 Major
All (21) Contraindicated (3) Major (18)

Contraindicated

Frovatriptan Dihydroergotamine Injection DHE-45® Injection Prolonged vasospastic reactions Details Frovatriptan Dihydroergotamine Nasal Spray Migranal Prolonged vasospastic reactions Details Frovatriptan Methylergonovine Methergine Prolonged vasospastic reactions Details

Major

Frovatriptan Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of serotonin syndrome Details Frovatriptan Amitriptyline Elavil Explained Increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Frovatriptan Sertraline Explained An increased risk of serotonin syndrome Details Frovatriptan Buprenorphine Belbuca Explained An increased risk of serotonin syndrome Details Frovatriptan Butorphanol Injection Butorphic Increased risk of serotonin syndrome Details Frovatriptan Butorphanol Nasal Spray Stadol® NS Increased risk of serotonin syndrome Details Frovatriptan Dolasetron Anzemet Increased risk of serotonin syndrome Details Frovatriptan Dolasetron Injection Anzemet Increased risk of serotonin syndrome Details Frovatriptan Fentanyl Transdermal Patch Duragesic® Increased risk of serotonin syndrome Details Frovatriptan Granisetron Transdermal Patch Sancuso Increased risk of serotonin syndrome Details Frovatriptan Granisetron Injection Granisol Increased risk of serotonin syndrome Details Frovatriptan Hydromorphone Injection Dilaudid Increased risk of serotonin syndrome Details Frovatriptan Hydromorphone Rectal available generically Increased risk of serotonin syndrome Details Frovatriptan Linezolid Injection Zyvox An increased risk of serotonin syndrome Details Frovatriptan Lithium Carbonate Lithobid Increased risk of serotonin syndrome Details Frovatriptan Morphine Injection Astramorph® PF Increased risk of serotonin syndrome Details Frovatriptan Nalbuphine Injection Nubain® Increased risk of serotonin syndrome Details Frovatriptan Palonosetron Injection Aloxi® An increased risk of serotonin syndrome Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.