Furosemide Injection

241 interactions 649 cited references

Also sold as: Disal Furoscix Furoscix® Lasix Lasix® Salix - substance

About Furosemide Injection

Furosemide injection is used in adults and children who cannot take oral medications or in emergency situations to treat edema (fluid retention; excess fluid held in body tissues) caused by various medical problems, including heart failure, pulmonary edema (excess fluid in the lungs), kidney, and liver disease. Furosem… Read the full Furosemide Injection drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Methenamine Desmopressin Vonoprazan Dexibuprofen Dasabuvir Dapagliflozin

2 Contraindicated 195 Major 41 Moderate 3 Minor

All (241) Contraindicated (2) Major (195) Moderate (41) Minor (3)

Major

Furosemide Injection Lumiracoxib Reduced diuretic effectiveness and possible nephrotoxicity Details Furosemide Injection Meclofenamate Meclodium® Reduced diuretic effectiveness and possible nephrotoxicity Details Furosemide Injection Mefenamic Acid Ponstel® Reduced diuretic effectiveness and possible nephrotoxicity Details Furosemide Injection Meloxicam Alloxate Reduced diuretic effectiveness and possible nephrotoxicity Details Furosemide Injection Meperidine Demerol Reduced efficacy of diuretics Details Furosemide Injection Methadone Diskets An increased risk of electrolyte disturbances (hypokalemia, hypomagnesemia) and reduced efficacy of diuretics Details Furosemide Injection Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related toxicity, altered (increased/reduced) furosemide exposu... Details Furosemide Injection Metolazone Increased risk of electrolyte and fluid imbalance Details Furosemide Injection Miglitol Glyset® An increased risk of hyperglycemia and an increased insulin requirement Details Furosemide Injection Moexipril Univasc® An increased risk of severe hypotension and deterioration in renal function, including renal failure Details Furosemide Injection Morniflumate Reduced diuretic effectiveness and possible nephrotoxicity Details Furosemide Injection Morphine Reduced efficacy of diuretics Details Furosemide Injection Morphine Sulfate Liposome Reduced efficacy of diuretics Details Furosemide Injection Nabumetone Relafen Reduced diuretic effectiveness and possible nephrotoxicity Details Furosemide Injection Naproxen Aleve Reduced diuretic effectiveness and possible nephrotoxicity Details Furosemide Injection Nateglinide Starlix® An increased risk of hyperglycemia and an increased insulin requirement Details Furosemide Injection Neomycin Increased neomycin exposure, an increased risk of neomycin toxicity and additive ototoxicity and/or nephrotoxicity Details Furosemide Injection Nepafenac Ilevro Reduced diuretic effectiveness and possible nephrotoxicity Details Furosemide Injection Netilmicin Increased netilmicin plasma and tissue concentrations and additive ototoxicity and/or nephrotoxicity Details Furosemide Injection Niflumic Acid Reduced diuretic effectiveness and possible nephrotoxicity Details Furosemide Injection Nimesulide Reduced diuretic effectiveness and possible nephrotoxicity Details Furosemide Injection Nimesulide Beta Cyclodextrin Reduced diuretic effectiveness and possible nephrotoxicity Details Furosemide Injection Nitisinone Increased OAT1 or OAT3 substrate exposure and an increased risk of OAT1 or OAT3 substrate-related adverse effects Details Furosemide Injection Norepinephrine Decreased arterial responsiveness (vasoconstricting effect) to norepinephrine Details Furosemide Injection Oliceridine Olinvyk Reduced efficacy of diuretics Details Furosemide Injection Olmesartan Benicar Severe hypotension and deterioration in renal function, including renal failure Details Furosemide Injection Oxaprozin Coxanto Reduced diuretic effectiveness and possible nephrotoxicity Details Furosemide Injection Oxymorphone Reduced efficacy of diuretics Details Furosemide Injection Oxyphenbutazone Reduced diuretic effectiveness and possible nephrotoxicity Details Furosemide Injection Pantoprazole Protonix An increased risk of serious adverse reactions Details Furosemide Injection Parecoxib Reduced diuretic effectiveness and possible nephrotoxicity Details Furosemide Injection Paromomycin An increased risk of ototoxicity Details Furosemide Injection Perindopril Aceon An increased risk of severe hypotension and deterioration in renal function, including renal failure Details Furosemide Injection Phenylbutazone Equi-Phar Reduced diuretic effectiveness and possible nephrotoxicity Details Furosemide Injection Phenytoin Dilantin Reduced furosemide exposure Details Furosemide Injection Piketoprofen Reduced diuretic effectiveness and possible nephrotoxicity Details Furosemide Injection Pioglitazone Actos An increased risk of hyperglycemia and an increased insulin requirement Details Furosemide Injection Piroxicam Feldene Reduced diuretic effectiveness and possible nephrotoxicity Details Furosemide Injection Plazomicin An increased risk of ototoxicity Details Furosemide Injection Pramlintide Symlin An increased risk of hyperglycemia and an increased insulin requirement Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.