Furosemide Injection

241 interactions 649 cited references
Also sold as: Disal Furoscix Furoscix® Lasix Lasix® Salix - substance
About Furosemide Injection

Furosemide injection is used in adults and children who cannot take oral medications or in emergency situations to treat edema (fluid retention; excess fluid held in body tissues) caused by various medical problems, including heart failure, pulmonary edema (excess fluid in the lungs), kidney, and liver disease. Furosem… Read the full Furosemide Injection drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Methenamine Desmopressin Vonoprazan Dexibuprofen Dasabuvir Dapagliflozin
2 Contraindicated 195 Major 41 Moderate 3 Minor
All (241) Contraindicated (2) Major (195) Moderate (41) Minor (3)

Major

Furosemide Injection Probenecid Altered furosemide exposure and reduced furosemide effectiveness Details Furosemide Injection Proglumetacin Reduced diuretic effectiveness and possible nephrotoxicity Details Furosemide Injection Propyphenazone Reduced diuretic effectiveness and possible nephrotoxicity Details Furosemide Injection Proquazone Reduced diuretic effectiveness and possible nephrotoxicity Details Furosemide Injection Quinapril Accupril An increased risk of severe hypotension and deterioration in renal function, including renal failure Details Furosemide Injection Ramipril Altace An increased risk of severe hypotension and deterioration in renal function, including renal failure Details Furosemide Injection Repaglinide Prandin® An increased risk of hyperglycemia and an increased insulin requirement Details Furosemide Injection Rofecoxib Reduced diuretic effectiveness and possible nephrotoxicity Details Furosemide Injection Rosiglitazone Avandia® An increased risk of hyperglycemia and an increased insulin requirement Details Furosemide Injection Salicylic Acid An increased risk of salicylate toxicity and reduced diuretic effectiveness and possible nephrotoxicity Details Furosemide Injection Salsalate Disalcid An increased risk of salicylate toxicity and reduced diuretic effectiveness and possible nephrotoxicity Details Furosemide Injection Saxagliptin Onglyza An increased risk of hyperglycemia and an increased insulin requirement Details Furosemide Injection Sitagliptin Brynovin An increased risk of hyperglycemia and an increased insulin requirement Details Furosemide Injection Sodium Salicylate Reduced diuretic effectiveness and possible nephrotoxicity Details Furosemide Injection Sotalol Betapace An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Furosemide Injection Spirapril An increased risk of severe hypotension and deterioration in renal function, including renal failure Details Furosemide Injection Streptomycin An increased risk of ototoxicity Details Furosemide Injection Sufentanil Dsuvia Reduced efficacy of diuretics Details Furosemide Injection Sulindac Clinoril® Reduced diuretic effectiveness and possible nephrotoxicity Details Furosemide Injection Tapentadol Nucynta Reduced efficacy of diuretics Details Furosemide Injection Teicoplanin Increased risk of nephrotoxicity and/or ototoxicity Details Furosemide Injection Telmisartan Micardis Severe hypotension and deterioration in renal function, including renal failure Details Furosemide Injection Tenoxicam Reduced diuretic effectiveness and possible nephrotoxicity Details Furosemide Injection Teriflunomide Aubagio Increased exposure of OAT3 substrate Details Furosemide Injection Tiaprofenic Acid Reduced diuretic effectiveness and possible nephrotoxicity Details Furosemide Injection Tobramycin Bethkis Increased tobramycin plasma and tissue concentrations and additive ototoxicity and/or nephrotoxicity Details Furosemide Injection Tolazamide Tolinase® An increased risk of hyperglycemia and an increased insulin requirement Details Furosemide Injection Tolbutamide Orinase® An increased risk of hyperglycemia and an increased insulin requirement Details Furosemide Injection Tolfenamic Acid Reduced diuretic effectiveness and possible nephrotoxicity Details Furosemide Injection Tolmetin Tolectin 600 Reduced diuretic effectiveness and possible nephrotoxicity Details Furosemide Injection Tramadol ConZip Reduced efficacy of diuretics Details Furosemide Injection Trandolapril Mavik® An increased risk of severe hypotension and deterioration in renal function, including renal failure Details Furosemide Injection Vadadustat Vafseo Increased OAT3 substrate exposure and an increased risk of OAT3 substrate-related adverse effect Details Furosemide Injection Valdecoxib Reduced diuretic effectiveness and possible nephrotoxicity Details Furosemide Injection Valsartan Diovan Severe hypotension and deterioration in renal function, including renal failure Details Furosemide Injection Vildagliptin An increased risk of hyperglycemia and an increased insulin requirement Details Furosemide Injection Vonoprazan Voquezna An increased risk of hypomagnesemia Details

Moderate

Furosemide Injection Alfentanil Reduced efficacy of diuretics Details Furosemide Injection Aliskiren Tekturna Decreased furosemide exposure Details Furosemide Injection Asenapine Saphris An increased risk of hypotension Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.