Futibatinib

72 interactions 255 cited references

Also sold as: Lytgobi Lytgobi®

About Futibatinib

Futibatinib is used in adults who have received previous therapy to treat a certain type of cholangiocarcinoma (bile duct cancer) that has spread to nearby tissues or other parts of the body and cannot be removed by surgery. Futibatinib is in a class of medications called kinase inhibitors. It works by blocking the act… Read the full Futibatinib drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Rubella Virus Vaccine, Live Mumps Virus Vaccine, Live Measles Virus Vaccine, Live Ensitrelvir Dengue Tetravalent Vaccine, Live Bacillus Of Calmette And Guerin Vaccine, Live

10 Contraindicated 54 Major 8 Moderate

All (72) Contraindicated (10) Major (54) Moderate (8)

Contraindicated

Futibatinib Bacillus Of Calmette And Guerin Vaccine, Live An increased risk of infection by the live vaccine Details Futibatinib Dengue Tetravalent Vaccine, Live An increased risk of infection by the live vaccine Details Futibatinib Ensitrelvir Increased CYP3A/P-gp substrate exposure and an increased risk of adverse reactions Details Futibatinib Measles Virus Vaccine, Live An increased risk of infection by the live vaccine Details Futibatinib Mumps Virus Vaccine, Live An increased risk of infection by the live vaccine Details Futibatinib Rubella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Futibatinib Smallpox Monkeypox Vaccine An increased risk of infection by the live vaccine Details Futibatinib Typhoid Vaccine Typhim VI® An increased risk of infection by the live vaccine Details Futibatinib Varicella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Futibatinib Yellow Fever Vaccine Stamaril An increased risk of infection by the live vaccine Details

Major

Futibatinib Encorafenib Braftovi Reduced futibatinib exposure and reduced efficacy Details Futibatinib Adagrasib Krazati Increased futibatinib exposure and increased risk of futibatinib-related adverse reactions Details Futibatinib Adenovirus Vaccine Type 4, Live An increased risk of infection by the live vaccine Details Futibatinib Adenovirus Vaccine Type 7, Live An increased risk of infection by the live vaccine Details Futibatinib Apalutamide Erleada Reduced futibatinib exposure and reduced efficacy Details Futibatinib Avacopan Tavneos Increased CYP3A4 substrate exposure Details Futibatinib Berotralstat Orladeyo Increased P-gp substrate exposure Details Futibatinib Boceprevir Increased futibatinib exposure and increased risk of futibatinib-related adverse reactions Details Futibatinib Carbamazepine Carbatrol Reduced futibatinib exposure and reduced efficacy Details Futibatinib Ceritinib Zykadia Increased futibatinib exposure and increased risk of futibatinib-related adverse reactions Details Futibatinib Cholera Vaccine Ipol An increased risk of infection by the live vaccine Details Futibatinib Clarithromycin Biaxin Increased futibatinib exposure and increased risk of futibatinib-related adverse reactions Details Futibatinib Cobicistat Tybost Increased futibatinib exposure and increased risk of futibatinib-related adverse reactions Details Futibatinib Ebola Zaire Vaccine, Live An increased risk of infection by the live vaccine Details Futibatinib Enzalutamide Xtandi Reduced futibatinib exposure and reduced efficacy Details Futibatinib Erythromycin Erythrocin Stearate Increased CYP3A4 substrate exposure and an increased risk of CYP3A4-substrate-related adverse effects Details Futibatinib Fosphenytoin Cerebyx Reduced futibatinib exposure and reduced efficacy Details Futibatinib Idelalisib Zydelig Increased futibatinib exposure and increased risk of futibatinib-related adverse reactions Details Futibatinib Indinavir Increased futibatinib exposure and increased risk of futibatinib-related adverse reactions Details Futibatinib Influenza Virus Vaccine, Live An increased risk of infection by the live vaccine Details Futibatinib Itraconazole Sporanox Increased futibatinib exposure and increased risk of futibatinib-related adverse reactions Details Futibatinib Ivosidenib Tibsovo Reduced futibatinib exposure and reduced efficacy Details Futibatinib Ketoconazole Extina Increased futibatinib exposure and increased risk of futibatinib-related adverse reactions Details Futibatinib Lenacapavir Sunlenca Increased P-gp substrate exposure and an increased risk of P-gp substrate-related adverse reactions Details Futibatinib Letermovir Prevymis Increased CYP3A substrate exposure Details Futibatinib Lonafarnib Zokinvy Increased futibatinib exposure and increased risk of futibatinib-related adverse reactions Details Futibatinib Lumacaftor Reduced futibatinib exposure and reduced efficacy Details Futibatinib Mifepristone Korlym Increased CYP3A4 substrate exposure Details Futibatinib Mitotane Lysodren Reduced futibatinib exposure and reduced efficacy Details Futibatinib Nefazodone Increased futibatinib exposure and increased risk of futibatinib-related adverse reactions Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.