Gestodene

47 interactions 2 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Isotretinoin Nafcillin Injection Colesevelam Meropenem Injection Penicillin V Potassium Bexarotene Topical

41 Major 6 Moderate

All (47) Major (41) Moderate (6)

Major

Gestodene Isotretinoin Absorica Explained Decreased effectiveness of hormonal contraceptives Details Gestodene Amoxicillin Amoxi Drop Reduced efficacy of oral contraceptive Details Gestodene Ampicillin Amcill® Decreased contraceptive effectiveness Details Gestodene Ampicillin Injection Omnipen-N® Decreased contraceptive effectiveness Details Gestodene Bexarotene Targretin Decreased contraceptive effectiveness Details Gestodene Bexarotene Topical Targretin Decreased contraceptive effectiveness Details Gestodene Cefaclor Ceclor® Decreased contraceptive effectiveness Details Gestodene Cefadroxil Duricef® Decreased contraceptive effectiveness Details Gestodene Cefdinir Omnicef® Decreased contraceptive effectiveness Details Gestodene Cefixime Suprax Decreased contraceptive effectiveness Details Gestodene Cefprozil Cefzil® Decreased contraceptive effectiveness Details Gestodene Ceftazidime Injection Fortaz Decreased contraceptive effectiveness Details Gestodene Cefuroxime Injection Kefurox® Decreased contraceptive effectiveness Details Gestodene Colesevelam Welchol Decreased contraceptive effectiveness Details Gestodene Cyclosporine Injection Atopica Increased cycloSPORINE exposure and an increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details Gestodene Cyclosporine Ophthalmic Cequa Increased cycloSPORINE exposure and an increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details Gestodene Dexamethasone Injection Decadron Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive, increased risk of breakthrough bleeding and/o... Details Gestodene Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive, increased risk of breakthrough bleeding and/o... Details Gestodene Doxycycline Injection Acticlate Reduced efficacy of oral contraceptive Details Gestodene Enasidenib Idhifa Reduced hormonal contraceptive exposure and reduced efficacy of hormonal contraceptive and an increased risk of breakthrough bleed... Details Gestodene Encorafenib Braftovi Reduced hormonal contraceptives exposure and reduced efficacy of hormonal contraceptives Details Gestodene Exenatide Injection Bydureon Reduced oral contraceptives absorption and reduced efficacy of oral contraceptives Details Gestodene Felbamate Felbatol Decreased contraceptive effectiveness and intermenstrual bleeding Details Gestodene Finerenone Kerendia Increased finerenone exposure and an increased risk of finerenone-related adverse effects Details Gestodene Hydrocortisone Ala-Cort Altered (reduced/increased) hydrocortisone exposure, reduced efficacy of hydrocortisone and an increased risk of hydrocortisone-re... Details Gestodene Hydrocortisone Injection A-Hydrocort® Altered (reduced/increased) hydrocortisone exposure, reduced efficacy of hydrocortisone and an increased risk of hydrocortisone-re... Details Gestodene Lixisenatide Injection Adlyxin® Decreased absorption of oral contraceptives Details Gestodene Loperamide Diamode Increased loperamide exposure and an increased risk of loperamide-related adverse effects Details Gestodene Meropenem Reduced hormonal contraceptive exposure and an increased risk of contraceptive failure Details Gestodene Meropenem Injection Merrem® Reduced hormonal contraceptive exposure and an increased risk of contraceptive failure Details Gestodene Methylergonovine Methergine Increased methylergonovine exposure Details Gestodene Minocycline Amzeeq Decreased contraceptive efficacy Details Gestodene Minocycline Topical Amzeeq Decreased contraceptive efficacy Details Gestodene Mitapivat Aqvesme Reduced hormonal contraceptive exposure Details Gestodene Nafcillin Injection Unipen® Injection Reduced hormonal contraceptive exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Gestodene Nevirapine Viramune Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and increased risk of breakthrough bleeding a... Details Gestodene Nifedipine Adalat® Increased NIFEdipine exposure Details Gestodene Octreotide Bynfezia Decreased bioavailability and decreased efficacy of combined oral contraceptives or increased breakthrough bleeding Details Gestodene Octreotide Injection Bynfezia Decreased bioavailability and decreased efficacy of combined oral contraceptives or increased breakthrough bleeding Details Gestodene Penicillin G Procaine Injection Bactracillin G Decreased contraceptive effectiveness Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.