Loperamide

429 interactions 426 cited references

Also sold as: Diamode Imodium Imodium® Imodium® AD Imotil® K-Pek II® Kao-Paverin® Kaopectate 1-D® Maalox® Anti-Diarrheal Pepto® Diarrhea Control

About Loperamide

Loperamide is an antidiarrheal medication used to control acute diarrhea and reduce bowel movements. Read the full Loperamide drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Pimozide Mesoridazine Levoketoconazole Posaconazole Ketoconazole Piperaquine

16 Contraindicated 406 Major 7 Moderate

All (429) Contraindicated (16) Major (406) Moderate (7)

Contraindicated

Loperamide Ketoconazole Topical Extina® Foam Increased CYP3A4 substrate exposure and an increased risk of QT interval prolongation Details Loperamide Bepridil An increased risk of QT interval prolongation Details Loperamide Cisapride Propulsid® Increased risk of QT interval prolongation Details Loperamide Dronedarone Multaq Increased loperamide exposure, an increased risk of loperamide-related adverse effects and an increased risk of QT interval prolon... Details Loperamide Ensitrelvir Increased CYP3A/P-gp substrate exposure and an increased risk of adverse reactions Details Loperamide Ketoconazole Extina Increased CYP3A4 substrate exposure and an increased risk of QT interval prolongation Details Loperamide Levoketoconazole Recorlev An increased risk of QT interval prolongation and an increased risk of torsade de pointes Details Loperamide Mesoridazine An increased risk of QT interval prolongation Details Loperamide Pimozide An increased risk of QT interval prolongation Details Loperamide Piperaquine An increased risk of QT interval prolongation Details Loperamide Posaconazole Noxafil Increased posaconazole exposure, an increased CYP3A4 substrate exposure and an increased risk of QT interval prolongation and tors... Details Loperamide Saquinavir An increased risk of QT interval prolongation Details Loperamide Sparfloxacin An increased risk of QT interval prolongation Details Loperamide Terfenadine An increased risk of QT interval prolongation Details Loperamide Thioridazine An increased risk of QT interval prolongation Details Loperamide Ziprasidone Geodon An increased risk of QT interval prolongation Details

Major

Loperamide Amitriptyline Elavil An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Loperamide Sertraline An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Loperamide Buprenorphine Belbuca An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Loperamide Relugolix Orgovyx Increased risk of QT interval prolongation Details Loperamide Abrocitinib Cibinqo Increased loperamide exposure and an increased risk of loperamide-related adverse effects Details Loperamide Amisulpride Injection Barhemsys An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Loperamide Arsenic Trioxide Trisenox An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Loperamide Aripiprazole Injection Abilify An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Loperamide Arsenic Trioxide Injection Trisenox An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Loperamide Asciminib Scemblix Increased loperamide exposure and an increased risk of loperamide-related adverse effects Details Loperamide Asenapine Transdermal Patch Secuado An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Loperamide Azithromycin AzaSite An increased risk of QT interval prolongation, an increased risk of other ventricular arrhythmias, cardiac arrest, an increased lo... Details Loperamide Belumosudil Rezurock Increased loperamide exposure and an increased risk of loperamide-related adverse reactions Details Loperamide Bicalutamide Casodex Increased loperamide exposure and an increased risk of loperamide-related adverse reactions Details Loperamide Atorvastatin Atorvaliq An increased loperamide exposure and an increased risk of loperamide-related adverse reactions Details Loperamide Abiraterone Abirtega Increased CYP2C8 substrate exposure and an increased risk of CYP2C8 substrate-related adverse effects Details Loperamide Alfuzosin UroXatral An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Loperamide Alogliptin Nesina Increased loperamide exposure and an increased risk of loperamide-related adverse effects Details Loperamide Amlodipine Amvaz® Increased loperamide exposure and an increased risk of loperamide-related adverse reactions Details Loperamide Anagrelide Agrylin An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Loperamide Bedaquiline Sirturo An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Loperamide Brigatinib Alunbrig Increased loperamide exposure and an increased risk of loperamide-related adverse effects Details Loperamide Brodalumab Injection Siliq Increased loperamide exposure and an increased risk of loperamide-related adverse reactions Details Loperamide Canagliflozin Invokana Increased loperamide exposure and an increased risk of loperamide-related adverse effects Details

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