Loperamide

429 interactions 426 cited references
Also sold as: Diamode Imodium Imodium® Imodium® AD Imotil® K-Pek II® Kao-Paverin® Kaopectate 1-D® Maalox® Anti-Diarrheal Pepto® Diarrhea Control
About Loperamide

Loperamide is an antidiarrheal medication used to control acute diarrhea and reduce bowel movements. Read the full Loperamide drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Pimozide Mesoridazine Levoketoconazole Posaconazole Ketoconazole Piperaquine
16 Contraindicated 406 Major 7 Moderate
All (429) Contraindicated (16) Major (406) Moderate (7)

Major

Loperamide Voclosporin Lupkynis Increased loperamide exposure, an increased risk of loperamide-related adverse effects and an increased risk of QT interval prolon... Details Loperamide Vonoprazan Voquezna Increased loperamide exposure and an increased risk of loperamide-related adverse reactions Details Loperamide Vorapaxar Zontivity Increased loperamide exposure and an increased risk of loperamide-related adverse effects Details Loperamide Voriconazole Vfend Increased loperamide exposure, an increased risk of loperamide-related adverse effects and an increased risk of QT interval prolon... Details Loperamide Vorinostat Zolinza An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Loperamide Voxelotor Oxbryta Increased loperamide exposure and an increased risk of loperamide-related adverse reactions Details Loperamide Voxilaprevir Increased loperamide exposure and an increased risk of loperamide-related adverse effects Details Loperamide Zanubrutinib Brukinsa Increased loperamide exposure and an increased risk of loperamide-related adverse effects Details Loperamide Zotepine An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Loperamide Zuclopenthixol An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Loperamide Medroxyprogesterone Injection Depo-Provera Increased loperamide exposure and an increased risk of loperamide-related adverse effects Details Loperamide Metronidazole Injection Flagyl An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Loperamide Metronidazole Topical MetroCream® An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Loperamide Metronidazole Vaginal MetroGel® Vaginal An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Loperamide Moxifloxacin Injection Avelox An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Loperamide Moxifloxacin Ophthalmic Moxeza® An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Loperamide Nafarelin Nasal Spray Synarel An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Loperamide Octreotide Injection Bynfezia An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Loperamide Ofloxacin Ophthalmic Ocuflox An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Loperamide Ofloxacin Otic Floxin® Otic An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Loperamide Olodaterol Oral Inhalation Striverdi An increased risk of QT interval prolongation and an increased risk of ventricular arrhythmias Details Loperamide Oxaliplatin Injection Eloxatin® An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details

Moderate

Loperamide Kratom Increased CYP3A substrate exposure Details Loperamide Levacetylleucine Aqneursa Increased P-gp inhibitor exposure and an increased risk of P-gp substrate-related adverse reactions Details Loperamide Mavacamten Camzyos Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Loperamide Rilzabrutinib Wayrilz Increased CYP3A substrate exposure and an increased risk of CYP3A substrate-related adverse reactions Details Loperamide Sparsentan Filspari Increased P-gp substrate exposure and an increased risk of P-gp substrate-related adverse effects Details Loperamide St John's Wort Delirium with symptoms of confusion, agitation, and disorientation Details Loperamide Valerian Delirium with symptoms of confusion, agitation, and disorientation Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.