Mercaptopurine

218 interactions 390 cited references

Also sold as: Purinethol® Purixan Purixan®

About Mercaptopurine

Mercaptopurine is a purine antagonist chemotherapy drug used to treat acute lymphocytic leukemia, a cancer of the white blood cells. Read the full Mercaptopurine drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Measles Virus Vaccine, Live Mumps Virus Vaccine, Live Rubella Virus Vaccine, Live Bacillus Of Calmette And Guerin Vaccine, Live Dengue Tetravalent Vaccine, Live Febuxostat

10 Contraindicated 205 Major 3 Moderate

All (218) Contraindicated (10) Major (205) Moderate (3)

Contraindicated

Mercaptopurine Febuxostat Uloric Increased azaTHIOprine exposure and an increased risk of hepatotoxicity Details Mercaptopurine Bacillus Of Calmette And Guerin Vaccine, Live An increased risk of infection by the live vaccine Details Mercaptopurine Dengue Tetravalent Vaccine, Live An increased risk of infection by the live vaccine Details Mercaptopurine Measles Virus Vaccine, Live An increased risk of infection by the live vaccine Details Mercaptopurine Mumps Virus Vaccine, Live An increased risk of infection by the live vaccine Details Mercaptopurine Rubella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Mercaptopurine Smallpox Monkeypox Vaccine An increased risk of infection by the live vaccine Details Mercaptopurine Typhoid Vaccine Typhim VI® An increased risk of infection by the live vaccine Details Mercaptopurine Varicella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Mercaptopurine Yellow Fever Vaccine Stamaril An increased risk of infection by the live vaccine Details

Major

Mercaptopurine Abacavir Ziagen An increased risk of hepatotoxicity Details Mercaptopurine Lisinopril Prinivil Myelosuppression Details Mercaptopurine Acarbose Prandase® An increased risk of hepatotoxicity Details Mercaptopurine Acetazolamide Diamox® Sequels® An increased risk of hepatotoxicity Details Mercaptopurine Adalimumab Injection Abrilada An increased risk of hepatotoxicity Details Mercaptopurine Albendazole Albendamax An increased risk of hepatotoxicity Details Mercaptopurine Allopurinol Aloprim An increased risk of myelosuppression, an increased risk of hepatotoxicity and an azaTHIOprine toxicity (nausea, vomiting, leukope... Details Mercaptopurine Allopurinol Injection Aloprim An increased risk of myelosuppression, an increased risk of hepatotoxicity and an azaTHIOprine toxicity (nausea, vomiting, leukope... Details Mercaptopurine Ambrisentan Letairis An increased risk of hepatotoxicity Details Mercaptopurine Atovaquone Mepron An increased risk of hepatotoxicity Details Mercaptopurine Azacitidine Onureg An increased risk of hepatotoxicity Details Mercaptopurine Azathioprine Azasan Myelosuppression, impaired renal function, and hepatotoxicity Details Mercaptopurine Azithromycin AzaSite An increased risk of hepatotoxicity Details Mercaptopurine Bicalutamide Casodex An increased risk of hepatotoxicity Details Mercaptopurine Benazepril Lotensin Myelosuppression Details Mercaptopurine Azacitidine Injection Onureg An increased risk of hepatotoxicity Details Mercaptopurine Bexarotene Targretin An increased risk of hepatotoxicity Details Mercaptopurine Bexarotene Topical Targretin An increased risk of hepatotoxicity Details Mercaptopurine Bortezomib Boruzu An increased risk of hepatotoxicity Details Mercaptopurine Busulfan Injection Busulfex An increased risk of hepatotoxicity Details Mercaptopurine Captopril Capoten® An increased risk of myelosuppression and an increased risk of hepatotoxicity Details Mercaptopurine Caspofungin Injection Cancidas An increased risk of hepatotoxicity Details Mercaptopurine Cefadroxil Duricef® An increased risk of hepatotoxicity Details Mercaptopurine Cefdinir Omnicef® An increased risk of hepatotoxicity Details Mercaptopurine Clofarabine Injection Clolar An increased risk of hepatotoxicity Details Mercaptopurine Clopidogrel Plavix An increased risk of hepatotoxicity Details Mercaptopurine Cyclosporine Injection Atopica Reduced cycloSPORINE exposure and an increased risk of hepatotoxicity Details Mercaptopurine Cyclosporine Ophthalmic Cequa Reduced cycloSPORINE exposure and an increased risk of hepatotoxicity Details Mercaptopurine Dactinomycin Cosmegen An increased risk of hepatotoxicity Details Mercaptopurine Danazol Danocrine® An increased risk of hepatotoxicity Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.