Molindone

21 interactions 2 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Metoclopramide Injection Metoclopramide Nasal Spray Acetaminophen And Codeine Diazepam Rectal Levodopa Oral Inhalation Nalbuphine Injection
2 Contraindicated 18 Major 1 Moderate
All (21) Contraindicated (2) Major (18) Moderate (1)

Contraindicated

Molindone Metoclopramide Injection Gimoti An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details Molindone Metoclopramide Nasal Spray Gimoti An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details

Major

Molindone Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of respiratory and CNS depression Details Molindone Buprenorphine Belbuca Explained An increased risk of respiratory depression and CNS depression Details Molindone Cabergoline Dostinex® Reduced efficacy of cabergoline and reduced efficacy of dopamine-2 receptors Details Molindone Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Molindone Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Molindone Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Molindone Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Molindone Diazepam Nasal Spray Valtoco Increased risk of CNS depression Details Molindone Diazepam Rectal Diastat Increased risk of CNS depression Details Molindone Esketamine Nasal Spray Spravato Increased risk of sedation Details Molindone Fentanyl Transdermal Patch Duragesic® Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Molindone Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression Details Molindone Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression Details Molindone Lacosamide Injection Motpoly An increased risk of CNS depression Details Molindone Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Molindone Lithium Carbonate Lithobid Weakness, dyskinesias, increased extrapyramidal symptoms, encephalopathy, and brain damage Details Molindone Morphine Injection Astramorph® PF Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Molindone Nalbuphine Injection Nubain® Increased risk of respiratory and CNS depression Details

Moderate

Molindone Clonidine Transdermal Patch Catapres An increased risk of sedation and somnolence Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.