Nabumetone

289 interactions 346 cited references
Also sold as: Relafen Relafen®
About Nabumetone

Nabumetone is an NSAID used to relieve pain, swelling, and stiffness from osteoarthritis and rheumatoid arthritis. Read the full Nabumetone drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Ketorolac Injection Ketorolac Nasal Spray Ketorolac Ophthalmic Eptifibatide Eplerenone
4 Contraindicated 226 Major 59 Moderate
All (289) Contraindicated (4) Major (226) Moderate (59)

Contraindicated

Nabumetone Ketorolac Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Nabumetone Ketorolac Injection Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Nabumetone Ketorolac Nasal Spray Sprix Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Nabumetone Ketorolac Ophthalmic Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details

Major

Nabumetone Amitriptyline Elavil An increased risk of bleeding Details Nabumetone Sertraline An increased risk of bleeding Details Nabumetone Apixaban Eliquis An increased risk of bleeding Details Nabumetone Aspirin Acuprin® An increased risk of bleeding, decreased renal function, and an increased risk of gastrointestinal adverse events Details Nabumetone Aspirin Rectal Aspirin An increased risk of bleeding, decreased renal function, and an increased risk of gastrointestinal adverse events Details Nabumetone Betrixaban Bevyxxa® An increased risk of bleeding Details Nabumetone Anagrelide Agrylin An increased risk of bleeding Details Nabumetone Bromfenac Ophthalmic Bromday® Increased risk of bleeding Details Nabumetone Budesonide Entocort Increased risk of gastrointestinal ulcer or bleeding Details Nabumetone Budesonide Nasal Spray Rhinocort Increased risk of gastrointestinal ulcer or bleeding Details Nabumetone Budesonide Oral Inhalation Pulmicort Increased risk of gastrointestinal ulcer or bleeding Details Nabumetone Clopidogrel Plavix An increased risk of bleeding Details Nabumetone Cyclosporine Injection Atopica An increased risk of cycloSPORINE nephrotoxicity Details Nabumetone Cyclosporine Ophthalmic Cequa An increased risk of cycloSPORINE nephrotoxicity Details Nabumetone Dabigatran Pradaxa® An increased risk of bleeding Details Nabumetone Dabigatran Etexilate An increased risk of bleeding Details Nabumetone Dalteparin Injection Fragmin An increased risk of bleeding Details Nabumetone Deflazacort Emflaza Increased risk of gastrointestinal ulcer or bleeding Details Nabumetone Dexamethasone Injection Decadron Increased risk of gastrointestinal ulcer or bleeding Details Nabumetone Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Increased risk of gastrointestinal ulcer or bleeding Details Nabumetone Diclofenac Ophthalmic Voltaren® Eye Drops Increased risk of bleeding Details Nabumetone Diclofenac Topical (Actinic Keratosis) Pennsaid Increased risk of bleeding Details Nabumetone Diclofenac Topical (Arthritis Pain) Pennsaid® Increased risk of bleeding Details Nabumetone Diclofenac Transdermal Patch Flector Increased risk of bleeding Details Nabumetone Digoxin Cardoxin® Increased digoxin exposure and prolonged half-life of digoxin Details Nabumetone Dipyridamole Permole® An increased risk of bleeding Details Nabumetone Edoxaban Savaysa An increased risk of bleeding Details Nabumetone Emtricitabine Emtriva Increased emtricitabine exposure and an increased risk of emtricitabine-related adverse effects Details Nabumetone Enoxaparin Lovenox An increased risk of bleeding Details Nabumetone Enoxaparin Injection Lovenox An increased risk of bleeding Details Nabumetone Epoprostenol Flolan An increased risk of bleeding Details Nabumetone Etodolac Lodine Increased risk of bleeding Details Nabumetone Fenoprofen Fenopron Increased risk of bleeding Details Nabumetone Flurbiprofen Ansaid Increased risk of bleeding Details Nabumetone Flurbiprofen Ophthalmic Ocufen Increased risk of bleeding Details Nabumetone Fondaparinux Arixtra An increased risk of bleeding Details

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