Nitroglycerin

20 interactions 500 cited references
Also sold as: Gonitro Nitro-Bid Nitro-Dur Nitrolingual NitroMist Nitrostat Rectiv

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Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Avanafil Vardenafil Tadalafil Sildenafil Riociguat Heparin
5 Contraindicated 5 Major 10 Moderate
All (20) Contraindicated (5) Major (5) Moderate (10)

Contraindicated

Nitroglycerin Avanafil Stendra Potentiation of hypotensive effects Details Nitroglycerin Riociguat Adempas Increased risk of hypotension Details Nitroglycerin Sildenafil Liqrev Potentiation of hypotensive effects Details Nitroglycerin Tadalafil Adcirca Increased hypotensive effects of nitrates Details Nitroglycerin Vardenafil Levitra Potentiation of hypotensive effects Details

Major

Nitroglycerin Heparin A decrease in partial thromboplastin time Details Nitroglycerin Heparin Injection Lipo-Hepin® A decrease in partial thromboplastin time Details Nitroglycerin Alteplase, Recombinant Activase Less coronary artery reperfusion, longer time to reperfusion, and more coronary artery reocclusion Details Nitroglycerin Articaine An increased risk of methemoglobinemia Details Nitroglycerin Lidocaine Akten An increased risk of methemoglobinemia Details

Moderate

Nitroglycerin Acetylcysteine Acetadote Enhanced hypotension and nitroglycerin-induced headache Details Nitroglycerin Acetylcysteine Oral Inhalation Mucomyst® Enhanced hypotension and nitroglycerin-induced headache Details Nitroglycerin Aspirin Acuprin® An increase in nitroglycerin concentrations and additive platelet function depression Details Nitroglycerin Aspirin Rectal Aspirin An increase in nitroglycerin concentrations and additive platelet function depression Details Nitroglycerin Dihydroergotamine Injection DHE-45® Injection Dihydroergotamine toxicity (peripheral ischemia, paresthesias, nausea, vomiting) Details Nitroglycerin Dihydroergotamine Nasal Spray Migranal Dihydroergotamine toxicity (peripheral ischemia, paresthesias, nausea, vomiting) Details Nitroglycerin Apomorphine Apokyn An increased risk of hypotension Details Nitroglycerin Dihydroergotamine Brekiya Dihydroergotamine toxicity (peripheral ischemia, paresthesias, nausea, vomiting) Details Nitroglycerin Nitric Oxide An increased risk of methemoglobinemia Details Nitroglycerin Pancuronium An increase in pancuronium duration of action Details

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