Pentobarbital

31 interactions 3 explained in plain English
Also sold as: Fatal-Plus Nembutal Pentobarsol
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Pentobarbital Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of respiratory and CNS depression Details Pentobarbital Amitriptyline Elavil Explained Reduced tricyclic antidepressant exposure and possible additive adverse effects Details Pentobarbital Buprenorphine Belbuca Explained An increased risk of respiratory depression and CNS depression Details Pentobarbital Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Pentobarbital Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Pentobarbital Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Pentobarbital Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Pentobarbital Diazepam Nasal Spray Valtoco An increased risk of CNS and respiratory depression Details Pentobarbital Diazepam Rectal Diastat An increased risk of CNS and respiratory depression Details Pentobarbital Doxorubicin Adriamycin Reduced DOXOrubicin exposure Details Pentobarbital Doxycycline Injection Acticlate Reduced doxycycline exposure and reduced efficacy of doxycycline Details Pentobarbital Esketamine Nasal Spray Spravato Increased risk of sedation Details Pentobarbital Fentanyl Transdermal Patch Duragesic® Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Pentobarbital Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression Details Pentobarbital Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression Details Pentobarbital Lacosamide Injection Motpoly An increased risk of CNS depression Details Pentobarbital Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Pentobarbital Levonorgestrel After banger Reduced levonorgestrel exposure, reduced efficacy of levonorgestrel and an increased risk of breakthrough bleeding or contraceptiv... Details Pentobarbital Levonorgestrel Intrauterine System Kyleena Reduced levonorgestrel exposure, reduced efficacy of levonorgestrel and an increased risk of breakthrough bleeding or contraceptiv... Details Pentobarbital Metoclopramide Injection Gimoti Increased risk of CNS depression Details Pentobarbital Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Pentobarbital Midazolam Nasal Spray Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Pentobarbital Midazolam Injection Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Pentobarbital Morphine Injection Astramorph® PF Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Pentobarbital Nalbuphine Injection Nubain® Increased risk of respiratory and CNS depression Details

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