Pentobarbital
31 interactions 3 explained in plain English
Also sold as:
Fatal-Plus
Nembutal
Pentobarsol
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Fentanyl Transdermal Patch
Doxorubicin
Nalbuphine Injection
Morphine Injection
Diazepam Nasal Spray
Midazolam Nasal Spray
Major
Pentobarbital Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of respiratory and CNS depression Details Pentobarbital Amitriptyline Elavil Explained Reduced tricyclic antidepressant exposure and possible additive adverse effects Details Pentobarbital Buprenorphine Belbuca Explained An increased risk of respiratory depression and CNS depression Details Pentobarbital Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Pentobarbital Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Pentobarbital Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Pentobarbital Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Pentobarbital Diazepam Nasal Spray Valtoco An increased risk of CNS and respiratory depression Details Pentobarbital Diazepam Rectal Diastat An increased risk of CNS and respiratory depression Details Pentobarbital Doxorubicin Adriamycin Reduced DOXOrubicin exposure Details Pentobarbital Doxycycline Injection Acticlate Reduced doxycycline exposure and reduced efficacy of doxycycline Details Pentobarbital Esketamine Nasal Spray Spravato Increased risk of sedation Details Pentobarbital Fentanyl Transdermal Patch Duragesic® Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Pentobarbital Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression Details Pentobarbital Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression Details Pentobarbital Lacosamide Injection Motpoly An increased risk of CNS depression Details Pentobarbital Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Pentobarbital Levonorgestrel After banger Reduced levonorgestrel exposure, reduced efficacy of levonorgestrel and an increased risk of breakthrough bleeding or contraceptiv... Details Pentobarbital Levonorgestrel Intrauterine System Kyleena Reduced levonorgestrel exposure, reduced efficacy of levonorgestrel and an increased risk of breakthrough bleeding or contraceptiv... Details Pentobarbital Metoclopramide Injection Gimoti Increased risk of CNS depression Details Pentobarbital Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Pentobarbital Midazolam Nasal Spray Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Pentobarbital Midazolam Injection Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Pentobarbital Morphine Injection Astramorph® PF Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Pentobarbital Nalbuphine Injection Nubain® Increased risk of respiratory and CNS depression DetailsModerate
Pentobarbital Capsaicin Arthricare for Women Moisturizing Increased or decreased effectiveness of barbiturates Details Pentobarbital Capsaicin Topical Aspercreme Warming® Increased or decreased effectiveness of barbiturates Details Pentobarbital Capsaicin Transdermal Patch Aspercreme Warming® Patch Increased or decreased effectiveness of barbiturates Details Pentobarbital Clonidine Transdermal Patch Catapres An increased risk of sedation and somnolence Details Pentobarbital Folic Acid Folacin Reduced folic acid exposure and reduced efficacy of folic acid Details Pentobarbital Ospemifene Osphena Decreased ospemifene exposure and efficacy DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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