Tolcapone

Name: Tolcapone Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

7 interactions

Also sold as: Tasmar Tasmar®

About Tolcapone

Tolcapone is used in combination with levodopa and carbidopa to treat the signs and symptoms of Parkinson's disease. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. Read the full Tolcapone drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Azathioprine Linezolid Injection Mercaptopurine Methotrexate Methotrexate Injection

5 Major 2 Moderate

All (7) Major (5) Moderate (2)

Major

Tolcapone Azathioprine Azasan An increased risk of hepatotoxicity Details Tolcapone Linezolid Injection Zyvox Decreased catecholamine metabolism and increased risk of hypertensive crisis Details Tolcapone Mercaptopurine Purinethol® An increased risk of hepatotoxicity Details Tolcapone Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Tolcapone Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details

Moderate

Tolcapone Dobutamine Inhibition of DOBUTamine metabolism Details Tolcapone Methyldopa Aldomet® Inhibition of methyldopa metabolism Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.