Zolmitriptan

33 interactions 4 explained in plain English
Also sold as: Zomig
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Linezolid Injection Methylergonovine Dihydroergotamine Injection Dihydroergotamine Nasal Spray Hydromorphone Rectal Palonosetron Injection
4 Contraindicated 24 Major 5 Moderate
All (33) Contraindicated (4) Major (24) Moderate (5)

Contraindicated

Zolmitriptan Dihydroergotamine Injection DHE-45® Injection Prolonged vasospastic reactions Details Zolmitriptan Dihydroergotamine Nasal Spray Migranal Prolonged vasospastic reactions Details Zolmitriptan Linezolid Injection Zyvox An increased risk of serotonin syndrome Details Zolmitriptan Methylergonovine Methergine Prolonged vasospastic reactions Details

Major

Zolmitriptan Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of serotonin syndrome Details Zolmitriptan Amitriptyline Elavil Explained An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Zolmitriptan Sertraline Explained An increased risk of serotonin syndrome Details Zolmitriptan Buprenorphine Belbuca Explained An increased risk of serotonin syndrome Details Zolmitriptan Chloroquine Aralen® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Zolmitriptan Disopyramide Norpace An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Zolmitriptan Dofetilide Tikosyn An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Zolmitriptan Dolasetron Anzemet Increased risk of serotonin syndrome Details Zolmitriptan Dolasetron Injection Anzemet Increased risk of serotonin syndrome Details Zolmitriptan Fentanyl Transdermal Patch Duragesic® Increased risk of serotonin syndrome Details Zolmitriptan Flecainide Tambocor® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Zolmitriptan Foscarnet Injection Foscavir An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Zolmitriptan Gemifloxacin Factive An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Zolmitriptan Granisetron Transdermal Patch Sancuso Increased risk of serotonin syndrome Details Zolmitriptan Granisetron Injection Granisol Increased risk of serotonin syndrome Details Zolmitriptan Hydromorphone Injection Dilaudid Increased risk of serotonin syndrome Details Zolmitriptan Hydromorphone Rectal available generically Increased risk of serotonin syndrome Details Zolmitriptan Isradipine DynaCirc® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Zolmitriptan Lithium Carbonate Lithobid Increased risk of serotonin syndrome Details Zolmitriptan Mefloquine Lariam® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Zolmitriptan Morphine Injection Astramorph® PF Increased risk of serotonin syndrome Details Zolmitriptan Octreotide Bynfezia An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Zolmitriptan Octreotide Injection Bynfezia An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Zolmitriptan Palonosetron Injection Aloxi® An increased risk of serotonin syndrome Details

Moderate

Zolmitriptan Estradiol Delestrogen An increased risk of zolmitriptan adverse effects Details Zolmitriptan Estradiol Topical Divigel An increased risk of zolmitriptan adverse effects Details Zolmitriptan Estradiol Transdermal Patch Alora® An increased risk of zolmitriptan adverse effects Details Zolmitriptan Levonorgestrel After banger An increased risk of zolmitriptan adverse effects Details Zolmitriptan Levonorgestrel Intrauterine System Kyleena An increased risk of zolmitriptan adverse effects Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.