Drug & supplement interaction

1-androsterone + Rifapentine

Rifapentine brand name: Priftin.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between 1-androsterone and Rifapentine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Rifapentine states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

1-androsterone and Rifapentine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Rifapentine and 1-androsterone in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

1-androsterone safety at a glance

1-androsterone overall Avoid It is a hormonal compound with real health risks and little safety testing.
Pregnancy Avoid Hormone-altering prohormones should never be used during pregnancy.
Breastfeeding Avoid Avoid while breastfeeding because of unknown hormonal risks to the baby.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Rifapentine and 1-androsterone? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Rifapentine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Rifapentine is filed under 4 classifications — including cytochrome p450 2c9 (cyp2c9) inducers, cytochrome p450 3a4 (cyp3a4) inducers, antibiotic drugs. 1-androsterone has documented interactions with 1 drug class — the most serious being testosterone (moderate) — and none of Rifapentine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

1-androsterone Does Interact With Other Medications

1-androsterone has 8 moderate known drug interactions in our database — Rifapentine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 8 No known interaction 2,822 (incl. Rifapentine)
Taking anything else?

Check Another of Your Medications Against 1-androsterone

Covers the 2,830 medications we’ve checked against 1-androsterone. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests 1-androsterone and Rifapentine May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Liver problems Worth acting on Additional detail

    1-androsterone

    “There is currently a limited amount of information on the adverse effects of 1-androsterone. A thorough evaluation of safety outcomes has not been conducted.

    Most Common Adverse Effects:

    Orally: Dyslipidemia, transaminitis, renal dysfunction.”

    1-androsterone · Natural Medicines adverse-effect record, reported in dyslipidemia.

    Rifapentine

    Listed in the ADVERSE REACTIONS section of the FDA label for Rifapentine. Read the label on DailyMed ›

Reported for 1-androsterone but not commonly for Rifapentine: kidney problems.

Effects for Rifapentine come from the ADVERSE REACTIONS section of its FDA label; effects for 1-androsterone come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

How to take them

Some Rifapentine Products Have a Food Rule — 1-androsterone Should Not Break It

At least one FDA label for a product containing Rifapentine says to take it with food. If you take 1-androsterone on an empty stomach out of habit, keep them separate — and take Rifapentine with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Rifapentine products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

( 2.2 ) Take with food.

From the Dosage and Administration section of the FDA label we read for Rifapentine — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Rifapentine

This page covers 1-androsterone only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Rifapentine page lists 64 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Alkanna (moderate), Alpine Ragwort (moderate), Bacillus Coagulans (moderate) and Bacillus Subtilis (moderate).

By severity: 1 major · 53 moderate · 10 minor.

From our pharmacist’s overview on the Rifapentine page

“Rifapentine (Priftin) treats tuberculosis and is often dosed just once or twice a week, so a single blunted dose costs more than it would with a daily pill. That is why I read this list of 64 interacting supplements as a real warning rather than routine fine print.”

Reviewed by 2 · Jul 18, 2026

Open the Rifapentine interaction page

One more smart check

Taking 1-androsterone as Part of a Dietary Supplement Product? Check It for Interactions

We hold 35 real supplement products containing 1-androsterone, each one broken down to its full ingredient list — and combination products often carry several ingredients besides 1-androsterone. Even though 1-androsterone itself has no known interaction with Rifapentine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where 1-androsterone and Rifapentine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement 1-androsterone
Top half

#563 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Rifapentine
Steady interest

#2,684 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every 1-androsterone reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The 1-androsterone and Rifapentine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About 1-androsterone

What is 1-androsterone?

1-androsterone
  • Muscle building
  • Increasing strength
  • Athletic performance
  • Body recomposition

1-Androsterone (1-DHEA or 1-Andro) is a synthetic prohormone marketed to bodybuilders for muscle and strength gains, but it has not been proven safe or effective in quality human studies. It can affect hormones and may harm the liver and other organs, so most pharmacists would recommend avoiding it.

Synthetic compound (not a plant part) · Capsules, tablets, sometimes combined with other prohormones

An interaction check asks whether these two react with each other — it does not ask whether 1-androsterone is a good idea for someone in your situation. Here is what our 1-androsterone record says about it on its own.

1-androsterone: dosing

There is no established safe or standard dose for 1-androsterone, and no medical guideline supports its use. Products vary widely in strength and ingredients.Because of the health risks involved, the safest choice for most people is not to use it at all. Never combine it with other prohormones or hormone products.

From our 1-androsterone monograph — the full record covers uses, side effects and every documented interaction.

Read the full 1-androsterone monograph & all interactions
Medication

About Rifapentine

What Is Rifapentine Used For?

Brand name: Priftin

Rifapentine tablets — sold as Priftin and as rifapentine tablets — are used to treat two forms of tuberculosis caused by Mycobacterium tuberculosis. For active pulmonary TB (a live TB infection in the lungs), it is approved for adults and children 12 years and older. It must always be combined with other anti-TB drugs — never taken alone.

For latent tuberculosis infection (LTBI) — where TB bacteria are in the body but not yet causing illness — it is approved for adults and children 2 years and older who are at high risk of the infection becoming active. For LTBI, it is always taken together with isoniazid, once weekly for 12 weeks. Active TB disease must be ruled out before starting LTBI treatment.

Most-Reported Side Effects for Rifapentine

From FAERS, the FDA’s public side-effect reporting system (509 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fever 66 reports
Nausea 52 reports
Fatigue 42 reports
Hypertension 40 reports
Vomiting 40 reports
See full Rifapentine drug information
Keep checking

Other Drugs & 1-androsterone

Browse every other medication we’ve checked against 1-androsterone — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
8Moderate
0Minor
2,821No known interaction
8 Moderate 2,821 No interaction
Moderate

8 interactions

No interaction 2,821 drugs checked — show the list

We also checked 1-androsterone against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,821 medications checked with no known interaction — see the full 1-androsterone list.

See the full 1-androsterone interactions page
See every supplement checked against Rifapentine, ranked by severity
Evidence & sources

1-androsterone References

The 2 references that drive our 1-androsterone monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Parr MK, Opfermann G, Geyer H, et al. Seized designer supplement named "1-Androsterone": identification as 3ß-hydroxy-5a-androst-1-en-17-one and its urinary elimination. Steroids 2011;76(6):540-7.
  2. Granados J, Gillum TL, Christmas KM, et al. Prohormone supplement 3b-hydroxy-5a-androst-1-en-17-one enhances resistance training gains but impairs user health. J Appl Physiol (1985). 2014;116(5):560-9.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking 1-androsterone and Rifapentine Together: Common Questions

Is it safe to take 1-androsterone with Rifapentine?
We do not list a known interaction between 1-androsterone and Rifapentine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do 1-androsterone and Rifapentine have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take 1-androsterone and Rifapentine at the same time of day?
At least one FDA label for a product containing Rifapentine says to take it with food. If you take 1-androsterone on an empty stomach out of habit, keep them separate and take Rifapentine with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Rifapentine products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the 1-androsterone and Rifapentine combination checked?
Interactions in our licensed database are recorded against drug classes. Rifapentine is filed under 4 classifications, and 1-androsterone has documented interactions with 1 drug class — none of Rifapentine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does 1-androsterone interact with any other medications?
Yes. 1-androsterone has 8 documented drug interactions in our database — Rifapentine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Rifapentine interact with any supplements?
Yes. Rifapentine has documented interactions with 64 supplements in our database — 1-androsterone is not one of them. The Rifapentine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

1-androsterone monograph Uses, safety profile, and every drug interaction in one place Rifapentine drug information The full plain-English guide to this medication Rifapentine supplement interactions Every supplement checked against Rifapentine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Rifapentine and 1-androsterone?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.